TY  - JOUR
AU  - Ćupić Miladinović, Dejana
AU  - Prevendar Crnić, Andreja
AU  - Peković, Sanja
AU  - Dacić, Sanja
AU  - Ivanović, Saša
AU  - Santibanez, Juan Francisco
AU  - Ćupić, Vitomir
AU  - Borozan, Nevena
AU  - Antonijević-Miljaković, Evica
AU  - Borozan, Sunčica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3810
AB  - Chlorpyrifos is a extensively used organophosphate pesticide (OP). In this study, we closely looked into neurotoxicity of CPF and effect of vitamin B1, by checking the levels of cholinesterases, determining the activity of parameters of oxidative stress, inflammation and also level of apoptotic regulator. The study was performed on a total of 80 male Japanese quails (Coturnix japonica), (two control and 6 experimental groups, n = 10). Three group of quails were given by gavage chlorpyrifos (CPF) for 7 consecutive days at doses of 1.50 mg/kg b.w., 3.00 mg/kg b.w., and 6.00 mg/kg b.w. Another three groups were treated with 10 mg/kg b.w. of vitamin B1 i.m. 30 min after CPF application (in above mentioned doses). Our study have proved that all doses of CPF significantly inhibited cholinesterases in brain, while vitamin B1 reactivated them. CPF has led to an increase in the concentration of malondialdehyde (MDA), and activity of catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), while tiamin changed the activity of antioxidant enzymes: CAT, SOD, GST. CPF stimulated apoptosis by decreasing B-cell lymphoma (Bcl-2) in brain, while application of vitamin B1 caused an increase of this parameter. CPF amplified inflammatory effect by elevating levels of inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2). Thiamine proved its anti-inflammatory property by decreasing the expression of iNOS and interleukin-1(IL-1) and interleukin-6(IL-6). This study is highly pertinent because there is little defense currently available to humans and animals to prevent toxic effects of pesticides.
PB  - Elsevier Ireland Ltd
T2  - Chemico-Biological Interactions
T1  - Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration
VL  - 333
DO  - 10.1016/j.cbi.2020.109312
ER  - 

@article{
author = "Ćupić Miladinović, Dejana and Prevendar Crnić, Andreja and Peković, Sanja and Dacić, Sanja and Ivanović, Saša and Santibanez, Juan Francisco and Ćupić, Vitomir and Borozan, Nevena and Antonijević-Miljaković, Evica and Borozan, Sunčica",
year = "2021",
abstract = "Chlorpyrifos is a extensively used organophosphate pesticide (OP). In this study, we closely looked into neurotoxicity of CPF and effect of vitamin B1, by checking the levels of cholinesterases, determining the activity of parameters of oxidative stress, inflammation and also level of apoptotic regulator. The study was performed on a total of 80 male Japanese quails (Coturnix japonica), (two control and 6 experimental groups, n = 10). Three group of quails were given by gavage chlorpyrifos (CPF) for 7 consecutive days at doses of 1.50 mg/kg b.w., 3.00 mg/kg b.w., and 6.00 mg/kg b.w. Another three groups were treated with 10 mg/kg b.w. of vitamin B1 i.m. 30 min after CPF application (in above mentioned doses). Our study have proved that all doses of CPF significantly inhibited cholinesterases in brain, while vitamin B1 reactivated them. CPF has led to an increase in the concentration of malondialdehyde (MDA), and activity of catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), while tiamin changed the activity of antioxidant enzymes: CAT, SOD, GST. CPF stimulated apoptosis by decreasing B-cell lymphoma (Bcl-2) in brain, while application of vitamin B1 caused an increase of this parameter. CPF amplified inflammatory effect by elevating levels of inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2). Thiamine proved its anti-inflammatory property by decreasing the expression of iNOS and interleukin-1(IL-1) and interleukin-6(IL-6). This study is highly pertinent because there is little defense currently available to humans and animals to prevent toxic effects of pesticides.",
publisher = "Elsevier Ireland Ltd",
journal = "Chemico-Biological Interactions",
title = "Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration",
volume = "333",
doi = "10.1016/j.cbi.2020.109312"
}

Ćupić Miladinović, D., Prevendar Crnić, A., Peković, S., Dacić, S., Ivanović, S., Santibanez, J. F., Ćupić, V., Borozan, N., Antonijević-Miljaković, E.,& Borozan, S.. (2021). Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration. in Chemico-Biological Interactions
Elsevier Ireland Ltd., 333.
https://doi.org/10.1016/j.cbi.2020.109312

Ćupić Miladinović D, Prevendar Crnić A, Peković S, Dacić S, Ivanović S, Santibanez JF, Ćupić V, Borozan N, Antonijević-Miljaković E, Borozan S. Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration. in Chemico-Biological Interactions. 2021;333.
doi:10.1016/j.cbi.2020.109312 .

