TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Manić, Luka
AU  - Grahovac, Lazar
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5513
AB  - In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ...
AB  - In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode
T1  - Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method
SP  - 154
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5513
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Marić, Đurđica and Vukelić, Dragana and Manić, Luka and Grahovac, Lazar and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ..., In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode, Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method",
pages = "154-156",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5513"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K., Marić, Đ., Vukelić, D., Manić, L., Grahovac, L., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513

Božić D, Baralić K, Živanović J, Živančević K, Marić Đ, Vukelić D, Manić L, Grahovac L, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Marić, Đurđica, Vukelić, Dragana, Manić, Luka, Grahovac, Lazar, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):154-156,
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Zhang, Yi
AU  - Yang, Li
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5425
AB  - Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ...
AB  - Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza
T1  - Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis
SP  - 61
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5425
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Zhang, Yi and Yang, Li and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ..., Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza, Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis",
pages = "61-62",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5425"
}

Božić, D., Baralić, K., Živančević, K., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B., Zhang, Y., Yang, L.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425

Božić D, Baralić K, Živančević K, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Zhang Y, Yang L, Đukić-Ćosić D. Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Zhang, Yi, Yang, Li, Đukić-Ćosić, Danijela, "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):61-62,
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5422
AB  - Široka upotreba bis(2-etilheksil) ftalata (DEHP), dibutil ftalata (DBP) i bisfenola A (BPA) otvara niz mogućnosti
za kombinovanu izloženost ljudi ovim toksičnim jedinjenjima u svakodnevnom životu i brojne štetne
ishode, uključujući hepatotoksičnost.  ...
AB  - The extensive usage of bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A
(BPA) creates a lot of opportunities for combined human exposure to these hazardous compounds in
everyday life and a variety of negative outcomes, including hepatotoxicity. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela
T1  - Three lines of evidence of the hepatotoxicity of a mixture containing phthalates and bisphenol a: In silico and two in vivo models
SP  - 55
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5422
ER  - 

@conference{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Široka upotreba bis(2-etilheksil) ftalata (DEHP), dibutil ftalata (DBP) i bisfenola A (BPA) otvara niz mogućnosti
za kombinovanu izloženost ljudi ovim toksičnim jedinjenjima u svakodnevnom životu i brojne štetne
ishode, uključujući hepatotoksičnost.  ..., The extensive usage of bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A
(BPA) creates a lot of opportunities for combined human exposure to these hazardous compounds in
everyday life and a variety of negative outcomes, including hepatotoxicity. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela, Three lines of evidence of the hepatotoxicity of a mixture containing phthalates and bisphenol a: In silico and two in vivo models",
pages = "55-56",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5422"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 55-56.
https://hdl.handle.net/21.15107/rcub_farfar_5422

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:55-56.
https://hdl.handle.net/21.15107/rcub_farfar_5422 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Tri nivoa dokaza hepatotoksičnosti smeše ftalata i bisfenola a: In silico i dva in vivo modela" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):55-56,
https://hdl.handle.net/21.15107/rcub_farfar_5422 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Šljivić, Jovana
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5171
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation
VL  - 384
IS  - S1
SP  - S114
EP  - S114
DO  - 10.1016/S0378-4274(23)00534-9
ER  - 

@conference{
author = "Živanović, Jovana and Šljivić, Jovana and Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation",
volume = "384",
number = "S1",
pages = "S114-S114",
doi = "10.1016/S0378-4274(23)00534-9"
}

Živanović, J., Šljivić, J., Božić, D., Baralić, K., Živančević, K., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters
Elsevier., 384(S1), S114-S114.
https://doi.org/10.1016/S0378-4274(23)00534-9

Živanović J, Šljivić J, Božić D, Baralić K, Živančević K, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation. in Toxicology Letters. 2023;384(S1):S114-S114.
doi:10.1016/S0378-4274(23)00534-9 .

