TY  - JOUR
AU  - Ninić, Ana
AU  - Sopić, Miron
AU  - Munjas, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Ivanišević, Jasmina
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3060
AB  - Background: Chronic renal failure, particularly end-stage renal disease, is a serious health problem associated with a high mortality rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Aims: To examine superoxide dismutase isoenzyme gene expression in peripheral blood mononuclear cells of patients on hemodialysis and to determine the associations between superoxide dismutase isoenzyme gene expression, oxidative stress, and non-enzymatic antioxidative protection. Study Design: Case control study. Methods: This study included 33 patients on hemodialysis (age, 55.33 +/- 15.31 years old) and 33 apparently healthy controls (age, 45.37 +/- 8.92 years old). Superoxide dismutase isoenzyme messenger ribonucleic acid levels were determined by real-time polymerase chain reaction. General biochemical parameters, high sensitivity C-reactive protein, total antioxidant status, thiobarbituric acid-reactive substances, and the superoxide anion radical were also determined. Results: Normalized Cu/Zn superoxide dismutase and Mn superoxide dismutase messenger ribonucleic acid levels were significantly higher in patients than controls (p lt 0.001 and p=0.011). A significant negative correlation was detected between normalized Cu/Zn superoxide dismutase messenger ribonucleic acid levels and total protein total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total antioxidant status. Normalized Mn superoxide dismutase messenger ribonucleic acid levels were negatively correlated with total protein and total antioxidant status. A multiple regression analysis revealed independent associations between total antioxidant status and normalized Cu/Zn superoxide dismutase (p=0.038) and between total antioxidant status and normalized Mn superoxide dismutase messenger ribonucleic acid levels (p=0.038 and p=0.018, respectively). Conclusion: The superoxide dismutase isoenzyme gene is expressed at a higher rate in patients with end-stage renal failure, probably due to increased oxidative stress and attenuated antioxidative defense. The plasma total antioxidant status is an independent predictor of normalized superoxide dismutase isoenzyme messenger ribonucleic acid levels.
PB  - Galenos Yayincilik, Findikzade
T2  - Balkan Medical Journal
T1  - Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease
VL  - 35
IS  - 6
SP  - 431
EP  - 436
DO  - 10.4274/balkanmedj.2018.0170
ER  - 

@article{
author = "Ninić, Ana and Sopić, Miron and Munjas, Jelena and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Ivanišević, Jasmina and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Background: Chronic renal failure, particularly end-stage renal disease, is a serious health problem associated with a high mortality rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Aims: To examine superoxide dismutase isoenzyme gene expression in peripheral blood mononuclear cells of patients on hemodialysis and to determine the associations between superoxide dismutase isoenzyme gene expression, oxidative stress, and non-enzymatic antioxidative protection. Study Design: Case control study. Methods: This study included 33 patients on hemodialysis (age, 55.33 +/- 15.31 years old) and 33 apparently healthy controls (age, 45.37 +/- 8.92 years old). Superoxide dismutase isoenzyme messenger ribonucleic acid levels were determined by real-time polymerase chain reaction. General biochemical parameters, high sensitivity C-reactive protein, total antioxidant status, thiobarbituric acid-reactive substances, and the superoxide anion radical were also determined. Results: Normalized Cu/Zn superoxide dismutase and Mn superoxide dismutase messenger ribonucleic acid levels were significantly higher in patients than controls (p lt 0.001 and p=0.011). A significant negative correlation was detected between normalized Cu/Zn superoxide dismutase messenger ribonucleic acid levels and total protein total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total antioxidant status. Normalized Mn superoxide dismutase messenger ribonucleic acid levels were negatively correlated with total protein and total antioxidant status. A multiple regression analysis revealed independent associations between total antioxidant status and normalized Cu/Zn superoxide dismutase (p=0.038) and between total antioxidant status and normalized Mn superoxide dismutase messenger ribonucleic acid levels (p=0.038 and p=0.018, respectively). Conclusion: The superoxide dismutase isoenzyme gene is expressed at a higher rate in patients with end-stage renal failure, probably due to increased oxidative stress and attenuated antioxidative defense. The plasma total antioxidant status is an independent predictor of normalized superoxide dismutase isoenzyme messenger ribonucleic acid levels.",
publisher = "Galenos Yayincilik, Findikzade",
journal = "Balkan Medical Journal",
title = "Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease",
volume = "35",
number = "6",
pages = "431-436",
doi = "10.4274/balkanmedj.2018.0170"
}

Ninić, A., Sopić, M., Munjas, J., Spasojević-Kalimanovska, V., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Ivanišević, J., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2018). Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease. in Balkan Medical Journal
Galenos Yayincilik, Findikzade., 35(6), 431-436.
https://doi.org/10.4274/balkanmedj.2018.0170

Ninić A, Sopić M, Munjas J, Spasojević-Kalimanovska V, Kotur-Stevuljević J, Bogavac-Stanojević N, Ivanišević J, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease. in Balkan Medical Journal. 2018;35(6):431-436.
doi:10.4274/balkanmedj.2018.0170 .

