TY  - CONF
AU  - Glišić, Teodora
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5337
AB  - Raspadanje tableta u gastrointestinalnim tečnostima i posledično rastvaranje lekovite supstance u korelaciji su sa kvašenjem i prodiranjem vode u tabletu, što je najčešće povezano sa fizičko-hemijskim osobinama ekscipijenasa. Pokazalo se da tečna faza prisutna u tečno-čvrstim (TČ) sistemima poboljšava njihovo kvašenje i posledično povećava bioraspoloživost. Cilj ovog rada bio je da se ispita sposobnost kvašenja TČ sistema pripremljenih sa četiri porozna nosača, korišćenjem različitih metoda ispitivanja. ..
AB  - Tablet disintegration in gastrointestinal fluids and subsequent drug dissolution correlate with
wettability and water penetration into the tablet which are usually related to the physicochemical
properties of excipients. Liquid phase present within Liquisolid (LS) system was shown to
improve wettability and consequently increase bioavailability. The aim of this study was to
examine the wetting properties of LS systems prepared with four porous carriers, by using
different testing methods. ...
PB  - Farmaceutska komora Crne Gore
PB  - Univerzitet Crne Gore, Medicinski fakultet, studijski program-farmacija
C3  - 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka
T1  - Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima
T1  - An investigation into the wetting properties of liquisolid systems with different carriers
VL  - PP-30
SP  - 140
EP  - 141
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5337
ER  - 

@conference{
author = "Glišić, Teodora and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2023",
abstract = "Raspadanje tableta u gastrointestinalnim tečnostima i posledično rastvaranje lekovite supstance u korelaciji su sa kvašenjem i prodiranjem vode u tabletu, što je najčešće povezano sa fizičko-hemijskim osobinama ekscipijenasa. Pokazalo se da tečna faza prisutna u tečno-čvrstim (TČ) sistemima poboljšava njihovo kvašenje i posledično povećava bioraspoloživost. Cilj ovog rada bio je da se ispita sposobnost kvašenja TČ sistema pripremljenih sa četiri porozna nosača, korišćenjem različitih metoda ispitivanja. .., Tablet disintegration in gastrointestinal fluids and subsequent drug dissolution correlate with
wettability and water penetration into the tablet which are usually related to the physicochemical
properties of excipients. Liquid phase present within Liquisolid (LS) system was shown to
improve wettability and consequently increase bioavailability. The aim of this study was to
examine the wetting properties of LS systems prepared with four porous carriers, by using
different testing methods. ...",
publisher = "Farmaceutska komora Crne Gore, Univerzitet Crne Gore, Medicinski fakultet, studijski program-farmacija",
journal = "4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka",
title = "Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima, An investigation into the wetting properties of liquisolid systems with different carriers",
volume = "PP-30",
pages = "140-141",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5337"
}

Glišić, T., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2023). Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima. in 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka
Farmaceutska komora Crne Gore., PP-30, 140-141.
https://hdl.handle.net/21.15107/rcub_farfar_5337

Glišić T, Vasiljević I, Parojčić J, Aleksić I. Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima. in 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka. 2023;PP-30:140-141.
https://hdl.handle.net/21.15107/rcub_farfar_5337 .

Glišić, Teodora, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima" in 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka, PP-30 (2023):140-141,
https://hdl.handle.net/21.15107/rcub_farfar_5337 .

TY  - JOUR
AU  - Glišić, Teodora
AU  - Đuriš, Jelena
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4581
AB  - The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.
PB  - MDPI
T2  - Pharmaceutics
T1  - Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers
VL  - 15
IS  - 3
SP  - 741
EP  - 761
DO  - 10.3390/pharmaceutics15030741
ER  - 

@article{
author = "Glišić, Teodora and Đuriš, Jelena and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2023",
abstract = "The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers",
volume = "15",
number = "3",
pages = "741-761",
doi = "10.3390/pharmaceutics15030741"
}

Glišić, T., Đuriš, J., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2023). Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics
MDPI., 15(3), 741-761.
https://doi.org/10.3390/pharmaceutics15030741

Glišić T, Đuriš J, Vasiljević I, Parojčić J, Aleksić I. Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics. 2023;15(3):741-761.
doi:10.3390/pharmaceutics15030741 .

Glišić, Teodora, Đuriš, Jelena, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers" in Pharmaceutics, 15, no. 3 (2023):741-761,
https://doi.org/10.3390/pharmaceutics15030741 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5319
AB  - Oralno-disperzibilne tablete (ODT) predstavljaju relativno nove čvrste farmaceutske oblike koji  se  brzo  raspadaju  u  usnoj  duplji,  bez  dodatkavode (1). Cilj ovog istraživanja bio je da se analiziraju ODT preparati dostupni na tržištu evropskih zemalja (Nemačka, SŠpanija, Slovenija, Hrvatska, Srbija). Istraživanje je zasnovano na pretrazi komercijalno dostupnih ODT-a  i  njihovog  sastava. Utvrđeno je da je u Nemačkoj dostupno 563 preparata tipa ODT (28 različitih lekovitih supstanci),  dok  je  u  Srbiji  prisutno  samo  19  ODT-a (8 različitih lekovitih supstanci). Većina ODT preparata sadrži lekovite supstance iz grupe antipsihotika (26,6–54,2%), najčešće olanzapin, što se može objasniti boljim prihvatanjem terapije. Izuzetak je SŠpanija, gde su ODT  sa  antimigrenicima  najčešće (22,3%), verovatno usled lakše primene i gutanja ODT preparata (1,2). Analizom sastava ODT-a primećeno je da se kombinacija manitol-mikrokristalna celuloza najčešće dodaje kao sredstvo za dopunjavanje (69,1%). Brza dezintegracija, kao kritično svojstvo kvaliteta ODT-a, postiže se različitim pristupima. Većina preparata (66,0%) sadrži krospovidon kao superdezintegrator. Prijatan ukus ODT obezbeđen je kombinovanjem zaslađivača i aroma. Aspartam je veoma zastupljen u preparatima (74,2%), i do devet puta češće od ostalih zaslađivača. Veća razlika među preparatima uočena je u slučaju aroma: komercijalno dostupne ODT sadržale su aromu peperminta (39,2%), pomorandže (20,6%), itd. Međutim, 17,5% ODT nije sadržalo aromu, što ukazuje da je prijatan ukus postignut pomoću sredstva za dopunjavanje i zaslađivača (npr. manitol, saharoza). Veliki broj komercijalno  dostupnih  ODT  preparata  ukazuje  na  prednosti  za  pacijente,  posebno  u  slučaju psihijatrijskih bolesti i migrene. Tipičan predstavnik ODT preparata na tržištu sadrži manitol-mikrokristalnu celulozu, krospovidon, aspartam i aromu.
AB  - Orodispersible tablets (ODTs) are relatively new solid dosage forms that disintegrate rapidly in the oral cavity, without the addition of water (1). The aim of this research was to analyze ODTs available  on  the  market  in  representative  European  countries  (Germany, Spain, Slovenia, Croatia, Serbia).  The  research  was  based  on  investigation  of  commercially  available  ODTs  and  their composition. In Germany, 563 ODT products are available (28 different active ingredients), while only 19  ODTs  are  present  in  Serbia(8 different active ingredients). The majority of ODTs contain antipsychotic  drugs  (26.6–54.2%),  particularly olanzapine,  presumably  due  to  better  patient compliance. The only exception is Spain, where antimigraine ODTs are the most frequent (22.3%), which may be attributed to easier administration and swallowing (1,2). Regarding ODT composition, the mannitol-microcrystalline cellulose combination was mostly used as a filler/diluent (69.1%). Fast disintegration, as ODT critical quality attribute, is achieved by different approaches. Crospovidone was found in the majority of formulations (66.0%). In order to ensure apleasant taste, sweeteners and flavors are combined. Aspartame was present up to nine times more than other sweeteners (74.2%). More flexibility was observed regarding flavoring and ODTs contained peppermint (39.2%), orange (20.6%), etc. However, 17.5% of products contained no flavoring, indicating that pleasant taste was achieved by fillers and sweeteners, e.g., mannitol and sucrose. The high number  of  ODTs  available on the market indicates the advantages for patients, particularly in the case of psychiatric diseases  and  migraine.  A  typical  ODT  product  contains  mannitol-microcrystalline  cellulose, crospovidone, aspartame and a flavor.
PB  - Savez farmaceutskih udruženja Srbije
C3  - Arhiv za farmaciju
T1  - Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope
T1  - An investigation into representation and composition of commercially available orodispersible tablets on the market of European countries
VL  - 73
IS  - Suppl. 4
SP  - S61
EP  - S62
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5319
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena",
year = "2023",
abstract = "Oralno-disperzibilne tablete (ODT) predstavljaju relativno nove čvrste farmaceutske oblike koji  se  brzo  raspadaju  u  usnoj  duplji,  bez  dodatkavode (1). Cilj ovog istraživanja bio je da se analiziraju ODT preparati dostupni na tržištu evropskih zemalja (Nemačka, SŠpanija, Slovenija, Hrvatska, Srbija). Istraživanje je zasnovano na pretrazi komercijalno dostupnih ODT-a  i  njihovog  sastava. Utvrđeno je da je u Nemačkoj dostupno 563 preparata tipa ODT (28 različitih lekovitih supstanci),  dok  je  u  Srbiji  prisutno  samo  19  ODT-a (8 različitih lekovitih supstanci). Većina ODT preparata sadrži lekovite supstance iz grupe antipsihotika (26,6–54,2%), najčešće olanzapin, što se može objasniti boljim prihvatanjem terapije. Izuzetak je SŠpanija, gde su ODT  sa  antimigrenicima  najčešće (22,3%), verovatno usled lakše primene i gutanja ODT preparata (1,2). Analizom sastava ODT-a primećeno je da se kombinacija manitol-mikrokristalna celuloza najčešće dodaje kao sredstvo za dopunjavanje (69,1%). Brza dezintegracija, kao kritično svojstvo kvaliteta ODT-a, postiže se različitim pristupima. Većina preparata (66,0%) sadrži krospovidon kao superdezintegrator. Prijatan ukus ODT obezbeđen je kombinovanjem zaslađivača i aroma. Aspartam je veoma zastupljen u preparatima (74,2%), i do devet puta češće od ostalih zaslađivača. Veća razlika među preparatima uočena je u slučaju aroma: komercijalno dostupne ODT sadržale su aromu peperminta (39,2%), pomorandže (20,6%), itd. Međutim, 17,5% ODT nije sadržalo aromu, što ukazuje da je prijatan ukus postignut pomoću sredstva za dopunjavanje i zaslađivača (npr. manitol, saharoza). Veliki broj komercijalno  dostupnih  ODT  preparata  ukazuje  na  prednosti  za  pacijente,  posebno  u  slučaju psihijatrijskih bolesti i migrene. Tipičan predstavnik ODT preparata na tržištu sadrži manitol-mikrokristalnu celulozu, krospovidon, aspartam i aromu., Orodispersible tablets (ODTs) are relatively new solid dosage forms that disintegrate rapidly in the oral cavity, without the addition of water (1). The aim of this research was to analyze ODTs available  on  the  market  in  representative  European  countries  (Germany, Spain, Slovenia, Croatia, Serbia).  The  research  was  based  on  investigation  of  commercially  available  ODTs  and  their composition. In Germany, 563 ODT products are available (28 different active ingredients), while only 19  ODTs  are  present  in  Serbia(8 different active ingredients). The majority of ODTs contain antipsychotic  drugs  (26.6–54.2%),  particularly olanzapine,  presumably  due  to  better  patient compliance. The only exception is Spain, where antimigraine ODTs are the most frequent (22.3%), which may be attributed to easier administration and swallowing (1,2). Regarding ODT composition, the mannitol-microcrystalline cellulose combination was mostly used as a filler/diluent (69.1%). Fast disintegration, as ODT critical quality attribute, is achieved by different approaches. Crospovidone was found in the majority of formulations (66.0%). In order to ensure apleasant taste, sweeteners and flavors are combined. Aspartame was present up to nine times more than other sweeteners (74.2%). More flexibility was observed regarding flavoring and ODTs contained peppermint (39.2%), orange (20.6%), etc. However, 17.5% of products contained no flavoring, indicating that pleasant taste was achieved by fillers and sweeteners, e.g., mannitol and sucrose. The high number  of  ODTs  available on the market indicates the advantages for patients, particularly in the case of psychiatric diseases  and  migraine.  A  typical  ODT  product  contains  mannitol-microcrystalline  cellulose, crospovidone, aspartame and a flavor.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope, An investigation into representation and composition of commercially available orodispersible tablets on the market of European countries",
volume = "73",
number = "Suppl. 4",
pages = "S61-S62",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5319"
}

Vasiljević, I., Turković, E.,& Parojčić, J.. (2023). Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije., 73(Suppl. 4), S61-S62.
https://hdl.handle.net/21.15107/rcub_farfar_5319

Vasiljević I, Turković E, Parojčić J. Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope. in Arhiv za farmaciju. 2023;73(Suppl. 4):S61-S62.
https://hdl.handle.net/21.15107/rcub_farfar_5319 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, "Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope" in Arhiv za farmaciju, 73, no. Suppl. 4 (2023):S61-S62,
https://hdl.handle.net/21.15107/rcub_farfar_5319 .

