TY  - CONF
AU  - Bonderović, Vera
AU  - Manić, Luka
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Stojilković, Nikola
AU  - Jorgovanović, Dragica
AU  - Grahovac, Lazar
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5510
AB  - Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ...
AB  - In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama
T1  - Informed mom, healthy baby - How to live safely with chemicals
SP  - 117
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5510
ER  - 

@conference{
author = "Bonderović, Vera and Manić, Luka and Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Stojilković, Nikola and Jorgovanović, Dragica and Grahovac, Lazar and Anđelković, Milena and Repić, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Poslednjih decenija prošlog veka naučnici su utvrdili da pojedine hemikalije, mogu uticati na brojne sisteme organa i izazvati štetne efekte po naše zdravlje. Među hemikalijama sa kojima dolazimo u kontakt gotovo svakodnevno, posebno mesto zauzimaju hemikalije koje mogu delovati na endokrini sistem. ..., In the last decades of the twentieth century, scientists have observed that exposure to certain, human-made chemicals can affect numerous organ systems and cause harmful effects on our health. Among the chemicals hiding in everyday products, substances of special concern are those that can affect the endocrine system. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama, Informed mom, healthy baby - How to live safely with chemicals",
pages = "117-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5510"
}

Bonderović, V., Manić, L., Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Stojilković, N., Jorgovanović, D., Grahovac, L., Anđelković, M., Repić, A., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2023). Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510

Bonderović V, Manić L, Živančević K, Baralić K, Vukelić D, Marić Đ, Stojilković N, Jorgovanović D, Grahovac L, Anđelković M, Repić A, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Buha-Đorđević A. Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:117-118.
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

Bonderović, Vera, Manić, Luka, Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Stojilković, Nikola, Jorgovanović, Dragica, Grahovac, Lazar, Anđelković, Milena, Repić, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Informisana mama, zdrava beba - Kako bezbedno živeti sa hemikalijama" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):117-118,
https://hdl.handle.net/21.15107/rcub_farfar_5510 .

TY  - CONF
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Čolaković, Nataša
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5509
AB  - Iako se poslednjih godina beleži pad koncentracija Cd i Pb u životnoj sredini, istraživanja nedvosmisleno
potvrđuju da i izloženost niskim dozama može dovesti do oštećenja različitih organskih sistema.
Imajući u vidu metaloestrogena svojstva, posebno činjenicu da deluju kao endokrini ometači i
oponašaju dejstvo estrogena, njihov uticaj na reprodukciju I uloga u etiologjji hormon zavisnih karcinomima se ne sme zanemariti. ...
AB  - Regardless of decreased environmental Cd and Pb levels in recent decades, research unequivocally confirms that exposure to low levels can damage numerous organs. Considering their metaloestrogen properties, especially the fact that they act as an endocrine disruptor and mimic the effects of estrogen, their potential role on the reproduction as well in the etiology of hormone related cancers must not be neglected. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma
T1  - Cadmium and lead as risk factors in development of hormone related cancer
SP  - 109
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5509
ER  - 

@conference{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević, Biljana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Čolaković, Nataša and Aćimović, Miodrag and Bulat, Zorica",
year = "2023",
abstract = "Iako se poslednjih godina beleži pad koncentracija Cd i Pb u životnoj sredini, istraživanja nedvosmisleno
potvrđuju da i izloženost niskim dozama može dovesti do oštećenja različitih organskih sistema.
Imajući u vidu metaloestrogena svojstva, posebno činjenicu da deluju kao endokrini ometači i
oponašaju dejstvo estrogena, njihov uticaj na reprodukciju I uloga u etiologjji hormon zavisnih karcinomima se ne sme zanemariti. ..., Regardless of decreased environmental Cd and Pb levels in recent decades, research unequivocally confirms that exposure to low levels can damage numerous organs. Considering their metaloestrogen properties, especially the fact that they act as an endocrine disruptor and mimic the effects of estrogen, their potential role on the reproduction as well in the etiology of hormone related cancers must not be neglected. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma, Cadmium and lead as risk factors in development of hormone related cancer",
pages = "109-110",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5509"
}

Anđelković, M., Buha-Đorđević, A., Vukelić, D., Baralić, K., Đukić-Ćosić, D., Antonijević, B., Ćurčić, M., Antonijević-Miljaković, E., Čolaković, N., Aćimović, M.,& Bulat, Z.. (2023). Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 109-110.
https://hdl.handle.net/21.15107/rcub_farfar_5509

Anđelković M, Buha-Đorđević A, Vukelić D, Baralić K, Đukić-Ćosić D, Antonijević B, Ćurčić M, Antonijević-Miljaković E, Čolaković N, Aćimović M, Bulat Z. Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:109-110.
https://hdl.handle.net/21.15107/rcub_farfar_5509 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević, Biljana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Čolaković, Nataša, Aćimović, Miodrag, Bulat, Zorica, "Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):109-110,
https://hdl.handle.net/21.15107/rcub_farfar_5509 .

TY  - CONF
AU  - Vukelić, Dragana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5423
AB  - Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ...
AB  - Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje
T1  - Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling
SP  - 57
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5423
ER  - 

@conference{
author = "Vukelić, Dragana and Anđelković, Milena and Repić, Aleksandra and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ..., Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje, Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling",
pages = "57-58",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5423"
}

Vukelić, D., Anđelković, M., Repić, A., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Kotur-Stevuljević, J., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423

Vukelić D, Anđelković M, Repić A, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Kotur-Stevuljević J, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

Vukelić, Dragana, Anđelković, Milena, Repić, Aleksandra, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):57-58,
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5033
AB  - The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes that are related to Pb and thyroid function, relationships between genes, biological processes, molecular processes, and pathways using an in silico approach. Male rats were randomized into seven groups (n = 42), one control group and six groups that received a range of Pb doses: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight (b.w.). Dose-response modelling was performed by PROAST software using model averaging method. The Comparative Toxicogenomics Database, GeneMANIA server, and ToppGene Suite portal were used as the main bioinformatic tools in this analysis. The results of our study have shown that low Pb doses induced elevation of thyroid hormones (T4, FT4, and TSH) in rats after subacute exposure, while had no impact on T3, FT3, anti-TPO, and anti-Tg, indicating hyperthyroidism. Dose-dependent effects were increases in T4 and FT4, with the lowest benchmark dose derived for FT4 levels. In silico toxicogenomic data analysis showed that the main molecular pathways/process related to Pb-induced hyperthyroidism are connected with 14 genes involved in antioxidant defense and Se-dependent processes. The results presented here may be useful in further investigation of the health impacts of low-level Pb exposure on thyroid function and endocrine disruption effects.
PB  - Elsevier
T2  - Environmental Research
T1  - In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function
VL  - 237
DO  - 10.1016/j.envres.2023.117035
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Baralić, Katarina and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes that are related to Pb and thyroid function, relationships between genes, biological processes, molecular processes, and pathways using an in silico approach. Male rats were randomized into seven groups (n = 42), one control group and six groups that received a range of Pb doses: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight (b.w.). Dose-response modelling was performed by PROAST software using model averaging method. The Comparative Toxicogenomics Database, GeneMANIA server, and ToppGene Suite portal were used as the main bioinformatic tools in this analysis. The results of our study have shown that low Pb doses induced elevation of thyroid hormones (T4, FT4, and TSH) in rats after subacute exposure, while had no impact on T3, FT3, anti-TPO, and anti-Tg, indicating hyperthyroidism. Dose-dependent effects were increases in T4 and FT4, with the lowest benchmark dose derived for FT4 levels. In silico toxicogenomic data analysis showed that the main molecular pathways/process related to Pb-induced hyperthyroidism are connected with 14 genes involved in antioxidant defense and Se-dependent processes. The results presented here may be useful in further investigation of the health impacts of low-level Pb exposure on thyroid function and endocrine disruption effects.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function",
volume = "237",
doi = "10.1016/j.envres.2023.117035"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Baralić, K., Ćurčić, M., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2023). In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function. in Environmental Research
Elsevier., 237.
https://doi.org/10.1016/j.envres.2023.117035

Vukelić D, Buha-Đorđević A, Anđelković M, Baralić K, Ćurčić M, Đukić-Ćosić D, Antonijević B, Bulat Z. In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function. in Environmental Research. 2023;237.
doi:10.1016/j.envres.2023.117035 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Baralić, Katarina, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function" in Environmental Research, 237 (2023),
https://doi.org/10.1016/j.envres.2023.117035 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Anđelković, Milena
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4915
AB  - The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats after the 28- and 90-day exposure to dose levels calculated on the basis of the previously conducted human study. Experimental groups included: 2 controls (28- and 90-day), treated groups - doses based on: median– F2 (28) and F2(90) and 95th percentile concentrations in the general human population – F3(28) and F3(90); calculated lower Benchmark dose confidence limit (BMDL) for effects on hormone levels – F1(28) and F1(90) and a group given the doses calculated on the basis of the reference values from the literature (F4(28)). Blood and ovarian samples were collected for sex hormones and ovary redox status analysis. After 28-day exposure, changes were present both in prooxidants and antioxidants. However, after the 90-day exposure redox status imbalance was majorly caused by the disturbance of antioxidants. Changes in some parameters were observed even after exposure to the lowest doses. After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2–related factor 2 (Nrf2) and toxic metal(oid)s. Low obtained BMDLs and narrow Benchmark intervals for toxic metal(oid)s and some of the parameters might confirm the “no-threshold” paradigm. This study indicates possible detrimental effects of prolonged exposure to real-life mixtures of toxic metal(oid) on female reproductive function.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different
VL  - 895
DO  - 10.1016/j.scitotenv.2023.165181
ER  - 

@article{
author = "Baralić, Katarina and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Anđelković, Milena and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats after the 28- and 90-day exposure to dose levels calculated on the basis of the previously conducted human study. Experimental groups included: 2 controls (28- and 90-day), treated groups - doses based on: median– F2 (28) and F2(90) and 95th percentile concentrations in the general human population – F3(28) and F3(90); calculated lower Benchmark dose confidence limit (BMDL) for effects on hormone levels – F1(28) and F1(90) and a group given the doses calculated on the basis of the reference values from the literature (F4(28)). Blood and ovarian samples were collected for sex hormones and ovary redox status analysis. After 28-day exposure, changes were present both in prooxidants and antioxidants. However, after the 90-day exposure redox status imbalance was majorly caused by the disturbance of antioxidants. Changes in some parameters were observed even after exposure to the lowest doses. After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2–related factor 2 (Nrf2) and toxic metal(oid)s. Low obtained BMDLs and narrow Benchmark intervals for toxic metal(oid)s and some of the parameters might confirm the “no-threshold” paradigm. This study indicates possible detrimental effects of prolonged exposure to real-life mixtures of toxic metal(oid) on female reproductive function.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different",
volume = "895",
doi = "10.1016/j.scitotenv.2023.165181"
}

Baralić, K., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Anđelković, M., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. in Science of the Total Environment
Elsevier B.V.., 895.
https://doi.org/10.1016/j.scitotenv.2023.165181

Baralić K, Marić Đ, Vukelić D, Antonijević-Miljaković E, Anđelković M, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. in Science of the Total Environment. 2023;895.
doi:10.1016/j.scitotenv.2023.165181 .

