TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5614
AB  - Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.
PB  - Elsevier Inc.
T2  - Environmental Research
T1  - Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
VL  - 252
IS  - 1
DO  - 10.1016/j.envres.2024.118680
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.",
publisher = "Elsevier Inc.",
journal = "Environmental Research",
title = "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach",
volume = "252",
number = "1",
doi = "10.1016/j.envres.2024.118680"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research
Elsevier Inc.., 252(1).
https://doi.org/10.1016/j.envres.2024.118680

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research. 2024;252(1).
doi:10.1016/j.envres.2024.118680 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach" in Environmental Research, 252, no. 1 (2024),
https://doi.org/10.1016/j.envres.2024.118680 . .

TY  - JOUR
AU  - Umićević, Nina
AU  - Kotur-Stevuljević, Jelena
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5592
AB  - This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic hydrocarbons, aromatic hydrocarbons, ketones, esters, ethers, and carboxylic acids. All measured VOCs were below the permitted occupational exposure limits. The control group included 50 unexposed participants (25 men and 25 women). The following plasma parameters were analysed: superoxide anion (O2•-), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidant-antioxidant balance (PAB), oxidative stress index (OSI), superoxide dismutase (SOD) and paraoxonase-1 (PON1) enzyme activity, total SH group content (SHG), and total antioxidant status (TAS). Trace metal levels (copper, zinc, iron, magnesium, and manganese) were analysed in whole blood. All oxidative stress and antioxidative defence parameters were higher in the exposed workers than controls, except for PON1 activity. Higher Fe, Mg, and Zn, and lower Cu were observed in the exposed vs control men, while the exposed women had higher Fe and lower Mg, Zn, and Cu than their controls. Our findings confirm that combined exposure to a mixture of VOCs, even at permitted levels, may result in additive or synergistic adverse health effects and related disorders. This raises concern about current risk assessments, which mainly rely on the effects of individual chemicals, and calls for risk assessment approaches that can explain combined exposure to multiple chemicals.
AB  - Cilj istraživanja bio je procijeniti redoks status i koncentracije metala u tragovima kod 49 radnika (11 muškaraca i 38 žena) zaposlenih u
industriji obuće, izloženih mješavini hlapljivih organskih spojeva (engl. volatile organic compounds, krat. VOC) koju su činili alifatski i aromatični
ugljikovodici, ketoni, esteri, eteri i karboksilne kiseline. Sve izmjerene razine VOC bile su ispod dozvoljenih granica profesionalne izloženosti.
U kontrolnoj je skupini bilo 50 neizloženih ispitanika (25 muškaraca i 25 žena). U plazmi obućarskih radnika analizirani su sljedeći parametri:
superoksid anion radikal (O2
•-
), uznapredovali produkti oksidacije proteina (AOPP), totalni oksidacijski status (TOS), prooksidacijsko-
antioksidacijski balans (PAB), indeks oksidacijskoga stresa (OSI), aktivnost superoksid-dismutaze (SOD), aktivnost enzima paraoksonaze-1
(PON1), ukupni sadržaj sulfhidrilnih grupa (SHG) i totalni antioksidacijski status (TAS). Koncentracije metala u tragovima (bakar, cink,
željezo, magnezij i mangan) analizirane su u punoj krvi. U usporedbi s kontrolnom skupinom, svi parametri oksidacijskoga stresa i
antioksidacijske obrane u izloženih radnika bili su povišeni, osim aktivnosti PON1. Povećana koncentracija Fe, Mg i Zn te smanjena
koncentracija Cu uočene su u izloženih muškaraca u usporedbi s kontrolnima, a u žena je primijećena povišena koncentracija Fe, a niža
koncentracija Mg, Zn i Cu u odnosu na kontrolnu skupinu. Naši nalazi potvrđuju da kombinirano izlaganje mješavini VOC, čak i pri
dozvoljenim koncentracijama, može dovesti do aditivnih ili sinergističkih štetnih učinaka na zdravlje i popratnih poremećaja. Trenutna
procjena rizika, koja se uglavnom oslanja na učinke pojedinačnih kemikalija, izaziva zabrinutost i upućuje na potrebu za novim pristupima
koji će objasniti kombiniranu izloženost većem broju kemikalija.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju
T1  - Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds
T1  - Povećani oksidacijski stres u obućarskih radnika izloženih mješavini niskih razina hlapljivih organskih spojeva
VL  - 75
IS  - 1
SP  - 51
EP  - 60
DO  - 10.2478/aiht-2024-75-3804
ER  - 

@article{
author = "Umićević, Nina and Kotur-Stevuljević, Jelena and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana",
year = "2024",
abstract = "This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic hydrocarbons, aromatic hydrocarbons, ketones, esters, ethers, and carboxylic acids. All measured VOCs were below the permitted occupational exposure limits. The control group included 50 unexposed participants (25 men and 25 women). The following plasma parameters were analysed: superoxide anion (O2•-), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidant-antioxidant balance (PAB), oxidative stress index (OSI), superoxide dismutase (SOD) and paraoxonase-1 (PON1) enzyme activity, total SH group content (SHG), and total antioxidant status (TAS). Trace metal levels (copper, zinc, iron, magnesium, and manganese) were analysed in whole blood. All oxidative stress and antioxidative defence parameters were higher in the exposed workers than controls, except for PON1 activity. Higher Fe, Mg, and Zn, and lower Cu were observed in the exposed vs control men, while the exposed women had higher Fe and lower Mg, Zn, and Cu than their controls. Our findings confirm that combined exposure to a mixture of VOCs, even at permitted levels, may result in additive or synergistic adverse health effects and related disorders. This raises concern about current risk assessments, which mainly rely on the effects of individual chemicals, and calls for risk assessment approaches that can explain combined exposure to multiple chemicals., Cilj istraživanja bio je procijeniti redoks status i koncentracije metala u tragovima kod 49 radnika (11 muškaraca i 38 žena) zaposlenih u
industriji obuće, izloženih mješavini hlapljivih organskih spojeva (engl. volatile organic compounds, krat. VOC) koju su činili alifatski i aromatični
ugljikovodici, ketoni, esteri, eteri i karboksilne kiseline. Sve izmjerene razine VOC bile su ispod dozvoljenih granica profesionalne izloženosti.
U kontrolnoj je skupini bilo 50 neizloženih ispitanika (25 muškaraca i 25 žena). U plazmi obućarskih radnika analizirani su sljedeći parametri:
superoksid anion radikal (O2
•-
), uznapredovali produkti oksidacije proteina (AOPP), totalni oksidacijski status (TOS), prooksidacijsko-
antioksidacijski balans (PAB), indeks oksidacijskoga stresa (OSI), aktivnost superoksid-dismutaze (SOD), aktivnost enzima paraoksonaze-1
(PON1), ukupni sadržaj sulfhidrilnih grupa (SHG) i totalni antioksidacijski status (TAS). Koncentracije metala u tragovima (bakar, cink,
željezo, magnezij i mangan) analizirane su u punoj krvi. U usporedbi s kontrolnom skupinom, svi parametri oksidacijskoga stresa i
antioksidacijske obrane u izloženih radnika bili su povišeni, osim aktivnosti PON1. Povećana koncentracija Fe, Mg i Zn te smanjena
koncentracija Cu uočene su u izloženih muškaraca u usporedbi s kontrolnima, a u žena je primijećena povišena koncentracija Fe, a niža
koncentracija Mg, Zn i Cu u odnosu na kontrolnu skupinu. Naši nalazi potvrđuju da kombinirano izlaganje mješavini VOC, čak i pri
dozvoljenim koncentracijama, može dovesti do aditivnih ili sinergističkih štetnih učinaka na zdravlje i popratnih poremećaja. Trenutna
procjena rizika, koja se uglavnom oslanja na učinke pojedinačnih kemikalija, izaziva zabrinutost i upućuje na potrebu za novim pristupima
koji će objasniti kombiniranu izloženost većem broju kemikalija.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju",
title = "Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds, Povećani oksidacijski stres u obućarskih radnika izloženih mješavini niskih razina hlapljivih organskih spojeva",
volume = "75",
number = "1",
pages = "51-60",
doi = "10.2478/aiht-2024-75-3804"
}

