TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Nenadović, Snežana
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3921
AB  - Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Investigation into liquisolid system processability based on the SeDeM Expert System approach
VL  - 605
DO  - 10.1016/j.ijpharm.2021.120847
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Nenadović, Snežana and Mirković, Miljana and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Investigation into liquisolid system processability based on the SeDeM Expert System approach",
volume = "605",
doi = "10.1016/j.ijpharm.2021.120847"
}

Vasiljević, I., Turković, E., Nenadović, S., Mirković, M., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 605.
https://doi.org/10.1016/j.ijpharm.2021.120847

Vasiljević I, Turković E, Nenadović S, Mirković M, Zimmer A, Parojčić J, Aleksić I. Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2021;605.
doi:10.1016/j.ijpharm.2021.120847 .

Vasiljević, Ivana, Turković, Erna, Nenadović, Snežana, Mirković, Miljana, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Investigation into liquisolid system processability based on the SeDeM Expert System approach" in International Journal of Pharmaceutics, 605 (2021),
https://doi.org/10.1016/j.ijpharm.2021.120847 . .

TY  - JOUR
AU  - Mladenović, Nataša
AU  - Kljajević,  Ljiljana
AU  - Nenadović, Snežana
AU  - Ivanović, Marija
AU  - Čalija, Bojan
AU  - Gulicovski, Jelena
AU  - Trivunac, Katarina
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3276
AB  - Fundamental research of inorganic polymers prepared from available aluminosilicate precursors represent an innovative class of materials characterized by low energy consumption for production. This is just one of the reasons why their use is focused in protecting the environment for removing of heavy metals from aqueous solutions. The concentration of hydroxide as activator solution plays an important role in the geopolymerization process. The present study examined the use of geopolymer materials, obtained in reaction of geopolymerizations of metakaolin as precursor activated with NaOH concentration 2.0, 4.0, 6.0 and 8.0 mol/dm3 for removal of cadmium ions from aqueous solutions. The structure and properties of the obtained geopolymer samples were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM) and diffuse reflection infrared spectroscopy (DRIFTS). To investigate the surface charge of geopolymers the zeta potential measurements were performed. Batch adsorption experiments conducted at room temperature (23 ± 1 °C) showed that the adsorption pattern followed the Freundlich isotherm model. The maximum removal of cadmium obtained from batch studies was 84.1% for GP6M at pH ≈ 6.7. The results generally showed that geopolymer samples could be considered as a potential adsorbent for cadmium removal from aqueous solutions.
PB  - Springer Nature
T2  - Journal of Inorganic and Organometallic Polymers and Materials
T1  - The Applications of New Inorganic Polymer for Adsorption Cadmium from Waste Water
VL  - 30
IS  - 2
SP  - 554
EP  - 563
DO  - 10.1007/s10904-019-01215-y
ER  - 

@article{
author = "Mladenović, Nataša and Kljajević,  Ljiljana and Nenadović, Snežana and Ivanović, Marija and Čalija, Bojan and Gulicovski, Jelena and Trivunac, Katarina",
year = "2020",
abstract = "Fundamental research of inorganic polymers prepared from available aluminosilicate precursors represent an innovative class of materials characterized by low energy consumption for production. This is just one of the reasons why their use is focused in protecting the environment for removing of heavy metals from aqueous solutions. The concentration of hydroxide as activator solution plays an important role in the geopolymerization process. The present study examined the use of geopolymer materials, obtained in reaction of geopolymerizations of metakaolin as precursor activated with NaOH concentration 2.0, 4.0, 6.0 and 8.0 mol/dm3 for removal of cadmium ions from aqueous solutions. The structure and properties of the obtained geopolymer samples were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM) and diffuse reflection infrared spectroscopy (DRIFTS). To investigate the surface charge of geopolymers the zeta potential measurements were performed. Batch adsorption experiments conducted at room temperature (23 ± 1 °C) showed that the adsorption pattern followed the Freundlich isotherm model. The maximum removal of cadmium obtained from batch studies was 84.1% for GP6M at pH ≈ 6.7. The results generally showed that geopolymer samples could be considered as a potential adsorbent for cadmium removal from aqueous solutions.",
publisher = "Springer Nature",
journal = "Journal of Inorganic and Organometallic Polymers and Materials",
title = "The Applications of New Inorganic Polymer for Adsorption Cadmium from Waste Water",
volume = "30",
number = "2",
pages = "554-563",
doi = "10.1007/s10904-019-01215-y"
}

Mladenović, N., Kljajević, L., Nenadović, S., Ivanović, M., Čalija, B., Gulicovski, J.,& Trivunac, K.. (2020). The Applications of New Inorganic Polymer for Adsorption Cadmium from Waste Water. in Journal of Inorganic and Organometallic Polymers and Materials
Springer Nature., 30(2), 554-563.
https://doi.org/10.1007/s10904-019-01215-y

Mladenović N, Kljajević L, Nenadović S, Ivanović M, Čalija B, Gulicovski J, Trivunac K. The Applications of New Inorganic Polymer for Adsorption Cadmium from Waste Water. in Journal of Inorganic and Organometallic Polymers and Materials. 2020;30(2):554-563.
doi:10.1007/s10904-019-01215-y .

Mladenović, Nataša, Kljajević,  Ljiljana, Nenadović, Snežana, Ivanović, Marija, Čalija, Bojan, Gulicovski, Jelena, Trivunac, Katarina, "The Applications of New Inorganic Polymer for Adsorption Cadmium from Waste Water" in Journal of Inorganic and Organometallic Polymers and Materials, 30, no. 2 (2020):554-563,
https://doi.org/10.1007/s10904-019-01215-y . .