Baralić, Katarina, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Anđelković, Milena, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different" in Science of the Total Environment, 895 (2023),
https://doi.org/10.1016/j.scitotenv.2023.165181 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Aćimović, Miodrag
AU  - Bojanić, Nebojša
AU  - Bartolović, Daniela
AU  - Bulat, Petar
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4675
AB  - Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a 1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity.
PB  - Elsevier Ltd
T2  - Chemosphere
T1  - Cadmium and lead implication in testis cancer; is there a connection?
VL  - 330
DO  - 10.1016/j.chemosphere.2023.138698
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Đukić-Ćosić, Danijela and Aćimović, Miodrag and Bojanić, Nebojša and Bartolović, Daniela and Bulat, Petar and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a 1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity.",
publisher = "Elsevier Ltd",
journal = "Chemosphere",
title = "Cadmium and lead implication in testis cancer; is there a connection?",
volume = "330",
doi = "10.1016/j.chemosphere.2023.138698"
}

Anđelković, M., Buha-Đorđević, A., Vukelić, D., Đukić-Ćosić, D., Aćimović, M., Bojanić, N., Bartolović, D., Bulat, P., Antonijević, B.,& Bulat, Z.. (2023). Cadmium and lead implication in testis cancer; is there a connection?. in Chemosphere
Elsevier Ltd., 330.
https://doi.org/10.1016/j.chemosphere.2023.138698

Anđelković M, Buha-Đorđević A, Vukelić D, Đukić-Ćosić D, Aćimović M, Bojanić N, Bartolović D, Bulat P, Antonijević B, Bulat Z. Cadmium and lead implication in testis cancer; is there a connection?. in Chemosphere. 2023;330.
doi:10.1016/j.chemosphere.2023.138698 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Đukić-Ćosić, Danijela, Aćimović, Miodrag, Bojanić, Nebojša, Bartolović, Daniela, Bulat, Petar, Antonijević, Biljana, Bulat, Zorica, "Cadmium and lead implication in testis cancer; is there a connection?" in Chemosphere, 330 (2023),
https://doi.org/10.1016/j.chemosphere.2023.138698 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Antonijević-Miljaković, Evica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Bulat, Petar
AU  - Radovanović, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4650
AB  - Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.
PB  - MDPI
T2  - Toxics
T1  - Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats
VL  - 11
IS  - 3
DO  - 10.3390/toxics11030256
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Antonijević-Miljaković, Evica and Baralić, Katarina and Živančević, Katarina and Bulat, Petar and Radovanović, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.",
publisher = "MDPI",
journal = "Toxics",
title = "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats",
volume = "11",
number = "3",
doi = "10.3390/toxics11030256"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Antonijević-Miljaković, E., Baralić, K., Živančević, K., Bulat, P., Radovanović, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2023). Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics
MDPI., 11(3).
https://doi.org/10.3390/toxics11030256

Vukelić D, Buha-Đorđević A, Anđelković M, Antonijević-Miljaković E, Baralić K, Živančević K, Bulat P, Radovanović J, Đukić-Ćosić D, Antonijević B, Bulat Z. Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics. 2023;11(3).
doi:10.3390/toxics11030256 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Antonijević-Miljaković, Evica, Baralić, Katarina, Živančević, Katarina, Bulat, Petar, Radovanović, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats" in Toxics, 11, no. 3 (2023),
https://doi.org/10.3390/toxics11030256 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Boričić, Novica
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4385
AB  - The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb.
PB  - Elsevier Ireland Ltd
T2  - Toxicology Letters
T1  - Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats
VL  - 375
SP  - 69
EP  - 76
DO  - 10.1016/j.toxlet.2023.01.001
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Repić, Aleksandra and Baralić, Katarina and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Boričić, Novica and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology Letters",
title = "Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats",
volume = "375",
pages = "69-76",
doi = "10.1016/j.toxlet.2023.01.001"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Repić, A., Baralić, K., Ćurčić, M., Đukić-Ćosić, D., Boričić, N., Antonijević, B.,& Bulat, Z.. (2023). Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats. in Toxicology Letters
Elsevier Ireland Ltd., 375, 69-76.
https://doi.org/10.1016/j.toxlet.2023.01.001

Vukelić D, Buha-Đorđević A, Anđelković M, Repić A, Baralić K, Ćurčić M, Đukić-Ćosić D, Boričić N, Antonijević B, Bulat Z. Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats. in Toxicology Letters. 2023;375:69-76.
doi:10.1016/j.toxlet.2023.01.001 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Repić, Aleksandra, Baralić, Katarina, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Boričić, Novica, Antonijević, Biljana, Bulat, Zorica, "Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats" in Toxicology Letters, 375 (2023):69-76,
https://doi.org/10.1016/j.toxlet.2023.01.001 . .

TY  - THES
AU  - Anđelković, Milena
PY  - 2022
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9084
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:29314/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/77263369
UR  - https://nardus.mpn.gov.rs/handle/123456789/21429
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4846
AB  - Kadmijum (Cd) i olovo (Pb) su neesencijalni metali prirodno prisutni u životnoj sredini, ali je razvojindustrije značajno povećao njihovu koncentraciju u vazduhu, vodi i hrani. Iako se poslednjih godinabeleži pad njihovih koncentracija u životnoj sredini, istraživanja nedvosmisleno potvrđuju da iizloženost niskim dozama može dovesti do oštećenja različitih organskih sistema, te i endokrinog, štoih čini značajnim faktorom u pojavi/razvoju hormon zavisnih karcinoma, poput karcinoma dojke,prostate i testisa. S tim u vezi, pri proceni toksičnih efekata Cd i Pb potrebno je razmotriti potencijalniuticaj istovremene izloženosti jer je realni scenario da je čovek izložen smeši toksičnih supstanci, a datoksični efekti smeše mogu biti kvalitativno i kvantitativno drugačiji u odnosu na efekte pojedinačnihsupstanci. Stoga je ova studija imala cilj da ispita potencijalnu ulogu Cd i Pb kao faktora rizika uetiologiji karcinoma dojke, prostate i testisa ispitivanjem oksidativnog statusa, profila bioelemenata inivoa polnih hormona kod pacijenata obolelih od ovih karcinoma, te da utvrdi eventualni prediktivnipotencijal pojedinačnih parametra za nastanak karcinoma dojke, prostate i testisa.Retrospektivnoj case control studiji prethodila je in vivo studija na mužjacima Wistar pacova koji suakutno bili izloženi Cd i/ili Pb sa ciljem da se u uslovima istovremene izloženosti ispita distribucijametala, kao i da se utvrde toksični efekti metala i njihova priroda i intenzitet na krv i krvotvorneorgane, jetru, bubrege, prostatu i testise evaluacijom parametara oksidativnog statusa i ispitivanjeminterakcija sa bioelementima, bakrom (Cu) i cinkom (Zn).Case control studija je obuhvatila 55 pacijentkinja sa karcinomom dojke, 41 pacijenta sa karcinomomprostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile uključene zdrave žene(41), odnosno zdravi muškarci (61). Značajno više koncentracije Cd, odnosno niže Pb u tumorskomtkivu dojke u odnosu na okolno zdravo tkivo utvrđene su kod pacijentkinja sa karcinomom dojke, doksu estrogen receptor pozitivne karcinome dojke karakterisale više koncentracije oba toksična metala utumorskim tkivima u odnosu na negativnu ekspresiju receptora. Pacijente sa karcinomima prostate itestisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave ispitanike, a pokazanaje i značajna akumulacija oba toksična metala u tumorskom tkivu prostate i testisa. Značajan odds ratiopokazan je za Cd u tkivu izmenjene strukture dojke (1,02), Cd u krvi pacijenata sa karcinomomprostate (1,18) i karcinomom testisa (1,98).Eksperimentalna in vivo studija utvrdila je hepato- i nefrotoksične efekte Cd i Pb, sa izraženijemefektom nakon akutne ekspozicije smeši. Oba toksična metala pokazala su sposobnost prolaska krv-testis barijere, međutim akutna izloženost nije značajno narušila homeostazu testosterona niti izmenilamorfološku strukturu prostate i testisa mužjaka pacova. Case control studija prepoznala je višekoncentracije Cd, ali ne i Pb značajnim prediktorom za nastanak karcinoma i potvrdila je narušenuhomeostazu oksidativnog statusa, redistribuciju Cu i Zn kao i disbalans polnih hormona kao važnemehanizme toksičnosti koji se nalaze u osnovi toksičnih efekata Cd i Pb kod obolelih od karcinomadojke, prostate i testisa.
AB  - Cadmium (Cd) and lead (Pb) are non-essential metals naturally present in the environment, but theindustry development significantly increased their levels in air, water and food. Regardless theirdecreased environmental levels in recent decades, research unequivocally confirms that exposure tolow levels of Cd and Pb can damage numerous organs, including endocrine system. Furthermore, bothof them have been recognized as significant factor in the occurrence/development of hormone-dependent cancers, such as breast, prostate and testis cancer. In this regard, it is necessary to considerthe potential impact of simultaneous Cd and Pb exposure because the more realistic scenario is thathumans are exposed to a mixture of toxic substances, and that the toxic effects of the mixture may bequalitatively and quantitatively different from the effects of individual substances. Therefore, the casecontrol study aimed to determine the potential implication of Cd and Pb in the etiology of breast,prostate and testis cancer by examining oxidative status, bioelement profiles and sex hormone levels,and to establish the parameters, significant for breast, prostate and testis cancer prediction.In vivo study with male Wistar rats acutely treated by Cd and/or Pb, conducted prior the retrospectivecase control study, aimed to investigate metals distribution as well the toxic metals effects and todetermine the nature and intensity of Cd and Pb co-exposure effects on blood, liver, kidney, prostateand testis by evaluating oxidative status parameters and examining interactions with bioelements,copper (Cu) and zinc (Zn).The case control study encompassed 55 breast, 41 prostate and 52 testis cancer patients, while controlgroups were represented by 41 healthy women and 61 healthy men. Significantly higher Cd levels, butlower Pb in breast tumor tissue compared to surrounding healthy tissue was established in patients,while estrogen receptor positive breast cancer characterized by higher levels of both toxic metals intumor tissues compared to negative receptor expression. Notably higher blood Cd levels weredocumented in prostate and testicular cancers patients in relation to healthy subjects, and a significantaccumulation of both toxic metals in prostate and testis tumor tissue was shown. Thy study recognizeda significant odds ratio for Cd in breast cancer tissue (1.02), Cd in blood of prostate (1.18) and testiscancer patients (1.98).The in vivo study showed Cd and Pb hepatotoxic and nephrotoxic effects, with more pronounced effectafter mixture exposure. Regardless ability to cross the blood-testis barrier Cd and Pb did notsignificantly disturb testosterone homeostasis neither morphological structure of prostate and testis.Case control study recognized higher Cd levels in breast cancer tissue as well in blood of prostate andtestis cancer patients, but no Pb levels as significant factor in cancer prediction and confirmed oxidativestress, Cu and Zn redistribution as well impaired sex hormones homeostasis as pivotal mechanisms ofCd and Pb toxicity in breast, prostate and testis cancer pathology.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Uticaj kadmijuma i olova na homeostazu bioelemenata i parametre oksidativnog stresa kod obolelih od karcinoma dojke, prostate i testisa
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21429
ER  - 