Umićević, N., Kotur-Stevuljević, J., Baralić, K., Đukić-Ćosić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z.,& Antonijević, B.. (2024). Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds. in Arhiv za higijenu rada i toksikologiju
Sciendo., 75(1), 51-60.
https://doi.org/10.2478/aiht-2024-75-3804

Umićević N, Kotur-Stevuljević J, Baralić K, Đukić-Ćosić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B. Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds. in Arhiv za higijenu rada i toksikologiju. 2024;75(1):51-60.
doi:10.2478/aiht-2024-75-3804 .

Umićević, Nina, Kotur-Stevuljević, Jelena, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, "Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds" in Arhiv za higijenu rada i toksikologiju, 75, no. 1 (2024):51-60,
https://doi.org/10.2478/aiht-2024-75-3804 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Grahovac, Lazar
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5516
AB  - Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.
PB  - MDPI
T2  - Antioxidants
T1  - Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies
VL  - 13
IS  - 2
DO  - 10.3390/antiox13020147
ER  - 

@article{
author = "Baralić, Katarina and Živanović, Jovana and Marić, Đurđica and Božić, Dragica and Grahovac, Lazar and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies",
volume = "13",
number = "2",
doi = "10.3390/antiox13020147"
}

Baralić, K., Živanović, J., Marić, Đ., Božić, D., Grahovac, L., Antonijević-Miljaković, E., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants
MDPI., 13(2).
https://doi.org/10.3390/antiox13020147

Baralić K, Živanović J, Marić Đ, Božić D, Grahovac L, Antonijević-Miljaković E, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants. 2024;13(2).
doi:10.3390/antiox13020147 .

Baralić, Katarina, Živanović, Jovana, Marić, Đurđica, Božić, Dragica, Grahovac, Lazar, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies" in Antioxidants, 13, no. 2 (2024),
https://doi.org/10.3390/antiox13020147 . .

TY  - JOUR
AU  - Radović, Biljana
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Marić, Đurđica
AU  - Živanović, Jovana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5530
AB  - The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.
PB  - Elsevier V. B.
T2  - Science of the Total Environment
T1  - Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms
VL  - 917
SP  - 170437
DO  - 10.1016/j.scitotenv.2024.170437
ER  - 

@article{
author = "Radović, Biljana and Baralić, Katarina and Ćurčić, Marijana and Marić, Đurđica and Živanović, Jovana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2024",
abstract = "The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.",
publisher = "Elsevier V. B.",
journal = "Science of the Total Environment",
title = "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms",
volume = "917",
pages = "170437",
doi = "10.1016/j.scitotenv.2024.170437"
}

Radović, B., Baralić, K., Ćurčić, M., Marić, Đ., Živanović, J., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2024). Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment
Elsevier V. B.., 917, 170437.
https://doi.org/10.1016/j.scitotenv.2024.170437

Radović B, Baralić K, Ćurčić M, Marić Đ, Živanović J, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Bulat Z, Antonijević B. Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment. 2024;917:170437.
doi:10.1016/j.scitotenv.2024.170437 .

Radović, Biljana, Baralić, Katarina, Ćurčić, Marijana, Marić, Đurđica, Živanović, Jovana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms" in Science of the Total Environment, 917 (2024):170437,
https://doi.org/10.1016/j.scitotenv.2024.170437 . .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5552
AB  - Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ...
AB  - Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji
T1  - Possibilities and challenges of applying artificial intelligence in toxicology
SP  - 159
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5552
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ..., Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji, Possibilities and challenges of applying artificial intelligence in toxicology",
pages = "159-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5552"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):159-160,
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Manić, Luka
AU  - Grahovac, Lazar
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5513
AB  - In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ...
AB  - In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode
T1  - Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method
SP  - 154
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5513
ER  - 

@conference{
author = "Božić, Dragica and Baralić, Katarina and Živanović, Jovana and Živančević, Katarina and Marić, Đurđica and Vukelić, Dragana and Manić, Luka and Grahovac, Lazar and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "In silico metode u toksikologiji podrazumevaju upotrebu kompjuterskih metoda koje omogućavaju analizu i predviđanje toksičnosti supstanci, pri čemu mogu usmeriti dalja eksperimentalna istraživanja. Sulforafan (SFN) je organosumporna supstanca iz grupe izotiocijanata, prisutna u povrću krstašica. 
Dok se SFN-glukozinolat ekstrahuje iz brokolija i uključen je u brojne kliničke studije, SFN je hemijski sintetisan i koristi se samo u istraživačke svrhe. ..., In silico methods in toxicology use computer methods to analyze and predict the toxicity of substances, which can serve as a basis for further experimental studies. Sulforaphane (SFN) is an organosulfur chemical from the isothiocyanate group, present in cruciferous vegetables. While SFN-glucosinolate is extracted from broccoli and is presently ongoing numerous clinical studies, SFN has been chemically synthetized, currently only for research purposes. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode, Sulforaphane and sulforaphane - glucosinolate toxicity prediction using the in silico US-EPA COMPTOX chemicals DASHBOARD method",
pages = "154-156",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5513"
}

Božić, D., Baralić, K., Živanović, J., Živančević, K., Marić, Đ., Vukelić, D., Manić, L., Grahovac, L., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513

Božić D, Baralić K, Živanović J, Živančević K, Marić Đ, Vukelić D, Manić L, Grahovac L, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:154-156.
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

Božić, Dragica, Baralić, Katarina, Živanović, Jovana, Živančević, Katarina, Marić, Đurđica, Vukelić, Dragana, Manić, Luka, Grahovac, Lazar, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Predviđanje toksičnosti sulforafana i sulforafan-glukozinolata primenom in silico US-EPA COMPTOX chemicals DASHBOARD metode" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):154-156,
https://hdl.handle.net/21.15107/rcub_farfar_5513 .