Ćupić Miladinović, Dejana, Prevendar Crnić, Andreja, Peković, Sanja, Dacić, Sanja, Ivanović, Saša, Santibanez, Juan Francisco, Ćupić, Vitomir, Borozan, Nevena, Antonijević-Miljaković, Evica, Borozan, Sunčica, "Recovery of brain cholinesterases and effect on parameters of oxidative stres and apoptosis in quails (Coturnix japonica) after chlorpyrifos and vitamin B1 administration" in Chemico-Biological Interactions, 333 (2021),
https://doi.org/10.1016/j.cbi.2020.109312 . .

TY  - CONF
AU  - Čupić-Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Peković, S.
AU  - Dacić, S.
AU  - Đukić-Ćosić, Danijela
AU  - Ćupić, Vitomir
AU  - Ivanović, S.
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3128
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos
VL  - 295
IS  - Supplement 1
SP  - S264
EP  - S264
DO  - 10.1016/j.toxlet.2018.06.1062
ER  - 

@conference{
author = "Čupić-Miladinović, Dejana and Borozan, Sunčica and Peković, S. and Dacić, S. and Đukić-Ćosić, Danijela and Ćupić, Vitomir and Ivanović, S.",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos",
volume = "295",
number = "Supplement 1",
pages = "S264-S264",
doi = "10.1016/j.toxlet.2018.06.1062"
}

Čupić-Miladinović, D., Borozan, S., Peković, S., Dacić, S., Đukić-Ćosić, D., Ćupić, V.,& Ivanović, S.. (2018). The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295(Supplement 1), S264-S264.
https://doi.org/10.1016/j.toxlet.2018.06.1062

Čupić-Miladinović D, Borozan S, Peković S, Dacić S, Đukić-Ćosić D, Ćupić V, Ivanović S. The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos. in Toxicology Letters. 2018;295(Supplement 1):S264-S264.
doi:10.1016/j.toxlet.2018.06.1062 .

Čupić-Miladinović, Dejana, Borozan, Sunčica, Peković, S., Dacić, S., Đukić-Ćosić, Danijela, Ćupić, Vitomir, Ivanović, S., "The effect of thiamine on oxidative stress and apoptosis in the liver of Japanese quails treated with chlorpyrifos" in Toxicology Letters, 295, no. Supplement 1 (2018):S264-S264,
https://doi.org/10.1016/j.toxlet.2018.06.1062 . .

TY  - JOUR
AU  - Novaković, Radmila
AU  - Radunović, Nebojša
AU  - Rajković, Jovana
AU  - Đokić, Vladimir
AU  - Petrović, Aleksandar V.
AU  - Ivković, Branka
AU  - Ćupić, Vitomir
AU  - Kanjuh, Vladimir
AU  - Helmut, Heinlev
AU  - Gojković-Bukarica, Ljiljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2769
AB  - Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels
VL  - 70
IS  - 3-4
SP  - 121
EP  - 129
DO  - 10.2298/VETGL1604121N
ER  - 

@article{
author = "Novaković, Radmila and Radunović, Nebojša and Rajković, Jovana and Đokić, Vladimir and Petrović, Aleksandar V. and Ivković, Branka and Ćupić, Vitomir and Kanjuh, Vladimir and Helmut, Heinlev and Gojković-Bukarica, Ljiljana",
year = "2016",
abstract = "Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels",
volume = "70",
number = "3-4",
pages = "121-129",
doi = "10.2298/VETGL1604121N"
}

Novaković, R., Radunović, N., Rajković, J., Đokić, V., Petrović, A. V., Ivković, B., Ćupić, V., Kanjuh, V., Helmut, H.,& Gojković-Bukarica, L.. (2016). Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(3-4), 121-129.
https://doi.org/10.2298/VETGL1604121N

Novaković R, Radunović N, Rajković J, Đokić V, Petrović AV, Ivković B, Ćupić V, Kanjuh V, Helmut H, Gojković-Bukarica L. Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels. in Veterinarski glasnik. 2016;70(3-4):121-129.
doi:10.2298/VETGL1604121N .