TY  - CONF
AU  - Turković, Erna
AU  - Velkoska, Elena
AU  - Nančeva, Ana Marija
AU  - Vasiljević, Ivana
AU  - Goračinova, Katerina
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5073
AB  - Semi-solid 3D printing technology has gained
increased interest in the pharmaceutical field as it enables
on-demand fabrication of personalized dosage forms.
Orodispersible films (ODFs) are good candidates for 3D
printing because of their relatively simple formulation,
flexible dosing, and suitability for administration in
different populations. The aim of this work was to
investigate the applicability of sodium carboxymethyl
cellulose and sodium alginate as film-forming agents for
3D printed ODFs incorporating amlodipine or warfarin as
selected model active pharmaceutical ingredients (API).
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing
VL  - 69
IS  - Suppl 1
SP  - 291
EP  - 292
DO  - 10.33320/maced.pharm.bull.2023.69.03.141
ER  - 

@conference{
author = "Turković, Erna and Velkoska, Elena and Nančeva, Ana Marija and Vasiljević, Ivana and Goračinova, Katerina and Parojčić, Jelena",
year = "2023",
abstract = "Semi-solid 3D printing technology has gained
increased interest in the pharmaceutical field as it enables
on-demand fabrication of personalized dosage forms.
Orodispersible films (ODFs) are good candidates for 3D
printing because of their relatively simple formulation,
flexible dosing, and suitability for administration in
different populations. The aim of this work was to
investigate the applicability of sodium carboxymethyl
cellulose and sodium alginate as film-forming agents for
3D printed ODFs incorporating amlodipine or warfarin as
selected model active pharmaceutical ingredients (API).",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing",
volume = "69",
number = "Suppl 1",
pages = "291-292",
doi = "10.33320/maced.pharm.bull.2023.69.03.141"
}

Turković, E., Velkoska, E., Nančeva, A. M., Vasiljević, I., Goračinova, K.,& Parojčić, J.. (2023). An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 291-292.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.141

Turković E, Velkoska E, Nančeva AM, Vasiljević I, Goračinova K, Parojčić J. An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):291-292.
doi:10.33320/maced.pharm.bull.2023.69.03.141 .

Turković, Erna, Velkoska, Elena, Nančeva, Ana Marija, Vasiljević, Ivana, Goračinova, Katerina, Parojčić, Jelena, "An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):291-292,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.141 . .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5064
AB  - Thin films are polymeric strips that disintegrate in the
oral cavity and consist of a film-forming agent and an
active pharmaceutical ingredient (API). Generally, thin
films disintegrate within seconds, but their composition
can be modified to allow slower disintegration and release
of the loaded API, depending on the properties of the film.
Research into various aspects of oral thin films is
progressing rapidly, but thin films are also being discussed
in the context of a broader range of other dosage forms,
such as carrier for multiparticulates or nano-based dosage
forms and for the fixed-dose combinations (Turković et al.,
2022). Large amounts of data are being generated over the
years, so integrating machine learning algorithms can be
beneficial to gain more in-depth knowledge about the thin
film properties and interactions between film constituents.
Gradient boosted tree is one of machine learning tools that
perform regression or classification by combining the
outputs from individual decision trees. This work is aimed
to explore the possibility of integrating a machine learning
approach in evaluation of experimental data obtained by
films characterization. Potential application of Gradient
boosted trees for thin films characterization based on their
disintegration properties as film critical quality attribute
was investigated.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Application of the Gradient boosted tree approach for thin film classification based on disintegration time
VL  - 69
IS  - Suppl 1
SP  - 113
EP  - 114
DO  - 10.33320/maced.pharm.bull.2023.69.03.055
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Parojčić, Jelena",
year = "2023",
abstract = "Thin films are polymeric strips that disintegrate in the
oral cavity and consist of a film-forming agent and an
active pharmaceutical ingredient (API). Generally, thin
films disintegrate within seconds, but their composition
can be modified to allow slower disintegration and release
of the loaded API, depending on the properties of the film.
Research into various aspects of oral thin films is
progressing rapidly, but thin films are also being discussed
in the context of a broader range of other dosage forms,
such as carrier for multiparticulates or nano-based dosage
forms and for the fixed-dose combinations (Turković et al.,
2022). Large amounts of data are being generated over the
years, so integrating machine learning algorithms can be
beneficial to gain more in-depth knowledge about the thin
film properties and interactions between film constituents.
Gradient boosted tree is one of machine learning tools that
perform regression or classification by combining the
outputs from individual decision trees. This work is aimed
to explore the possibility of integrating a machine learning
approach in evaluation of experimental data obtained by
films characterization. Potential application of Gradient
boosted trees for thin films characterization based on their
disintegration properties as film critical quality attribute
was investigated.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Application of the Gradient boosted tree approach for thin film classification based on disintegration time",
volume = "69",
number = "Suppl 1",
pages = "113-114",
doi = "10.33320/maced.pharm.bull.2023.69.03.055"
}

Turković, E., Vasiljević, I.,& Parojčić, J.. (2023). Application of the Gradient boosted tree approach for thin film classification based on disintegration time. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 113-114.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.055

Turković E, Vasiljević I, Parojčić J. Application of the Gradient boosted tree approach for thin film classification based on disintegration time. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):113-114.
doi:10.33320/maced.pharm.bull.2023.69.03.055 .

Turković, Erna, Vasiljević, Ivana, Parojčić, Jelena, "Application of the Gradient boosted tree approach for thin film classification based on disintegration time" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):113-114,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.055 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5052
AB  - Multiparticulate unit systems (MPUs) represent
versatile drug delivery systems which provide flexible
dosing and reproducible drug release profile (Al-Hashimi
et al., 2018). They are usually filled in capsules/sachets or
compressed into tablets, and, in order to ensure good
processability, thorough MPU characterization is required.
The aim of this work was to explore the impact of
composition and preparation method on MPU
characteristics and identify potential patterns between the
data using advanced computational analysis. ...
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Data mining implementation in multiparticulate unit systems characterization
VL  - 69
IS  - Suppl 1
SP  - 103
EP  - 104
DO  - 10.33320/maced.pharm.bull.2023.69.03.050
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena",
year = "2023",
abstract = "Multiparticulate unit systems (MPUs) represent
versatile drug delivery systems which provide flexible
dosing and reproducible drug release profile (Al-Hashimi
et al., 2018). They are usually filled in capsules/sachets or
compressed into tablets, and, in order to ensure good
processability, thorough MPU characterization is required.
The aim of this work was to explore the impact of
composition and preparation method on MPU
characteristics and identify potential patterns between the
data using advanced computational analysis. ...",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Data mining implementation in multiparticulate unit systems characterization",
volume = "69",
number = "Suppl 1",
pages = "103-104",
doi = "10.33320/maced.pharm.bull.2023.69.03.050"
}

Vasiljević, I., Turković, E.,& Parojčić, J.. (2023). Data mining implementation in multiparticulate unit systems characterization. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 103-104.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.050

Vasiljević I, Turković E, Parojčić J. Data mining implementation in multiparticulate unit systems characterization. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):103-104.
doi:10.33320/maced.pharm.bull.2023.69.03.050 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, "Data mining implementation in multiparticulate unit systems characterization" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):103-104,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.050 . .

TY  - CONF
AU  - Glišić, Teodora
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4570
AB  - Tablet disintegration in gastrointestinal fluids and the resulting increase in surface
area available for drug dissolution is one of the preconditions for achieving acceptable
bioavailability (1). Disintegrant addition shortens the disintegration time, but it can also
affect flowability and mechanical properties of liquisolid systems (2). The aim of this study
was to examine the influence of superdisintegrant type and concentration on flowability,
tensile strength and disintegration time of liquisolid systems prepared using three different
carriers.
The admixtures were prepared in a fluid bed processor. Syloid ® XDP3050, Neusilin®
US2 and Fujicalin ® were used as carriers, with liquid phase (macrogol 400) content of
40.4%, 54.8% and 14.8%, respectively, and carrier to coating material (colloidal silicon
dioxide) ratio R=30. Superdisintegrant (croscarmellose sodium, crospovidone, sodium starch
glycolate) concentration ranged from 2 to 5%. Admixtures’ flowability and compacts’ tensile
strength and disintegration time were determined. Admixtures with Fujicalin® showed the
best flowability. Superdisintegrant addition decreased flowability, except for Syloid®
XDP3050 admixtures where flowability improved with increase in disintegrant
concentration. Sodium starch glycolate had the most pronounced influence on the compact
tensile strength. Regardless of the carrier used, the increase in its concentration led to
decrease in tensile strength. Notable differences in the disintegration time were observed,
depending on the type of carrier and superdisintegrant. Compacts with Fujicalin®
disintegrated within the required time without the superdisintegrant addition. The shortest
disintegration time, for compacts with Syloid ® XDP3050 and Neusilin® US2, as well as the
highest tensile strength, for compacts with Syloid ® XDP3050, were achieved with
croscarmellose sodium.
AB  - Raspadanje tablete u kontaktu sa gastrointestinalnim tečnostima i posledično
povećanje površine dostupne za rastvaranje lekovite supstance jedan je od preduslova za
postizanje željene biološke raspoloživosti (1). Dodatak dezintegratora u tečno-čvrste
formulacije skraćuje vreme raspadanja, ali može uticati na protočna i mehanička svojstva
pripremljenih smeša, odnosno tableta (2). Cilj ovog istraživanja bio je ispitati uticaj vrste i
koncentracije tri tipa superdezintegratora na protočnost, zateznu čvrstinu i raspadljivost
tečno-čvrstih sistema pripremljenih upotrebom tri različita nosača. Smeše su pripremljene u
uređaju tipa fluidizirajućeg sistema. Syloid ® XDP3050, Neusilin® US2 i Fujicalin® su korišćeni
kao nosači, uz udeo tečne faze (makrogol 400) od 40,4%, 54,8% i 14,8%, redom, pri odnosu
nosača i sredstva za oblaganje (koloidni silicijum-dioksid) R=30. Udeo superdezintegratora
(kroskarmeloza-natrijum, krospovidon, natrijum-skrobglikolat) variran je u opsegu 2-5%.
Ispitana je protočnost, a nakon komprimovanja na ekscentar tablet mašini, kompaktima
određene zatezna čvrstina i raspadljivost. Najbolja protočnost primećena je kod smeša sa
Fujicalin®‐om. Dodatak superdezintegratora je snižavao protočnost, osim kod smeša sa
Syloid ® XDP3050 gde se povećanjem koncentracije superdezintegratora protočnost
poboljšavala. Najizraženiji uticaj na zateznu čvrstinu kompakata, bez obzira na vrstu nosača,
pokazao je natrijum-skrobglikolat. Povećanje udela ovog superdezintegratora dovelo je do
sniženja zatezne čvrstine kod ispitivanih kompakata. Uočene su znatne razlike u vremenu
raspadanja kompakata u zavisnosti od vrste nosača i superdezintegratora, a kompakti sa
Fujicalin®‐om su se raspadali za predviđeno vreme i bez dodatka superdezintegratora.
Kroskarmeloza-natrijum je superdezintegrator sa kojim je postignuto najkraće vreme
raspadanja tečno-čvrstih kompakata sa nosačima Syloid ® XDP3050 i Neusilin® US2, kao i
najveća zatezna čvrstina za kompakte sa Syloid ® XDP3050.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers
T1  - Ispitivanje uticaja vrste superdezintegratora na svojstva tečno‐ čvrstih sistema sa različitim nosačima
VL  - 72
IS  - 4 suplement
SP  - S402
EP  - S403
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4570
ER  - 