TY  - CONF
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Čolaković, Nataša
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5509
AB  - Iako se poslednjih godina beleži pad koncentracija Cd i Pb u životnoj sredini, istraživanja nedvosmisleno
potvrđuju da i izloženost niskim dozama može dovesti do oštećenja različitih organskih sistema.
Imajući u vidu metaloestrogena svojstva, posebno činjenicu da deluju kao endokrini ometači i
oponašaju dejstvo estrogena, njihov uticaj na reprodukciju I uloga u etiologjji hormon zavisnih karcinomima se ne sme zanemariti. ...
AB  - Regardless of decreased environmental Cd and Pb levels in recent decades, research unequivocally confirms that exposure to low levels can damage numerous organs. Considering their metaloestrogen properties, especially the fact that they act as an endocrine disruptor and mimic the effects of estrogen, their potential role on the reproduction as well in the etiology of hormone related cancers must not be neglected. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma
T1  - Cadmium and lead as risk factors in development of hormone related cancer
SP  - 109
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5509
ER  - 

@conference{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević, Biljana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Čolaković, Nataša and Aćimović, Miodrag and Bulat, Zorica",
year = "2023",
abstract = "Iako se poslednjih godina beleži pad koncentracija Cd i Pb u životnoj sredini, istraživanja nedvosmisleno
potvrđuju da i izloženost niskim dozama može dovesti do oštećenja različitih organskih sistema.
Imajući u vidu metaloestrogena svojstva, posebno činjenicu da deluju kao endokrini ometači i
oponašaju dejstvo estrogena, njihov uticaj na reprodukciju I uloga u etiologjji hormon zavisnih karcinomima se ne sme zanemariti. ..., Regardless of decreased environmental Cd and Pb levels in recent decades, research unequivocally confirms that exposure to low levels can damage numerous organs. Considering their metaloestrogen properties, especially the fact that they act as an endocrine disruptor and mimic the effects of estrogen, their potential role on the reproduction as well in the etiology of hormone related cancers must not be neglected. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma, Cadmium and lead as risk factors in development of hormone related cancer",
pages = "109-110",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5509"
}

Anđelković, M., Buha-Đorđević, A., Vukelić, D., Baralić, K., Đukić-Ćosić, D., Antonijević, B., Ćurčić, M., Antonijević-Miljaković, E., Čolaković, N., Aćimović, M.,& Bulat, Z.. (2023). Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 109-110.
https://hdl.handle.net/21.15107/rcub_farfar_5509

Anđelković M, Buha-Đorđević A, Vukelić D, Baralić K, Đukić-Ćosić D, Antonijević B, Ćurčić M, Antonijević-Miljaković E, Čolaković N, Aćimović M, Bulat Z. Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:109-110.
https://hdl.handle.net/21.15107/rcub_farfar_5509 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević, Biljana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Čolaković, Nataša, Aćimović, Miodrag, Bulat, Zorica, "Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):109-110,
https://hdl.handle.net/21.15107/rcub_farfar_5509 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5170
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
T1  - Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor
VL  - 384
IS  - S1
SP  - S78
EP  - S78
DO  - 10.1016/S0378-4274(23)00454-X
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5170
ER  - 

@conference{
author = "Živančević, Katarina and Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia",
title = "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor",
volume = "384",
number = "S1",
pages = "S78-S78",
doi = "10.1016/S0378-4274(23)00454-X",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5170"
}

Živančević, K., Živanović, J., Baralić, K., Božić, D., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
Elsevier., 384(S1), S78-S78.
https://doi.org/10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170

Živančević K, Živanović J, Baralić K, Božić D, Marić Đ, Vukelić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia. 2023;384(S1):S78-S78.
doi:10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

Živančević, Katarina, Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor" in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia, 384, no. S1 (2023):S78-S78,
https://doi.org/10.1016/S0378-4274(23)00454-X .,
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5485
AB  - Aktivnosti prilikom rastavljanje e-otpada predstavljaju značajan izvor mnogih štetnih komponenti, što dovodi do svakodnevnog izlaganja radnika toksičnim isparenjima koja se sastoje od različitih metala i organskih jedinjenja. Svaka od ovih hemikalija iz životne sredine ponaosob ispoljava toksične efekte ometajući homeostazu hormona, a njihov potencijal da deluju kao endokrini ometači je već potvrđen. ...
AB  - E-waste dismantling activities constitute a significant source of many harmful components, resulting in everyday exposure of workers to toxic fumes consisting of different metals and organic compounds. Each of these environmental chemicals individually exerts toxic effects by interfering with hormone homeostasis and their potential to act as endocrine disruptors (EDs) has already been confirmed. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58
T1  - Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem
T1  - Dust from e - waste dismantling as a source of endocrine disrupting chemicals: In silico testing of mixture toxicity on thyroid gland and male reproductive system
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5485
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Aktivnosti prilikom rastavljanje e-otpada predstavljaju značajan izvor mnogih štetnih komponenti, što dovodi do svakodnevnog izlaganja radnika toksičnim isparenjima koja se sastoje od različitih metala i organskih jedinjenja. Svaka od ovih hemikalija iz životne sredine ponaosob ispoljava toksične efekte ometajući homeostazu hormona, a njihov potencijal da deluju kao endokrini ometači je već potvrđen. ..., E-waste dismantling activities constitute a significant source of many harmful components, resulting in everyday exposure of workers to toxic fumes consisting of different metals and organic compounds. Each of these environmental chemicals individually exerts toxic effects by interfering with hormone homeostasis and their potential to act as endocrine disruptors (EDs) has already been confirmed. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58",
title = "Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem, Dust from e - waste dismantling as a source of endocrine disrupting chemicals: In silico testing of mixture toxicity on thyroid gland and male reproductive system",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5485"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić, D., Baralić, K., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58
Udruženje toksikologa Srbije..
https://hdl.handle.net/21.15107/rcub_farfar_5485

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić D, Baralić K, Đukić-Ćosić D, Bulat Z, Antonijević B. Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_5485 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Prašina od rastavljanja e-otpada kao izvor hemikalija koje ometaju rad endokrinog sistema: In silico testiranje toksičnosti smeše na štitnu žlezdu i muški reproduktivni sistem" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book, 2023, 57-58 (2023),
https://hdl.handle.net/21.15107/rcub_farfar_5485 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5440
AB  - Dekabromovani difenil etar (BDE-209) je široko rasprostranjena toksična supstanca u životnoj sredini,
posebno na mestima odlaganja električnog i elektronskog otpada. Sa deponija se BDE-209 može oslo-
boditi u životnu sredini i dospeti do organizma čoveka, i eventualno uzrokovati štetne efekte. ...
AB  - Deca brominated diphenyl ether (BDE-209) is a widely present toxic substance in the environment,
particularly in electrical and electronic waste sites. From landfill sites, BDE-209 can be released into the
environment, reach humans and possibly induce adverse effects. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?
T1  - Are the zinc and copper involved in toxic effects induced by BDE-209 in the brain of Wistar rats?
SP  - 25
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5440
ER  - 

@conference{
author = "Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Dekabromovani difenil etar (BDE-209) je široko rasprostranjena toksična supstanca u životnoj sredini,
posebno na mestima odlaganja električnog i elektronskog otpada. Sa deponija se BDE-209 može oslo-
boditi u životnu sredini i dospeti do organizma čoveka, i eventualno uzrokovati štetne efekte. ..., Deca brominated diphenyl ether (BDE-209) is a widely present toxic substance in the environment,
particularly in electrical and electronic waste sites. From landfill sites, BDE-209 can be released into the
environment, reach humans and possibly induce adverse effects. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?, Are the zinc and copper involved in toxic effects induced by BDE-209 in the brain of Wistar rats?",
pages = "25-26",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5440"
}

Ćurčić, M., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 25-26.
https://hdl.handle.net/21.15107/rcub_farfar_5440

Ćurčić M, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Bulat Z, Antonijević B. Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:25-26.
https://hdl.handle.net/21.15107/rcub_farfar_5440 .

Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):25-26,
https://hdl.handle.net/21.15107/rcub_farfar_5440 .

