TY  - JOUR
AU  - Parojčić, Jelena
AU  - Durić, J
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Jovanović, D
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/486
AB  - The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution methodology. Although the use of non-linear modelling could be advantageous, the need for a simple and meaningful nonlinear relationship is pointed out.
PB  - Wiley, Hoboken
T2  - Journal of Pharmacy and Pharmacology
T1  - Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers
VL  - 56
IS  - 6
SP  - 735
EP  - 741
DO  - 10.1211/0022357023583
ER  - 

@article{
author = "Parojčić, Jelena and Durić, J and Jovanović, M and Ibrić, Svetlana and Jovanović, D",
year = "2004",
abstract = "The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution methodology. Although the use of non-linear modelling could be advantageous, the need for a simple and meaningful nonlinear relationship is pointed out.",
publisher = "Wiley, Hoboken",
journal = "Journal of Pharmacy and Pharmacology",
title = "Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers",
volume = "56",
number = "6",
pages = "735-741",
doi = "10.1211/0022357023583"
}

Parojčić, J., Durić, J., Jovanović, M., Ibrić, S.,& Jovanović, D.. (2004). Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers. in Journal of Pharmacy and Pharmacology
Wiley, Hoboken., 56(6), 735-741.
https://doi.org/10.1211/0022357023583

Parojčić J, Durić J, Jovanović M, Ibrić S, Jovanović D. Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers. in Journal of Pharmacy and Pharmacology. 2004;56(6):735-741.
doi:10.1211/0022357023583 .

Parojčić, Jelena, Durić, J, Jovanović, M, Ibrić, Svetlana, Jovanović, D, "Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers" in Journal of Pharmacy and Pharmacology, 56, no. 6 (2004):735-741,
https://doi.org/10.1211/0022357023583 . .