Živanović, Jovana, Šljivić, Jovana, Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predicting sulforaphane-induces adverse effects  in prostatic cancer patients via in silico investigation" in Toxicology Letters, 384, no. S1 (2023):S114-S114,
https://doi.org/10.1016/S0378-4274(23)00534-9 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Filipović, Teodora
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4201
AB  - Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality.
AB  - COVID-19 (engl. coronavirus disease 2019) respiratorna je bolest prouzročena infekcijom SARS-CoV-2 virusom (engl. severe acute respiratory
syndrome coronavirus 2). Pretpostavlja se da postoji utjecaj atmosferskih čimbenika, uključujući i onečišćenje zraka, na prenošenje koronavirusa,
njegovu težinu i stopu smrtnosti. Stoga je cilj ovoga in silico istraživanja bio utvrditi odnos između ključnih onečišćivača zraka [sumporova
dioksida (SO2), ugljikova monoksida (CO), lebdećih čestica (PMx), dušikova dioksida (NO2), ozona (O3)] i komplikacija COVID-a 19
korištenjem: (i) komparativne toksikogenomičke baze podataka (engl. Comparative Toxicogenomic Database, CTD) za dobivanje gena, međusobno
povezanih s onečišćivačima zraka i komplikacijama COVID-a 19, (ii) GeneMANIA servera za konstruiranje mreže između dobivenih i
srodnih gena, (iii) ToppGene Suite za izdvajanje najvažnijih bioloških procesa/molekularnih puteva i (iv) DisGeNET baze podataka za
traženje najvažnijih parova gen-bolest. Za SO2, CO, PMx, NO2 odnosno O3 utvrđena je interakcija sa 6, 6, 18, 9, odnosno 12 gena povezanih
s komplikacijama COVID-a 19. Četiri su zajednička (IL10, IL6, IL1B i TNF) i u najvećem postotku (77,64 %) sudjeluju u fizičkim
interakcijama. Vezivanje citokina i signalni put posredovan citokinima izdvojeni su kao najvažnija molekularna funkcija i biološki proces.
Druge molekularne funkcije i biološki procesi uglavnom su bili povezani s aktivnošću citokina i upalom, što bi se moglo dovesti u vezu s
citokinskom olujom i posljedičnim komplikacijama COVID-a 19. Utvrđena je veza između različitih bolesti i ispitivanih gena, posebice
između CEBPA i akutne mijelogene leukemije (AML) te između TNFRSF1A i sindroma periodične vrućice povezanoga s TNF receptorom.
To upozorava na moguće komplikacije u osoba zaraženih koronavirusom koje boluju od tih bolesti, poglavito kada su dodatno potaknute
poremećajem funkcije spomenutih gena.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis
T1  - Zajednički utjecaj ključnih onečišćivača zraka na težinu COVID-a 19 – predviđanje zasnovano na analizi toksikogenomičkih
podataka
VL  - 73
IS  - 2
SP  - 119
EP  - 125
DO  - 10.2478/aiht-2022-73-3631
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Filipović, Teodora and Božić, Dragica and Živančević, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Ćurčić, Marijana",
year = "2022",
abstract = "Considering that some researchers point to a possible influence of air pollution on COVID-19 transmission, severity, and death rate, the aim of our in silico study was to determine the relationship between the key air pollutants [sulphur dioxide (SO2), carbon monoxide (CO), particulate matter (PMx), nitrogen dioxide (NO2), and ozone (O3)] and COVID-19 complications using the publicly available toxicogenomic analytical and prediction tools: (i) Comparative Toxicogenomic Database (CTD) to identify genes common to air pollutants and COVID-19 complications; (ii) GeneMANIA to construct a network of these common and related genes; (iii) ToppGene Suite to extract the most important biological processes and molecular pathways; and (iv) DisGeNET to search for the top gene-disease pairs. SO2, CO, PMx, NO2 , and O 3 interacted with 6, 6, 18, 9, and 12 COVID-19-related genes, respectively. Four of these are common for all pollutants (IL10, IL6, IL1B, and TNF) and participate in most (77.64 %) physical interactions. Further analysis pointed to cytokine binding and cytokine-mediated signalling pathway as the most important molecular function and biological process, respectively. Other molecular functions and biological processes are mostly related to cytokine activity and inflammation, which might be connected to the cytokine storm and resulting COVID-19 complications. The final step singled out the link between the CEBPA gene and acute myelocytic leukaemia and between TNFRSF1A and TNF receptor-associated periodic fever syndrome. This indicates possible complications in COVID-19 patients suffering from these diseases, especially those living in urban areas with poor air quality., COVID-19 (engl. coronavirus disease 2019) respiratorna je bolest prouzročena infekcijom SARS-CoV-2 virusom (engl. severe acute respiratory
syndrome coronavirus 2). Pretpostavlja se da postoji utjecaj atmosferskih čimbenika, uključujući i onečišćenje zraka, na prenošenje koronavirusa,
njegovu težinu i stopu smrtnosti. Stoga je cilj ovoga in silico istraživanja bio utvrditi odnos između ključnih onečišćivača zraka [sumporova
dioksida (SO2), ugljikova monoksida (CO), lebdećih čestica (PMx), dušikova dioksida (NO2), ozona (O3)] i komplikacija COVID-a 19
korištenjem: (i) komparativne toksikogenomičke baze podataka (engl. Comparative Toxicogenomic Database, CTD) za dobivanje gena, međusobno
povezanih s onečišćivačima zraka i komplikacijama COVID-a 19, (ii) GeneMANIA servera za konstruiranje mreže između dobivenih i
srodnih gena, (iii) ToppGene Suite za izdvajanje najvažnijih bioloških procesa/molekularnih puteva i (iv) DisGeNET baze podataka za
traženje najvažnijih parova gen-bolest. Za SO2, CO, PMx, NO2 odnosno O3 utvrđena je interakcija sa 6, 6, 18, 9, odnosno 12 gena povezanih
s komplikacijama COVID-a 19. Četiri su zajednička (IL10, IL6, IL1B i TNF) i u najvećem postotku (77,64 %) sudjeluju u fizičkim
interakcijama. Vezivanje citokina i signalni put posredovan citokinima izdvojeni su kao najvažnija molekularna funkcija i biološki proces.
Druge molekularne funkcije i biološki procesi uglavnom su bili povezani s aktivnošću citokina i upalom, što bi se moglo dovesti u vezu s
citokinskom olujom i posljedičnim komplikacijama COVID-a 19. Utvrđena je veza između različitih bolesti i ispitivanih gena, posebice
između CEBPA i akutne mijelogene leukemije (AML) te između TNFRSF1A i sindroma periodične vrućice povezanoga s TNF receptorom.
To upozorava na moguće komplikacije u osoba zaraženih koronavirusom koje boluju od tih bolesti, poglavito kada su dodatno potaknute
poremećajem funkcije spomenutih gena.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis, Zajednički utjecaj ključnih onečišćivača zraka na težinu COVID-a 19 – predviđanje zasnovano na analizi toksikogenomičkih
podataka",
volume = "73",
number = "2",
pages = "119-125",
doi = "10.2478/aiht-2022-73-3631"
}