TY  - CONF
AU  - Antonijević-Miljaković, Evica
AU  - Andrys, Rudolf
AU  - Antonijević, Biljana
AU  - Musilek, Kamil
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5435
AB  - Imobilizacija enzima predstavlja značajnu naučnu metodologiju zbog odličnog funkcionalnog poboljšanja
svojstava proteina kao što su ponovna upotreba, ekonomičnost i lako odvajanje od reakcionog medijuma. ..
AB  - Enzyme immobilization presents substantial scientific methodology due to excellent functional improvement
of protein properties such as reusability, cost-effectiveness and easy separation from the reaction medium. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Imobilizacija enzima kao strategija za efikasno i održivo određivanje inhibitora i reaktivatora holinesteraza
T1  - Enzyme immobilization as a strategy towards efficient and sustainable determination of cholinesterase inhibitors and reactivators
SP  - 78
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5435
ER  - 

@conference{
author = "Antonijević-Miljaković, Evica and Andrys, Rudolf and Antonijević, Biljana and Musilek, Kamil",
year = "2023",
abstract = "Imobilizacija enzima predstavlja značajnu naučnu metodologiju zbog odličnog funkcionalnog poboljšanja
svojstava proteina kao što su ponovna upotreba, ekonomičnost i lako odvajanje od reakcionog medijuma. .., Enzyme immobilization presents substantial scientific methodology due to excellent functional improvement
of protein properties such as reusability, cost-effectiveness and easy separation from the reaction medium. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Imobilizacija enzima kao strategija za efikasno i održivo određivanje inhibitora i reaktivatora holinesteraza, Enzyme immobilization as a strategy towards efficient and sustainable determination of cholinesterase inhibitors and reactivators",
pages = "78-79",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5435"
}

Antonijević-Miljaković, E., Andrys, R., Antonijević, B.,& Musilek, K.. (2023). Imobilizacija enzima kao strategija za efikasno i održivo određivanje inhibitora i reaktivatora holinesteraza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 78-79.
https://hdl.handle.net/21.15107/rcub_farfar_5435

Antonijević-Miljaković E, Andrys R, Antonijević B, Musilek K. Imobilizacija enzima kao strategija za efikasno i održivo određivanje inhibitora i reaktivatora holinesteraza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:78-79.
https://hdl.handle.net/21.15107/rcub_farfar_5435 .

Antonijević-Miljaković, Evica, Andrys, Rudolf, Antonijević, Biljana, Musilek, Kamil, "Imobilizacija enzima kao strategija za efikasno i održivo određivanje inhibitora i reaktivatora holinesteraza" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):78-79,
https://hdl.handle.net/21.15107/rcub_farfar_5435 .

TY  - CONF
AU  - Vukelić, Dragana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5423
AB  - Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ...
AB  - Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje
T1  - Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling
SP  - 57
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5423
ER  - 

@conference{
author = "Vukelić, Dragana and Anđelković, Milena and Repić, Aleksandra and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ..., Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje, Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling",
pages = "57-58",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5423"
}

Vukelić, D., Anđelković, M., Repić, A., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Kotur-Stevuljević, J., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423

Vukelić D, Anđelković M, Repić A, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Kotur-Stevuljević J, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

Vukelić, Dragana, Anđelković, Milena, Repić, Aleksandra, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):57-58,
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5168
AB  - Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ...
AB  - Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19
T1  - In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5168
ER  - 

@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ..., Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19, In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5168"
}

Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168

Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5429
AB  - Sobzirom na to da su ljudi u svakodnevnom životu konstantno izloženi smešama hemikalija koje deluju
putem zajedničkih mehanizama, važno je proceniti da li su ovi „koktel efekti“ izraženiji u poređenju sa
dejstvom pojedinačnih hemikalija. ...
AB  - Due to the fact that in daily life humans are constantly exposed to mixtures of chemicals acting by
a common mechanism of action, it is important to assess whether these "cocktail effects" are more
pronounced compared to the effects of single chemicals. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova
T1  - Assessment of lead and polychlorinated biphenyls mixture toxic effects on redox status in rat kidneys
SP  - 67
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5429
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Sobzirom na to da su ljudi u svakodnevnom životu konstantno izloženi smešama hemikalija koje deluju
putem zajedničkih mehanizama, važno je proceniti da li su ovi „koktel efekti“ izraženiji u poređenju sa
dejstvom pojedinačnih hemikalija. ..., Due to the fact that in daily life humans are constantly exposed to mixtures of chemicals acting by
a common mechanism of action, it is important to assess whether these "cocktail effects" are more
pronounced compared to the effects of single chemicals. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova, Assessment of lead and polychlorinated biphenyls mixture toxic effects on redox status in rat kidneys",
pages = "67-68",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5429"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić, D., Baralić, K., Marić, Đ., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 67-68.
https://hdl.handle.net/21.15107/rcub_farfar_5429

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić D, Baralić K, Marić Đ, Đukić-Ćosić D, Bulat Z, Antonijević B. Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:67-68.
https://hdl.handle.net/21.15107/rcub_farfar_5429 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Procena toksičnih efekata smeše olova i polihlorovanih bifenila na redoks status u bubrezima pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):67-68,
https://hdl.handle.net/21.15107/rcub_farfar_5429 .

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5175
AB  - Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats
VL  - 384
IS  - S1
SP  - S223
EP  - S223
DO  - 10.1016/S0378-4274(23)00790-7
ER  - 

@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Vukelić, Dragana and Đukić-Ćosić, Danijela and Marić, Đurđica and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats",
volume = "384",
number = "S1",
pages = "S223-S223",
doi = "10.1016/S0378-4274(23)00790-7"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Vukelić, D., Đukić-Ćosić, D., Marić, Đ., Bulat, Z.,& Antonijević, B.. (2023). Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters
Elsevier., 384(S1), S223-S223.
https://doi.org/10.1016/S0378-4274(23)00790-7

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Vukelić D, Đukić-Ćosić D, Marić Đ, Bulat Z, Antonijević B. Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters. 2023;384(S1):S223-S223.
doi:10.1016/S0378-4274(23)00790-7 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Vukelić, Dragana, Đukić-Ćosić, Danijela, Marić, Đurđica, Bulat, Zorica, Antonijević, Biljana, "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats" in Toxicology Letters, 384, no. S1 (2023):S223-S223,
https://doi.org/10.1016/S0378-4274(23)00790-7 . .

TY  - JOUR
AU  - Stojilković, Nikola
AU  - Radović, Biljana
AU  - Vukelić, Dragana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5142
AB  - Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. This in silico toxicogenomic study aims to provide evidence for the selected environmental (organo)metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture involvement in the possible alteration of thyroid, and male reproductive system function, and furthermore to predict the possible toxic mechanisms of the environmental cocktail. The Comparative Toxicogenomic Database, GeneMANIA online software, and ToppGene Suite portal were used as the main tools for toxicogenomic data mining and gene ontology analysis. The results show that 35 annotated common genes between selected chemicals and endocrine system diseases can interact on the co-expression level. Our study highlighted the disruption of the cytokines, the cell's response to oxidative stress, and the influence of the transcription factors as the potential core of toxicological mechanisms of the discussed mixture's effects. The connected toxicological effects of the tested mixture were abnormal sperm cells, a disrupted level of testosterone, and thyroid hormones. The core mechanisms of these effects were inflammation, oxidative stress, disruption of androgen receptor signaling, and the alteration of the FOXO3-Keap-1/NRF2-HMOX1-NQO1 pathway signaling most likely controlled by the co-expression of overlapped genes among used chemicals. This in silico research can be used as a potential core for the determination of biomarkers that can be monitored in future further in vitro and in vivo experiments.
PB  - Elsevier
T2  - Environmental Research
T1  - Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining
DO  - 10.1016/j.envres.2023.117274
ER  - 