@phdthesis{
author = "Anđelković, Milena",
year = "2022",
abstract = "Kadmijum (Cd) i olovo (Pb) su neesencijalni metali prirodno prisutni u životnoj sredini, ali je razvojindustrije značajno povećao njihovu koncentraciju u vazduhu, vodi i hrani. Iako se poslednjih godinabeleži pad njihovih koncentracija u životnoj sredini, istraživanja nedvosmisleno potvrđuju da iizloženost niskim dozama može dovesti do oštećenja različitih organskih sistema, te i endokrinog, štoih čini značajnim faktorom u pojavi/razvoju hormon zavisnih karcinoma, poput karcinoma dojke,prostate i testisa. S tim u vezi, pri proceni toksičnih efekata Cd i Pb potrebno je razmotriti potencijalniuticaj istovremene izloženosti jer je realni scenario da je čovek izložen smeši toksičnih supstanci, a datoksični efekti smeše mogu biti kvalitativno i kvantitativno drugačiji u odnosu na efekte pojedinačnihsupstanci. Stoga je ova studija imala cilj da ispita potencijalnu ulogu Cd i Pb kao faktora rizika uetiologiji karcinoma dojke, prostate i testisa ispitivanjem oksidativnog statusa, profila bioelemenata inivoa polnih hormona kod pacijenata obolelih od ovih karcinoma, te da utvrdi eventualni prediktivnipotencijal pojedinačnih parametra za nastanak karcinoma dojke, prostate i testisa.Retrospektivnoj case control studiji prethodila je in vivo studija na mužjacima Wistar pacova koji suakutno bili izloženi Cd i/ili Pb sa ciljem da se u uslovima istovremene izloženosti ispita distribucijametala, kao i da se utvrde toksični efekti metala i njihova priroda i intenzitet na krv i krvotvorneorgane, jetru, bubrege, prostatu i testise evaluacijom parametara oksidativnog statusa i ispitivanjeminterakcija sa bioelementima, bakrom (Cu) i cinkom (Zn).Case control studija je obuhvatila 55 pacijentkinja sa karcinomom dojke, 41 pacijenta sa karcinomomprostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile uključene zdrave žene(41), odnosno zdravi muškarci (61). Značajno više koncentracije Cd, odnosno niže Pb u tumorskomtkivu dojke u odnosu na okolno zdravo tkivo utvrđene su kod pacijentkinja sa karcinomom dojke, doksu estrogen receptor pozitivne karcinome dojke karakterisale više koncentracije oba toksična metala utumorskim tkivima u odnosu na negativnu ekspresiju receptora. Pacijente sa karcinomima prostate itestisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave ispitanike, a pokazanaje i značajna akumulacija oba toksična metala u tumorskom tkivu prostate i testisa. Značajan odds ratiopokazan je za Cd u tkivu izmenjene strukture dojke (1,02), Cd u krvi pacijenata sa karcinomomprostate (1,18) i karcinomom testisa (1,98).Eksperimentalna in vivo studija utvrdila je hepato- i nefrotoksične efekte Cd i Pb, sa izraženijemefektom nakon akutne ekspozicije smeši. Oba toksična metala pokazala su sposobnost prolaska krv-testis barijere, međutim akutna izloženost nije značajno narušila homeostazu testosterona niti izmenilamorfološku strukturu prostate i testisa mužjaka pacova. Case control studija prepoznala je višekoncentracije Cd, ali ne i Pb značajnim prediktorom za nastanak karcinoma i potvrdila je narušenuhomeostazu oksidativnog statusa, redistribuciju Cu i Zn kao i disbalans polnih hormona kao važnemehanizme toksičnosti koji se nalaze u osnovi toksičnih efekata Cd i Pb kod obolelih od karcinomadojke, prostate i testisa., Cadmium (Cd) and lead (Pb) are non-essential metals naturally present in the environment, but theindustry development significantly increased their levels in air, water and food. Regardless theirdecreased environmental levels in recent decades, research unequivocally confirms that exposure tolow levels of Cd and Pb can damage numerous organs, including endocrine system. Furthermore, bothof them have been recognized as significant factor in the occurrence/development of hormone-dependent cancers, such as breast, prostate and testis cancer. In this regard, it is necessary to considerthe potential impact of simultaneous Cd and Pb exposure because the more realistic scenario is thathumans are exposed to a mixture of toxic substances, and that the toxic effects of the mixture may bequalitatively and quantitatively different from the effects of individual substances. Therefore, the casecontrol study aimed to determine the potential implication of Cd and Pb in the etiology of breast,prostate and testis cancer by examining oxidative status, bioelement profiles and sex hormone levels,and to establish the parameters, significant for breast, prostate and testis cancer prediction.In vivo study with male Wistar rats acutely treated by Cd and/or Pb, conducted prior the retrospectivecase control study, aimed to investigate metals distribution as well the toxic metals effects and todetermine the nature and intensity of Cd and Pb co-exposure effects on blood, liver, kidney, prostateand testis by evaluating oxidative status parameters and examining interactions with bioelements,copper (Cu) and zinc (Zn).The case control study encompassed 55 breast, 41 prostate and 52 testis cancer patients, while controlgroups were represented by 41 healthy women and 61 healthy men. Significantly higher Cd levels, butlower Pb in breast tumor tissue compared to surrounding healthy tissue was established in patients,while estrogen receptor positive breast cancer characterized by higher levels of both toxic metals intumor tissues compared to negative receptor expression. Notably higher blood Cd levels weredocumented in prostate and testicular cancers patients in relation to healthy subjects, and a significantaccumulation of both toxic metals in prostate and testis tumor tissue was shown. Thy study recognizeda significant odds ratio for Cd in breast cancer tissue (1.02), Cd in blood of prostate (1.18) and testiscancer patients (1.98).The in vivo study showed Cd and Pb hepatotoxic and nephrotoxic effects, with more pronounced effectafter mixture exposure. Regardless ability to cross the blood-testis barrier Cd and Pb did notsignificantly disturb testosterone homeostasis neither morphological structure of prostate and testis.Case control study recognized higher Cd levels in breast cancer tissue as well in blood of prostate andtestis cancer patients, but no Pb levels as significant factor in cancer prediction and confirmed oxidativestress, Cu and Zn redistribution as well impaired sex hormones homeostasis as pivotal mechanisms ofCd and Pb toxicity in breast, prostate and testis cancer pathology.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Uticaj kadmijuma i olova na homeostazu bioelemenata i parametre oksidativnog stresa kod obolelih od karcinoma dojke, prostate i testisa",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21429"
}

Anđelković, M.. (2022). Uticaj kadmijuma i olova na homeostazu bioelemenata i parametre oksidativnog stresa kod obolelih od karcinoma dojke, prostate i testisa. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21429

Anđelković M. Uticaj kadmijuma i olova na homeostazu bioelemenata i parametre oksidativnog stresa kod obolelih od karcinoma dojke, prostate i testisa. in Универзитет у Београду. 2022;.
https://hdl.handle.net/21.15107/rcub_nardus_21429 .

Anđelković, Milena, "Uticaj kadmijuma i olova na homeostazu bioelemenata i parametre oksidativnog stresa kod obolelih od karcinoma dojke, prostate i testisa" in Универзитет у Београду (2022),
https://hdl.handle.net/21.15107/rcub_nardus_21429 .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević-Miljaković, Evica
AU  - Anđelković, Milena
AU  - Antonijević, Biljana
AU  - Aschner, Michael
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4351
AB  - The main objective of this research was to conduct a dose–response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The study included 207 male participants from subjects of 5 different cohorts (patients with prostate, testicular, and pancreatic cancer, patients suffering from various thyroid and metabolic disorders, as well as healthy volunteers), enrolled from January 2019 to May 2021 at the Clinical Centre of Serbia in Belgrade, Serbia. Benchmark dose–response modeling analysis was performed with the PROAST software version 70.1, showing the hormone levels as quantal data. The averaging technique was applied to compute the Benchmark dose (BMD) interval (BMDI), with benchmark response set at 10%. Dose-response relationships between metal/metalloid blood concentration and serum hormone levels were confirmed for all the investigated metals/metalloid and hormones. The narrowest BMDI was found for Cd-testosterone and Hg-LH pairs, indicative of high confidence in these estimates. Although further research is needed, the observed findings demonstrate that the BMD approach may prove to be significant in the dose–response modeling of human data.
PB  - Elsevier B.V.
T2  - Environment International
T1  - Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study
VL  - 165
DO  - 10.1016/j.envint.2022.107313
ER  - 

@article{
author = "Baralić, Katarina and Javorac, Dragana and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević-Miljaković, Evica and Anđelković, Milena and Antonijević, Biljana and Aschner, Michael and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "The main objective of this research was to conduct a dose–response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The study included 207 male participants from subjects of 5 different cohorts (patients with prostate, testicular, and pancreatic cancer, patients suffering from various thyroid and metabolic disorders, as well as healthy volunteers), enrolled from January 2019 to May 2021 at the Clinical Centre of Serbia in Belgrade, Serbia. Benchmark dose–response modeling analysis was performed with the PROAST software version 70.1, showing the hormone levels as quantal data. The averaging technique was applied to compute the Benchmark dose (BMD) interval (BMDI), with benchmark response set at 10%. Dose-response relationships between metal/metalloid blood concentration and serum hormone levels were confirmed for all the investigated metals/metalloid and hormones. The narrowest BMDI was found for Cd-testosterone and Hg-LH pairs, indicative of high confidence in these estimates. Although further research is needed, the observed findings demonstrate that the BMD approach may prove to be significant in the dose–response modeling of human data.",
publisher = "Elsevier B.V.",
journal = "Environment International",
title = "Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study",
volume = "165",
doi = "10.1016/j.envint.2022.107313"
}

Baralić, K., Javorac, D., Marić, Đ., Đukić-Ćosić, D., Bulat, Z., Antonijević-Miljaković, E., Anđelković, M., Antonijević, B., Aschner, M.,& Buha-Đorđević, A.. (2022). Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study. in Environment International
Elsevier B.V.., 165.
https://doi.org/10.1016/j.envint.2022.107313

Baralić K, Javorac D, Marić Đ, Đukić-Ćosić D, Bulat Z, Antonijević-Miljaković E, Anđelković M, Antonijević B, Aschner M, Buha-Đorđević A. Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study. in Environment International. 2022;165.
doi:10.1016/j.envint.2022.107313 .