Đukić-Ćosić, D., Baralić, K., Filipović, T., Božić, D., Živančević, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Ćurčić, M.. (2022). Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 73(2), 119-125.
https://doi.org/10.2478/aiht-2022-73-3631

Đukić-Ćosić D, Baralić K, Filipović T, Božić D, Živančević K, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Ćurčić M. Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2022;73(2):119-125.
doi:10.2478/aiht-2022-73-3631 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Filipović, Teodora, Božić, Dragica, Živančević, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Ćurčić, Marijana, "Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 73, no. 2 (2022):119-125,
https://doi.org/10.2478/aiht-2022-73-3631 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Durgo, Ksenija
AU  - Vučinić, Slavica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4626
AB  - Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd.
AB  - Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats
T1  - Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova
VL  - 72
IS  - 4 suplement
SP  - S575
EP  - S576
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4626
ER  - 

@conference{
author = "Ćurčić, Marijana and Janković, Saša and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Durgo, Ksenija and Vučinić, Slavica and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd., Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats, Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova",
volume = "72",
number = "4 suplement",
pages = "S575-S576",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4626"
}

Ćurčić, M., Janković, S., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Živančević, K., Božić, D., Durgo, K., Vučinić, S., Bulat, Z.,& Antonijević, B.. (2022). Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626

Ćurčić M, Janković S, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Živančević K, Božić D, Durgo K, Vučinić S, Bulat Z, Antonijević B. Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju. 2022;72(4 suplement):S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

Ćurčić, Marijana, Janković, Saša, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Durgo, Ksenija, Vučinić, Slavica, Bulat, Zorica, Antonijević, Biljana, "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S575-S576,
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