@article{
author = "Stojilković, Nikola and Radović, Biljana and Vukelić, Dragana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Marić, Đurđica and Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Biljana",
year = "2023",
abstract = "Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. This in silico toxicogenomic study aims to provide evidence for the selected environmental (organo)metals (lead, cadmium, methyl mercury) + polychlorinated biphenyls mixture involvement in the possible alteration of thyroid, and male reproductive system function, and furthermore to predict the possible toxic mechanisms of the environmental cocktail. The Comparative Toxicogenomic Database, GeneMANIA online software, and ToppGene Suite portal were used as the main tools for toxicogenomic data mining and gene ontology analysis. The results show that 35 annotated common genes between selected chemicals and endocrine system diseases can interact on the co-expression level. Our study highlighted the disruption of the cytokines, the cell's response to oxidative stress, and the influence of the transcription factors as the potential core of toxicological mechanisms of the discussed mixture's effects. The connected toxicological effects of the tested mixture were abnormal sperm cells, a disrupted level of testosterone, and thyroid hormones. The core mechanisms of these effects were inflammation, oxidative stress, disruption of androgen receptor signaling, and the alteration of the FOXO3-Keap-1/NRF2-HMOX1-NQO1 pathway signaling most likely controlled by the co-expression of overlapped genes among used chemicals. This in silico research can be used as a potential core for the determination of biomarkers that can be monitored in future further in vitro and in vivo experiments.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining",
doi = "10.1016/j.envres.2023.117274"
}

Stojilković, N., Radović, B., Vukelić, D., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Marić, Đ., Bulat, Z., Đukić-Ćosić, D.,& Antonijević, B.. (2023). Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining. in Environmental Research
Elsevier..
https://doi.org/10.1016/j.envres.2023.117274

Stojilković N, Radović B, Vukelić D, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Marić Đ, Bulat Z, Đukić-Ćosić D, Antonijević B. Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining. in Environmental Research. 2023;.
doi:10.1016/j.envres.2023.117274 .

Stojilković, Nikola, Radović, Biljana, Vukelić, Dragana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Marić, Đurđica, Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Biljana, "Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining" in Environmental Research (2023),
https://doi.org/10.1016/j.envres.2023.117274 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Anđelković, Milena
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4915
AB  - The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats after the 28- and 90-day exposure to dose levels calculated on the basis of the previously conducted human study. Experimental groups included: 2 controls (28- and 90-day), treated groups - doses based on: median– F2 (28) and F2(90) and 95th percentile concentrations in the general human population – F3(28) and F3(90); calculated lower Benchmark dose confidence limit (BMDL) for effects on hormone levels – F1(28) and F1(90) and a group given the doses calculated on the basis of the reference values from the literature (F4(28)). Blood and ovarian samples were collected for sex hormones and ovary redox status analysis. After 28-day exposure, changes were present both in prooxidants and antioxidants. However, after the 90-day exposure redox status imbalance was majorly caused by the disturbance of antioxidants. Changes in some parameters were observed even after exposure to the lowest doses. After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2–related factor 2 (Nrf2) and toxic metal(oid)s. Low obtained BMDLs and narrow Benchmark intervals for toxic metal(oid)s and some of the parameters might confirm the “no-threshold” paradigm. This study indicates possible detrimental effects of prolonged exposure to real-life mixtures of toxic metal(oid) on female reproductive function.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different
VL  - 895
DO  - 10.1016/j.scitotenv.2023.165181
ER  - 

@article{
author = "Baralić, Katarina and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Anđelković, Milena and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats after the 28- and 90-day exposure to dose levels calculated on the basis of the previously conducted human study. Experimental groups included: 2 controls (28- and 90-day), treated groups - doses based on: median– F2 (28) and F2(90) and 95th percentile concentrations in the general human population – F3(28) and F3(90); calculated lower Benchmark dose confidence limit (BMDL) for effects on hormone levels – F1(28) and F1(90) and a group given the doses calculated on the basis of the reference values from the literature (F4(28)). Blood and ovarian samples were collected for sex hormones and ovary redox status analysis. After 28-day exposure, changes were present both in prooxidants and antioxidants. However, after the 90-day exposure redox status imbalance was majorly caused by the disturbance of antioxidants. Changes in some parameters were observed even after exposure to the lowest doses. After 28-day exposure, the strongest dose-response relationship was found between hormones: LH and FSH and toxic metal(oid)s and, after 90-day exposure, between investigated redox status parameters: sulfhydryl groups, ischemia-modified albumin and nuclear factor erythroid 2–related factor 2 (Nrf2) and toxic metal(oid)s. Low obtained BMDLs and narrow Benchmark intervals for toxic metal(oid)s and some of the parameters might confirm the “no-threshold” paradigm. This study indicates possible detrimental effects of prolonged exposure to real-life mixtures of toxic metal(oid) on female reproductive function.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different",
volume = "895",
doi = "10.1016/j.scitotenv.2023.165181"
}

Baralić, K., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Anđelković, M., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. in Science of the Total Environment
Elsevier B.V.., 895.
https://doi.org/10.1016/j.scitotenv.2023.165181

Baralić K, Marić Đ, Vukelić D, Antonijević-Miljaković E, Anđelković M, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different. in Science of the Total Environment. 2023;895.
doi:10.1016/j.scitotenv.2023.165181 .

Baralić, Katarina, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Anđelković, Milena, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different" in Science of the Total Environment, 895 (2023),
https://doi.org/10.1016/j.scitotenv.2023.165181 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4651
AB  - Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.
PB  - Academic Press Inc.
T2  - Environmental Research
T1  - Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study
VL  - 227
DO  - 10.1016/j.envres.2023.115818
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Božić, Dragica and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.",
publisher = "Academic Press Inc.",
journal = "Environmental Research",
title = "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study",
volume = "227",
doi = "10.1016/j.envres.2023.115818"
}

Baralić, K., Živančević, K., Marić, Đ., Božić, D., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research
Academic Press Inc.., 227.
https://doi.org/10.1016/j.envres.2023.115818

Baralić K, Živančević K, Marić Đ, Božić D, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research. 2023;227.
doi:10.1016/j.envres.2023.115818 .

Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Božić, Dragica, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study" in Environmental Research, 227 (2023),
https://doi.org/10.1016/j.envres.2023.115818 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Antonijević-Miljaković, Evica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Bulat, Petar
AU  - Radovanović, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4650
AB  - Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.
PB  - MDPI
T2  - Toxics
T1  - Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats
VL  - 11
IS  - 3
DO  - 10.3390/toxics11030256
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Antonijević-Miljaković, Evica and Baralić, Katarina and Živančević, Katarina and Bulat, Petar and Radovanović, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found to induce various toxic mechanisms leading to organ physiological disruption. Therefore, the purpose of the study was to simulate low-dose Pb exposure in an animal model with the aim of assessing oxidative status and essential element levels as the main mechanism of Pb toxicity in the liver and kidneys. Furthermore, dose–response modelling was performed in order to determine the benchmark dose (BMD). Forty-two male Wistar rats were divided into seven groups: one control group, and six groups treated for 28 days with 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg b.w./day, respectively. Oxidative status parameters (superoxide dismutase activity (SOD), superoxide anion radical (O2−), malondialdehyde (MDA), total sulfhydryl groups (SHG), and advanced oxidation protein products (AOPP)) and Pb, copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) levels were measured. Lowering Cu levels (BMD: 2.7 ng/kg b.w./day), raising AOPP levels (BMD: 0.25 µg/kg b.w./day) in the liver, and inhibiting SOD (BMD: 1.3 ng/kg b.w./day) in the kidneys appear to be the main mechanisms of Pb toxicity. The lowest BMD was derived for a decrease in Cu levels in liver, indicating that this effect is the most sensitive.",
publisher = "MDPI",
journal = "Toxics",
title = "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats",
volume = "11",
number = "3",
doi = "10.3390/toxics11030256"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Antonijević-Miljaković, E., Baralić, K., Živančević, K., Bulat, P., Radovanović, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2023). Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics
MDPI., 11(3).
https://doi.org/10.3390/toxics11030256