Ninić, Ana, Sopić, Miron, Munjas, Jelena, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Ivanišević, Jasmina, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Association Between Superoxide Dismutase Isoenzyme Gene Expression and Total Antioxidant Status in Patients with an End-Stage Renal Disease" in Balkan Medical Journal, 35, no. 6 (2018):431-436,
https://doi.org/10.4274/balkanmedj.2018.0170 . .

TY  - CONF
AU  - Munjas, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2927
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease
VL  - 263
SP  - e198
EP  - e198
DO  - 10.1016/j.atherosclerosis.2017.06.636
ER  - 

@conference{
author = "Munjas, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease",
volume = "263",
pages = "e198-e198",
doi = "10.1016/j.atherosclerosis.2017.06.636"
}

Munjas, J., Sopić, M., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2017). Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 263, e198-e198.
https://doi.org/10.1016/j.atherosclerosis.2017.06.636

Munjas J, Sopić M, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease. in Atherosclerosis. 2017;263:e198-e198.
doi:10.1016/j.atherosclerosis.2017.06.636 .

Munjas, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with chronic kidney disease" in Atherosclerosis, 263 (2017):e198-e198,
https://doi.org/10.1016/j.atherosclerosis.2017.06.636 . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2750
AB  - Background: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients
VL  - 35
IS  - 4
SP  - 436
EP  - 442
DO  - 10.1515/jomb-2016-0007
ER  - 

@article{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients",
volume = "35",
number = "4",
pages = "436-442",
doi = "10.1515/jomb-2016-0007"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2016). Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 436-442.
https://doi.org/10.1515/jomb-2016-0007

Sopić M, Joksić J, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients. in Journal of Medical Biochemistry. 2016;35(4):436-442.
doi:10.1515/jomb-2016-0007 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients" in Journal of Medical Biochemistry, 35, no. 4 (2016):436-442,
https://doi.org/10.1515/jomb-2016-0007 . .

TY  - JOUR
AU  - Savić, Jasna
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Gojković, Tamara
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2126
AB  - Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.
PB  - Informa Healthcare, London
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease
VL  - 74
IS  - 7
SP  - 637
EP  - 643
DO  - 10.3109/00365513.2014.928944
ER  - 

@article{
author = "Savić, Jasna and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Stošović, Milan and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Gojković, Tamara and Spasić, Slavica",
year = "2014",
abstract = "Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.",
publisher = "Informa Healthcare, London",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease",
volume = "74",
number = "7",
pages = "637-643",
doi = "10.3109/00365513.2014.928944"
}

Savić, J., Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M., Stošović, M., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Gojković, T.,& Spasić, S.. (2014). Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation
Informa Healthcare, London., 74(7), 637-643.
https://doi.org/10.3109/00365513.2014.928944

Savić J, Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Stošović M, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Gojković T, Spasić S. Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(7):637-643.
doi:10.3109/00365513.2014.928944 .

Savić, Jasna, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Stošović, Milan, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Gojković, Tamara, Spasić, Slavica, "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 7 (2014):637-643,
https://doi.org/10.3109/00365513.2014.928944 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bogavac-Stanojević, Nataša
AU  - Vucković, Maja
AU  - Dopsaj, Violeta
AU  - Giga, Vojislav
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1719
AB  - The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation
VL  - 226
IS  - 2
SP  - 137
EP  - 144
DO  - 10.1620/tjem.226.137
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bogavac-Stanojević, Nataša and Vucković, Maja and Dopsaj, Violeta and Giga, Vojislav and Kravljaca, Milica and Stošović, Milan and Lezaić, Višnja",
year = "2012",
abstract = "The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation",
volume = "226",
number = "2",
pages = "137-144",
doi = "10.1620/tjem.226.137"
}

Simić-Ogrizović, S., Bogavac-Stanojević, N., Vucković, M., Dopsaj, V., Giga, V., Kravljaca, M., Stošović, M.,& Lezaić, V.. (2012). Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 226(2), 137-144.
https://doi.org/10.1620/tjem.226.137

Simić-Ogrizović S, Bogavac-Stanojević N, Vucković M, Dopsaj V, Giga V, Kravljaca M, Stošović M, Lezaić V. Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry. 2012;226(2):137-144.
doi:10.1620/tjem.226.137 .

Simić-Ogrizović, Sanja, Bogavac-Stanojević, Nataša, Vucković, Maja, Dopsaj, Violeta, Giga, Vojislav, Kravljaca, Milica, Stošović, Milan, Lezaić, Višnja, "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation" in Toxicological and Environmental Chemistry, 226, no. 2 (2012):137-144,
https://doi.org/10.1620/tjem.226.137 . .