Novaković, Radmila, Radunović, Nebojša, Rajković, Jovana, Đokić, Vladimir, Petrović, Aleksandar V., Ivković, Branka, Ćupić, Vitomir, Kanjuh, Vladimir, Helmut, Heinlev, Gojković-Bukarica, Ljiljana, "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels" in Veterinarski glasnik, 70, no. 3-4 (2016):121-129,
https://doi.org/10.2298/VETGL1604121N . .

TY  - JOUR
AU  - Jović, Slavoljub
AU  - Ćupić, Vitomir
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Dimitrijević, Blagoje
AU  - Čupić-Miladinović, Dejana
AU  - Živković, Lada
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2776
AB  - The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %).
AB  - Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days
T1  - Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej
T1  - Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana
VL  - 70
IS  - 1-2
SP  - 13
EP  - 29
DO  - 10.2298/VETGL1602013J
ER  - 

@article{
author = "Jović, Slavoljub and Ćupić, Vitomir and Ristić, Gordana and Vakanjac, Slobodanka and Dimitrijević, Blagoje and Čupić-Miladinović, Dejana and Živković, Lada",
year = "2016",
abstract = "The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %)., Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days, Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej, Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana",
volume = "70",
number = "1-2",
pages = "13-29",
doi = "10.2298/VETGL1602013J"
}

Jović, S., Ćupić, V., Ristić, G., Vakanjac, S., Dimitrijević, B., Čupić-Miladinović, D.,& Živković, L.. (2016). The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(1-2), 13-29.
https://doi.org/10.2298/VETGL1602013J

Jović S, Ćupić V, Ristić G, Vakanjac S, Dimitrijević B, Čupić-Miladinović D, Živković L. The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski glasnik. 2016;70(1-2):13-29.
doi:10.2298/VETGL1602013J .

Jović, Slavoljub, Ćupić, Vitomir, Ristić, Gordana, Vakanjac, Slobodanka, Dimitrijević, Blagoje, Čupić-Miladinović, Dejana, Živković, Lada, "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days" in Veterinarski glasnik, 70, no. 1-2 (2016):13-29,
https://doi.org/10.2298/VETGL1602013J . .

TY  - CONF
AU  - Čupić-Miladinović, Dejana
AU  - Borozan, Sunčica
AU  - Popović, Z.
AU  - Ćupić, Vitomir
AU  - Velev, R.
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2367
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail
VL  - 238
IS  - 2, Supplement
SP  - S111
EP  - S111
DO  - 10.1016/j.toxlet.2015.08.360
ER  - 

@conference{
author = "Čupić-Miladinović, Dejana and Borozan, Sunčica and Popović, Z. and Ćupić, Vitomir and Velev, R. and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail",
volume = "238",
number = "2, Supplement",
pages = "S111-S111",
doi = "10.1016/j.toxlet.2015.08.360"
}

Čupić-Miladinović, D., Borozan, S., Popović, Z., Ćupić, V., Velev, R.,& Antonijević, B.. (2015). The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S111-S111.
https://doi.org/10.1016/j.toxlet.2015.08.360

Čupić-Miladinović D, Borozan S, Popović Z, Ćupić V, Velev R, Antonijević B. The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail. in Toxicology Letters. 2015;238(2, Supplement):S111-S111.
doi:10.1016/j.toxlet.2015.08.360 .

