@article{
author = "Peco-Antić, Amira and Paripović, Dušan and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Scekić, Gordana and Miloševski-Lomić, Gordana",
year = "2012",
abstract = "Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Renal functional reserve in children with apparently normal congenital solitary functioning kidney",
volume = "45",
number = "15",
pages = "1173-1177",
doi = "10.1016/j.clinbiochem.2012.06.018"
}