@conference{
author = "Glišić, Teodora and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2022",
abstract = "Tablet disintegration in gastrointestinal fluids and the resulting increase in surface
area available for drug dissolution is one of the preconditions for achieving acceptable
bioavailability (1). Disintegrant addition shortens the disintegration time, but it can also
affect flowability and mechanical properties of liquisolid systems (2). The aim of this study
was to examine the influence of superdisintegrant type and concentration on flowability,
tensile strength and disintegration time of liquisolid systems prepared using three different
carriers.
The admixtures were prepared in a fluid bed processor. Syloid ® XDP3050, Neusilin®
US2 and Fujicalin ® were used as carriers, with liquid phase (macrogol 400) content of
40.4%, 54.8% and 14.8%, respectively, and carrier to coating material (colloidal silicon
dioxide) ratio R=30. Superdisintegrant (croscarmellose sodium, crospovidone, sodium starch
glycolate) concentration ranged from 2 to 5%. Admixtures’ flowability and compacts’ tensile
strength and disintegration time were determined. Admixtures with Fujicalin® showed the
best flowability. Superdisintegrant addition decreased flowability, except for Syloid®
XDP3050 admixtures where flowability improved with increase in disintegrant
concentration. Sodium starch glycolate had the most pronounced influence on the compact
tensile strength. Regardless of the carrier used, the increase in its concentration led to
decrease in tensile strength. Notable differences in the disintegration time were observed,
depending on the type of carrier and superdisintegrant. Compacts with Fujicalin®
disintegrated within the required time without the superdisintegrant addition. The shortest
disintegration time, for compacts with Syloid ® XDP3050 and Neusilin® US2, as well as the
highest tensile strength, for compacts with Syloid ® XDP3050, were achieved with
croscarmellose sodium., Raspadanje tablete u kontaktu sa gastrointestinalnim tečnostima i posledično
povećanje površine dostupne za rastvaranje lekovite supstance jedan je od preduslova za
postizanje željene biološke raspoloživosti (1). Dodatak dezintegratora u tečno-čvrste
formulacije skraćuje vreme raspadanja, ali može uticati na protočna i mehanička svojstva
pripremljenih smeša, odnosno tableta (2). Cilj ovog istraživanja bio je ispitati uticaj vrste i
koncentracije tri tipa superdezintegratora na protočnost, zateznu čvrstinu i raspadljivost
tečno-čvrstih sistema pripremljenih upotrebom tri različita nosača. Smeše su pripremljene u
uređaju tipa fluidizirajućeg sistema. Syloid ® XDP3050, Neusilin® US2 i Fujicalin® su korišćeni
kao nosači, uz udeo tečne faze (makrogol 400) od 40,4%, 54,8% i 14,8%, redom, pri odnosu
nosača i sredstva za oblaganje (koloidni silicijum-dioksid) R=30. Udeo superdezintegratora
(kroskarmeloza-natrijum, krospovidon, natrijum-skrobglikolat) variran je u opsegu 2-5%.
Ispitana je protočnost, a nakon komprimovanja na ekscentar tablet mašini, kompaktima
određene zatezna čvrstina i raspadljivost. Najbolja protočnost primećena je kod smeša sa
Fujicalin®‐om. Dodatak superdezintegratora je snižavao protočnost, osim kod smeša sa
Syloid ® XDP3050 gde se povećanjem koncentracije superdezintegratora protočnost
poboljšavala. Najizraženiji uticaj na zateznu čvrstinu kompakata, bez obzira na vrstu nosača,
pokazao je natrijum-skrobglikolat. Povećanje udela ovog superdezintegratora dovelo je do
sniženja zatezne čvrstine kod ispitivanih kompakata. Uočene su znatne razlike u vremenu
raspadanja kompakata u zavisnosti od vrste nosača i superdezintegratora, a kompakti sa
Fujicalin®‐om su se raspadali za predviđeno vreme i bez dodatka superdezintegratora.
Kroskarmeloza-natrijum je superdezintegrator sa kojim je postignuto najkraće vreme
raspadanja tečno-čvrstih kompakata sa nosačima Syloid ® XDP3050 i Neusilin® US2, kao i
najveća zatezna čvrstina za kompakte sa Syloid ® XDP3050.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers, Ispitivanje uticaja vrste superdezintegratora na svojstva tečno‐ čvrstih sistema sa različitim nosačima",
volume = "72",
number = "4 suplement",
pages = "S402-S403",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4570"
}

Glišić, T., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2022). An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S402-S403.
https://hdl.handle.net/21.15107/rcub_farfar_4570

Glišić T, Vasiljević I, Parojčić J, Aleksić I. An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers. in Arhiv za farmaciju. 2022;72(4 suplement):S402-S403.
https://hdl.handle.net/21.15107/rcub_farfar_4570 .

Glišić, Teodora, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S402-S403,
https://hdl.handle.net/21.15107/rcub_farfar_4570 .

TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4336
AB  - Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.
PB  - Elsevier B.V.
T2  - Journal of Drug Delivery Science and Technology
T1  - Orodispersible films — Pharmaceutical development for improved performance: A review
VL  - 75
DO  - 10.1016/j.jddst.2022.103708
ER  - 

@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Parojčić, Jelena",
year = "2022",
abstract = "Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.",
publisher = "Elsevier B.V.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Orodispersible films — Pharmaceutical development for improved performance: A review",
volume = "75",
doi = "10.1016/j.jddst.2022.103708"
}

Turković, E., Vasiljević, I., Drašković, M.,& Parojčić, J.. (2022). Orodispersible films — Pharmaceutical development for improved performance: A review. in Journal of Drug Delivery Science and Technology
Elsevier B.V.., 75.
https://doi.org/10.1016/j.jddst.2022.103708

Turković E, Vasiljević I, Drašković M, Parojčić J. Orodispersible films — Pharmaceutical development for improved performance: A review. in Journal of Drug Delivery Science and Technology. 2022;75.
doi:10.1016/j.jddst.2022.103708 .

Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Parojčić, Jelena, "Orodispersible films — Pharmaceutical development for improved performance: A review" in Journal of Drug Delivery Science and Technology, 75 (2022),
https://doi.org/10.1016/j.jddst.2022.103708 . .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Piller, Michael
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4318
AB  - 3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), using different polymers, and investigate their processability based on the SeDeM Expert System approach. MPUs (1- or 2-mm size) were prepared with model drug (ibuprofen or caffeine), polymer (poly(ethylene)oxide (PEO), ethyl cellulose (EC) or methacrylic acid-ethyl acrylate copolymer (MA-EA)) and printing aid. Comprehensive sample characterization was performed and experimentally obtained parameters were mathematically transformed and evaluated using the SeDeM Expert System framework. The obtained samples exhibited irregular shape, despite the spherical printing object design. Polymer incorporated notably affected MPUs properties. The obtained samples exhibited low bulk density, good flowability-, as well as stability-related parameters, which indicated their suitability for filling into capsules or sachets. Low density values implied that compressibility enhancing excipients may be required for MPUs incorporation in tablets. Samples containing EC and MA-EA were found suitable for compression, due to high compacts tensile strength. The obtained results indicate that SeDeM Expert System may extended from powder compressibility evaluation tool to framework facilitating powders/multiparticulate units processing.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach
VL  - 629
DO  - 10.1016/j.ijpharm.2022.122337
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Piller, Michael and Mirković, Miljana and Zimmer, Andreas and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), using different polymers, and investigate their processability based on the SeDeM Expert System approach. MPUs (1- or 2-mm size) were prepared with model drug (ibuprofen or caffeine), polymer (poly(ethylene)oxide (PEO), ethyl cellulose (EC) or methacrylic acid-ethyl acrylate copolymer (MA-EA)) and printing aid. Comprehensive sample characterization was performed and experimentally obtained parameters were mathematically transformed and evaluated using the SeDeM Expert System framework. The obtained samples exhibited irregular shape, despite the spherical printing object design. Polymer incorporated notably affected MPUs properties. The obtained samples exhibited low bulk density, good flowability-, as well as stability-related parameters, which indicated their suitability for filling into capsules or sachets. Low density values implied that compressibility enhancing excipients may be required for MPUs incorporation in tablets. Samples containing EC and MA-EA were found suitable for compression, due to high compacts tensile strength. The obtained results indicate that SeDeM Expert System may extended from powder compressibility evaluation tool to framework facilitating powders/multiparticulate units processing.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach",
volume = "629",
doi = "10.1016/j.ijpharm.2022.122337"
}

Vasiljević, I., Turković, E., Piller, M., Mirković, M., Zimmer, A., Aleksić, I., Ibrić, S.,& Parojčić, J.. (2022). Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 629.
https://doi.org/10.1016/j.ijpharm.2022.122337

Vasiljević I, Turković E, Piller M, Mirković M, Zimmer A, Aleksić I, Ibrić S, Parojčić J. Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2022;629.
doi:10.1016/j.ijpharm.2022.122337 .