Vukelić D, Buha-Đorđević A, Anđelković M, Antonijević-Miljaković E, Baralić K, Živančević K, Bulat P, Radovanović J, Đukić-Ćosić D, Antonijević B, Bulat Z. Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats. in Toxics. 2023;11(3).
doi:10.3390/toxics11030256 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Antonijević-Miljaković, Evica, Baralić, Katarina, Živančević, Katarina, Bulat, Petar, Radovanović, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats" in Toxics, 11, no. 3 (2023),
https://doi.org/10.3390/toxics11030256 . .

TY  - JOUR
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić-Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4613
AB  - The current study aimed to assess the connection between the mixture of lead (Pb), cadmium (Cd), arsenic (As), methylmercury (MeHg) and decabrominated diphenyl ether (decaBDE) and thyroid function, by using in silico toxicogenomic data-mining approach. To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal. The analysis has shown 10 genes connected to all chemicals present in the mixture and TDs (CAT, GSR, IFNG, IL1B, IL4, IL6, MAPK1, SOD2, TGFB1, TNF), most of which were in co-expression (45.68%), or belonged to the same pathway (30.47%). Top 5 biological processes and molecular functions affected by the investigated mixture emphasized the role of two common mechanisms – oxidative stress and inflammation. Cytokines and inflammatory response was listed as the main molecular pathway that may be triggered by simultaneous exposure to toxic metal(oid)s and decaBDE and connected to TDs. The direct relations between Pb/decaBDE and redox status impairment in thyroid tissue was confirmed by our chemical-phenotype interaction analysis, while the strongest linkage between Pb, As and decaBDE and thyroid disorders was found. The obtained results provide better understanding of molecular mechanisms involved in the thyrotoxicity of the investigated mixture, and can be used to direct further research.
PB  - Elsevier Ireland Ltd
T2  - Toxicology
T1  - In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether
VL  - 489
DO  - 10.1016/j.tox.2023.153496
ER  - 

@article{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić-Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "The current study aimed to assess the connection between the mixture of lead (Pb), cadmium (Cd), arsenic (As), methylmercury (MeHg) and decabrominated diphenyl ether (decaBDE) and thyroid function, by using in silico toxicogenomic data-mining approach. To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal. The analysis has shown 10 genes connected to all chemicals present in the mixture and TDs (CAT, GSR, IFNG, IL1B, IL4, IL6, MAPK1, SOD2, TGFB1, TNF), most of which were in co-expression (45.68%), or belonged to the same pathway (30.47%). Top 5 biological processes and molecular functions affected by the investigated mixture emphasized the role of two common mechanisms – oxidative stress and inflammation. Cytokines and inflammatory response was listed as the main molecular pathway that may be triggered by simultaneous exposure to toxic metal(oid)s and decaBDE and connected to TDs. The direct relations between Pb/decaBDE and redox status impairment in thyroid tissue was confirmed by our chemical-phenotype interaction analysis, while the strongest linkage between Pb, As and decaBDE and thyroid disorders was found. The obtained results provide better understanding of molecular mechanisms involved in the thyrotoxicity of the investigated mixture, and can be used to direct further research.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology",
title = "In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether",
volume = "489",
doi = "10.1016/j.tox.2023.153496"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić-Javorac, D., Baralić, K., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. in Toxicology
Elsevier Ireland Ltd., 489.
https://doi.org/10.1016/j.tox.2023.153496

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić-Javorac D, Baralić K, Đukić-Ćosić D, Bulat Z, Antonijević B. In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. in Toxicology. 2023;489.
doi:10.1016/j.tox.2023.153496 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić-Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether" in Toxicology, 489 (2023),
https://doi.org/10.1016/j.tox.2023.153496 . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4425
AB  - Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.
PB  - Elsevier
T2  - Biomedicine and Pharmacotherapy
T1  - Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
VL  - 160
DO  - 10.1016/j.biopha.2023.114316
ER  - 

@article{
author = "Božić, Dragica and Živančević, Katarina and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.",
publisher = "Elsevier",
journal = "Biomedicine and Pharmacotherapy",
title = "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells",
volume = "160",
doi = "10.1016/j.biopha.2023.114316"
}

Božić, D., Živančević, K., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy
Elsevier., 160.
https://doi.org/10.1016/j.biopha.2023.114316

Božić D, Živančević K, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy. 2023;160.
doi:10.1016/j.biopha.2023.114316 .

Božić, Dragica, Živančević, Katarina, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells" in Biomedicine and Pharmacotherapy, 160 (2023),
https://doi.org/10.1016/j.biopha.2023.114316 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4334
AB  - Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).
PB  - Elsevier B.V.
T2  - Journal of Hazardous Materials
T1  - Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
VL  - 445
DO  - 10.1016/j.jhazmat.2022.130404
ER  - 

@article{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).",
publisher = "Elsevier B.V.",
journal = "Journal of Hazardous Materials",
title = "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A",
volume = "445",
doi = "10.1016/j.jhazmat.2022.130404"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials
Elsevier B.V.., 445.
https://doi.org/10.1016/j.jhazmat.2022.130404

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials. 2023;445.
doi:10.1016/j.jhazmat.2022.130404 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A" in Journal of Hazardous Materials, 445 (2023),
https://doi.org/10.1016/j.jhazmat.2022.130404 . .

TY  - JOUR
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Hayes, Wallace
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4326
AB  - The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.
PB  - Elsevier Inc
T2  - Environmental Research
T1  - New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
VL  - 217
DO  - 10.1016/j.envres.2022.114829
ER  - 

@article{
author = "Buha-Đorđević, Aleksandra and Milovanović, Vesna and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Bulat, Zorica and Đukić-Ćosić, Danijela and Janković, Saša and Vučinić, Slavica and Hayes, Wallace and Antonijević, Biljana",
year = "2023",
abstract = "The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.",
publisher = "Elsevier Inc",
journal = "Environmental Research",
title = "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model",
volume = "217",
doi = "10.1016/j.envres.2022.114829"
}

Buha-Đorđević, A., Milovanović, V., Ćurčić, M., Antonijević-Miljaković, E., Bulat, Z., Đukić-Ćosić, D., Janković, S., Vučinić, S., Hayes, W.,& Antonijević, B.. (2023). New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research
Elsevier Inc., 217.
https://doi.org/10.1016/j.envres.2022.114829

Buha-Đorđević A, Milovanović V, Ćurčić M, Antonijević-Miljaković E, Bulat Z, Đukić-Ćosić D, Janković S, Vučinić S, Hayes W, Antonijević B. New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research. 2023;217.
doi:10.1016/j.envres.2022.114829 .

