TY  - CONF
AU  - Stefanović, D.
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/866
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats
T1  - Primena modela pri evaluaciji efikasnosti trimedoksima, atropina i natrijum-hidrogenkarbonata kod trovanja dihlorvosom u pacova
VL  - 56
IS  - 4
SP  - 602
EP  - 603
UR  - https://hdl.handle.net/21.15107/rcub_farfar_866
ER  - 

@conference{
author = "Stefanović, D. and Antonijević, Biljana and Bokonjić, Dubravko and Milovanović, Zoran A. and Stojiljković, Miloš P. and Nedeljković, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats, Primena modela pri evaluaciji efikasnosti trimedoksima, atropina i natrijum-hidrogenkarbonata kod trovanja dihlorvosom u pacova",
volume = "56",
number = "4",
pages = "602-603",
url = "https://hdl.handle.net/21.15107/rcub_farfar_866"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Milovanović, Z. A., Stojiljković, M. P.,& Nedeljković, M.. (2006). Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 602-603.
https://hdl.handle.net/21.15107/rcub_farfar_866

Stefanović D, Antonijević B, Bokonjić D, Milovanović ZA, Stojiljković MP, Nedeljković M. Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Arhiv za farmaciju. 2006;56(4):602-603.
https://hdl.handle.net/21.15107/rcub_farfar_866 .

Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, M., "Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats" in Arhiv za farmaciju, 56, no. 4 (2006):602-603,
https://hdl.handle.net/21.15107/rcub_farfar_866 .

TY  - CONF
AU  - Stefanović, D.
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/711
PB  - Elsevier
C3  - Toxicology Letters
T1  - Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats
VL  - 164, Supplement
SP  - S244
EP  - S244
DO  - 10.1016/j.toxlet.2006.07.167
ER  - 

@conference{
author = "Stefanović, D. and Antonijević, Biljana and Bokonjić, Dubravko and Milovanović, Zoran A. and Stojiljković, Miloš P. and Nedeljković, Mirjana",
year = "2006",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats",
volume = "164, Supplement",
pages = "S244-S244",
doi = "10.1016/j.toxlet.2006.07.167"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Milovanović, Z. A., Stojiljković, M. P.,& Nedeljković, M.. (2006). Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Toxicology Letters
Elsevier., 164, Supplement, S244-S244.
https://doi.org/10.1016/j.toxlet.2006.07.167

Stefanović D, Antonijević B, Bokonjić D, Milovanović ZA, Stojiljković MP, Nedeljković M. Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Toxicology Letters. 2006;164, Supplement:S244-S244.
doi:10.1016/j.toxlet.2006.07.167 .

Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, Mirjana, "Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats" in Toxicology Letters, 164, Supplement (2006):S244-S244,
https://doi.org/10.1016/j.toxlet.2006.07.167 . .

TY  - JOUR
AU  - Stefanović, D
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Milovanović, Zoran A.
AU  - Nedeljković, M
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/773
AB  - The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos
VL  - 98
IS  - 2
SP  - 173
EP  - 180
DO  - 10.1111/j.1742-7843.2006.pto_68.x
ER  - 

@article{
author = "Stefanović, D and Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Milovanović, Zoran A. and Nedeljković, M",
year = "2006",
abstract = "The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos",
volume = "98",
number = "2",
pages = "173-180",
doi = "10.1111/j.1742-7843.2006.pto_68.x"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Stojiljković, M. P., Milovanović, Z. A.,& Nedeljković, M.. (2006). Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 98(2), 173-180.
https://doi.org/10.1111/j.1742-7843.2006.pto_68.x

Stefanović D, Antonijević B, Bokonjić D, Stojiljković MP, Milovanović ZA, Nedeljković M. Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. in Basic & Clinical Pharmacology & Toxicology. 2006;98(2):173-180.
doi:10.1111/j.1742-7843.2006.pto_68.x .

Stefanović, D, Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Milovanović, Zoran A., Nedeljković, M, "Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos" in Basic & Clinical Pharmacology & Toxicology, 98, no. 2 (2006):173-180,
https://doi.org/10.1111/j.1742-7843.2006.pto_68.x . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Kilibarda, Vesna
AU  - Milovanović, Zoran A.
AU  - Nedeljković, M
AU  - Maksimović, M
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/632
AB  - The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos
VL  - 96
IS  - 2
SP  - 111
EP  - 117
DO  - 10.1111/j.1742-7843.2005.pto960204.x
ER  - 

@article{
author = "Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Kilibarda, Vesna and Milovanović, Zoran A. and Nedeljković, M and Maksimović, M",
year = "2005",
abstract = "The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos",
volume = "96",
number = "2",
pages = "111-117",
doi = "10.1111/j.1742-7843.2005.pto960204.x"
}

Antonijević, B., Bokonjić, D., Stojiljković, M. P., Kilibarda, V., Milovanović, Z. A., Nedeljković, M.,& Maksimović, M.. (2005). Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 96(2), 111-117.
https://doi.org/10.1111/j.1742-7843.2005.pto960204.x

Antonijević B, Bokonjić D, Stojiljković MP, Kilibarda V, Milovanović ZA, Nedeljković M, Maksimović M. Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. in Basic & Clinical Pharmacology & Toxicology. 2005;96(2):111-117.
doi:10.1111/j.1742-7843.2005.pto960204.x .

Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Kilibarda, Vesna, Milovanović, Zoran A., Nedeljković, M, Maksimović, M, "Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos" in Basic & Clinical Pharmacology & Toxicology, 96, no. 2 (2005):111-117,
https://doi.org/10.1111/j.1742-7843.2005.pto960204.x . .