Vasiljević, Ivana, Turković, Erna, Piller, Michael, Mirković, Miljana, Zimmer, Andreas, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, "Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach" in International Journal of Pharmaceutics, 629 (2022),
https://doi.org/10.1016/j.ijpharm.2022.122337 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5317
AB  - Additive manufacturing represents an emerging shift in the
pharmaceutical research, due to the opportunity for dosage
form individualization to the patient’s needs. Selective laser
sintering (SLS) is a novel 3D printing technology recently
introduced as the drug preparation method (1). Its potential
in the different dosage forms preparation, mainly tablets,
e.g. orodispersible tablets, was described in the literature
(2). However, the attempts in 3D printing of
multiparticulate dosage forms are scarce (3) and no SLS
printed granules were described in the literature.
The aim of this work was to prepare granules by SLS
printing and investigate the effect of formulation factors
(polymer type, model drug and particle size) on the critical
quality attributes of the obtained granules. ...
C3  - 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands
T1  - An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5317
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "Additive manufacturing represents an emerging shift in the
pharmaceutical research, due to the opportunity for dosage
form individualization to the patient’s needs. Selective laser
sintering (SLS) is a novel 3D printing technology recently
introduced as the drug preparation method (1). Its potential
in the different dosage forms preparation, mainly tablets,
e.g. orodispersible tablets, was described in the literature
(2). However, the attempts in 3D printing of
multiparticulate dosage forms are scarce (3) and no SLS
printed granules were described in the literature.
The aim of this work was to prepare granules by SLS
printing and investigate the effect of formulation factors
(polymer type, model drug and particle size) on the critical
quality attributes of the obtained granules. ...",
journal = "13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands",
title = "An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5317"
}

Vasiljević, I., Turković, E., Aleksić, I., Ibrić, S.,& Parojčić, J.. (2022). An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering. in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands.
https://hdl.handle.net/21.15107/rcub_farfar_5317

Vasiljević I, Turković E, Aleksić I, Ibrić S, Parojčić J. An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering. in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands. 2022;.
https://hdl.handle.net/21.15107/rcub_farfar_5317 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, "An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering" in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands (2022),
https://hdl.handle.net/21.15107/rcub_farfar_5317 .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Vasiljević, Dragana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4758
AB  - 1. INTRODUCTION
Orodispersible films (ODF) have emerged as innovative dosage forms that provide wide variety of advantages for patients and manufacturers over conventional dosage forms. The prominent characteristic of ODFs is fast disintegration followed by good patients acceptability [1]. Therefore, relevant disintegration time (DT) is usually considered as ODF critical quality attribute. Extensive research on ODFs is generating a lot of data, but lack of standardization is the main obstacle that limits their comparative evaluation. The following work aims to explore literature data on ODFs characteristics using the predictive data-classification algorithm Support vector machine (SVM) and assess its applicability in pharmaceutical development based on the set of experimentally obtained data.
2. MATERIALS AND METHODS
2.1. Materials
Hydroxypropyl cellulose (Klucel GF, Ashland, USA), ethanol (≥99.8%, Honeywell, Charlotte, NC, USA) and glycerol, 85% (w/w) (Ph. Eur.) were used for preparation of printing and casting dispersion.
2.2. Data pre-processing
Comprehensive data exploration has been conducted in the PubMed database using most common synonyms for ODFs with fifteen synonyms in singular and plural. Built database had following attributes: manufacturing approach, polymer selection, polymer molecular weight (KDa), polymer load (%), mechanical properties (tensile strength (MPa), Young's modulus (MPa), elongation at break (%)), disintegration method and disintegration time (DT) (s).
2.3. ODF preparation and characterisation
Polymer dispersions for solvent casting and semi-solid extrusion 3D printing were prepared by dispersing HPC in ethanol:glicerol solution followed by continuous stirring on the magnetic stirrer. Prepared dispersions were: (i) casted on a unit-dose plexiglas plates, or (ii) printed using Ultimaker 2+ (Ultimaker, , Netherlands). ODFs were characterized in terms of mechanical properties using Z-LX Table-Top Testing Machine (Shimadzu, Japan) and DT using adapted compendial tester (Erweka ZT52, Germany) with a weight.
3. RESULTS AND DISCUSSION
3.1. Data pre-processing
274 papers (without reviews) were identified via search, of which 112 were included in the database. Nominal data from literature was transformed into numerical, using coding operator so that each nominal data had corresponding numerical value. Critical attributes for films fast disintegration were derived. 18 polymers were included as categorical data and were further differentiated on the basis of molecular weight. Values for most commonly evaluated mechanical properties were included as numerical data. Different DT methods were classified in seven classes (Table 1), while the manufacturing methods were classified in five classes. RapidMiner Studio 9.10 (RapidMiner, Dortmund, Germany) was used to transform data and employ SMV algorithm.
3.2. SVM model prediction
Attributes with the highest weight were polymer load and DT method employed (Figure 1). The polymer type and characteristic did have conclusive effects on DT as their weight varied during data mining. This can be attributed to inconclusive data provided in papers and lot of missing values for those attributes. Mechanical properties had low weight, which can be explained with the broad value range for those attributes. Different research groups had different approach to disintegration testing, which lowered model precision as it was reported that SVM does not have high accuracy when data is imbalanced [3]. Relative error value was 20%, which can be considered as high, but, having in mind great diversity in presented data and methodology, obtained value is still acceptable for the pilot study.
3.3. Experimental validation
HPC-based films prepared by 3D printing had tensile strength, elongation at break and Young’s modulus of 3.5 MPa, 137% and 5 MPa, respectively. Average DT was 69 s. For casted films, relevant values were 3.4 MPa, 105% and 3 MPa, and DT was 27 s. Experimentally obtained results were entered into model simulator (Figure 2) to simulate situation reflecting the experimental set up in which HPC-based films were prepared by 3D printing and solvent casting, and relevant attribute values obtained by samples characterization. In the case were manufacturing method was set to be 3D printing (coded as 1) predicted DT value was close to experimentally obtained value, i.e. 71.7 and 69 s, respectively. When solvent casting method was considered, predicted DT value was remarkedly higher than the experimentally obtained one, indicating bad predictability. It might be assumed that good predictability obtained in the case of 3D printed films is associated with lower data variability due to more simple sample composition and robust preparation method. In the case of casted films, data was much more complex due to a higher number of research papers and approaches to characterisation.
4. CONCLUSION
The obtained results indicate that SVM algorithm can be employed to predict ODF DT value based on the dataset created using literature data. However, in order to obtain meaningful predictions, larger dataset, with fewer inconsistences and less missing values would be advantageous.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - Application of support vector machine learning for orodispersible films disintegration time prediction
SP  - 239
EP  - 240
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4758
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Vasiljević, Dragana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "1. INTRODUCTION
Orodispersible films (ODF) have emerged as innovative dosage forms that provide wide variety of advantages for patients and manufacturers over conventional dosage forms. The prominent characteristic of ODFs is fast disintegration followed by good patients acceptability [1]. Therefore, relevant disintegration time (DT) is usually considered as ODF critical quality attribute. Extensive research on ODFs is generating a lot of data, but lack of standardization is the main obstacle that limits their comparative evaluation. The following work aims to explore literature data on ODFs characteristics using the predictive data-classification algorithm Support vector machine (SVM) and assess its applicability in pharmaceutical development based on the set of experimentally obtained data.
2. MATERIALS AND METHODS
2.1. Materials
Hydroxypropyl cellulose (Klucel GF, Ashland, USA), ethanol (≥99.8%, Honeywell, Charlotte, NC, USA) and glycerol, 85% (w/w) (Ph. Eur.) were used for preparation of printing and casting dispersion.
2.2. Data pre-processing
Comprehensive data exploration has been conducted in the PubMed database using most common synonyms for ODFs with fifteen synonyms in singular and plural. Built database had following attributes: manufacturing approach, polymer selection, polymer molecular weight (KDa), polymer load (%), mechanical properties (tensile strength (MPa), Young's modulus (MPa), elongation at break (%)), disintegration method and disintegration time (DT) (s).
2.3. ODF preparation and characterisation
Polymer dispersions for solvent casting and semi-solid extrusion 3D printing were prepared by dispersing HPC in ethanol:glicerol solution followed by continuous stirring on the magnetic stirrer. Prepared dispersions were: (i) casted on a unit-dose plexiglas plates, or (ii) printed using Ultimaker 2+ (Ultimaker, , Netherlands). ODFs were characterized in terms of mechanical properties using Z-LX Table-Top Testing Machine (Shimadzu, Japan) and DT using adapted compendial tester (Erweka ZT52, Germany) with a weight.
3. RESULTS AND DISCUSSION
3.1. Data pre-processing
274 papers (without reviews) were identified via search, of which 112 were included in the database. Nominal data from literature was transformed into numerical, using coding operator so that each nominal data had corresponding numerical value. Critical attributes for films fast disintegration were derived. 18 polymers were included as categorical data and were further differentiated on the basis of molecular weight. Values for most commonly evaluated mechanical properties were included as numerical data. Different DT methods were classified in seven classes (Table 1), while the manufacturing methods were classified in five classes. RapidMiner Studio 9.10 (RapidMiner, Dortmund, Germany) was used to transform data and employ SMV algorithm.
3.2. SVM model prediction
Attributes with the highest weight were polymer load and DT method employed (Figure 1). The polymer type and characteristic did have conclusive effects on DT as their weight varied during data mining. This can be attributed to inconclusive data provided in papers and lot of missing values for those attributes. Mechanical properties had low weight, which can be explained with the broad value range for those attributes. Different research groups had different approach to disintegration testing, which lowered model precision as it was reported that SVM does not have high accuracy when data is imbalanced [3]. Relative error value was 20%, which can be considered as high, but, having in mind great diversity in presented data and methodology, obtained value is still acceptable for the pilot study.
3.3. Experimental validation
HPC-based films prepared by 3D printing had tensile strength, elongation at break and Young’s modulus of 3.5 MPa, 137% and 5 MPa, respectively. Average DT was 69 s. For casted films, relevant values were 3.4 MPa, 105% and 3 MPa, and DT was 27 s. Experimentally obtained results were entered into model simulator (Figure 2) to simulate situation reflecting the experimental set up in which HPC-based films were prepared by 3D printing and solvent casting, and relevant attribute values obtained by samples characterization. In the case were manufacturing method was set to be 3D printing (coded as 1) predicted DT value was close to experimentally obtained value, i.e. 71.7 and 69 s, respectively. When solvent casting method was considered, predicted DT value was remarkedly higher than the experimentally obtained one, indicating bad predictability. It might be assumed that good predictability obtained in the case of 3D printed films is associated with lower data variability due to more simple sample composition and robust preparation method. In the case of casted films, data was much more complex due to a higher number of research papers and approaches to characterisation.
4. CONCLUSION
The obtained results indicate that SVM algorithm can be employed to predict ODF DT value based on the dataset created using literature data. However, in order to obtain meaningful predictions, larger dataset, with fewer inconsistences and less missing values would be advantageous.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "Application of support vector machine learning for orodispersible films disintegration time prediction",
pages = "239-240",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4758"
}

Turković, E., Vasiljević, I., Vasiljević, D., Ibrić, S.,& Parojčić, J.. (2022). Application of support vector machine learning for orodispersible films disintegration time prediction. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 239-240.
https://hdl.handle.net/21.15107/rcub_farfar_4758

Turković E, Vasiljević I, Vasiljević D, Ibrić S, Parojčić J. Application of support vector machine learning for orodispersible films disintegration time prediction. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:239-240.
https://hdl.handle.net/21.15107/rcub_farfar_4758 .

Turković, Erna, Vasiljević, Ivana, Vasiljević, Dragana, Ibrić, Svetlana, Parojčić, Jelena, "Application of support vector machine learning for orodispersible films disintegration time prediction" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):239-240,
https://hdl.handle.net/21.15107/rcub_farfar_4758 .

