TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Filipović, Teodora
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4201
AB  - Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.
AB  - COVID-19 (engl. coronavirus disease 2019) respiratorna je bolest prouzročena infekcijom SARS-CoV-2 virusom (engl. severe acute respiratory
syndrome coronavirus 2). Pretpostavlja se da postoji utjecaj atmosferskih čimbenika, uključujući i onečišćenje zraka, na prenošenje koronavirusa,
njegovu težinu i stopu smrtnosti. Stoga je cilj ovoga in silico istraživanja bio utvrditi odnos između ključnih onečišćivača zraka [sumporova
dioksida (SO2), ugljikova monoksida (CO), lebdećih čestica (PMx), dušikova dioksida (NO2), ozona (O3)] i komplikacija COVID-a 19
korištenjem: (i) komparativne toksikogenomičke baze podataka (engl. Comparative Toxicogenomic Database, CTD) za dobivanje gena, međusobno
povezanih s onečišćivačima zraka i komplikacijama COVID-a 19, (ii) GeneMANIA servera za konstruiranje mreže između dobivenih i
srodnih gena, (iii) ToppGene Suite za izdvajanje najvažnijih bioloških procesa/molekularnih puteva i (iv) DisGeNET baze podataka za
traženje najvažnijih parova gen-bolest. Za SO2, CO, PMx, NO2 odnosno O3 utvrđena je interakcija sa 6, 6, 18, 9, odnosno 12 gena povezanih
s komplikacijama COVID-a 19. Četiri su zajednička (IL10, IL6, IL1B i TNF) i u najvećem postotku (77,64 %) sudjeluju u fizičkim
interakcijama. Vezivanje citokina i signalni put posredovan citokinima izdvojeni su kao najvažnija molekularna funkcija i biološki proces.
Druge molekularne funkcije i biološki procesi uglavnom su bili povezani s aktivnošću citokina i upalom, što bi se moglo dovesti u vezu s
citokinskom olujom i posljedičnim komplikacijama COVID-a 19. Utvrđena je veza između različitih bolesti i ispitivanih gena, posebice
između CEBPA i akutne mijelogene leukemije (AML) te između TNFRSF1A i sindroma periodične vrućice povezanoga s TNF receptorom.
To upozorava na moguće komplikacije u osoba zaraženih koronavirusom koje boluju od tih bolesti, poglavito kada su dodatno potaknute
poremećajem funkcije spomenutih gena.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis
T1  - Zajednički utjecaj ključnih onečišćivača zraka na težinu COVID-a 19 – predviđanje zasnovano na analizi toksikogenomičkih
podataka
VL  - 73
IS  - 2
SP  - 119
EP  - 125
DO  - 10.2478/aiht-2022-73-3631
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Filipović, Teodora and Božić, Dragica and Živančević, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Ćurčić, Marijana",
year = "2022",
abstract = "Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality., COVID-19 (engl. coronavirus disease 2019) respiratorna je bolest prouzročena infekcijom SARS-CoV-2 virusom (engl. severe acute respiratory
syndrome coronavirus 2). Pretpostavlja se da postoji utjecaj atmosferskih čimbenika, uključujući i onečišćenje zraka, na prenošenje koronavirusa,
njegovu težinu i stopu smrtnosti. Stoga je cilj ovoga in silico istraživanja bio utvrditi odnos između ključnih onečišćivača zraka [sumporova
dioksida (SO2), ugljikova monoksida (CO), lebdećih čestica (PMx), dušikova dioksida (NO2), ozona (O3)] i komplikacija COVID-a 19
korištenjem: (i) komparativne toksikogenomičke baze podataka (engl. Comparative Toxicogenomic Database, CTD) za dobivanje gena, međusobno
povezanih s onečišćivačima zraka i komplikacijama COVID-a 19, (ii) GeneMANIA servera za konstruiranje mreže između dobivenih i
srodnih gena, (iii) ToppGene Suite za izdvajanje najvažnijih bioloških procesa/molekularnih puteva i (iv) DisGeNET baze podataka za
traženje najvažnijih parova gen-bolest. Za SO2, CO, PMx, NO2 odnosno O3 utvrđena je interakcija sa 6, 6, 18, 9, odnosno 12 gena povezanih
s komplikacijama COVID-a 19. Četiri su zajednička (IL10, IL6, IL1B i TNF) i u najvećem postotku (77,64 %) sudjeluju u fizičkim
interakcijama. Vezivanje citokina i signalni put posredovan citokinima izdvojeni su kao najvažnija molekularna funkcija i biološki proces.
Druge molekularne funkcije i biološki procesi uglavnom su bili povezani s aktivnošću citokina i upalom, što bi se moglo dovesti u vezu s
citokinskom olujom i posljedičnim komplikacijama COVID-a 19. Utvrđena je veza između različitih bolesti i ispitivanih gena, posebice
između CEBPA i akutne mijelogene leukemije (AML) te između TNFRSF1A i sindroma periodične vrućice povezanoga s TNF receptorom.
To upozorava na moguće komplikacije u osoba zaraženih koronavirusom koje boluju od tih bolesti, poglavito kada su dodatno potaknute
poremećajem funkcije spomenutih gena.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis, Zajednički utjecaj ključnih onečišćivača zraka na težinu COVID-a 19 – predviđanje zasnovano na analizi toksikogenomičkih
podataka",
volume = "73",
number = "2",
pages = "119-125",
doi = "10.2478/aiht-2022-73-3631"
}

Đukić-Ćosić, D., Baralić, K., Filipović, T., Božić, D., Živančević, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Ćurčić, M.. (2022). Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 73(2), 119-125.
https://doi.org/10.2478/aiht-2022-73-3631

Đukić-Ćosić D, Baralić K, Filipović T, Božić D, Živančević K, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Ćurčić M. Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2022;73(2):119-125.
doi:10.2478/aiht-2022-73-3631 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Filipović, Teodora, Božić, Dragica, Živančević, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Ćurčić, Marijana, "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 73, no. 2 (2022):119-125,
https://doi.org/10.2478/aiht-2022-73-3631 . .

