TY  - JOUR
AU  - Jovanović, MS
AU  - Brborić, Jasmina
AU  - Vladimirov, S
AU  - Zmbova, B
AU  - Vuksanović, LJ
AU  - Živanov-Stakić, Dobrila
AU  - Obradović, V
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/219
AB  - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
PB  - Springer
PB  - Elsevier Science B. V., Amsterdam
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
VL  - 240
IS  - 1
SP  - 321
EP  - 324
DO  - 10.1007/BF02349171
ER  - 

@article{
author = "Jovanović, MS and Brborić, Jasmina and Vladimirov, S and Zmbova, B and Vuksanović, LJ and Živanov-Stakić, Dobrila and Obradović, V",
year = "1999",
abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.",
publisher = "Springer, Elsevier Science B. V., Amsterdam",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging",
volume = "240",
number = "1",
pages = "321-324",
doi = "10.1007/BF02349171"
}

Jovanović, M., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanović, L., Živanov-Stakić, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry
Springer., 240(1), 321-324.
https://doi.org/10.1007/BF02349171

Jovanović M, Brborić J, Vladimirov S, Zmbova B, Vuksanović L, Živanov-Stakić D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324.
doi:10.1007/BF02349171 .

Jovanović, MS, Brborić, Jasmina, Vladimirov, S, Zmbova, B, Vuksanović, LJ, Živanov-Stakić, Dobrila, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324,
https://doi.org/10.1007/BF02349171 . .