TY  - CONF
AU  - Ćetković, Zora
AU  - Vasiljević, Ivana
AU  - Cvijić, Sandra
AU  - Vasiljević, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4567
AB  - Mixing selected liquid SMEDDS with polymethacrylate polymers (Eudragit ®) led to
solidification of the samples to form solid, ductile, transparent systems (1). The purpose of
this study was to define mechanical properties and long-term stability of novel simvastatin-
loaded SMEDDS-based drug delivery systems. SMEDDS-based formulations were prepared
by adding liquid SMEDDS (10% oleoyl macrogol-6 glycerides and 90% caprylocaproyl
macrogol-8 glycerides/macrogol-15-hydroxystearate, in 3 ratios: 1:1, 2:1 and 3:1) to
Eudragit ® S100 or Eudragit ® S100/Eudragit ® L100 combination (in 1:1 ratio), until
SMEDDS/polymer ratio 2:1 w/w was reached. SMEDDS-based formulations with simvastatin
(SV) were prepared by dissolving SV (5%) into liquid SMEDDS and mixing with
polymethacrylate polymers in the same ratio. Prepared formulations were evaluated in
terms of their mechanical properties and long-term stability. The results indicated that the
increase in the caprylocaproyl macrogol-8 glycerides concentration resulted in higher
penetration force (F1 S100–F3 S100 = 5.83-7.22 N and F1 SL100-F3 SL100 = 4.20-5.99 N).
However, addition of SV was negatively correlated with the hardness, i.e. samples with SV
were softer in comparison to unloaded samples. Moreover, it was noticeable that
formulations with Eudragit ® S100 had greater penetration force values compared to
formulations containing Eudragit ® S100/Eudragit ® L100. After six months of storage at
room and elevated temperature, only slight decrease in SV content (less than 5%) was
observed in these samples. This study demonstrated that novel SMEDDS-based formulations
with higher concentration of caprylocaproyl macrogol-8 glycerides and those with Eudragit ®
S100 were more robust, which may further serve as a guide for formulating tailor-made
formulations.
AB  - Mešanje odabranih tečnih samomikroemulgujućih sistema (SMEDDS) sa
kopolimerima metakrilne kiseline (Eudragit ® ) dovodi do očvršćavanja uzoraka i formiranja
čvrstih, rastegljivih, transparentnih sistema (1). Cilj ovog rada je bio ispitivanje mehaničkih
svojstva i dugotrajne stabilnosti novih lipidnih sistema sa simvastatinom (SV). Lipidne
formulacije su izrađene mešanjem tečnih SMEDDS (10% oleoil makrogol-6 glicerida i 90%
kaprilokaproil makrogol-8 glicerida/makrogol-15-hidroksistearat, u 3 odnosa: 1:1, 2:1 i 3:1)
i Eudragit ® S100 ili kombinacije Eudragit ® S100/Eudragit ® L100 (u odnosu 1:1). Odnos
SMEDDS/polimer bio je 2:1, m/m. Uzorci sa SV su izrađeni rastvaranjem SV (5%) u tečnim
SMEDDS i mešanjem sa kopolimerima metakrilne kiseline u navedenom odnosu. Sprovedena
su ispitivanja mehaničkih osobina i dugotrajne stabilnosti izrađenih lipidnih formulacija.
Rezultati su pokazali da povećanje koncentracije kaprilokaproil makrogol-8 glicerida dovodi
do povećanja vrednosti sile penetracije (F1 S100–F3 S100 = 5,83-7,22 N i F1 SL100-F3
SL100 = 4,20-5,99 N). Uzorci sa SV su bili mekši, u poređenju sa uzorcima bez lekovite
supstance. Takođe, uočeno je da uzorci sa polimerom Eudragit ® S100 imaju već e vrednosti
sile penetracije, u poređenju sa formulacijama koje sadrže kombinaciju Eudragit ®
S100/Eudragit ® L100. Posle šest meseci skladištenja uzoraka na sobnoj i povišenoj
temperaturi, sadržaj SV je neznatno smanjen (manje od 5%). Ova studija je pokazala da nove
lipidne formulacije izrađene sa većom koncentracijom kaprilokaproil makrogol-8 glicerida i
sa Eudragit ® S100 polimerom imaju veće vrednosti sile penetracije i prihvatljivu dugotrajnu
stabilnost, što je od značaja za razvoj lipidnih formulacija željenih karakteristika.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Mechanical properties and long-term stability of novel lipid formulations with simvastatin
T1  - Mehanička svojstva i dugotrajna stabilnost novih lipidnih formulacija sa simvastatinom
VL  - 72
IS  - 4 suplement
SP  - S396
EP  - S397
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4567
ER  - 

@conference{
author = "Ćetković, Zora and Vasiljević, Ivana and Cvijić, Sandra and Vasiljević, Dragana",
year = "2022",
abstract = "Mixing selected liquid SMEDDS with polymethacrylate polymers (Eudragit ®) led to
solidification of the samples to form solid, ductile, transparent systems (1). The purpose of
this study was to define mechanical properties and long-term stability of novel simvastatin-
loaded SMEDDS-based drug delivery systems. SMEDDS-based formulations were prepared
by adding liquid SMEDDS (10% oleoyl macrogol-6 glycerides and 90% caprylocaproyl
macrogol-8 glycerides/macrogol-15-hydroxystearate, in 3 ratios: 1:1, 2:1 and 3:1) to
Eudragit ® S100 or Eudragit ® S100/Eudragit ® L100 combination (in 1:1 ratio), until
SMEDDS/polymer ratio 2:1 w/w was reached. SMEDDS-based formulations with simvastatin
(SV) were prepared by dissolving SV (5%) into liquid SMEDDS and mixing with
polymethacrylate polymers in the same ratio. Prepared formulations were evaluated in
terms of their mechanical properties and long-term stability. The results indicated that the
increase in the caprylocaproyl macrogol-8 glycerides concentration resulted in higher
penetration force (F1 S100–F3 S100 = 5.83-7.22 N and F1 SL100-F3 SL100 = 4.20-5.99 N).
However, addition of SV was negatively correlated with the hardness, i.e. samples with SV
were softer in comparison to unloaded samples. Moreover, it was noticeable that
formulations with Eudragit ® S100 had greater penetration force values compared to
formulations containing Eudragit ® S100/Eudragit ® L100. After six months of storage at
room and elevated temperature, only slight decrease in SV content (less than 5%) was
observed in these samples. This study demonstrated that novel SMEDDS-based formulations
with higher concentration of caprylocaproyl macrogol-8 glycerides and those with Eudragit ®
S100 were more robust, which may further serve as a guide for formulating tailor-made
formulations., Mešanje odabranih tečnih samomikroemulgujućih sistema (SMEDDS) sa
kopolimerima metakrilne kiseline (Eudragit ® ) dovodi do očvršćavanja uzoraka i formiranja
čvrstih, rastegljivih, transparentnih sistema (1). Cilj ovog rada je bio ispitivanje mehaničkih
svojstva i dugotrajne stabilnosti novih lipidnih sistema sa simvastatinom (SV). Lipidne
formulacije su izrađene mešanjem tečnih SMEDDS (10% oleoil makrogol-6 glicerida i 90%
kaprilokaproil makrogol-8 glicerida/makrogol-15-hidroksistearat, u 3 odnosa: 1:1, 2:1 i 3:1)
i Eudragit ® S100 ili kombinacije Eudragit ® S100/Eudragit ® L100 (u odnosu 1:1). Odnos
SMEDDS/polimer bio je 2:1, m/m. Uzorci sa SV su izrađeni rastvaranjem SV (5%) u tečnim
SMEDDS i mešanjem sa kopolimerima metakrilne kiseline u navedenom odnosu. Sprovedena
su ispitivanja mehaničkih osobina i dugotrajne stabilnosti izrađenih lipidnih formulacija.
Rezultati su pokazali da povećanje koncentracije kaprilokaproil makrogol-8 glicerida dovodi
do povećanja vrednosti sile penetracije (F1 S100–F3 S100 = 5,83-7,22 N i F1 SL100-F3
SL100 = 4,20-5,99 N). Uzorci sa SV su bili mekši, u poređenju sa uzorcima bez lekovite
supstance. Takođe, uočeno je da uzorci sa polimerom Eudragit ® S100 imaju već e vrednosti
sile penetracije, u poređenju sa formulacijama koje sadrže kombinaciju Eudragit ®
S100/Eudragit ® L100. Posle šest meseci skladištenja uzoraka na sobnoj i povišenoj
temperaturi, sadržaj SV je neznatno smanjen (manje od 5%). Ova studija je pokazala da nove
lipidne formulacije izrađene sa većom koncentracijom kaprilokaproil makrogol-8 glicerida i
sa Eudragit ® S100 polimerom imaju veće vrednosti sile penetracije i prihvatljivu dugotrajnu
stabilnost, što je od značaja za razvoj lipidnih formulacija željenih karakteristika.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Mechanical properties and long-term stability of novel lipid formulations with simvastatin, Mehanička svojstva i dugotrajna stabilnost novih lipidnih formulacija sa simvastatinom",
volume = "72",
number = "4 suplement",
pages = "S396-S397",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4567"
}

Ćetković, Z., Vasiljević, I., Cvijić, S.,& Vasiljević, D.. (2022). Mechanical properties and long-term stability of novel lipid formulations with simvastatin. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S396-S397.
https://hdl.handle.net/21.15107/rcub_farfar_4567

Ćetković Z, Vasiljević I, Cvijić S, Vasiljević D. Mechanical properties and long-term stability of novel lipid formulations with simvastatin. in Arhiv za farmaciju. 2022;72(4 suplement):S396-S397.
https://hdl.handle.net/21.15107/rcub_farfar_4567 .

Ćetković, Zora, Vasiljević, Ivana, Cvijić, Sandra, Vasiljević, Dragana, "Mechanical properties and long-term stability of novel lipid formulations with simvastatin" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S396-S397,
https://hdl.handle.net/21.15107/rcub_farfar_4567 .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4409
AB  - An understanding of material properties and processing effects on solid dosage forms
performance is required within the Quality-by-design approach to pharmaceutical development.
Several research groups have developed mathematical approaches aiming to facilitate the
selection of formulation composition and the manufacturing technology. These approaches are
based on material particulate, bulk and compression-related properties. This paper provides
theoretical assumptions and a critical review of different mathematical approaches for
processability characterization of powders and multiparticulate units.
Mathematical approaches have mainly been developed for directly compressible materials,
but sometimes other manufacturing technologies, such as roller compaction and wet granulation,
are also considered. The obtained compact tensile strength has been implemented in the majority
of approaches, as an important characteristic describing compact mechanical properties.
Flowability should be also evaluated, since it affects sample processability. Additionally, particle
size and shape, material density and compressibility, compactibility and tabletability profiles have
been also distinguished as relevant properties for solid dosage form development.
The application of mathematical approaches may contribute to the mechanistic
understanding of critical material attributes and facilitate dosage form development and
optimization. However, it is essential to select the appropriate one, based on the intended dosage
form characteristics, in order to ensure that all relevant powder/multiparticulate units
characteristics are implemented and critically evaluated.
AB  - Poznavanje uticaja svojstava materijala i procesnih parametara na karakteristike čvrstih farmaceutskih oblika predstavlja osnovu Quality-by-design pristupa razvoju lekova. Kako bi bio olakšan razvoj formulacije i izbor proizvodne tehnologije, više istraživačkih grupa opisalo je matematičke pristupe, koji se zasnivaju na čestičnim karakteristikama čestica, osobinama praška i ponašanju materijala pri kompresiji. U ovom radu prikazana su teorijska razmatranja i kritički pregled matematičkih pristupa razvijenih za karakterizaciju praškova i višečestičnih sistema. Ovi matematički pristupi su, generalno, razvijeni za karakterizaciju materijala pogodnih za direktnu kompresiju. Međutim, u nekim slučajevima se razmatraju i druge tehnologije, kao što su suva i vlažna granulacija. Među opisanim karakteristikama materijala, zatezna čvrstina se izdvaja kao jedna od najznačajnijih za procenu mehaničkih svojstava kompakta. Potrebno je ispitati i protočnost materijala. Takođe, veličina i oblik čestica, gustina materijala i profili koji opisuju kompresibilnost, kompaktibilnost i tabletabilnost materijala prepoznati su kao karakteristike koje značajno utiču na razvoj čvrstih farmaceutskih oblika. Primena matematičkih pristupa u karakterizaciji praškova i višečestičnih sistema može doprineti mehanističkom razumevanju svojstava materijala i olakšati razvoj i optimizaciju čvrstih farmaceutskih oblika lekova. Međutim, ključno je odabrati odgovarajući pristup, zavisno od željenih karakteristika finalnog preparata, kako bi sva kritična svojstva materijala bila ispitana i kritički razmotrena.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development
T1  - Pregled i kritička analiza matematičkih pristupa za karakterizaciju praškova i višečestičnih sistema u razvoju lekova
VL  - 72
IS  - 6
SP  - 637
EP  - 660
DO  - 10.5937/arhfarm72-40961
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Parojčić, Jelena",
year = "2022",
abstract = "An understanding of material properties and processing effects on solid dosage forms
performance is required within the Quality-by-design approach to pharmaceutical development.
Several research groups have developed mathematical approaches aiming to facilitate the
selection of formulation composition and the manufacturing technology. These approaches are
based on material particulate, bulk and compression-related properties. This paper provides
theoretical assumptions and a critical review of different mathematical approaches for
processability characterization of powders and multiparticulate units.
Mathematical approaches have mainly been developed for directly compressible materials,
but sometimes other manufacturing technologies, such as roller compaction and wet granulation,
are also considered. The obtained compact tensile strength has been implemented in the majority
of approaches, as an important characteristic describing compact mechanical properties.
Flowability should be also evaluated, since it affects sample processability. Additionally, particle
size and shape, material density and compressibility, compactibility and tabletability profiles have
been also distinguished as relevant properties for solid dosage form development.
The application of mathematical approaches may contribute to the mechanistic
understanding of critical material attributes and facilitate dosage form development and
optimization. However, it is essential to select the appropriate one, based on the intended dosage
form characteristics, in order to ensure that all relevant powder/multiparticulate units
characteristics are implemented and critically evaluated., Poznavanje uticaja svojstava materijala i procesnih parametara na karakteristike čvrstih farmaceutskih oblika predstavlja osnovu Quality-by-design pristupa razvoju lekova. Kako bi bio olakšan razvoj formulacije i izbor proizvodne tehnologije, više istraživačkih grupa opisalo je matematičke pristupe, koji se zasnivaju na čestičnim karakteristikama čestica, osobinama praška i ponašanju materijala pri kompresiji. U ovom radu prikazana su teorijska razmatranja i kritički pregled matematičkih pristupa razvijenih za karakterizaciju praškova i višečestičnih sistema. Ovi matematički pristupi su, generalno, razvijeni za karakterizaciju materijala pogodnih za direktnu kompresiju. Međutim, u nekim slučajevima se razmatraju i druge tehnologije, kao što su suva i vlažna granulacija. Među opisanim karakteristikama materijala, zatezna čvrstina se izdvaja kao jedna od najznačajnijih za procenu mehaničkih svojstava kompakta. Potrebno je ispitati i protočnost materijala. Takođe, veličina i oblik čestica, gustina materijala i profili koji opisuju kompresibilnost, kompaktibilnost i tabletabilnost materijala prepoznati su kao karakteristike koje značajno utiču na razvoj čvrstih farmaceutskih oblika. Primena matematičkih pristupa u karakterizaciji praškova i višečestičnih sistema može doprineti mehanističkom razumevanju svojstava materijala i olakšati razvoj i optimizaciju čvrstih farmaceutskih oblika lekova. Međutim, ključno je odabrati odgovarajući pristup, zavisno od željenih karakteristika finalnog preparata, kako bi sva kritična svojstva materijala bila ispitana i kritički razmotrena.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development, Pregled i kritička analiza matematičkih pristupa za karakterizaciju praškova i višečestičnih sistema u razvoju lekova",
volume = "72",
number = "6",
pages = "637-660",
doi = "10.5937/arhfarm72-40961"
}

