TY  - JOUR
AU  - Rudić, Jelena S.
AU  - Ćulafić, Đorđe
AU  - Mirković, Duško
AU  - Jesić, Rada S.
AU  - Krstić, Miodrag N.
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1365
AB  - AIM: To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS: This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS: The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 +/- 24.2 nmol/L vs 65.4 +/- 18.7 nmol/L, P  lt  0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P  lt  0.01). CONCLUSION: Free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients.
PB  - Baishideng Publ Grp Co Ltd, Beijing
T2  - World Journal of Microbiology & Biotechnology
T1  - Role of serotonin in development of esophageal and gastric fundal varices
VL  - 16
IS  - 48
SP  - 6135
EP  - 6138
DO  - 10.3748/wjg.v16.i48.6135
ER  - 

@article{
author = "Rudić, Jelena S. and Ćulafić, Đorđe and Mirković, Duško and Jesić, Rada S. and Krstić, Miodrag N.",
year = "2010",
abstract = "AIM: To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS: This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS: The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 +/- 24.2 nmol/L vs 65.4 +/- 18.7 nmol/L, P  lt  0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P  lt  0.01). CONCLUSION: Free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients.",
publisher = "Baishideng Publ Grp Co Ltd, Beijing",
journal = "World Journal of Microbiology & Biotechnology",
title = "Role of serotonin in development of esophageal and gastric fundal varices",
volume = "16",
number = "48",
pages = "6135-6138",
doi = "10.3748/wjg.v16.i48.6135"
}

Rudić, J. S., Ćulafić, Đ., Mirković, D., Jesić, R. S.,& Krstić, M. N.. (2010). Role of serotonin in development of esophageal and gastric fundal varices. in World Journal of Microbiology & Biotechnology
Baishideng Publ Grp Co Ltd, Beijing., 16(48), 6135-6138.
https://doi.org/10.3748/wjg.v16.i48.6135

Rudić JS, Ćulafić Đ, Mirković D, Jesić RS, Krstić MN. Role of serotonin in development of esophageal and gastric fundal varices. in World Journal of Microbiology & Biotechnology. 2010;16(48):6135-6138.
doi:10.3748/wjg.v16.i48.6135 .

Rudić, Jelena S., Ćulafić, Đorđe, Mirković, Duško, Jesić, Rada S., Krstić, Miodrag N., "Role of serotonin in development of esophageal and gastric fundal varices" in World Journal of Microbiology & Biotechnology, 16, no. 48 (2010):6135-6138,
https://doi.org/10.3748/wjg.v16.i48.6135 . .