Baralić, Katarina, Javorac, Dragana, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević-Miljaković, Evica, Anđelković, Milena, Antonijević, Biljana, Aschner, Michael, Buha-Đorđević, Aleksandra, "Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study" in Environment International, 165 (2022),
https://doi.org/10.1016/j.envint.2022.107313 . .

TY  - JOUR
AU  - Pizent, Alica
AU  - Anđelković, Milena
AU  - Tariba Lovaković, Blanka
AU  - Živković Semren, Tanja
AU  - Buha-Đorđević, Aleksandra
AU  - Gamulin, Marija
AU  - Bonderović, Vera
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4301
AB  - We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.
PB  - MDPI
T2  - Antioxidants
T1  - Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts
VL  - 11
IS  - 10
DO  - 10.3390/antiox11102044
ER  - 

@article{
author = "Pizent, Alica and Anđelković, Milena and Tariba Lovaković, Blanka and Živković Semren, Tanja and Buha-Đorđević, Aleksandra and Gamulin, Marija and Bonderović, Vera and Aćimović, Miodrag and Bulat, Zorica",
year = "2022",
abstract = "We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts",
volume = "11",
number = "10",
doi = "10.3390/antiox11102044"
}

Pizent, A., Anđelković, M., Tariba Lovaković, B., Živković Semren, T., Buha-Đorđević, A., Gamulin, M., Bonderović, V., Aćimović, M.,& Bulat, Z.. (2022). Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts. in Antioxidants
MDPI., 11(10).
https://doi.org/10.3390/antiox11102044

Pizent A, Anđelković M, Tariba Lovaković B, Živković Semren T, Buha-Đorđević A, Gamulin M, Bonderović V, Aćimović M, Bulat Z. Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts. in Antioxidants. 2022;11(10).
doi:10.3390/antiox11102044 .

Pizent, Alica, Anđelković, Milena, Tariba Lovaković, Blanka, Živković Semren, Tanja, Buha-Đorđević, Aleksandra, Gamulin, Marija, Bonderović, Vera, Aćimović, Miodrag, Bulat, Zorica, "Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts" in Antioxidants, 11, no. 10 (2022),
https://doi.org/10.3390/antiox11102044 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Repić, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Čolaković, Nataša
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4103
AB  - Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered lipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence.
PB  - Springer Nature
T2  - Environmental Science and Pollution Research
T1  - Possible role of lead in breast cancer — a case-control study
VL  - 29
SP  - 65211
EP  - 65221
DO  - 10.1007/s11356-022-20439-z
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Repić, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Čolaković, Nataša and Bulat, Zorica",
year = "2022",
abstract = "Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered lipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence.",
publisher = "Springer Nature",
journal = "Environmental Science and Pollution Research",
title = "Possible role of lead in breast cancer — a case-control study",
volume = "29",
pages = "65211-65221",
doi = "10.1007/s11356-022-20439-z"
}

Anđelković, M., Buha-Đorđević, A., Javorac, D., Baralić, K., Đukić-Ćosić, D., Repić, A., Zeljković, A., Vekić, J., Čolaković, N.,& Bulat, Z.. (2022). Possible role of lead in breast cancer — a case-control study. in Environmental Science and Pollution Research
Springer Nature., 29, 65211-65221.
https://doi.org/10.1007/s11356-022-20439-z

Anđelković M, Buha-Đorđević A, Javorac D, Baralić K, Đukić-Ćosić D, Repić A, Zeljković A, Vekić J, Čolaković N, Bulat Z. Possible role of lead in breast cancer — a case-control study. in Environmental Science and Pollution Research. 2022;29:65211-65221.
doi:10.1007/s11356-022-20439-z .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Repić, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Čolaković, Nataša, Bulat, Zorica, "Possible role of lead in breast cancer — a case-control study" in Environmental Science and Pollution Research, 29 (2022):65211-65221,
https://doi.org/10.1007/s11356-022-20439-z . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Tatović, Simona
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Batinić, Bojan
AU  - Boričić, Novica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4089
AB  - Lead (Pb) is a toxic metal that affects almost all human’s system and organs, with the nervous system as the most sensitive. Better understanding of the Pb neurobehavioral effects and neurotoxicity requires realistic study scenarios based on low level exposure. The aim of this study was to determine neurotoxic effects and mechanisms of Pb in six low doses and to establish dose-response relationship for these effects and related Benchmark dose (BMD). Forty-two, male albino Wistar rats were randomized into seven groups, control and Pb-exposed: 0.1, 0.5, 1, 3, 7 and 15 mg Pb/kg body weight/day (oral gavage) for 28 days. Behavioural tests (Elevated plus maze test, Spontaneous locomotor activity test and Novel object recognition test) were conducted in the last week of experiment, in the control, lower (0.5 mg Pb/kg), middle (3 mg Pb/kg) and higher (15 mg Pb/kg) dose groups. The acetylcholinesterase activity, oxidative status and essential elements levels (Cu, Zn, Mn and Fe) were measured in brain tissue along with histological analyses. External and internal dose-response analyses were performed using PROASTweb 70.1 software. The results have shown that subacute exposure to very low doses of Pb resulted in memory deficits in rats that was accompanied with acetylcholinesterase enzyme activity decrease. The observed hyperactive behaviour was accompanied by dose-dependent induction of brain oxidative stress and Zn elevation. The histological alterations in Purkinje cells were only detected in the group treated with the highest Pb dose. The lowest BMD considering entire oxidative status was calculated based on total oxidative status (4.5e-06 mg Pb/kg b.w./day). The findings reported in our study may be beneficial in further evaluating the health consequences and human health risk assessment of low-level Pb exposure.
PB  - Elsevier Ireland Ltd
T2  - Chemico-Biological Interactions
T1  - Comprehensive insight into the neurotoxic mechanisms of low dose Pb exposure in Wistar rats: Benchmark dose analysis
VL  - 360
DO  - 10.1016/j.cbi.2022.109932
ER  - 

@article{
author = "Javorac, Dragana and Anđelković, Milena and Repić, Aleksandra and Tatović, Simona and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Batinić, Bojan and Boričić, Novica and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Lead (Pb) is a toxic metal that affects almost all human’s system and organs, with the nervous system as the most sensitive. Better understanding of the Pb neurobehavioral effects and neurotoxicity requires realistic study scenarios based on low level exposure. The aim of this study was to determine neurotoxic effects and mechanisms of Pb in six low doses and to establish dose-response relationship for these effects and related Benchmark dose (BMD). Forty-two, male albino Wistar rats were randomized into seven groups, control and Pb-exposed: 0.1, 0.5, 1, 3, 7 and 15 mg Pb/kg body weight/day (oral gavage) for 28 days. Behavioural tests (Elevated plus maze test, Spontaneous locomotor activity test and Novel object recognition test) were conducted in the last week of experiment, in the control, lower (0.5 mg Pb/kg), middle (3 mg Pb/kg) and higher (15 mg Pb/kg) dose groups. The acetylcholinesterase activity, oxidative status and essential elements levels (Cu, Zn, Mn and Fe) were measured in brain tissue along with histological analyses. External and internal dose-response analyses were performed using PROASTweb 70.1 software. The results have shown that subacute exposure to very low doses of Pb resulted in memory deficits in rats that was accompanied with acetylcholinesterase enzyme activity decrease. The observed hyperactive behaviour was accompanied by dose-dependent induction of brain oxidative stress and Zn elevation. The histological alterations in Purkinje cells were only detected in the group treated with the highest Pb dose. The lowest BMD considering entire oxidative status was calculated based on total oxidative status (4.5e-06 mg Pb/kg b.w./day). The findings reported in our study may be beneficial in further evaluating the health consequences and human health risk assessment of low-level Pb exposure.",
publisher = "Elsevier Ireland Ltd",
journal = "Chemico-Biological Interactions",
title = "Comprehensive insight into the neurotoxic mechanisms of low dose Pb exposure in Wistar rats: Benchmark dose analysis",
volume = "360",
doi = "10.1016/j.cbi.2022.109932"
}

Javorac, D., Anđelković, M., Repić, A., Tatović, S., Buha-Đorđević, A., Antonijević-Miljaković, E., Batinić, B., Boričić, N., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2022). Comprehensive insight into the neurotoxic mechanisms of low dose Pb exposure in Wistar rats: Benchmark dose analysis. in Chemico-Biological Interactions
Elsevier Ireland Ltd., 360.
https://doi.org/10.1016/j.cbi.2022.109932

Javorac D, Anđelković M, Repić A, Tatović S, Buha-Đorđević A, Antonijević-Miljaković E, Batinić B, Boričić N, Đukić-Ćosić D, Antonijević B, Bulat Z. Comprehensive insight into the neurotoxic mechanisms of low dose Pb exposure in Wistar rats: Benchmark dose analysis. in Chemico-Biological Interactions. 2022;360.
doi:10.1016/j.cbi.2022.109932 .

Javorac, Dragana, Anđelković, Milena, Repić, Aleksandra, Tatović, Simona, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Batinić, Bojan, Boričić, Novica, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Comprehensive insight into the neurotoxic mechanisms of low dose Pb exposure in Wistar rats: Benchmark dose analysis" in Chemico-Biological Interactions, 360 (2022),
https://doi.org/10.1016/j.cbi.2022.109932 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Tatović, Simona
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Baralić, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Mihajlović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4046
AB  - Exposure to toxic metals, including lead (Pb), were found as important risk factor for cardiovascular diseases. The aim of the study was to simulate low-level subacute Pb exposure scenario and to determine redox status, redox scores (OXY-score, damage score and protective score) and copper (Cu), zinc (Zn), iron (Fe) and manganese (Mn) levels in cardiac tissue of Wistar rats. Based on the obtained results we have established dose-toxic response relationship and derived Benchmark dose. The male Wistar rats were divided in seven groups (n = 6), six threated groups that received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, by oral gavage and control group. The results of the presented study demonstrated that Pb affect cardiac tissue by inducing production of superoxide anion radical (O2.-) and consequently raising malondialdehyde (MDA) levels. The positive trend in OXY-score and damage score were determined. Effect size analysis showed that the main toxic effects were oxidative damage and elevation of MDA. The lowest BMD was calculated for MDA (2.2e-0.6 mg Pb/kg b.w./day). Obtained BMD may be useful in further assessing point of departure in the human health risks assessment of low-level Pb exposure scenario.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling
VL  - 161
DO  - 10.1016/j.fct.2022.112825
ER  - 

@article{
author = "Javorac, Dragana and Tatović, Simona and Anđelković, Milena and Repić, Aleksandra and Baralić, Katarina and Buha-Đorđević, Aleksandra and Mihajlović, Marija and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Exposure to toxic metals, including lead (Pb), were found as important risk factor for cardiovascular diseases. The aim of the study was to simulate low-level subacute Pb exposure scenario and to determine redox status, redox scores (OXY-score, damage score and protective score) and copper (Cu), zinc (Zn), iron (Fe) and manganese (Mn) levels in cardiac tissue of Wistar rats. Based on the obtained results we have established dose-toxic response relationship and derived Benchmark dose. The male Wistar rats were divided in seven groups (n = 6), six threated groups that received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, by oral gavage and control group. The results of the presented study demonstrated that Pb affect cardiac tissue by inducing production of superoxide anion radical (O2.-) and consequently raising malondialdehyde (MDA) levels. The positive trend in OXY-score and damage score were determined. Effect size analysis showed that the main toxic effects were oxidative damage and elevation of MDA. The lowest BMD was calculated for MDA (2.2e-0.6 mg Pb/kg b.w./day). Obtained BMD may be useful in further assessing point of departure in the human health risks assessment of low-level Pb exposure scenario.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling",
volume = "161",
doi = "10.1016/j.fct.2022.112825"
}

Javorac, D., Tatović, S., Anđelković, M., Repić, A., Baralić, K., Buha-Đorđević, A., Mihajlović, M., Kotur-Stevuljević, J., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2022). Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling. in Food and Chemical Toxicology
Elsevier Ltd., 161.
https://doi.org/10.1016/j.fct.2022.112825

Javorac D, Tatović S, Anđelković M, Repić A, Baralić K, Buha-Đorđević A, Mihajlović M, Kotur-Stevuljević J, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling. in Food and Chemical Toxicology. 2022;161.
doi:10.1016/j.fct.2022.112825 .