Čupić-Miladinović, Dejana, Borozan, Sunčica, Popović, Z., Ćupić, Vitomir, Velev, R., Antonijević, Biljana, "The influence of chlorpyrifos on the activity of butyryilcholinesterase and catalase, as well as concentration of malondialdehyde in plasma of Japanese quail" in Toxicology Letters, 238, no. 2, Supplement (2015):S111-S111,
https://doi.org/10.1016/j.toxlet.2015.08.360 . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Vladimirov, Sote
AU  - Živanović, Vladimir
AU  - Šćepanović, Radisav
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2297
AB  - By applying of aconitictest in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone. The animals were divided into four experimental groups. The first (aconitine group) was treated with aconitine at a dose of 60 μg/kg, which led to pronounced cardiac rhythm disorder in a short period of time. The appearance of ventricular extrasystole (VES) was taken as a parameter for ascertainment of cardiac rhytm disorder. The remaining three animal groups were taken for testing the potential of propafenone and propafenone fluorinated derivatives to stop the arrhythmia, and which was induced by i.v. aconitine injection (60 μg/kg). Propafenone, as well as 50F derivative, did not convert the disturbed cardiac rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of 6 mg/kg, the animals survived with occasional establishment of sinus rhythm.
AB  - Primenom akonitinskog testa, u in vivo eksperimentima na pacovima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal novosintetisanih fluoriranih derivata propafenona. Životinje su podeljene u četiri eksperimentalne grupe. Prva grupa (akonitinska grupa) je tretirana akonitinom u dozi od 60 μg/kg t.m., koja dovodi do vidnog poremećaja srčanog ritma u kratkom vremenskom periodu. Kao parameter za registrovanje poremećaja srčanog ritma uzetaje pojava ventrikularne ekstrasistole (VES). Ostale (tri) eksperimentalne grupe činile su životinje na kojima je ispitivan potencijal propafenona i fluoriranih derivata propafenona da zaustave aritmiju indukovanu i.v. injekcijom akonitina (60 μg/kg t.m.). Propafenon, kao i 50F derivat, nisu uspeli da konvertuju poremećen srčani ritam (preživljavanje životinja je 0 %). Prilikom aplikacije 5PF derivata u dozi od 6 mg/kg t.m. životinje su preživele, uz povremeno uspostavljanje sinusnog ritma.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats
T1  - Issledovanie antiaritmičeskoj aktivnosti vnov' sintezirovannyh proizvodnyh propafenona pri modelirovanii akonitovoi aritmii serdca u krys
T1  - Ispitivanje antiaritmijske aktivnosti novosintetisanih derivata propafenona u akonitinskom modelu srčane aritmije kod pacova
VL  - 68
IS  - 5-6
SP  - 281
EP  - 290
DO  - 10.2298/VETGL1406281I
ER  - 

@article{
author = "Ivković, Branka and Gojković-Bukarica, Ljiljana and Novaković, Radmila and Ćupić, Vitomir and Vladimirov, Sote and Živanović, Vladimir and Šćepanović, Radisav",
year = "2014",
abstract = "By applying of aconitictest in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone. The animals were divided into four experimental groups. The first (aconitine group) was treated with aconitine at a dose of 60 μg/kg, which led to pronounced cardiac rhythm disorder in a short period of time. The appearance of ventricular extrasystole (VES) was taken as a parameter for ascertainment of cardiac rhytm disorder. The remaining three animal groups were taken for testing the potential of propafenone and propafenone fluorinated derivatives to stop the arrhythmia, and which was induced by i.v. aconitine injection (60 μg/kg). Propafenone, as well as 50F derivative, did not convert the disturbed cardiac rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of 6 mg/kg, the animals survived with occasional establishment of sinus rhythm., Primenom akonitinskog testa, u in vivo eksperimentima na pacovima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal novosintetisanih fluoriranih derivata propafenona. Životinje su podeljene u četiri eksperimentalne grupe. Prva grupa (akonitinska grupa) je tretirana akonitinom u dozi od 60 μg/kg t.m., koja dovodi do vidnog poremećaja srčanog ritma u kratkom vremenskom periodu. Kao parameter za registrovanje poremećaja srčanog ritma uzetaje pojava ventrikularne ekstrasistole (VES). Ostale (tri) eksperimentalne grupe činile su životinje na kojima je ispitivan potencijal propafenona i fluoriranih derivata propafenona da zaustave aritmiju indukovanu i.v. injekcijom akonitina (60 μg/kg t.m.). Propafenon, kao i 50F derivat, nisu uspeli da konvertuju poremećen srčani ritam (preživljavanje životinja je 0 %). Prilikom aplikacije 5PF derivata u dozi od 6 mg/kg t.m. životinje su preživele, uz povremeno uspostavljanje sinusnog ritma.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats, Issledovanie antiaritmičeskoj aktivnosti vnov' sintezirovannyh proizvodnyh propafenona pri modelirovanii akonitovoi aritmii serdca u krys, Ispitivanje antiaritmijske aktivnosti novosintetisanih derivata propafenona u akonitinskom modelu srčane aritmije kod pacova",
volume = "68",
number = "5-6",
pages = "281-290",
doi = "10.2298/VETGL1406281I"
}