Buha-Đorđević, Aleksandra, Milovanović, Vesna, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Bulat, Zorica, Đukić-Ćosić, Danijela, Janković, Saša, Vučinić, Slavica, Hayes, Wallace, Antonijević, Biljana, "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model" in Environmental Research, 217 (2023),
https://doi.org/10.1016/j.envres.2022.114829 . .

TY  - CONF
AU  - Umićević, Nina
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4608
AB  - Organic solvents are still widely used in various industries and considered the most
common chemicals associated with liver injury in workers. For research into the
relationships between these chemicals and genes, interactions among chemicals, molecular
pathways and biological processes, a significant place in toxicity testing has been taken by in
silico methodologies. This study aims to provide evidence for the involvement of a selected
mixture of organic solvents (toluene, styrene, ethanol) in liver disease development and
show the potential of in silico toxicogenomic data-mining in determining possible
mechanisms of mixture toxicity. The Comparative Toxicogenomics Database (CTD),
GeneMania and ToppGene Suite were used for data-mining. The results showed that there
were 17 genes connected with liver injury common for all the tested solvents. Co-expression
(61.73%) was the most prominent interaction between the genes, while physical
interactions were present at 14.56%, co-localization at 12.54% and interactions predicted by
the server at 6.62%. Gene ontology analysis revealed biological processes affected by the
investigated mixture (reactive oxygen species metabolic and biosynthetic process, response
to oxidative stress, and response to organic cyclic compound). Oxidative stress response,
antioxidant and oxidoreductase activity, vitamin B12 metabolism were noted as the key
molecular pathways contributing to liver disease development. Our results emphasize the
role of oxidative stress as one of the mechanisms of organic solvents' mixture toxicity and
provide new insights into molecular mechanisms involved in hepatotoxicity.
AB  - Organski rastvarači se još uvek široko koriste u raznim industrijama i smatraju se
najčešćim hemikalijama povezanim sa oštećenjem jetre kod radnika. Za istraživanje odnosa
između ovih hemikalija i gena, interakcija među hemikalijama, molekularnih puteva i
bioloških procesa, značajno mjesto pripada i in silico metodologijama. Cilj ove studije je da
pruži dokaze za povezanost odabrane smeše organskih rastvarača (toluen, stiren, etanol) u
razvoju bolesti jetre, i da pokaže potencijal in silico toksikogenomičke analize podataka u
određivanju mogućih mehanizama toksičnosti smješe. Za prikupljanje podataka korišteni su
Comparative Toxicogenomics Database (CTD), GeneMania i ToppGene Suite. Rezultati ove
analize su pokazali da postoji 17 gena povezanih s oštećenjem jetre zajedničkih za sva tri
navedena rastvarača. Koekspresija (61,73%) bila je najistaknutija interakcija između gena,
dok su fizičke interakcije bile prisutne sa 14,56%, kolokalizacije sa 12,54%, a interakcije
predviđene od strane servera sa 6,62%. Analiza ontologije gena izdvojila je biološke procese
na koje utiče ispitivana smeša (metabolički i biosintetski proces reaktivnih kiseonikovih
vrsta, odgovor na oksidativni stres i odgovor na organska ciklična jedinjenja). Odgovor na
oksidativni stres, aktivnost antioksidanata i oksidoreduktaze, i metabolizam vitamina B12 su
navedeni kao ključni molekularni putevi koji dobrinose razvoju bolesti jetre. Rezultati ovog
rada naglašavaju ulogu oksidativnog stresa kao jednog od mehanizama toksičnosti smeše
organskih rastvarača i daju novi uvid u molekularne mehanizme uključene u
hepatotoksičnost.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining
T1  - Hepatotoksični potencijal smeše toluena, stirena i etanola: in silico toksikogenomička analiza
VL  - 72
IS  - 4 suplement
SP  - S567
EP  - S568
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4608
ER  - 

@conference{
author = "Umićević, Nina and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "Organic solvents are still widely used in various industries and considered the most
common chemicals associated with liver injury in workers. For research into the
relationships between these chemicals and genes, interactions among chemicals, molecular
pathways and biological processes, a significant place in toxicity testing has been taken by in
silico methodologies. This study aims to provide evidence for the involvement of a selected
mixture of organic solvents (toluene, styrene, ethanol) in liver disease development and
show the potential of in silico toxicogenomic data-mining in determining possible
mechanisms of mixture toxicity. The Comparative Toxicogenomics Database (CTD),
GeneMania and ToppGene Suite were used for data-mining. The results showed that there
were 17 genes connected with liver injury common for all the tested solvents. Co-expression
(61.73%) was the most prominent interaction between the genes, while physical
interactions were present at 14.56%, co-localization at 12.54% and interactions predicted by
the server at 6.62%. Gene ontology analysis revealed biological processes affected by the
investigated mixture (reactive oxygen species metabolic and biosynthetic process, response
to oxidative stress, and response to organic cyclic compound). Oxidative stress response,
antioxidant and oxidoreductase activity, vitamin B12 metabolism were noted as the key
molecular pathways contributing to liver disease development. Our results emphasize the
role of oxidative stress as one of the mechanisms of organic solvents' mixture toxicity and
provide new insights into molecular mechanisms involved in hepatotoxicity., Organski rastvarači se još uvek široko koriste u raznim industrijama i smatraju se
najčešćim hemikalijama povezanim sa oštećenjem jetre kod radnika. Za istraživanje odnosa
između ovih hemikalija i gena, interakcija među hemikalijama, molekularnih puteva i
bioloških procesa, značajno mjesto pripada i in silico metodologijama. Cilj ove studije je da
pruži dokaze za povezanost odabrane smeše organskih rastvarača (toluen, stiren, etanol) u
razvoju bolesti jetre, i da pokaže potencijal in silico toksikogenomičke analize podataka u
određivanju mogućih mehanizama toksičnosti smješe. Za prikupljanje podataka korišteni su
Comparative Toxicogenomics Database (CTD), GeneMania i ToppGene Suite. Rezultati ove
analize su pokazali da postoji 17 gena povezanih s oštećenjem jetre zajedničkih za sva tri
navedena rastvarača. Koekspresija (61,73%) bila je najistaknutija interakcija između gena,
dok su fizičke interakcije bile prisutne sa 14,56%, kolokalizacije sa 12,54%, a interakcije
predviđene od strane servera sa 6,62%. Analiza ontologije gena izdvojila je biološke procese
na koje utiče ispitivana smeša (metabolički i biosintetski proces reaktivnih kiseonikovih
vrsta, odgovor na oksidativni stres i odgovor na organska ciklična jedinjenja). Odgovor na
oksidativni stres, aktivnost antioksidanata i oksidoreduktaze, i metabolizam vitamina B12 su
navedeni kao ključni molekularni putevi koji dobrinose razvoju bolesti jetre. Rezultati ovog
rada naglašavaju ulogu oksidativnog stresa kao jednog od mehanizama toksičnosti smeše
organskih rastvarača i daju novi uvid u molekularne mehanizme uključene u
hepatotoksičnost.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining, Hepatotoksični potencijal smeše toluena, stirena i etanola: in silico toksikogenomička analiza",
volume = "72",
number = "4 suplement",
pages = "S567-S568",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4608"
}

Umićević, N., Baralić, K., Đukić-Ćosić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z.,& Antonijević, B.. (2022). The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S567-S568.
https://hdl.handle.net/21.15107/rcub_farfar_4608

Umićević N, Baralić K, Đukić-Ćosić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B. The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining. in Arhiv za farmaciju. 2022;72(4 suplement):S567-S568.
https://hdl.handle.net/21.15107/rcub_farfar_4608 .