Javorac, Dragana, Tatović, Simona, Anđelković, Milena, Repić, Aleksandra, Baralić, Katarina, Buha-Đorđević, Aleksandra, Mihajlović, Marija, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling" in Food and Chemical Toxicology, 161 (2022),
https://doi.org/10.1016/j.fct.2022.112825 . .

TY  - CONF
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Anđelković, Milena
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Mandić-Rajčević, Stefan
AU  - Aćimović, Miodrag
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4609
AB  - Exposure to lead (Pb) and cadmium (Cd) poses risk to human health. It is known that
these metals have toxic impact on male reproductive system, leading to physiological
disorders and infertility. Limited data indicates the carcinogenic potential of Pb, while Cd has
been recognized as carcinogen. Benchmark dose-effect modeling can be applied to data from
human, animal and ecotoxicological studies with the aim to obtain Benchmark dose (BMD),
starting point in human health risk assessment. The aim of this study was to use Benchmark
modeling to determine the dose-effect relationship between Pb and Cd levels in tissues of
testicular and prostate cancer patients and serum testosterone levels. The study was
conducted at the Clinical Center of Serbia, and included 104 patients with prostate and
testicular cancer. Cd and Pb levels (ng/g) were measured by atomic absorption
spectrophotometry in isolated healthy surrounding and carcinoma-affected tissues.
Testosterone levels (ng/mL) were measured using the chemiluminescence immunoassay
(CLIA) method. Dose-effect modeling was performed using PROAST70.1 software with
continuous data. The dose dependence was obtained between Cd levels in tumor tissue and
testosterone levels (BMD: 0.0024 ng Cd/g, prostate cancer and 0.0038 ng Cd/g, testicular
cancer). Dose dependence was obtained between Cd levels in healthy surrounding tissue and
testosterone levels (BMD: 0.0092 ng Cd/g). No dose dependence was obtained when
modeling Pb levels as a dose. The data from this study indicate a potential link between Cd
and testosterone levels, i.e. potential association of Cd exposure with male reproductive
health.
AB  - Izloženost olovu (Pb) i kadmijumu (Cd) predstavlja rizik po zdravlje ljudi. Poznato je da ovi
metali deluju toksično na muški reproduktivni sistem dovodeći do poremećaja fizioloških
funkcija i neplodnosti. Ograničen broj studija ukazuje na kancerogeni potencijal Pb, dok je Cd
poznatihumani karcinogen. Benchmark modelovanje odnosa doza-efekat se teoretski može
primeniti na podacima iz humanih, animalnih i ekotoksikoloških studija, sa ciljem dobijanja
Benchmark doze (BMD) kao polazne tačke u proceni rizika po zdravlje ljudi. Cilj ovog rada
bio je da se Benchmark modelovanjem utvrdi odnos doza-efekat između nivoa Pb i Cd u
tkivima karcinoma testisa i prostate pacijenata i nivoa testosterona u serumu. Studija je
sprovedena na Kliničkom centru Srbije i uključila je 104 pacijenta sa karcinomom prostate i
testisa. Nivoi Cd i Pb (ng/g) su izmereni metodom atomske apsorpcione spektrofotometrije u
izolovanim zdravim okolonim i karcinomom zahvaćenim tkivima. Nivoi testosterona
(ng/mL) su mereni pomoću metode direktnog kompetitivnog hemiluminiscentnog
imunoeseja (CLIA). Modelovanje odnosa doza-efekat je vršeno pomoću PROAST 70.1
softvera (RIVM, Holandija) uz upotrebu kontinuiranih podataka. Dozna zavisnost je dobijena
između nivoa Cd u tumorskom tkivu i nivoa testosterona gde je BMD vrednost iznosila
0,0024 ng Cd/g (karcinom prostate) i 0,0038 ng Cd/g (karcinom testisa). Dozna zavisnost je
dobijena i za modelovanje odnosa nivoa Cd u zdravom tkivu i testosterona, sa BMD
vrednošću 0,0092 ng Cd/g. Pri modelovanju nivoa Pb nije dobijena dozna zavisnost. Podaci
ove studije ukazuju na potencijalnu vezu između nivoa Cd u tkivu i nivoa testosterona,
ukazujući na efekte izloženosti ovom metalu na muško reproduktivno zdravlje.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels
T1  - Modelovanje odnosa doza‐odgovor između nivoa Pb i Cd u tkivima karcinoma testisa i prostate i nivoa testosterona
VL  - 72
IS  - 4 suplement
SP  - S569
EP  - S570
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4609
ER  - 

@conference{
author = "Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Anđelković, Milena and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Mandić-Rajčević, Stefan and Aćimović, Miodrag and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "Exposure to lead (Pb) and cadmium (Cd) poses risk to human health. It is known that
these metals have toxic impact on male reproductive system, leading to physiological
disorders and infertility. Limited data indicates the carcinogenic potential of Pb, while Cd has
been recognized as carcinogen. Benchmark dose-effect modeling can be applied to data from
human, animal and ecotoxicological studies with the aim to obtain Benchmark dose (BMD),
starting point in human health risk assessment. The aim of this study was to use Benchmark
modeling to determine the dose-effect relationship between Pb and Cd levels in tissues of
testicular and prostate cancer patients and serum testosterone levels. The study was
conducted at the Clinical Center of Serbia, and included 104 patients with prostate and
testicular cancer. Cd and Pb levels (ng/g) were measured by atomic absorption
spectrophotometry in isolated healthy surrounding and carcinoma-affected tissues.
Testosterone levels (ng/mL) were measured using the chemiluminescence immunoassay
(CLIA) method. Dose-effect modeling was performed using PROAST70.1 software with
continuous data. The dose dependence was obtained between Cd levels in tumor tissue and
testosterone levels (BMD: 0.0024 ng Cd/g, prostate cancer and 0.0038 ng Cd/g, testicular
cancer). Dose dependence was obtained between Cd levels in healthy surrounding tissue and
testosterone levels (BMD: 0.0092 ng Cd/g). No dose dependence was obtained when
modeling Pb levels as a dose. The data from this study indicate a potential link between Cd
and testosterone levels, i.e. potential association of Cd exposure with male reproductive
health., Izloženost olovu (Pb) i kadmijumu (Cd) predstavlja rizik po zdravlje ljudi. Poznato je da ovi
metali deluju toksično na muški reproduktivni sistem dovodeći do poremećaja fizioloških
funkcija i neplodnosti. Ograničen broj studija ukazuje na kancerogeni potencijal Pb, dok je Cd
poznatihumani karcinogen. Benchmark modelovanje odnosa doza-efekat se teoretski može
primeniti na podacima iz humanih, animalnih i ekotoksikoloških studija, sa ciljem dobijanja
Benchmark doze (BMD) kao polazne tačke u proceni rizika po zdravlje ljudi. Cilj ovog rada
bio je da se Benchmark modelovanjem utvrdi odnos doza-efekat između nivoa Pb i Cd u
tkivima karcinoma testisa i prostate pacijenata i nivoa testosterona u serumu. Studija je
sprovedena na Kliničkom centru Srbije i uključila je 104 pacijenta sa karcinomom prostate i
testisa. Nivoi Cd i Pb (ng/g) su izmereni metodom atomske apsorpcione spektrofotometrije u
izolovanim zdravim okolonim i karcinomom zahvaćenim tkivima. Nivoi testosterona
(ng/mL) su mereni pomoću metode direktnog kompetitivnog hemiluminiscentnog
imunoeseja (CLIA). Modelovanje odnosa doza-efekat je vršeno pomoću PROAST 70.1
softvera (RIVM, Holandija) uz upotrebu kontinuiranih podataka. Dozna zavisnost je dobijena
između nivoa Cd u tumorskom tkivu i nivoa testosterona gde je BMD vrednost iznosila
0,0024 ng Cd/g (karcinom prostate) i 0,0038 ng Cd/g (karcinom testisa). Dozna zavisnost je
dobijena i za modelovanje odnosa nivoa Cd u zdravom tkivu i testosterona, sa BMD
vrednošću 0,0092 ng Cd/g. Pri modelovanju nivoa Pb nije dobijena dozna zavisnost. Podaci
ove studije ukazuju na potencijalnu vezu između nivoa Cd u tkivu i nivoa testosterona,
ukazujući na efekte izloženosti ovom metalu na muško reproduktivno zdravlje.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels, Modelovanje odnosa doza‐odgovor između nivoa Pb i Cd u tkivima karcinoma testisa i prostate i nivoa testosterona",
volume = "72",
number = "4 suplement",
pages = "S569-S570",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4609"
}

Javorac, D., Baralić, K., Marić, Đ., Antonijević-Miljaković, E., Anđelković, M., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B., Mandić-Rajčević, S., Aćimović, M.,& Buha-Đorđević, A.. (2022). Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S569-S570.
https://hdl.handle.net/21.15107/rcub_farfar_4609

Javorac D, Baralić K, Marić Đ, Antonijević-Miljaković E, Anđelković M, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Mandić-Rajčević S, Aćimović M, Buha-Đorđević A. Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels. in Arhiv za farmaciju. 2022;72(4 suplement):S569-S570.
https://hdl.handle.net/21.15107/rcub_farfar_4609 .

Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Anđelković, Milena, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Mandić-Rajčević, Stefan, Aćimović, Miodrag, Buha-Đorđević, Aleksandra, "Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S569-S570,
https://hdl.handle.net/21.15107/rcub_farfar_4609 .