TY  - CONF
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4495
AB  - The aim of this study was to: (1) examine subacute toxicity of bis (2-ethylhexyl)
phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture in rats and
compare it with individual substance effects; (2) investigate the mechanisms of toxicity on
critical target organ, testes (in vivo/in silico study); (3) examine multibiotic ability to mitigate
mixture toxicity. Male rats were divided into groups (n = 6): (1) Control; (2) P (probiotic
(8.78*10 8 CFU/kg bw/day)); (3) DEHP (50 mg/kg bw/day); (4) DBP (50 mg/kg bw/day); (5)
BPA (25 mg/kg bw/day); and (6) MIX (50 mg/kg bw/day DEHP + 50 mg/kg bw/day DBP +
25 mg/kg bw/day BPA) (7) MIX + P. In silico toxicogenomic analysis was performed by
Comparative Toxicogenomic Database (CTD), Citoscape software and ToppGene Suite portal.
MIX led to significant changes in tissue structure (liver, kidney, spleen and testis),
biochemical parameters and testosterone level of rats compared to the control group and
individual substances. In silico analysis revealed 20 genes associated with DEHP/DBP/BPA
and male reproductive system disorders, while the most probable mechanisms included
metabolism, aryl hydrocarbon receptor pathway, apoptosis, and oxidative stress. Oxidative
stress was confirmed in vivo, and changes in parameters in testicular tissue homogenates
were most pronounced or present only in MIX group. Probiotic annulled/mitigated changes
in biochemical, hematological, and oxidative stress parameters, relative liver mass, food
consumption, and organ pathohistology. Hence, the obtained results indicate the possibility
of future considerations of protective probiotic effects against phthalates and BPA mixture
toxicity.
AB  - Cilj ove studije bio je: (1) ispitati subakutnu toksičnost smeše bis (2-etilheksil) ftalata
(DEHP), dibutil ftalata (DBP), bisfenola A (BPA) na pacovima i uporediti je sa efektima
pojedinačnih supstanci; (2) istražiti mehanizme toksičnosti na kritičnom ciljnom organu,
testisima (in vivo/in silico studija); (3) ispitati sposobnost višekomponentnog probiotika da
ublaži toksičnost smeše. Mužjaci pacova podeljeni su u grupe (n = 6): (1) Kontrola; (2) P
(probiotik (8.78 * 108 CFU/kg/day)); (3) DEHP (50 mg/kg t.m/dan); (4) DBP (50 mg/kg
t.m/dan); (5) BPA (25 mg/kg t.m/dan); i (6) MIX (50 mg/kg t.m/dan DEHP + 50 mg/kg
t.m/dan DBP + 25 mg/kg t.m/dan BPA) (7) MIX + P. In silico toksikogenomička analiza
sprovedena je Komparativnom toksikogenomičkom bazom podataka (CTD), Citoscape
softverom i ToppGene Suite portalom. Smeša je dovela do značajnih promena u strukturi
tkiva (jetra, bubreg, slezina i testis), biohemijskim parametrima i nivou testosterona pacova
u poređenju sa kontrolnom grupom i pojedinačnim supstancama. In silico analizom
otkriveno je 20 gena povezanih sa smešom DEHP/DBP/BPA i poremećajima muškog
reproduktivnog sistema, dok su najverovatniji mehanizmi uključili metabolizam,
molekularni put povezan sa receptorom za aromatične ugljovodinike, apoptozu i oksidativni
stres. Oksidativni stres potvrđen je in vivo, a promene u parametrima u homogenatu tkiva
testisa bile su najizraženije ili prisutne samo u MIX grupi. Probiotik je otklonio ili ublažio
promene u biohemijskim, hematološkim, i parametrima oksidativnog stresa, kao i relativnoj
masi jetre, unosu hrane i patohistološkim nalazima izazvanim smešom ispitivanih supstanci.
Dobijeni rezultati ukazuju na mogućnost budućih razmatranja protektivnih efekata
probiotika protiv toksičnosti smeše ftalata i BPA.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects
T1  - Subakutna toksičnost smeše ftalata i bisfenola a: procena protektivnog dejstva probiotika
VL  - 72
IS  - 4 suplement
SP  - S207
EP  - S208
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4495
ER  - 