Vasiljević, I., Turković, E., Aleksić, I.,& Parojčić, J.. (2022). Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 637-660.
https://doi.org/10.5937/arhfarm72-40961

Vasiljević I, Turković E, Aleksić I, Parojčić J. Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development. in Arhiv za farmaciju. 2022;72(6):637-660.
doi:10.5937/arhfarm72-40961 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Parojčić, Jelena, "Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development" in Arhiv za farmaciju, 72, no. 6 (2022):637-660,
https://doi.org/10.5937/arhfarm72-40961 . .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4575
AB  - Thin films are relatively new drug forms, which contain one or more active
substances, dispersed or adsorbed on a polymeric carrier (1). The aim of this work was to
evaluate the effects of the preparation and formulation factors on film critical quality
attributes. Films were prepared by solvent-casting and 3D printing of dispersion on a
Ultimaker 2+. Dispersion consisted of hydroxypropylcellulose with or without the addition
of sodium-alginate. Caffeine and ibuprofen were used as model drugs. The films were
characterized in terms of mass, thickness, moisture content (LJ16-Moisture Analizer) and
mechanical characteristics (EZ-LKS-Table-TopMachine). Obtained results indicate that 3D
films had higher mass and thickness compared to casted films, except for
hydroxypropylcellulose/sodium alginate/caffeine sample (37.6 and 59.0 mg/cm2 ; 526 and
642 μm). High content of dispersed substances can cause a change in polymer drying
behavior, which is reflected in film characteristics. Dissolving ibuprofen in the initial
dispersion, led to film increased elasticity and decreased tensile strength, negatively
affecting handling and stickiness of the films prepared by either method. Differences
between methods were most pronounced in films with dispersed caffeine or sodium-
alginate. Sodium-alginate generally decreased, and caffeine increased flexibility. The
preparation process did not affect the moisture content in samples, although the polymer
drying differed between two preparation methods. Increased moisture content was
generally accompanied by decreased flexibility, except for samples with ibuprofen. Obtained
results indicate significant effects of the formulation process and composition on the film
characteristics. Dissolved or dispersed substance content in formulation should be adapted
to the chosen preparation method.
AB  - Tanki oralni filmovi predstavljaju noviji farmaceutski oblik leka, koji sadrži jednu ili
više aktivnih supstanci dispergovanih ili adsorbovanih na polimernom nosaču (1). Cilj ovog
rada bio je ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva
kvaliteta filmova. Filmovi su izrađivani izlivanjem disperzije u kalupe ili metodom 3D štampe
(Ultimaker 2+). Disperzija se sastojala od hidroksipropilceluloze, sa ili bez dodatka natrijum-
alginata. Model aktivne supstance bile su kofein i ibuprofen. Karakterizacija filmova
obuhvatila je određivanje mase, debljine, udela vlage (LJ16-MoistureAnalyzer) i mehaničkih
karakteristika (EZ-LX-Table-TopMachine). Dobijeni rezultati su pokazali da su 3D štampani
filmovi imali veću masu i debljinu u odnosu na izlivene filmove, osim u slučaju uzorka
hidroksipropilceluloza/natrijum-alginat/kofein (37,6 i 59,0 mg/cm 2; 526 i 642 μm). Visok
udeo dispergovanih supstanci u uzorku može uzrokovati promenu u ponašanju polimera
prilikom sušenja što se odražava na karakteristike filmova. Rastvaranje ibuprofena dovelo je
do povećanja elastičnosti i smanjenja zatezne čvrstine filmova u slučaju oba postupka izrade,
što je imalo negativan efekat na lakoću rukovanja i lepljivost. Postupak izrade imao je najveći
uticaj na karakteristike filmova sa natrijum-alginatom i filmova koji su sadržali kofein.
Natrijum-alginat je generalno smanjivao, a kofein povećavao fleksibilnost filmova. Postupak
izrade nije imao uticaj na udeo vlage, iako je sušenje filmova bilo značajno različito kod ova
dva postupka. Povećanje udela vlage uglavnom je pratilo smanjenje fleksibilnosti filmova,
osim kod uzoraka sa ibuprofenom. Dobijeni rezultati ukazuju na značajan uticaj postupka
izrade i sastava formulacije na karakteristike tankih filmova. Udeo rastvorenih ili
dispergovanih supstanci u formulaciji moraju biti prilagođeni odabranom postupku izrade.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into the effects of preparation methods and composition on thin film critical quality attributes
T1  - Ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva kvaliteta tankih oralnih filmova
VL  - 72
IS  - 4 suplement
SP  - S422
EP  - S423
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4575
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Vasiljević, Dragana and Parojčić, Jelena",
year = "2022",
abstract = "Thin films are relatively new drug forms, which contain one or more active
substances, dispersed or adsorbed on a polymeric carrier (1). The aim of this work was to
evaluate the effects of the preparation and formulation factors on film critical quality
attributes. Films were prepared by solvent-casting and 3D printing of dispersion on a
Ultimaker 2+. Dispersion consisted of hydroxypropylcellulose with or without the addition
of sodium-alginate. Caffeine and ibuprofen were used as model drugs. The films were
characterized in terms of mass, thickness, moisture content (LJ16-Moisture Analizer) and
mechanical characteristics (EZ-LKS-Table-TopMachine). Obtained results indicate that 3D
films had higher mass and thickness compared to casted films, except for
hydroxypropylcellulose/sodium alginate/caffeine sample (37.6 and 59.0 mg/cm2 ; 526 and
642 μm). High content of dispersed substances can cause a change in polymer drying
behavior, which is reflected in film characteristics. Dissolving ibuprofen in the initial
dispersion, led to film increased elasticity and decreased tensile strength, negatively
affecting handling and stickiness of the films prepared by either method. Differences
between methods were most pronounced in films with dispersed caffeine or sodium-
alginate. Sodium-alginate generally decreased, and caffeine increased flexibility. The
preparation process did not affect the moisture content in samples, although the polymer
drying differed between two preparation methods. Increased moisture content was
generally accompanied by decreased flexibility, except for samples with ibuprofen. Obtained
results indicate significant effects of the formulation process and composition on the film
characteristics. Dissolved or dispersed substance content in formulation should be adapted
to the chosen preparation method., Tanki oralni filmovi predstavljaju noviji farmaceutski oblik leka, koji sadrži jednu ili
više aktivnih supstanci dispergovanih ili adsorbovanih na polimernom nosaču (1). Cilj ovog
rada bio je ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva
kvaliteta filmova. Filmovi su izrađivani izlivanjem disperzije u kalupe ili metodom 3D štampe
(Ultimaker 2+). Disperzija se sastojala od hidroksipropilceluloze, sa ili bez dodatka natrijum-
alginata. Model aktivne supstance bile su kofein i ibuprofen. Karakterizacija filmova
obuhvatila je određivanje mase, debljine, udela vlage (LJ16-MoistureAnalyzer) i mehaničkih
karakteristika (EZ-LX-Table-TopMachine). Dobijeni rezultati su pokazali da su 3D štampani
filmovi imali veću masu i debljinu u odnosu na izlivene filmove, osim u slučaju uzorka
hidroksipropilceluloza/natrijum-alginat/kofein (37,6 i 59,0 mg/cm 2; 526 i 642 μm). Visok
udeo dispergovanih supstanci u uzorku može uzrokovati promenu u ponašanju polimera
prilikom sušenja što se odražava na karakteristike filmova. Rastvaranje ibuprofena dovelo je
do povećanja elastičnosti i smanjenja zatezne čvrstine filmova u slučaju oba postupka izrade,
što je imalo negativan efekat na lakoću rukovanja i lepljivost. Postupak izrade imao je najveći
uticaj na karakteristike filmova sa natrijum-alginatom i filmova koji su sadržali kofein.
Natrijum-alginat je generalno smanjivao, a kofein povećavao fleksibilnost filmova. Postupak
izrade nije imao uticaj na udeo vlage, iako je sušenje filmova bilo značajno različito kod ova
dva postupka. Povećanje udela vlage uglavnom je pratilo smanjenje fleksibilnosti filmova,
osim kod uzoraka sa ibuprofenom. Dobijeni rezultati ukazuju na značajan uticaj postupka
izrade i sastava formulacije na karakteristike tankih filmova. Udeo rastvorenih ili
dispergovanih supstanci u formulaciji moraju biti prilagođeni odabranom postupku izrade.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into the effects of preparation methods and composition on thin film critical quality attributes, Ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva kvaliteta tankih oralnih filmova",
volume = "72",
number = "4 suplement",
pages = "S422-S423",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4575"
}

Turković, E., Vasiljević, I., Vasiljević, D.,& Parojčić, J.. (2022). An investigation into the effects of preparation methods and composition on thin film critical quality attributes. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S422-S423.
https://hdl.handle.net/21.15107/rcub_farfar_4575

Turković E, Vasiljević I, Vasiljević D, Parojčić J. An investigation into the effects of preparation methods and composition on thin film critical quality attributes. in Arhiv za farmaciju. 2022;72(4 suplement):S422-S423.
https://hdl.handle.net/21.15107/rcub_farfar_4575 .