TY  - CONF
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Čolaković, Nataša
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4497
AB  - The endocrine potential of Cd and Pb, an important mechanism of their toxicity, has
been established in certain hormone-dependent cancers (1,2). This study aimed to
determine Cd and Pb levels in blood, tumor and healthy surrounding tissue of patients with
breast, prostate and testis cancer and investigate the correlation of Cd and Pb with sex
hormone levels in the patient's blood. The study involved 55 breast, 41 prostate and 52 testis
cancer patients, while healthy women (41) and men (61) represented control groups.
Electrothermal atomic absorption spectrophotometry was used for Cd and Pb levels
determination. Significantly higher Cd levels, i.e. lower Pb in tumor tissue compared to the
healthy surrounding tissue were found in patients with breast cancer. A positive correlation
was confirmed between Cd levels in the changed tissue and both human gonadotropins, and
a negative correlation with estradiol, as well between Pb in tumor tissue and testosterone
levels. Patients with prostate and testis cancer were characterized by significantly higher
blood Cd levels compared to healthy subjects. Furthermore, significant Cd and Pb tumor
tissue accumulation was shown in prostate and testis cancer patients. A significant positive
correlation was found between blood Cd and estradiol levels in patients with prostate
cancer. The study highlighted higher Cd level as a significant predictor of cancer, and
confirmed impaired sex hormone homeostasis as pivotal mechanism of toxicity underlying
the toxic effects of Cd and Pb in patients with breast, prostate and testis cancer.
AB  - Endokrini potencijal kadmijuma (Cd) i olova (Pb), kao važan mehanizam toksičnosti
oba metala, potvrđen je kod određenih hormon-zavisnih karcinoma (1,2). Ova studija je
imala za cilj da utvrdi koncentracije Cd i Pb u krvi, tumorskom i okolnom zdravom tkivu
pacijenata sa karcinomom dojke, prostate i testisa i ispita korelaciju Cd i Pb sa nivoom polnih
hormona u krvi pacijenata. Obuhvatila je 55 pacijentkinja sa karcinomom dojke, 41 pacijenta
sa karcinomom prostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile
uključene zdrave žene (41) i zdravi muškarci (61). Koncentracije Cd i Pb su analizirane
elektrotermalnom atomskom apsorpcionom spektrofotometrijom. Značajno više
koncentracije Cd, odnosno niže Pb u tumorskom u odnosu na okolno zdravo tkivo utvrđene
su kod pacijentkinja sa karcinomom dojke. Pozitivna korelacija je potvrđena između
koncentracija Cd u tkivu izmenjene strukture i oba humana gonadotropina, a negativna sa
estradiolom, te između Pb u tumorskom tkivu i testosterona. Pacijente sa karcinomom
prostate i testisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave
ispitanike, a pokazana je i značajna akumulacija Cd i Pb u tumorskom tkivu prostate i testisa.
Značajna pozitivna korelacija utvrđena je između koncentracije Cd i estradiola u krvi kod
pacijenata sa karcinom prostate. Studija je pokazala da su više koncentracije Cd značajan
prediktor za nastanak karcinoma i potvrdilanarušenu homeostazu polnih hormona kao
važan mehanizam toksičnosti koji se nalazi u osnovi toksičnih efekata Cd i Pb kod obolelih od
karcinoma dojke, prostate i testisa.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?
T1  - Narušena homeostaza polnih hormona kod pacijenata sa karcinom dojke, prostate i testisa: koja je uloga kadmijuma i olova
VL  - 72
IS  - 4 suplement
SP  - S211
EP  - S212
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4497
ER  - 

@conference{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević, Biljana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Čolaković, Nataša and Aćimović, Miodrag and Bulat, Zorica",
year = "2022",
abstract = "The endocrine potential of Cd and Pb, an important mechanism of their toxicity, has
been established in certain hormone-dependent cancers (1,2). This study aimed to
determine Cd and Pb levels in blood, tumor and healthy surrounding tissue of patients with
breast, prostate and testis cancer and investigate the correlation of Cd and Pb with sex
hormone levels in the patient's blood. The study involved 55 breast, 41 prostate and 52 testis
cancer patients, while healthy women (41) and men (61) represented control groups.
Electrothermal atomic absorption spectrophotometry was used for Cd and Pb levels
determination. Significantly higher Cd levels, i.e. lower Pb in tumor tissue compared to the
healthy surrounding tissue were found in patients with breast cancer. A positive correlation
was confirmed between Cd levels in the changed tissue and both human gonadotropins, and
a negative correlation with estradiol, as well between Pb in tumor tissue and testosterone
levels. Patients with prostate and testis cancer were characterized by significantly higher
blood Cd levels compared to healthy subjects. Furthermore, significant Cd and Pb tumor
tissue accumulation was shown in prostate and testis cancer patients. A significant positive
correlation was found between blood Cd and estradiol levels in patients with prostate
cancer. The study highlighted higher Cd level as a significant predictor of cancer, and
confirmed impaired sex hormone homeostasis as pivotal mechanism of toxicity underlying
the toxic effects of Cd and Pb in patients with breast, prostate and testis cancer., Endokrini potencijal kadmijuma (Cd) i olova (Pb), kao važan mehanizam toksičnosti
oba metala, potvrđen je kod određenih hormon-zavisnih karcinoma (1,2). Ova studija je
imala za cilj da utvrdi koncentracije Cd i Pb u krvi, tumorskom i okolnom zdravom tkivu
pacijenata sa karcinomom dojke, prostate i testisa i ispita korelaciju Cd i Pb sa nivoom polnih
hormona u krvi pacijenata. Obuhvatila je 55 pacijentkinja sa karcinomom dojke, 41 pacijenta
sa karcinomom prostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile
uključene zdrave žene (41) i zdravi muškarci (61). Koncentracije Cd i Pb su analizirane
elektrotermalnom atomskom apsorpcionom spektrofotometrijom. Značajno više
koncentracije Cd, odnosno niže Pb u tumorskom u odnosu na okolno zdravo tkivo utvrđene
su kod pacijentkinja sa karcinomom dojke. Pozitivna korelacija je potvrđena između
koncentracija Cd u tkivu izmenjene strukture i oba humana gonadotropina, a negativna sa
estradiolom, te između Pb u tumorskom tkivu i testosterona. Pacijente sa karcinomom
prostate i testisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave
ispitanike, a pokazana je i značajna akumulacija Cd i Pb u tumorskom tkivu prostate i testisa.
Značajna pozitivna korelacija utvrđena je između koncentracije Cd i estradiola u krvi kod
pacijenata sa karcinom prostate. Studija je pokazala da su više koncentracije Cd značajan
prediktor za nastanak karcinoma i potvrdilanarušenu homeostazu polnih hormona kao
važan mehanizam toksičnosti koji se nalazi u osnovi toksičnih efekata Cd i Pb kod obolelih od
karcinoma dojke, prostate i testisa.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?, Narušena homeostaza polnih hormona kod pacijenata sa karcinom dojke, prostate i testisa: koja je uloga kadmijuma i olova",
volume = "72",
number = "4 suplement",
pages = "S211-S212",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4497"
}

Anđelković, M., Buha-Đorđević, A., Javorac, D., Baralić, K., Đukić-Ćosić, D., Antonijević, B., Ćurčić, M., Antonijević-Miljaković, E., Čolaković, N., Aćimović, M.,& Bulat, Z.. (2022). Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S211-S212.
https://hdl.handle.net/21.15107/rcub_farfar_4497

Anđelković M, Buha-Đorđević A, Javorac D, Baralić K, Đukić-Ćosić D, Antonijević B, Ćurčić M, Antonijević-Miljaković E, Čolaković N, Aćimović M, Bulat Z. Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?. in Arhiv za farmaciju. 2022;72(4 suplement):S211-S212.
https://hdl.handle.net/21.15107/rcub_farfar_4497 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević, Biljana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Čolaković, Nataša, Aćimović, Miodrag, Bulat, Zorica, "Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S211-S212,
https://hdl.handle.net/21.15107/rcub_farfar_4497 .

TY  - CONF
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Anđelković, Milena
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4496
AB  - Lead (Pb) is one of the most important toxic metals without known physiological role.
Recent data indicate that any exposure, even low, can be harmful. Therefore, safe blood lead
levels, as well as tolerating daily intake, have not been identified. In adults, the most sensitive
effect is increase in systolic blood pressure, while in children, the most sensitive effect is on
cognition. Therefore, the aim of this study was to examine the effects of low lead doses on the
central nervous and cardiovascular system in a rat model. The study was conducted on
Wistar rats (n = 42; 7 groups) treated for 28 days, with increasing doses of 0.1; 0.5; 1; 3; 7;
15 mgPb/kg b.w./day to simulate real exposure. After the sacrifice, the brain and heart were
isolated, in which the parameters of oxidative status, bioelements and lead levels were
determined. Benchmark modelling of the dose-effect relationship was performed using
PROAST 70.1 software (RIVM, Netherlands). The obtained results indicate that lead leads to
the induction of oxidative stress and dishomeostasis of bioelements. The lowest value of the
Benchmark dose (BMD) was obtained for increase the total oxidative status in the brain
(4.49e-06 mgPb/kg/b.w./day), which is the most sensitive effect. In the case of heart, the
most sensitive effect was increase in malondialdehyde (BMD: 0.000248 mgPb/kg/b.w./day).
Obtained results indicate that low lead doses have toxic effects on heart and brain. Obtained
BMD may be useful in assessing human health risk of low lead dose exposure.
AB  - Olovo (Pb) je jedan od najznačajnijih toksičnih metala bez poznate fiziološke uloge u
organizmu. Novija istraživanja ukazuju da potencijalno svaka izloženost olovu, čak i niskim
dozama, može biti štetna, te tolerišući dnevni unos, kao ni bezbedan nivo u krvi, nisu
utvrđeni. Kod odraslih, kao najosetljiviji efekat izdvaja se povećanje sistolnog krvnog
pritiska, dok je kod dece to poremećaj kognicije. Imajući navedeno u vidu, cilj ove studije bio
je da se na animalnom modelu ispita uticaj niskih doza olova na centralni nervni i
kardiovaskularni sistem, koji su do sada identifikovani kao najosetljiviji na dejstvo olova, i
odrede Benchmark doze (BMD). Studija je sprovedena na modelu Wistar pacova koji su
podeljeni u 7 grupa tretiranih tokom 28 dana rastućim dozama olova 0, 0,1; 0,5; 1; 3; 7; 15
mg Pb/kg t.m./dan kako bi se simulirala realna izloženost. Nakon žrtvovanja pacova,
izolovani su mozak i srce u kojima su određeni olovo, bioelementi i parametri oksidativnog
statusa. Benchmark modelovanje odnosa doza-efekat vršeno je pomoću PROAST 70.1
softvera (RIVM, Holandija). Dobijeni rezultati ukazuju da olovo dovodi do indukcije
oksidativnog stresa i poremećaja homeostaze bioelemenata. Najniža BMD dobijena je za
povećanje totalnog oksidativnog statusa u mozgu (4,49e-06 mg Pb/kg t.m./dan), što
predstavlja najosetljiviji efekat, a u srcu je to povećanje koncentracije malondialdehida
(BMD: 0,000248 mg Pb/kg t.m./dan). Dobijeni rezultati ukazuju da i niske doze olova mogu
ispoljiti toksične efekte na srce i mozak, a dobijene BMD su od značaja za procenu rizika
olova po zdravlje ljudi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Old lead, new challenges: Is there a safe level of exposure?
T1  - Staro olovo, novi izazovi: postoji li bezbedan nivo izloženosti?
VL  - 72
IS  - 4 suplement
SP  - S209
EP  - S210
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4496
ER  - 

