TY  - CONF
AU  - Petrović, Maša
AU  - Nedelkov, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4789
AB  - Последњих година све већи напори се улажу у развој нових, in silico метода за биофармацеутску карактеризацију лековитих супстанци и  фармацеутских препарата. У те сврхе дизајнирани су физиолошки засновани модели хуманог организма који симулирају апсорпцију и расподелу лековите супстанце.
AB  - Within the last years, substantial efforts have been allocated to develop in silico methods for the biopharmaceutical characterization of drugs and pharmaceutical products. Consequently, physiologically based models of the human organism have been designed to simulate absorption and distribution of drugs.
T1  - Процена утицаја варијација у вредностима физиолошлих параметара на апсорпцију перорално примењеног арипипразола применом рачунарски подржаног моделовања
T1  - Assessment of the influence of variation in the physiological parameters values on aripiprazole oral apsorption  using computer-based modeling
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4789
ER  - 

@conference{
author = "Petrović, Maša and Nedelkov, Ivana",
year = "2023",
abstract = "Последњих година све већи напори се улажу у развој нових, in silico метода за биофармацеутску карактеризацију лековитих супстанци и  фармацеутских препарата. У те сврхе дизајнирани су физиолошки засновани модели хуманог организма који симулирају апсорпцију и расподелу лековите супстанце., Within the last years, substantial efforts have been allocated to develop in silico methods for the biopharmaceutical characterization of drugs and pharmaceutical products. Consequently, physiologically based models of the human organism have been designed to simulate absorption and distribution of drugs.",
title = "Процена утицаја варијација у вредностима физиолошлих параметара на апсорпцију перорално примењеног арипипразола применом рачунарски подржаног моделовања, Assessment of the influence of variation in the physiological parameters values on aripiprazole oral apsorption  using computer-based modeling",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4789"
}

Petrović, M.,& Nedelkov, I.. (2023). Процена утицаја варијација у вредностима физиолошлих параметара на апсорпцију перорално примењеног арипипразола применом рачунарски подржаног моделовања. .
https://hdl.handle.net/21.15107/rcub_farfar_4789

Petrović M, Nedelkov I. Процена утицаја варијација у вредностима физиолошлих параметара на апсорпцију перорално примењеног арипипразола применом рачунарски подржаног моделовања. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_4789 .

Petrović, Maša, Nedelkov, Ivana, "Процена утицаја варијација у вредностима физиолошлих параметара на апсорпцију перорално примењеног арипипразола применом рачунарски подржаног моделовања" (2023),
https://hdl.handle.net/21.15107/rcub_farfar_4789 .

TY  - CONF
AU  - Krstevska, Aleksandra
AU  - Nedelkov, Ivana
AU  - Petrović, Maša
AU  - Ibrić, Svetlana
AU  - Mirković, Dušica
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5053
AB  - Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound
VL  - 69
IS  - Suppl 1
SP  - 127
EP  - 128
DO  - 10.33320/maced.pharm.bull.2023.69.03.062
ER  - 

@conference{
author = "Krstevska, Aleksandra and Nedelkov, Ivana and Petrović, Maša and Ibrić, Svetlana and Mirković, Dušica and Cvijić, Sandra",
year = "2023",
abstract = "Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound",
volume = "69",
number = "Suppl 1",
pages = "127-128",
doi = "10.33320/maced.pharm.bull.2023.69.03.062"
}

Krstevska, A., Nedelkov, I., Petrović, M., Ibrić, S., Mirković, D.,& Cvijić, S.. (2023). In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 127-128.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.062

Krstevska A, Nedelkov I, Petrović M, Ibrić S, Mirković D, Cvijić S. In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):127-128.
doi:10.33320/maced.pharm.bull.2023.69.03.062 .

Krstevska, Aleksandra, Nedelkov, Ivana, Petrović, Maša, Ibrić, Svetlana, Mirković, Dušica, Cvijić, Sandra, "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):127-128,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.062 . .