Turković, Erna, Vasiljević, Ivana, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into the effects of preparation methods and composition on thin film critical quality attributes" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S422-S423,
https://hdl.handle.net/21.15107/rcub_farfar_4575 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
AU  - Vasiljević, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4521
AB  - The estimated prevalence of swallowing problems and dysphagia is 22%, particularly
among pediatric and geriatric population. The drug administration for these individuals is
challenging and efforts are being made to enhance solid dosage forms swallowing. The aim of
this work was to characterize inulin-based puddings as potential vehicula for solid dosage
forms administration. Three marketed instant puddings were prepared according to
instructions provided by the manufacturer (mixing with the appropriate amount of cold
milk, without cooking) and characterized regarding pH value, rheological characteristics and
textural properties (hardness and adhesiveness). The investigated samples differed in terms
of inulin content, as gelling agent (3.3-8%), and aroma (vanilla, chocolate, coco). Generally,
samples exhibited comparable characteristics. pH values of prepared puddings ranged from
6.57 to 6.90. Apparent viscosity values, measured at 50 s -1 , were 4850-16800 mPas,
indicating that puddings belong to class 4 (extremely thick drinks), according to
International Dysphagia Diet Standardization Initiative Framework (1), suitable for patients
suffering from advanced dysphagia. Samples’ hardness values ranged from 54.6 mN (coco
pudding) to 63.9 mN (chocolate pudding), whereas adhesiveness ranged from 30.26 gs (coco
pudding) to 40.64 gs (chocolate pudding), indicating the soft structure and swallowing
suitability, without the need for intense chewing (2). The investigated puddings exhibited
suitable characteristics in terms of viscosity and textural properties for patients with
advanced dysphagia and represent promising approach as vehicula for solid dosage forms
administration in the case of this population.
AB  - Procenjuje se da oko 22% stanovništva ima probleme sa gutanjem i disfagijom, pri
čemu je problem naročito izražen u pedijatrijskoj i gerijatrijskoj populaciji. Primena lekova
kod ovih osoba je otežana i potrebno je razviti odgovarajuće pristupe koji olakšavaju gutanje
čvrstih farmaceutskih oblika. Cilj ovog rada bio je karakterizacija komercijalno dostupnih
instant pudinga, kao potencijalnih vehikuluma za primenu čvrstih farmaceutskih oblika
lekova. Tri komercijalno dostupna instant pudinga su pripremljena prema uputstvu
proizvođača (mešanje sa propisanom zapreminom hladnog mleka, bez kuvanja) i
okarakterisana u pogledu pH vrednosti, reoloških karakteristika i teksture (čvrstina i
adhezivnost). Sastav ispitivanih uzoraka se razlikovao u pogledu udela inulina kao sredstva
za geliranje (3,3-8%) i arome (vanila, čokolada, kokos). Generalno, svojstva ispitivanih
proizvoda bila su uporediva. pH vrednost pripremljenih pudinga bila je 6,57-6,90. Svi uzorci
pokazali su tiksotropno ponašanje. Vrednosti prividnog viskoziteta, izmerene na 50 s -1 , bile
su 4850-16800 mPas, ukazujući da pudinzi spadaju u klasu 4 (veoma guste tečnosti) prema
Smernicama Inicijative za međunarodnu standardizaciju ishrane u disfagiji (1) i da su pogodni
za pacijente sa uznapredovalom disfagijom. Čvrstina uzoraka bila je u rasponu od 54,6 mN
(puding od kokosa) do 63,9 mN (puding od čokolade), a adhezivnost od 30,26 gs (puding od
kokosa) do 40,64 gs (puding od čokolade), ukazujući na meku strukturu i pogodnost za
gutanje bez intenzivnog žvakanja (2). Ispitivani pudinzi pokazali su pogodni viskozitet i
teksturu za primenu kod pacijenata sa uznapredovalom disfagijom i predstavljaju
obećavajući pristup za primenu čvrstih farmaceutskih oblika kod ove populacije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia
T1  - Ispitivanje instant pudinga kao potencijalnih vehikuluma za primenu lekova kod pacijenata sa disfagijom
VL  - 72
IS  - 4 suplement
SP  - S237
EP  - S238
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4521
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena and Vasiljević, Dragana",
year = "2022",
abstract = "The estimated prevalence of swallowing problems and dysphagia is 22%, particularly
among pediatric and geriatric population. The drug administration for these individuals is
challenging and efforts are being made to enhance solid dosage forms swallowing. The aim of
this work was to characterize inulin-based puddings as potential vehicula for solid dosage
forms administration. Three marketed instant puddings were prepared according to
instructions provided by the manufacturer (mixing with the appropriate amount of cold
milk, without cooking) and characterized regarding pH value, rheological characteristics and
textural properties (hardness and adhesiveness). The investigated samples differed in terms
of inulin content, as gelling agent (3.3-8%), and aroma (vanilla, chocolate, coco). Generally,
samples exhibited comparable characteristics. pH values of prepared puddings ranged from
6.57 to 6.90. Apparent viscosity values, measured at 50 s -1 , were 4850-16800 mPas,
indicating that puddings belong to class 4 (extremely thick drinks), according to
International Dysphagia Diet Standardization Initiative Framework (1), suitable for patients
suffering from advanced dysphagia. Samples’ hardness values ranged from 54.6 mN (coco
pudding) to 63.9 mN (chocolate pudding), whereas adhesiveness ranged from 30.26 gs (coco
pudding) to 40.64 gs (chocolate pudding), indicating the soft structure and swallowing
suitability, without the need for intense chewing (2). The investigated puddings exhibited
suitable characteristics in terms of viscosity and textural properties for patients with
advanced dysphagia and represent promising approach as vehicula for solid dosage forms
administration in the case of this population., Procenjuje se da oko 22% stanovništva ima probleme sa gutanjem i disfagijom, pri
čemu je problem naročito izražen u pedijatrijskoj i gerijatrijskoj populaciji. Primena lekova
kod ovih osoba je otežana i potrebno je razviti odgovarajuće pristupe koji olakšavaju gutanje
čvrstih farmaceutskih oblika. Cilj ovog rada bio je karakterizacija komercijalno dostupnih
instant pudinga, kao potencijalnih vehikuluma za primenu čvrstih farmaceutskih oblika
lekova. Tri komercijalno dostupna instant pudinga su pripremljena prema uputstvu
proizvođača (mešanje sa propisanom zapreminom hladnog mleka, bez kuvanja) i
okarakterisana u pogledu pH vrednosti, reoloških karakteristika i teksture (čvrstina i
adhezivnost). Sastav ispitivanih uzoraka se razlikovao u pogledu udela inulina kao sredstva
za geliranje (3,3-8%) i arome (vanila, čokolada, kokos). Generalno, svojstva ispitivanih
proizvoda bila su uporediva. pH vrednost pripremljenih pudinga bila je 6,57-6,90. Svi uzorci
pokazali su tiksotropno ponašanje. Vrednosti prividnog viskoziteta, izmerene na 50 s -1 , bile
su 4850-16800 mPas, ukazujući da pudinzi spadaju u klasu 4 (veoma guste tečnosti) prema
Smernicama Inicijative za međunarodnu standardizaciju ishrane u disfagiji (1) i da su pogodni
za pacijente sa uznapredovalom disfagijom. Čvrstina uzoraka bila je u rasponu od 54,6 mN
(puding od kokosa) do 63,9 mN (puding od čokolade), a adhezivnost od 30,26 gs (puding od
kokosa) do 40,64 gs (puding od čokolade), ukazujući na meku strukturu i pogodnost za
gutanje bez intenzivnog žvakanja (2). Ispitivani pudinzi pokazali su pogodni viskozitet i
teksturu za primenu kod pacijenata sa uznapredovalom disfagijom i predstavljaju
obećavajući pristup za primenu čvrstih farmaceutskih oblika kod ove populacije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia, Ispitivanje instant pudinga kao potencijalnih vehikuluma za primenu lekova kod pacijenata sa disfagijom",
volume = "72",
number = "4 suplement",
pages = "S237-S238",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4521"
}

Vasiljević, I., Turković, E., Parojčić, J.,& Vasiljević, D.. (2022). An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S237-S238.
https://hdl.handle.net/21.15107/rcub_farfar_4521

Vasiljević I, Turković E, Parojčić J, Vasiljević D. An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia. in Arhiv za farmaciju. 2022;72(4 suplement):S237-S238.
https://hdl.handle.net/21.15107/rcub_farfar_4521 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, Vasiljević, Dragana, "An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S237-S238,
https://hdl.handle.net/21.15107/rcub_farfar_4521 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5526
AB  - Introduction: Expert System for Drug Development (SeDeM) was introduced as a method intended for powder processability assessment (1). Its applicability was extended to multiparticulate materials (2-3), but the contribution to liquisolid admixtures/pellets characterization remains to be explored. The aim of this work was to investigate the applicability of SeDeM on liquisolid admixtures/pellets. Methods: Liquisolid admixtures (A) were prepared by manual kneading and subsequently extruded/spheronized into liquisolid pellets (P). ...
C3  - Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting
T1  - Investigation into applicability of Expert System for Drug Development on the model liquisolid systems
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5526
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Parojčić, Jelena",
year = "2021",
abstract = "Introduction: Expert System for Drug Development (SeDeM) was introduced as a method intended for powder processability assessment (1). Its applicability was extended to multiparticulate materials (2-3), but the contribution to liquisolid admixtures/pellets characterization remains to be explored. The aim of this work was to investigate the applicability of SeDeM on liquisolid admixtures/pellets. Methods: Liquisolid admixtures (A) were prepared by manual kneading and subsequently extruded/spheronized into liquisolid pellets (P). ...",
journal = "Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting",
title = "Investigation into applicability of Expert System for Drug Development on the model liquisolid systems",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5526"
}

Vasiljević, I., Turković, E., Aleksić, I.,& Parojčić, J.. (2021). Investigation into applicability of Expert System for Drug Development on the model liquisolid systems. in Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting.
https://hdl.handle.net/21.15107/rcub_farfar_5526

Vasiljević I, Turković E, Aleksić I, Parojčić J. Investigation into applicability of Expert System for Drug Development on the model liquisolid systems. in Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_5526 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Parojčić, Jelena, "Investigation into applicability of Expert System for Drug Development on the model liquisolid systems" in Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting (2021),
https://hdl.handle.net/21.15107/rcub_farfar_5526 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - German Ilić, Ilija
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5315
AB  - Software assisted image analysis represents emerging approach, which may provide useful insight
into sample properties [1]. However, its application in the pharmaceutical field is scarce. The aim of
this work was to investigate the applicability of software assisted porosity evaluation in liquisolid
pellets characterization. ...
PB  - Medical University of Gdansk
PB  - Polskie Towarzystwo Farmaceutyczne
C3  - Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
T1  - Applicability of software assisted porosity evaluation in liquisolid pellets characterization
SP  - 75
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5315
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and German Ilić, Ilija and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Software assisted image analysis represents emerging approach, which may provide useful insight
into sample properties [1]. However, its application in the pharmaceutical field is scarce. The aim of
this work was to investigate the applicability of software assisted porosity evaluation in liquisolid
pellets characterization. ...",
publisher = "Medical University of Gdansk, Polskie Towarzystwo Farmaceutyczne",
journal = "Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland",
title = "Applicability of software assisted porosity evaluation in liquisolid pellets characterization",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5315"
}

Vasiljević, I., Turković, E., German Ilić, I., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Applicability of software assisted porosity evaluation in liquisolid pellets characterization. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
Medical University of Gdansk., 75-75.
https://hdl.handle.net/21.15107/rcub_farfar_5315

Vasiljević I, Turković E, German Ilić I, Zimmer A, Parojčić J, Aleksić I. Applicability of software assisted porosity evaluation in liquisolid pellets characterization. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland. 2021;:75-75.
https://hdl.handle.net/21.15107/rcub_farfar_5315 .