@conference{
author = "Javorac, Dragana and Marić, Đurđica and Baralić, Katarina and Anđelković, Milena and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Lead (Pb) is one of the most important toxic metals without known physiological role.
Recent data indicate that any exposure, even low, can be harmful. Therefore, safe blood lead
levels, as well as tolerating daily intake, have not been identified. In adults, the most sensitive
effect is increase in systolic blood pressure, while in children, the most sensitive effect is on
cognition. Therefore, the aim of this study was to examine the effects of low lead doses on the
central nervous and cardiovascular system in a rat model. The study was conducted on
Wistar rats (n = 42; 7 groups) treated for 28 days, with increasing doses of 0.1; 0.5; 1; 3; 7;
15 mgPb/kg b.w./day to simulate real exposure. After the sacrifice, the brain and heart were
isolated, in which the parameters of oxidative status, bioelements and lead levels were
determined. Benchmark modelling of the dose-effect relationship was performed using
PROAST 70.1 software (RIVM, Netherlands). The obtained results indicate that lead leads to
the induction of oxidative stress and dishomeostasis of bioelements. The lowest value of the
Benchmark dose (BMD) was obtained for increase the total oxidative status in the brain
(4.49e-06 mgPb/kg/b.w./day), which is the most sensitive effect. In the case of heart, the
most sensitive effect was increase in malondialdehyde (BMD: 0.000248 mgPb/kg/b.w./day).
Obtained results indicate that low lead doses have toxic effects on heart and brain. Obtained
BMD may be useful in assessing human health risk of low lead dose exposure., Olovo (Pb) je jedan od najznačajnijih toksičnih metala bez poznate fiziološke uloge u
organizmu. Novija istraživanja ukazuju da potencijalno svaka izloženost olovu, čak i niskim
dozama, može biti štetna, te tolerišući dnevni unos, kao ni bezbedan nivo u krvi, nisu
utvrđeni. Kod odraslih, kao najosetljiviji efekat izdvaja se povećanje sistolnog krvnog
pritiska, dok je kod dece to poremećaj kognicije. Imajući navedeno u vidu, cilj ove studije bio
je da se na animalnom modelu ispita uticaj niskih doza olova na centralni nervni i
kardiovaskularni sistem, koji su do sada identifikovani kao najosetljiviji na dejstvo olova, i
odrede Benchmark doze (BMD). Studija je sprovedena na modelu Wistar pacova koji su
podeljeni u 7 grupa tretiranih tokom 28 dana rastućim dozama olova 0, 0,1; 0,5; 1; 3; 7; 15
mg Pb/kg t.m./dan kako bi se simulirala realna izloženost. Nakon žrtvovanja pacova,
izolovani su mozak i srce u kojima su određeni olovo, bioelementi i parametri oksidativnog
statusa. Benchmark modelovanje odnosa doza-efekat vršeno je pomoću PROAST 70.1
softvera (RIVM, Holandija). Dobijeni rezultati ukazuju da olovo dovodi do indukcije
oksidativnog stresa i poremećaja homeostaze bioelemenata. Najniža BMD dobijena je za
povećanje totalnog oksidativnog statusa u mozgu (4,49e-06 mg Pb/kg t.m./dan), što
predstavlja najosetljiviji efekat, a u srcu je to povećanje koncentracije malondialdehida
(BMD: 0,000248 mg Pb/kg t.m./dan). Dobijeni rezultati ukazuju da i niske doze olova mogu
ispoljiti toksične efekte na srce i mozak, a dobijene BMD su od značaja za procenu rizika
olova po zdravlje ljudi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Old lead, new challenges: Is there a safe level of exposure?, Staro olovo, novi izazovi: postoji li bezbedan nivo izloženosti?",
volume = "72",
number = "4 suplement",
pages = "S209-S210",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4496"
}

Javorac, D., Marić, Đ., Baralić, K., Anđelković, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2022). Old lead, new challenges: Is there a safe level of exposure?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S209-S210.
https://hdl.handle.net/21.15107/rcub_farfar_4496

Javorac D, Marić Đ, Baralić K, Anđelković M, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Old lead, new challenges: Is there a safe level of exposure?. in Arhiv za farmaciju. 2022;72(4 suplement):S209-S210.
https://hdl.handle.net/21.15107/rcub_farfar_4496 .

Javorac, Dragana, Marić, Đurđica, Baralić, Katarina, Anđelković, Milena, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Old lead, new challenges: Is there a safe level of exposure?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S209-S210,
https://hdl.handle.net/21.15107/rcub_farfar_4496 .

TY  - CONF
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Anđelković, Milena
AU  - Ćurčić, Marijana
AU  - Repić, Aleksandra
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4346
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data
VL  - 368
IS  - Supplement
SP  - S277
EP  - S277
DO  - 10.1016/j.toxlet.2022.07.732
ER  - 

@conference{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Javorac, Dragana and Marić, Đurđica and Anđelković, Milena and Ćurčić, Marijana and Repić, Aleksandra and Antonijević, Biljana and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data",
volume = "368",
number = "Supplement",
pages = "S277-S277",
doi = "10.1016/j.toxlet.2022.07.732"
}

Đukić-Ćosić, D., Baralić, K., Javorac, D., Marić, Đ., Anđelković, M., Ćurčić, M., Repić, A., Antonijević, B., Bulat, Z.,& Buha-Đorđević, A.. (2022). The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S277-S277.
https://doi.org/10.1016/j.toxlet.2022.07.732

Đukić-Ćosić D, Baralić K, Javorac D, Marić Đ, Anđelković M, Ćurčić M, Repić A, Antonijević B, Bulat Z, Buha-Đorđević A. The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data. in Toxicology Letters. 2022;368(Supplement):S277-S277.
doi:10.1016/j.toxlet.2022.07.732 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Javorac, Dragana, Marić, Đurđica, Anđelković, Milena, Ćurčić, Marijana, Repić, Aleksandra, Antonijević, Biljana, Bulat, Zorica, Buha-Đorđević, Aleksandra, "The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data" in Toxicology Letters, 368, no. Supplement (2022):S277-S277,
https://doi.org/10.1016/j.toxlet.2022.07.732 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Kačavenda, Elena
AU  - Javorac, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4074
AB  - Cadmium (Cd), one of the most abundant environmental pollutants, is considered to have endocrine disrupting properties. However, data on the dose-response relationship between Cd dose and levels of hormones have been insufficiently studied, especially in human data sets. Thus, the aim of this study was to determine the possibility of analyzing data obtained from a case- control study in female patients with benign/malignant breast tumors, using the Benchmark dose (BMD) concept. The collected data on Cd levels in breast tissue and estrogen serum levels were processed in PROAST software using different variables. The dose-response relationship between the internal dose of Cd and estradiol levels in the serum was investigated and BMD intervals were calculated. The dose-response relationship between the Cd concentration in breast tissue and the estradiol serum level was shown, indicating lower estradiol serum levels as a consequence of higher Cd concentrations in breast tissue. As one of the few studies analyzing human data using the BMD approach, these findings could have a pivotal role in dose response analysis of data collected from human studies.
AB  - Kadmijum (Cd), jedan od najzastupljenijih zagađivača životne sredine, dokazan je endokrini ometač. Međutim, podaci o postojanju odnosa između doze Cd i odgovora-nivoa hormona nisu dovoljno istraženi, posebno podaci sakupljeni iz studija na ljudima. Stoga je cilj ove studije bio da se utvrdi mogućnost analize podataka dobijenih iz studije slučaja-kontrole kod pacijentkinja sa benignim/malignim tumorom dojke, primenom koncepta Benčmark doze (BMD). Prikupljeni podaci o nivoima Cd u tkivu dojke i serumskim nivoima estrogena obrađeni su u PROAST softveru uz korišćenje različitih varijabli. Ispitivan je odnos doza-odgovor između unutrašnje doze Cd (koncentracije u tkivu dojke) i estradiola u serumu i izračunati BMD intervali. Utvrđeno je postojanje odnosa između koncentracije Cd u tkivu dojke i nivoa estradiola u serumu koje ukazuje na niže nivoe estradiola u serumu kao posledica veće koncentracije Cd u tkivu dojke. Kao jedno od retkih istraživanja ovog tipa, dobijeni rezultati mogli bi predstavljati početak otkrivanja mogućnosti analize podataka prikupljenih u studijama na ljudima primenom BMD pristupa.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Cadmium levels in human breast tissue and
estradiol serum levels:
Is there a connection?
T1  - Nivoi kadmijuma u humanom tkivu dojke i nivoi
estradiola u serumu:
Postoji li veza?
VL  - 71
IS  - 6
SP  - 581
EP  - 595
DO  - 10.5937/ARHFARM71-34280
ER  - 

@article{
author = "Anđelković, Milena and Kačavenda, Elena and Javorac, Dragana and Antonijević-Miljaković, Evica and Marić, Đurđica and Baralić, Katarina and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "Cadmium (Cd), one of the most abundant environmental pollutants, is considered to have endocrine disrupting properties. However, data on the dose-response relationship between Cd dose and levels of hormones have been insufficiently studied, especially in human data sets. Thus, the aim of this study was to determine the possibility of analyzing data obtained from a case- control study in female patients with benign/malignant breast tumors, using the Benchmark dose (BMD) concept. The collected data on Cd levels in breast tissue and estrogen serum levels were processed in PROAST software using different variables. The dose-response relationship between the internal dose of Cd and estradiol levels in the serum was investigated and BMD intervals were calculated. The dose-response relationship between the Cd concentration in breast tissue and the estradiol serum level was shown, indicating lower estradiol serum levels as a consequence of higher Cd concentrations in breast tissue. As one of the few studies analyzing human data using the BMD approach, these findings could have a pivotal role in dose response analysis of data collected from human studies., Kadmijum (Cd), jedan od najzastupljenijih zagađivača životne sredine, dokazan je endokrini ometač. Međutim, podaci o postojanju odnosa između doze Cd i odgovora-nivoa hormona nisu dovoljno istraženi, posebno podaci sakupljeni iz studija na ljudima. Stoga je cilj ove studije bio da se utvrdi mogućnost analize podataka dobijenih iz studije slučaja-kontrole kod pacijentkinja sa benignim/malignim tumorom dojke, primenom koncepta Benčmark doze (BMD). Prikupljeni podaci o nivoima Cd u tkivu dojke i serumskim nivoima estrogena obrađeni su u PROAST softveru uz korišćenje različitih varijabli. Ispitivan je odnos doza-odgovor između unutrašnje doze Cd (koncentracije u tkivu dojke) i estradiola u serumu i izračunati BMD intervali. Utvrđeno je postojanje odnosa između koncentracije Cd u tkivu dojke i nivoa estradiola u serumu koje ukazuje na niže nivoe estradiola u serumu kao posledica veće koncentracije Cd u tkivu dojke. Kao jedno od retkih istraživanja ovog tipa, dobijeni rezultati mogli bi predstavljati početak otkrivanja mogućnosti analize podataka prikupljenih u studijama na ljudima primenom BMD pristupa.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Cadmium levels in human breast tissue and
estradiol serum levels:
Is there a connection?, Nivoi kadmijuma u humanom tkivu dojke i nivoi
estradiola u serumu:
Postoji li veza?",
volume = "71",
number = "6",
pages = "581-595",
doi = "10.5937/ARHFARM71-34280"
}

Anđelković, M., Kačavenda, E., Javorac, D., Antonijević-Miljaković, E., Marić, Đ., Baralić, K., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2021). Cadmium levels in human breast tissue and
estradiol serum levels:
Is there a connection?. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 71(6), 581-595.
https://doi.org/10.5937/ARHFARM71-34280

Anđelković M, Kačavenda E, Javorac D, Antonijević-Miljaković E, Marić Đ, Baralić K, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Cadmium levels in human breast tissue and
estradiol serum levels:
Is there a connection?. in Arhiv za farmaciju. 2021;71(6):581-595.
doi:10.5937/ARHFARM71-34280 .