TY  - JOUR
AU  - Todorović, T
AU  - Vujanović, Dragana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/315
AB  - Many authors in different studies have reported the antagonism between Mg and Pb. Our previous results suggested that oral Mg treatment have better effect on investigation biochemical parameters (protoporphyrins, aminolevulinic acid - ALA and d-aminolevulinic dehydrataseALA-D) used in evaluating Pb intoxication, then CaNa(2)EDTA, chelation agens, currently used in therapy of Pb intoxication. The toxic effect of Pb induced considerably modifies the activity of many other enzymes. In this work we have examined the influence of Mg (as alternative therapy of Ph poisoning) on enzymes activity biochemical markers for general health conditions - aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in condition of lead intoxication. Many studies showed disturbances of activity ALT, AST and ALP The aim of this study was to confirm positive effects of Mg intake in condition of such intoxication at the level on activity of investigated enzymes. The experiment was performed on 45 male Wister rats, divided in three groups. I - control group; II - group treated daily for 30 days with 100 mg Pb, per kg body weight and next 60 without Pb treatment (spontaneous detoxication); III group - the same treatment as II group for the first 30 days, but next 60 days rats were treated orally with 40 mg Mg/kg body weight. Activity of AST and ALT was significant increased in condition of Pb poisoning, but ALP activity was significant reduced. Influence of excessive oral Mg treatment was positive: decrease of AST activity and ALT activity, which was probably in correlation with significant elimination of Ph from liver and increase of ALT enzyme activity at the normal level.
PB  - John Libbey & Co Ltd, London
T2  - Magnesium Research
T1  - The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues
VL  - 15
IS  - 3-4
SP  - 173
EP  - 177
UR  - https://hdl.handle.net/21.15107/rcub_farfar_315
ER  - 

@article{
author = "Todorović, T and Vujanović, Dragana",
year = "2002",
abstract = "Many authors in different studies have reported the antagonism between Mg and Pb. Our previous results suggested that oral Mg treatment have better effect on investigation biochemical parameters (protoporphyrins, aminolevulinic acid - ALA and d-aminolevulinic dehydrataseALA-D) used in evaluating Pb intoxication, then CaNa(2)EDTA, chelation agens, currently used in therapy of Pb intoxication. The toxic effect of Pb induced considerably modifies the activity of many other enzymes. In this work we have examined the influence of Mg (as alternative therapy of Ph poisoning) on enzymes activity biochemical markers for general health conditions - aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in condition of lead intoxication. Many studies showed disturbances of activity ALT, AST and ALP The aim of this study was to confirm positive effects of Mg intake in condition of such intoxication at the level on activity of investigated enzymes. The experiment was performed on 45 male Wister rats, divided in three groups. I - control group; II - group treated daily for 30 days with 100 mg Pb, per kg body weight and next 60 without Pb treatment (spontaneous detoxication); III group - the same treatment as II group for the first 30 days, but next 60 days rats were treated orally with 40 mg Mg/kg body weight. Activity of AST and ALT was significant increased in condition of Pb poisoning, but ALP activity was significant reduced. Influence of excessive oral Mg treatment was positive: decrease of AST activity and ALT activity, which was probably in correlation with significant elimination of Ph from liver and increase of ALT enzyme activity at the normal level.",
publisher = "John Libbey & Co Ltd, London",
journal = "Magnesium Research",
title = "The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues",
volume = "15",
number = "3-4",
pages = "173-177",
url = "https://hdl.handle.net/21.15107/rcub_farfar_315"
}

Todorović, T.,& Vujanović, D.. (2002). The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues. in Magnesium Research
John Libbey & Co Ltd, London., 15(3-4), 173-177.
https://hdl.handle.net/21.15107/rcub_farfar_315

Todorović T, Vujanović D. The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues. in Magnesium Research. 2002;15(3-4):173-177.
https://hdl.handle.net/21.15107/rcub_farfar_315 .

Todorović, T, Vujanović, Dragana, "The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues" in Magnesium Research, 15, no. 3-4 (2002):173-177,
https://hdl.handle.net/21.15107/rcub_farfar_315 .

TY  - JOUR
AU  - Popović, R
AU  - Todorović, S
AU  - Nikolić, Katarina
PY  - 1973
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Oculometric determination of cupric salts
T1  - Kulometrijsko odredivanje kupri soli
VL  - 30
IS  - 3
SP  - 178
EP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3
ER  - 

@article{
author = "Popović, R and Todorović, S and Nikolić, Katarina",
year = "1973",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Oculometric determination of cupric salts, Kulometrijsko odredivanje kupri soli",
volume = "30",
number = "3",
pages = "178-181",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3"
}

Popović, R., Todorović, S.,& Nikolić, K.. (1973). Oculometric determination of cupric salts. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 30(3), 178-181.
https://hdl.handle.net/21.15107/rcub_farfar_3

Popović R, Todorović S, Nikolić K. Oculometric determination of cupric salts. in Vojnosanitetski pregled. 1973;30(3):178-181.
https://hdl.handle.net/21.15107/rcub_farfar_3 .

Popović, R, Todorović, S, Nikolić, Katarina, "Oculometric determination of cupric salts" in Vojnosanitetski pregled, 30, no. 3 (1973):178-181,
https://hdl.handle.net/21.15107/rcub_farfar_3 .