Vasiljević, Ivana, Turković, Erna, German Ilić, Ilija, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Applicability of software assisted porosity evaluation in liquisolid pellets characterization" in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland (2021):75-75,
https://hdl.handle.net/21.15107/rcub_farfar_5315 .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4670
AB  - Growing demands for environmental sustainability and responsible exploitation of
natural resources has led to increased research on the potential use and reprocessing of
different waste materials as primary source of starting materials for different industries.
Rigorous quality requirements for pharmaceutical active and auxiliary substances is
hindering wider use of reprocessed waste materials in pharmaceutical industry. However,
certain advances have been recently introduced in the field of natural polymers
(biopolymers) production (1).
Biocompatible, biodegradable and, generally, non-toxic biopolymers offer numerous
advantages in different drug delivery systems development. In this review, focus is on
biopolymers used as potential film-forming agents (FFA) for pharmaceutical oral films. An
overview of the most commonly used biopolymers produced from different waste materials,
resources used, and their application in pharmaceutical oral films manufacture is
schematically presented in Figure 1.
AB  - Održiva životna sredina i odgovorno korišćenje prirodnih resursa postali su značajan
zadatak za moderno društvo, što je dovelo do povećanja aktivnosti na polju istraživanja o
mogućnosti korišćenja i obradi različitih otpadnih materijala kao primarnog izvora polaznih
supstanci za različite grane industrije. Rigorozni zahtevi za kvalitet aktivnih i pomoćnih
supstanci ograničavaju širu upotrebu prerađenih materijala u farmaceutskoj industriji. Ipak,
određeni pomaci postoje na polju dobijanja prirodnih polimera (biopolimera) (1).
Biokompatibilni, biorazgradivi i netoksični biopolimeri nude brojne prednosti. Ovaj pregled
usmeren je na biopolimere koji potencijalno mogu da se koriste kao sredstva za formiranje
filma prilikom razvoja oralnih filmova kao farmaceutskog oblika leka. Pregled najčešće
korišćenih biopolimera koji se proizvode iz različitih otpadnih materijala, korišćeni izvori za
proizvodnju i njihova primena u izradi farmaceutskih oralnih filmova je shematski prikazana
na Slici 1.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review
T1  - Pregled polimera za izradu farmaceutskih oralnih filmova dobijenih preradom različitih otpadnih materijala
VL  - 71
IS  - 5 suplement
SP  - S76
EP  - S79
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4670
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Parojčić, Jelena",
year = "2021",
abstract = "Growing demands for environmental sustainability and responsible exploitation of
natural resources has led to increased research on the potential use and reprocessing of
different waste materials as primary source of starting materials for different industries.
Rigorous quality requirements for pharmaceutical active and auxiliary substances is
hindering wider use of reprocessed waste materials in pharmaceutical industry. However,
certain advances have been recently introduced in the field of natural polymers
(biopolymers) production (1).
Biocompatible, biodegradable and, generally, non-toxic biopolymers offer numerous
advantages in different drug delivery systems development. In this review, focus is on
biopolymers used as potential film-forming agents (FFA) for pharmaceutical oral films. An
overview of the most commonly used biopolymers produced from different waste materials,
resources used, and their application in pharmaceutical oral films manufacture is
schematically presented in Figure 1., Održiva životna sredina i odgovorno korišćenje prirodnih resursa postali su značajan
zadatak za moderno društvo, što je dovelo do povećanja aktivnosti na polju istraživanja o
mogućnosti korišćenja i obradi različitih otpadnih materijala kao primarnog izvora polaznih
supstanci za različite grane industrije. Rigorozni zahtevi za kvalitet aktivnih i pomoćnih
supstanci ograničavaju širu upotrebu prerađenih materijala u farmaceutskoj industriji. Ipak,
određeni pomaci postoje na polju dobijanja prirodnih polimera (biopolimera) (1).
Biokompatibilni, biorazgradivi i netoksični biopolimeri nude brojne prednosti. Ovaj pregled
usmeren je na biopolimere koji potencijalno mogu da se koriste kao sredstva za formiranje
filma prilikom razvoja oralnih filmova kao farmaceutskog oblika leka. Pregled najčešće
korišćenih biopolimera koji se proizvode iz različitih otpadnih materijala, korišćeni izvori za
proizvodnju i njihova primena u izradi farmaceutskih oralnih filmova je shematski prikazana
na Slici 1.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review, Pregled polimera za izradu farmaceutskih oralnih filmova dobijenih preradom različitih otpadnih materijala",
volume = "71",
number = "5 suplement",
pages = "S76-S79",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4670"
}

Turković, E., Vasiljević, I.,& Parojčić, J.. (2021). Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S76-S79.
https://hdl.handle.net/21.15107/rcub_farfar_4670

Turković E, Vasiljević I, Parojčić J. Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review. in Arhiv za farmaciju. 2021;71(5 suplement):S76-S79.
https://hdl.handle.net/21.15107/rcub_farfar_4670 .

Turković, Erna, Vasiljević, Ivana, Parojčić, Jelena, "Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S76-S79,
https://hdl.handle.net/21.15107/rcub_farfar_4670 .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Nenadović, Snežana
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3921
AB  - Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Investigation into liquisolid system processability based on the SeDeM Expert System approach
VL  - 605
DO  - 10.1016/j.ijpharm.2021.120847
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Nenadović, Snežana and Mirković, Miljana and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Investigation into liquisolid system processability based on the SeDeM Expert System approach",
volume = "605",
doi = "10.1016/j.ijpharm.2021.120847"
}

Vasiljević, I., Turković, E., Nenadović, S., Mirković, M., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 605.
https://doi.org/10.1016/j.ijpharm.2021.120847

Vasiljević I, Turković E, Nenadović S, Mirković M, Zimmer A, Parojčić J, Aleksić I. Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2021;605.
doi:10.1016/j.ijpharm.2021.120847 .

Vasiljević, Ivana, Turković, Erna, Nenadović, Snežana, Mirković, Miljana, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Investigation into liquisolid system processability based on the SeDeM Expert System approach" in International Journal of Pharmaceutics, 605 (2021),
https://doi.org/10.1016/j.ijpharm.2021.120847 . .

TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Obradović, Nataša
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3819
AB  - Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.
PB  - MDPI
T2  - Pharmaceutics
T1  - An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
VL  - 13
IS  - 4
DO  - 10.3390/pharmaceutics13040468
ER  - 

@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Obradović, Nataša and Vasiljević, Dragana and Parojčić, Jelena",
year = "2021",
abstract = "Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films",
volume = "13",
number = "4",
doi = "10.3390/pharmaceutics13040468"
}

Turković, E., Vasiljević, I., Drašković, M., Obradović, N., Vasiljević, D.,& Parojčić, J.. (2021). An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics
MDPI., 13(4).
https://doi.org/10.3390/pharmaceutics13040468

Turković E, Vasiljević I, Drašković M, Obradović N, Vasiljević D, Parojčić J. An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics. 2021;13(4).
doi:10.3390/pharmaceutics13040468 .

Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Obradović, Nataša, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films" in Pharmaceutics, 13, no. 4 (2021),
https://doi.org/10.3390/pharmaceutics13040468 . .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Piller, Michael
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3763
AB  - Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.
PB  - Elsevier B.V.
T2  - Powder Technology
T1  - An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization
VL  - 379
SP  - 526
EP  - 536
DO  - 10.1016/j.powtec.2020.10.085
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Piller, Michael and Zimmer, Andreas and Parojčić, Jelena",
year = "2021",
abstract = "Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.",
publisher = "Elsevier B.V.",
journal = "Powder Technology",
title = "An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization",
volume = "379",
pages = "526-536",
doi = "10.1016/j.powtec.2020.10.085"
}

Vasiljević, I., Turković, E., Piller, M., Zimmer, A.,& Parojčić, J.. (2021). An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization. in Powder Technology
Elsevier B.V.., 379, 526-536.
https://doi.org/10.1016/j.powtec.2020.10.085

Vasiljević I, Turković E, Piller M, Zimmer A, Parojčić J. An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization. in Powder Technology. 2021;379:526-536.
doi:10.1016/j.powtec.2020.10.085 .

Vasiljević, Ivana, Turković, Erna, Piller, Michael, Zimmer, Andreas, Parojčić, Jelena, "An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization" in Powder Technology, 379 (2021):526-536,
https://doi.org/10.1016/j.powtec.2020.10.085 . .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Medarević, Đorđe
AU  - Krstić, Marko
AU  - Vasiljević, Ivana
AU  - Mašić, Ivana
AU  - Ibrić, Svetlana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1745
AB  - The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters. They were varied in the first set of experiments in order to estimate their influences on critical quality attributes, that is, granules characteristics (size distribution, flowability, bulk density, tapped density, Carr's index, Hausner's ratio, and moisture content) using Plackett-Burman experimental design. Type of diluent and atomization pressure were selected as the most important parameters. In the second set of experiments, design space for process parameters (atomization pressure and compression force) and its influence on tablets characteristics was developed. Percent of paracetamol released and tablets hardness were determined as critical quality attributes. Artificial neural networks (ANNs) were applied in order to determine design space. ANNs models showed that atomization pressure influences mostly on the dissolution profile, whereas compression force affects mainly the tablets hardness. Based on the obtained ANNs models, it is possible to predict tablet hardness and paracetamol release profile for any combination of analyzed factors.
PB  - Hindawi Publishing Corporation, New York
T2  - Sensors
T1  - Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
DO  - 10.1100/2012/185085
ER  - 

@article{
author = "Đuriš, Jelena and Medarević, Đorđe and Krstić, Marko and Vasiljević, Ivana and Mašić, Ivana and Ibrić, Svetlana",
year = "2012",
abstract = "The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters. They were varied in the first set of experiments in order to estimate their influences on critical quality attributes, that is, granules characteristics (size distribution, flowability, bulk density, tapped density, Carr's index, Hausner's ratio, and moisture content) using Plackett-Burman experimental design. Type of diluent and atomization pressure were selected as the most important parameters. In the second set of experiments, design space for process parameters (atomization pressure and compression force) and its influence on tablets characteristics was developed. Percent of paracetamol released and tablets hardness were determined as critical quality attributes. Artificial neural networks (ANNs) were applied in order to determine design space. ANNs models showed that atomization pressure influences mostly on the dissolution profile, whereas compression force affects mainly the tablets hardness. Based on the obtained ANNs models, it is possible to predict tablet hardness and paracetamol release profile for any combination of analyzed factors.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Sensors",
title = "Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process",
doi = "10.1100/2012/185085"
}

Đuriš, J., Medarević, Đ., Krstić, M., Vasiljević, I., Mašić, I.,& Ibrić, S.. (2012). Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process. in Sensors
Hindawi Publishing Corporation, New York..
https://doi.org/10.1100/2012/185085

Đuriš J, Medarević Đ, Krstić M, Vasiljević I, Mašić I, Ibrić S. Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process. in Sensors. 2012;.
doi:10.1100/2012/185085 .

Đuriš, Jelena, Medarević, Đorđe, Krstić, Marko, Vasiljević, Ivana, Mašić, Ivana, Ibrić, Svetlana, "Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process" in Sensors (2012),
https://doi.org/10.1100/2012/185085 . .