Anđelković, Milena, Kačavenda, Elena, Javorac, Dragana, Antonijević-Miljaković, Evica, Marić, Đurđica, Baralić, Katarina, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Cadmium levels in human breast tissue and
estradiol serum levels:
Is there a connection?" in Arhiv za farmaciju, 71, no. 6 (2021):581-595,
https://doi.org/10.5937/ARHFARM71-34280 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Antonijević, Biljana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Bulat, Petar
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonić, Tamara
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3962
AB  - Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL cholesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.
PB  - Elsevier Ltd
T2  - Environmental Pollution
T1  - Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses
VL  - 291
DO  - 10.1016/j.envpol.2021.118103
ER  - 

@article{
author = "Javorac, Dragana and Antonijević, Biljana and Anđelković, Milena and Repić, Aleksandra and Bulat, Petar and Buha-Đorđević, Aleksandra and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonić, Tamara and Bulat, Zorica",
year = "2021",
abstract = "Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL cholesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.",
publisher = "Elsevier Ltd",
journal = "Environmental Pollution",
title = "Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses",
volume = "291",
doi = "10.1016/j.envpol.2021.118103"
}

Javorac, D., Antonijević, B., Anđelković, M., Repić, A., Bulat, P., Buha-Đorđević, A., Baralić, K., Đukić-Ćosić, D., Antonić, T.,& Bulat, Z.. (2021). Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses. in Environmental Pollution
Elsevier Ltd., 291.
https://doi.org/10.1016/j.envpol.2021.118103

Javorac D, Antonijević B, Anđelković M, Repić A, Bulat P, Buha-Đorđević A, Baralić K, Đukić-Ćosić D, Antonić T, Bulat Z. Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses. in Environmental Pollution. 2021;291.
doi:10.1016/j.envpol.2021.118103 .

Javorac, Dragana, Antonijević, Biljana, Anđelković, Milena, Repić, Aleksandra, Bulat, Petar, Buha-Đorđević, Aleksandra, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonić, Tamara, Bulat, Zorica, "Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses" in Environmental Pollution, 291 (2021),
https://doi.org/10.1016/j.envpol.2021.118103 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Javorac, Dragana
AU  - Čolaković, Nataša
AU  - Oprić, Svetlana
AU  - Petričević, Simona
AU  - Granić, Miroslav
AU  - Kotur-Stevuljević, Jelena
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3915
AB  - Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.
PB  - Elsevier
T2  - Environmental Research
T1  - Cadmium tissue level in women diagnosed with breast cancer – A case control study
VL  - 199
DO  - 10.1016/j.envres.2021.111300
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Javorac, Dragana and Čolaković, Nataša and Oprić, Svetlana and Petričević, Simona and Granić, Miroslav and Kotur-Stevuljević, Jelena and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Cadmium tissue level in women diagnosed with breast cancer – A case control study",
volume = "199",
doi = "10.1016/j.envres.2021.111300"
}

Anđelković, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Javorac, D., Čolaković, N., Oprić, S., Petričević, S., Granić, M., Kotur-Stevuljević, J., Antonijević, B.,& Bulat, Z.. (2021). Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research
Elsevier., 199.
https://doi.org/10.1016/j.envres.2021.111300

Anđelković M, Buha-Đorđević A, Antonijević-Miljaković E, Javorac D, Čolaković N, Oprić S, Petričević S, Granić M, Kotur-Stevuljević J, Antonijević B, Bulat Z. Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research. 2021;199.
doi:10.1016/j.envres.2021.111300 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Javorac, Dragana, Čolaković, Nataša, Oprić, Svetlana, Petričević, Simona, Granić, Miroslav, Kotur-Stevuljević, Jelena, Antonijević, Biljana, Bulat, Zorica, "Cadmium tissue level in women diagnosed with breast cancer – A case control study" in Environmental Research, 199 (2021),
https://doi.org/10.1016/j.envres.2021.111300 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Tatović, Simona
AU  - Baralić, Katarina
AU  - Antonijević, Evica
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3715
AB  - Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity.
AB  - Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture
T1  - Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova
VL  - 71
IS  - 3
SP  - 197
EP  - 204
DO  - 10.2478/aiht-2020-71-3425
ER  - 

@article{
author = "Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Tatović, Simona and Baralić, Katarina and Antonijević, Evica and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2020",
abstract = "Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity., Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture, Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova",
volume = "71",
number = "3",
pages = "197-204",
doi = "10.2478/aiht-2020-71-3425"
}

Javorac, D., Buha-Đorđević, A., Anđelković, M., Tatović, S., Baralić, K., Antonijević, E., Kotur-Stevuljević, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2020). Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 71(3), 197-204.
https://doi.org/10.2478/aiht-2020-71-3425

Javorac D, Buha-Đorđević A, Anđelković M, Tatović S, Baralić K, Antonijević E, Kotur-Stevuljević J, Đukić-Ćosić D, Antonijević B, Bulat Z. Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2020;71(3):197-204.
doi:10.2478/aiht-2020-71-3425 .

Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Tatović, Simona, Baralić, Katarina, Antonijević, Evica, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 71, no. 3 (2020):197-204,
https://doi.org/10.2478/aiht-2020-71-3425 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Jorgovanović, Dragica
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3634
AB  - Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats
VL  - 143
DO  - 10.1016/j.fct.2020.111540
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Jorgovanović, Dragica and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats",
volume = "143",
doi = "10.1016/j.fct.2020.111540"
}

Baralić, K., Živančević, K., Javorac, D., Buha-Đorđević, A., Anđelković, M., Jorgovanović, D., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology
Elsevier Ltd., 143.
https://doi.org/10.1016/j.fct.2020.111540

Baralić K, Živančević K, Javorac D, Buha-Đorđević A, Anđelković M, Jorgovanović D, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology. 2020;143.
doi:10.1016/j.fct.2020.111540 .

Baralić, Katarina, Živančević, Katarina, Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Jorgovanović, Dragica, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats" in Food and Chemical Toxicology, 143 (2020),
https://doi.org/10.1016/j.fct.2020.111540 . .

TY  - JOUR
AU  - Wallace, David R.
AU  - Taalab, Yasmeen M.
AU  - Heinze, Sarah
AU  - Tariba Lovaković, Sarah
AU  - Pizent, Alica
AU  - Renieri, Elisavit
AU  - Tsatsakis, Aristidis
AU  - Farooqi, Ammad Ahmad
AU  - Javorac, Dragana
AU  - Anđelković, Milena
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3578
AB  - Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).
PB  - MDPI
T2  - Cells
T1  - Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development
VL  - 9
IS  - 4
DO  - 10.3390/cells9040901
ER  - 

@article{
author = "Wallace, David R. and Taalab, Yasmeen M. and Heinze, Sarah and Tariba Lovaković, Sarah and Pizent, Alica and Renieri, Elisavit and Tsatsakis, Aristidis and Farooqi, Ammad Ahmad and Javorac, Dragana and Anđelković, Milena and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2020",
abstract = "Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).",
publisher = "MDPI",
journal = "Cells",
title = "Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development",
volume = "9",
number = "4",
doi = "10.3390/cells9040901"
}

Wallace, D. R., Taalab, Y. M., Heinze, S., Tariba Lovaković, S., Pizent, A., Renieri, E., Tsatsakis, A., Farooqi, A. A., Javorac, D., Anđelković, M., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2020). Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development. in Cells
MDPI., 9(4).
https://doi.org/10.3390/cells9040901

Wallace DR, Taalab YM, Heinze S, Tariba Lovaković S, Pizent A, Renieri E, Tsatsakis A, Farooqi AA, Javorac D, Anđelković M, Bulat Z, Antonijević B, Buha-Đorđević A. Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development. in Cells. 2020;9(4).
doi:10.3390/cells9040901 .

Wallace, David R., Taalab, Yasmeen M., Heinze, Sarah, Tariba Lovaković, Sarah, Pizent, Alica, Renieri, Elisavit, Tsatsakis, Aristidis, Farooqi, Ammad Ahmad, Javorac, Dragana, Anđelković, Milena, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development" in Cells, 9, no. 4 (2020),
https://doi.org/10.3390/cells9040901 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Živančević, Katarina
AU  - Antonijević, Evica
AU  - Anđelković, Milena
AU  - Javorac, Dragana
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3499
AB  - Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and aect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through dierent biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.
PB  - MDPI
T2  - International Journal of Environmental Research and Public Health
T1  - Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats
VL  - 17
IS  - 3
DO  - 10.3390/ijerph17030746
ER  - 

@article{
author = "Baralić, Katarina and Buha-Đorđević, Aleksandra and Živančević, Katarina and Antonijević, Evica and Anđelković, Milena and Javorac, Dragana and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and aect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through dierent biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.",
publisher = "MDPI",
journal = "International Journal of Environmental Research and Public Health",
title = "Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats",
volume = "17",
number = "3",
doi = "10.3390/ijerph17030746"
}

Baralić, K., Buha-Đorđević, A., Živančević, K., Antonijević, E., Anđelković, M., Javorac, D., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. in International Journal of Environmental Research and Public Health
MDPI., 17(3).
https://doi.org/10.3390/ijerph17030746

Baralić K, Buha-Đorđević A, Živančević K, Antonijević E, Anđelković M, Javorac D, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. in International Journal of Environmental Research and Public Health. 2020;17(3).
doi:10.3390/ijerph17030746 .

Baralić, Katarina, Buha-Đorđević, Aleksandra, Živančević, Katarina, Antonijević, Evica, Anđelković, Milena, Javorac, Dragana, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats" in International Journal of Environmental Research and Public Health, 17, no. 3 (2020),
https://doi.org/10.3390/ijerph17030746 . .