TY  - JOUR
AU  - Antonijević, Evica
AU  - Kotur-Stevuljević, Jelena
AU  - Musilek, Kamil
AU  - Kosvancova, Andrea
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Spasojević-Kalimanovska, Vesna
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3170
AB  - Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative-superoxide anion (O-2 (center dot-)) and total oxidative status (TOS); antioxidative-superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden-prooxidative-antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage-malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.
PB  - Springer Heidelberg, Heidelberg
T2  - Archives of Toxicology
T1  - Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
VL  - 92
IS  - 2
SP  - 745
EP  - 757
DO  - 10.1007/s00204-017-2101-z
ER  - 

@article{
author = "Antonijević, Evica and Kotur-Stevuljević, Jelena and Musilek, Kamil and Kosvancova, Andrea and Kuca, Kamil and Đukić-Ćosić, Danijela and Spasojević-Kalimanovska, Vesna and Antonijević, Biljana",
year = "2018",
abstract = "Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative-superoxide anion (O-2 (center dot-)) and total oxidative status (TOS); antioxidative-superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden-prooxidative-antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage-malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Archives of Toxicology",
title = "Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain",
volume = "92",
number = "2",
pages = "745-757",
doi = "10.1007/s00204-017-2101-z"
}

Antonijević, E., Kotur-Stevuljević, J., Musilek, K., Kosvancova, A., Kuca, K., Đukić-Ćosić, D., Spasojević-Kalimanovska, V.,& Antonijević, B.. (2018). Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain. in Archives of Toxicology
Springer Heidelberg, Heidelberg., 92(2), 745-757.
https://doi.org/10.1007/s00204-017-2101-z

Antonijević E, Kotur-Stevuljević J, Musilek K, Kosvancova A, Kuca K, Đukić-Ćosić D, Spasojević-Kalimanovska V, Antonijević B. Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain. in Archives of Toxicology. 2018;92(2):745-757.
doi:10.1007/s00204-017-2101-z .

Antonijević, Evica, Kotur-Stevuljević, Jelena, Musilek, Kamil, Kosvancova, Andrea, Kuca, Kamil, Đukić-Ćosić, Danijela, Spasojević-Kalimanovska, Vesna, Antonijević, Biljana, "Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain" in Archives of Toxicology, 92, no. 2 (2018):745-757,
https://doi.org/10.1007/s00204-017-2101-z . .