Umićević, Nina, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, "The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S567-S568,
https://hdl.handle.net/21.15107/rcub_farfar_4608 .

TY  - CONF
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4642
AB  - Polluted air is significant factor with a negative impact on human health. Solving the
problem of polluted air requires involvement of the health system and health workers,
among whom pharmacists in public pharmacies can stand out as the most accessible health
workers with the highest knowledge in the field of toxicology. Considering the indisputable
role of pharmacists in improving health and disease prevention, raising public awareness of
air pollution health impact and advising patients on activities in case of air pollution,
pharmacists would contribute to maintaining health, reducing the burden on the health
system and its efficiency and sustainability. The pharmaceutical profession can make a
significant contribution to combating the impact of air pollution on human health by
increasing the availability of guidelines in the case of polluted air, increasing the availability
of air quality monitoring tools, strengthening educational capacity models, participating in
regulatory frameworks and improving funding for pharmaceutical services. In order for
these responsibilities to be fully incorporated into pharmaceutical practice, it is necessary to:
implement education in the field of toxicology, both at basic and higher levels of study in
order to develop the necessary competencies; increase public awareness of the health
consequences of air pollution, as well as the new roles of pharmacists; develop appropriate
guidelines, regulatory and financial support as well as screening tools. With this in mind, the
role of pharmacists in reducing the impact of air pollution on human health should be
recognized and developed in order to protect human health.
AB  - Zagađen vazduh predstavlja značajan faktor koji ima negativan uticaj na zdravlje ljudi.
Rešavanje problema zagađenog vazduha zahteva uključivanje zdravstvenog sistema i
zdravstvenih radnika, među kojima se mogu istaći farmaceuti u javnim apotekama kao
najdostupniji zdravstveni radnici, sa najvišim znanjima iz oblasti toksikologije. Imajući u
vidu neospornu ulogu farmaceuta u unapređenju zdravlja i prevenciji bolesti, podizanjem
svesti javnosti o uticaju zagađenja vazduha na zdravlje ljudi i davanjem saveta pacijentima o
aktivnostima u slučaju zagađenja vazduha, farmaceuti bi doprineli očuvanju zdravlja,
smanjenju opterećenja zdravstvenog sistema i njegovoj efikasnosti i održivosti.
Farmaceutska profesija može značajno doprineti suzbijanju uticaja zagađenja vazduha na
zdravlje ljudi i to: povećanjem dostupnosti smernica u slučaju zagađenog vazduha,
povećanjem dostupnosti alata za monitoring kvaliteta vazduha, jačanjem obrazovnih
kapaciteta, učestvovanjem u donošenju regulatornih okvira i poboljšanjem modela
finansiranja farmaceutskih usluga kako bi se obezbedila održivost. Da bi navedene
odgovornosti bile u potpunosti inkorporirane u farmaceutsku praksu, potrebno je:
implementirati edukaciju iz oblasti toksikologije, kako na osnovnim tako i na višim nivoima
studija kako bi se razvile neophodne kompetencije; povećati svest javnosti o zdravstvenim
posledicama zagađenja vazduha, kao i o novim ulogama farmaceuta; razviti odgovarajuće
smernice, regulatornu i finansijsku podršku kao i alate za skrining. Imajući navedeno u vidu,
uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi treba biti
prepoznata i razvijena sa ciljem očuvanja zdravlja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - The role of pharmacist in reducing the impact of air pollution on human health
T1  - Uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi
VL  - 72
IS  - 4 suplement
SP  - S613
EP  - S614
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4642
ER  - 

@conference{
author = "Javorac, Dragana and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Polluted air is significant factor with a negative impact on human health. Solving the
problem of polluted air requires involvement of the health system and health workers,
among whom pharmacists in public pharmacies can stand out as the most accessible health
workers with the highest knowledge in the field of toxicology. Considering the indisputable
role of pharmacists in improving health and disease prevention, raising public awareness of
air pollution health impact and advising patients on activities in case of air pollution,
pharmacists would contribute to maintaining health, reducing the burden on the health
system and its efficiency and sustainability. The pharmaceutical profession can make a
significant contribution to combating the impact of air pollution on human health by
increasing the availability of guidelines in the case of polluted air, increasing the availability
of air quality monitoring tools, strengthening educational capacity models, participating in
regulatory frameworks and improving funding for pharmaceutical services. In order for
these responsibilities to be fully incorporated into pharmaceutical practice, it is necessary to:
implement education in the field of toxicology, both at basic and higher levels of study in
order to develop the necessary competencies; increase public awareness of the health
consequences of air pollution, as well as the new roles of pharmacists; develop appropriate
guidelines, regulatory and financial support as well as screening tools. With this in mind, the
role of pharmacists in reducing the impact of air pollution on human health should be
recognized and developed in order to protect human health., Zagađen vazduh predstavlja značajan faktor koji ima negativan uticaj na zdravlje ljudi.
Rešavanje problema zagađenog vazduha zahteva uključivanje zdravstvenog sistema i
zdravstvenih radnika, među kojima se mogu istaći farmaceuti u javnim apotekama kao
najdostupniji zdravstveni radnici, sa najvišim znanjima iz oblasti toksikologije. Imajući u
vidu neospornu ulogu farmaceuta u unapređenju zdravlja i prevenciji bolesti, podizanjem
svesti javnosti o uticaju zagađenja vazduha na zdravlje ljudi i davanjem saveta pacijentima o
aktivnostima u slučaju zagađenja vazduha, farmaceuti bi doprineli očuvanju zdravlja,
smanjenju opterećenja zdravstvenog sistema i njegovoj efikasnosti i održivosti.
Farmaceutska profesija može značajno doprineti suzbijanju uticaja zagađenja vazduha na
zdravlje ljudi i to: povećanjem dostupnosti smernica u slučaju zagađenog vazduha,
povećanjem dostupnosti alata za monitoring kvaliteta vazduha, jačanjem obrazovnih
kapaciteta, učestvovanjem u donošenju regulatornih okvira i poboljšanjem modela
finansiranja farmaceutskih usluga kako bi se obezbedila održivost. Da bi navedene
odgovornosti bile u potpunosti inkorporirane u farmaceutsku praksu, potrebno je:
implementirati edukaciju iz oblasti toksikologije, kako na osnovnim tako i na višim nivoima
studija kako bi se razvile neophodne kompetencije; povećati svest javnosti o zdravstvenim
posledicama zagađenja vazduha, kao i o novim ulogama farmaceuta; razviti odgovarajuće
smernice, regulatornu i finansijsku podršku kao i alate za skrining. Imajući navedeno u vidu,
uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi treba biti
prepoznata i razvijena sa ciljem očuvanja zdravlja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "The role of pharmacist in reducing the impact of air pollution on human health, Uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi",
volume = "72",
number = "4 suplement",
pages = "S613-S614",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4642"
}

Javorac, D., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2022). The role of pharmacist in reducing the impact of air pollution on human health. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S613-S614.
https://hdl.handle.net/21.15107/rcub_farfar_4642

Javorac D, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. The role of pharmacist in reducing the impact of air pollution on human health. in Arhiv za farmaciju. 2022;72(4 suplement):S613-S614.
https://hdl.handle.net/21.15107/rcub_farfar_4642 .

Javorac, Dragana, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "The role of pharmacist in reducing the impact of air pollution on human health" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S613-S614,
https://hdl.handle.net/21.15107/rcub_farfar_4642 .