TY  - JOUR
AU  - Dukić, M
AU  - Jovanović, M
AU  - Nedeljković, M
AU  - Ignjatović, Svetlana
AU  - Antonijević, Biljana
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/226
AB  - Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics
VL  - 18
IS  - 4
SP  - 161
EP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_farfar_226
ER  - 

@article{
author = "Dukić, M and Jovanović, M and Nedeljković, M and Ignjatović, Svetlana and Antonijević, Biljana",
year = "1999",
abstract = "Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics",
volume = "18",
number = "4",
pages = "161-165",
url = "https://hdl.handle.net/21.15107/rcub_farfar_226"
}

Dukić, M., Jovanović, M., Nedeljković, M., Ignjatović, S.,& Antonijević, B.. (1999). Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 18(4), 161-165.
https://hdl.handle.net/21.15107/rcub_farfar_226

Dukić M, Jovanović M, Nedeljković M, Ignjatović S, Antonijević B. Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics. in Jugoslovenska medicinska biohemija. 1999;18(4):161-165.
https://hdl.handle.net/21.15107/rcub_farfar_226 .

Dukić, M, Jovanović, M, Nedeljković, M, Ignjatović, Svetlana, Antonijević, Biljana, "Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics" in Jugoslovenska medicinska biohemija, 18, no. 4 (1999):161-165,
https://hdl.handle.net/21.15107/rcub_farfar_226 .

TY  - JOUR
AU  - Milić, B
AU  - Nedeljković, M
AU  - Đukić, Mirjana
PY  - 1995
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/124
AB  - A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 and trimedoxime concentrations in small volumes of plasma. The HPLC system comprised a high-pressure pump (model 2150), a multiwavelenght detector (model 2140) set at 284 nm and 295 nm for detection of trimedoxime and HI-6, respectively, and a sample injector (Rheodyne, model 7125) with a 20 μL sample loop. A Superpac starter kit 5 μm ODS 2; 4 x 250 mm (Pharmacia LKB) stainless steel column was used. To plasma sample, 10 μL of 20% trichlorocetic acid, was added. From the supernatant, 20 μL was injected directly into HPLC. The solvent was 25% acetonitrile in 0.08 mol/L acetic acid (pH 3) containing 0.01 mol/L heptane-1-sulfonic acid (sodium salt) and 0.0025 mol/L tetramethylammonium chloride. The flow rate was 0.8 mL/min HI-6, and trimedoxime eluted at about 6.0 min and 8.0 min, respectively. The limit of sensitivity was 1.4 μmol/L of trimedoxime and 2.5 μmol/L of HI-6. Recovery rates were 99.02% in determination of HI-6 and 100.6% in determination of trimedoxime. Coefficients of variation for HI-6 and trimedoxime ranged from 1.4% to 8.2% and 0.9% to 3.4%, respectively. Our results indicate that the method is sensitive, accurate and precise.
T2  - Jugoslovenska medicinska biohemija
T1  - HPLC method for determination of oximes HI-6 and trimedoxime in plasma
T1  - HPLC metoda za odredivanje oksima hi-6 i trimedoksima u plazmi
VL  - 14
IS  - 3-4
SP  - 125
EP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_farfar_124
ER  - 

@article{
author = "Milić, B and Nedeljković, M and Đukić, Mirjana",
year = "1995",
abstract = "A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 and trimedoxime concentrations in small volumes of plasma. The HPLC system comprised a high-pressure pump (model 2150), a multiwavelenght detector (model 2140) set at 284 nm and 295 nm for detection of trimedoxime and HI-6, respectively, and a sample injector (Rheodyne, model 7125) with a 20 μL sample loop. A Superpac starter kit 5 μm ODS 2; 4 x 250 mm (Pharmacia LKB) stainless steel column was used. To plasma sample, 10 μL of 20% trichlorocetic acid, was added. From the supernatant, 20 μL was injected directly into HPLC. The solvent was 25% acetonitrile in 0.08 mol/L acetic acid (pH 3) containing 0.01 mol/L heptane-1-sulfonic acid (sodium salt) and 0.0025 mol/L tetramethylammonium chloride. The flow rate was 0.8 mL/min HI-6, and trimedoxime eluted at about 6.0 min and 8.0 min, respectively. The limit of sensitivity was 1.4 μmol/L of trimedoxime and 2.5 μmol/L of HI-6. Recovery rates were 99.02% in determination of HI-6 and 100.6% in determination of trimedoxime. Coefficients of variation for HI-6 and trimedoxime ranged from 1.4% to 8.2% and 0.9% to 3.4%, respectively. Our results indicate that the method is sensitive, accurate and precise.",
journal = "Jugoslovenska medicinska biohemija",
title = "HPLC method for determination of oximes HI-6 and trimedoxime in plasma, HPLC metoda za odredivanje oksima hi-6 i trimedoksima u plazmi",
volume = "14",
number = "3-4",
pages = "125-129",
url = "https://hdl.handle.net/21.15107/rcub_farfar_124"
}

Milić, B., Nedeljković, M.,& Đukić, M.. (1995). HPLC method for determination of oximes HI-6 and trimedoxime in plasma. in Jugoslovenska medicinska biohemija, 14(3-4), 125-129.
https://hdl.handle.net/21.15107/rcub_farfar_124

Milić B, Nedeljković M, Đukić M. HPLC method for determination of oximes HI-6 and trimedoxime in plasma. in Jugoslovenska medicinska biohemija. 1995;14(3-4):125-129.
https://hdl.handle.net/21.15107/rcub_farfar_124 .

Milić, B, Nedeljković, M, Đukić, Mirjana, "HPLC method for determination of oximes HI-6 and trimedoxime in plasma" in Jugoslovenska medicinska biohemija, 14, no. 3-4 (1995):125-129,
https://hdl.handle.net/21.15107/rcub_farfar_124 .