@conference{
author = "Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "The aim of this study was to: (1) examine subacute toxicity of bis (2-ethylhexyl)
phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture in rats and
compare it with individual substance effects; (2) investigate the mechanisms of toxicity on
critical target organ, testes (in vivo/in silico study); (3) examine multibiotic ability to mitigate
mixture toxicity. Male rats were divided into groups (n = 6): (1) Control; (2) P (probiotic
(8.78*10 8 CFU/kg bw/day)); (3) DEHP (50 mg/kg bw/day); (4) DBP (50 mg/kg bw/day); (5)
BPA (25 mg/kg bw/day); and (6) MIX (50 mg/kg bw/day DEHP + 50 mg/kg bw/day DBP +
25 mg/kg bw/day BPA) (7) MIX + P. In silico toxicogenomic analysis was performed by
Comparative Toxicogenomic Database (CTD), Citoscape software and ToppGene Suite portal.
MIX led to significant changes in tissue structure (liver, kidney, spleen and testis),
biochemical parameters and testosterone level of rats compared to the control group and
individual substances. In silico analysis revealed 20 genes associated with DEHP/DBP/BPA
and male reproductive system disorders, while the most probable mechanisms included
metabolism, aryl hydrocarbon receptor pathway, apoptosis, and oxidative stress. Oxidative
stress was confirmed in vivo, and changes in parameters in testicular tissue homogenates
were most pronounced or present only in MIX group. Probiotic annulled/mitigated changes
in biochemical, hematological, and oxidative stress parameters, relative liver mass, food
consumption, and organ pathohistology. Hence, the obtained results indicate the possibility
of future considerations of protective probiotic effects against phthalates and BPA mixture
toxicity., Cilj ove studije bio je: (1) ispitati subakutnu toksičnost smeše bis (2-etilheksil) ftalata
(DEHP), dibutil ftalata (DBP), bisfenola A (BPA) na pacovima i uporediti je sa efektima
pojedinačnih supstanci; (2) istražiti mehanizme toksičnosti na kritičnom ciljnom organu,
testisima (in vivo/in silico studija); (3) ispitati sposobnost višekomponentnog probiotika da
ublaži toksičnost smeše. Mužjaci pacova podeljeni su u grupe (n = 6): (1) Kontrola; (2) P
(probiotik (8.78 * 108 CFU/kg/day)); (3) DEHP (50 mg/kg t.m/dan); (4) DBP (50 mg/kg
t.m/dan); (5) BPA (25 mg/kg t.m/dan); i (6) MIX (50 mg/kg t.m/dan DEHP + 50 mg/kg
t.m/dan DBP + 25 mg/kg t.m/dan BPA) (7) MIX + P. In silico toksikogenomička analiza
sprovedena je Komparativnom toksikogenomičkom bazom podataka (CTD), Citoscape
softverom i ToppGene Suite portalom. Smeša je dovela do značajnih promena u strukturi
tkiva (jetra, bubreg, slezina i testis), biohemijskim parametrima i nivou testosterona pacova
u poređenju sa kontrolnom grupom i pojedinačnim supstancama. In silico analizom
otkriveno je 20 gena povezanih sa smešom DEHP/DBP/BPA i poremećajima muškog
reproduktivnog sistema, dok su najverovatniji mehanizmi uključili metabolizam,
molekularni put povezan sa receptorom za aromatične ugljovodinike, apoptozu i oksidativni
stres. Oksidativni stres potvrđen je in vivo, a promene u parametrima u homogenatu tkiva
testisa bile su najizraženije ili prisutne samo u MIX grupi. Probiotik je otklonio ili ublažio
promene u biohemijskim, hematološkim, i parametrima oksidativnog stresa, kao i relativnoj
masi jetre, unosu hrane i patohistološkim nalazima izazvanim smešom ispitivanih supstanci.
Dobijeni rezultati ukazuju na mogućnost budućih razmatranja protektivnih efekata
probiotika protiv toksičnosti smeše ftalata i BPA.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects, Subakutna toksičnost smeše ftalata i bisfenola a: procena protektivnog dejstva probiotika",
volume = "72",
number = "4 suplement",
pages = "S207-S208",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4495"
}

Baralić, K., Božić, D., Živančević, K., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S207-S208.
https://hdl.handle.net/21.15107/rcub_farfar_4495

Baralić K, Božić D, Živančević K, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects. in Arhiv za farmaciju. 2022;72(4 suplement):S207-S208.
https://hdl.handle.net/21.15107/rcub_farfar_4495 .

Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Subacute toxicity of phthalate and bisphenol A mixture: assessment of probiotic protective effects" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S207-S208,
https://hdl.handle.net/21.15107/rcub_farfar_4495 .