Ivković, B., Gojković-Bukarica, L., Novaković, R., Ćupić, V., Vladimirov, S., Živanović, V.,& Šćepanović, R.. (2014). Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(5-6), 281-290.
https://doi.org/10.2298/VETGL1406281I

Ivković B, Gojković-Bukarica L, Novaković R, Ćupić V, Vladimirov S, Živanović V, Šćepanović R. Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats. in Veterinarski glasnik. 2014;68(5-6):281-290.
doi:10.2298/VETGL1406281I .

Ivković, Branka, Gojković-Bukarica, Ljiljana, Novaković, Radmila, Ćupić, Vitomir, Vladimirov, Sote, Živanović, Vladimir, Šćepanović, Radisav, "Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats" in Veterinarski glasnik, 68, no. 5-6 (2014):281-290,
https://doi.org/10.2298/VETGL1406281I . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Gojković-Bukarica, Ljiljana
AU  - Vladimirov, S.
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Lešić, A.
AU  - Bumbaširević, M.
AU  - Šćepanović, Radisav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2063
AB  - The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl) on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP) and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM), but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary.
AB  - Informacije o efektima propafenona na vaskularne glatke mišiće su oskudne. Propafenon blokira voltažno-zavisne Na+ kanale, Ca2+ kanale L-tipa, voltažno-senzitivne K+ (Kv) kanale i β-adrenergičke receptore u srcu. Uvođenje različitih hemijskih grupa u benzilni deo molekula propafenona utiče na promenu njegovih farmakoloških osobina. U ovoj studiji je ispitivan uticaj novog orto-hloro derivata (5OCl) propafenona na vaskularni tonus prekontrahovane aorte pacova. Orto hlorni derivat (5OCl) je izazvao endotel-nezavisnu relaksaciju aortnih prstenova. Da bi se ispitala uloga različitih jonskih kanala u ovoj relaksaciji, korišćeni su lidokain, (antagonist Na+ kanala), 4-aminopiridin (antagonist Kv kanala) i nifedipin (antagonist Ca2+ kanala L-tipa). Testirani antagonisti jonskih kanala nisu uticali na relaksaciju aorte pacova izazvanu visokom koncentracijom 5OCl (≥10 μM), ali su zato antagonizovali relaksaciju aorte koncentracijama 5OCl koje su bile manje od 10 μM. Prema tome, 5OCl derivat ima sličnu jačinu i efikasnost kao propafenon. Prema njegovoj interakciji sa lidokainom, 4-AP i nifedipinom može se reći da je mehanizam dejstva 5OCl sličan propafenonu. Mehanizam vazodilatacije 5OCl derivata u koncentracijama većim od 10 μM nije definisan i za to su potrebna dalja istraživanja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta
T1  - Relaksacija aorte pacova indukovana novosintetisanim orto-hlornim derivatom propafenona
VL  - 63
IS  - 4
SP  - 363
EP  - 371
DO  - 10.2298/AVB1304363I
ER  - 

@article{
author = "Ivković, Branka and Gojković-Bukarica, Ljiljana and Vladimirov, S. and Novaković, Radmila and Ćupić, Vitomir and Lešić, A. and Bumbaširević, M. and Šćepanović, Radisav",
year = "2013",
abstract = "The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl) on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP) and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM), but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary., Informacije o efektima propafenona na vaskularne glatke mišiće su oskudne. Propafenon blokira voltažno-zavisne Na+ kanale, Ca2+ kanale L-tipa, voltažno-senzitivne K+ (Kv) kanale i β-adrenergičke receptore u srcu. Uvođenje različitih hemijskih grupa u benzilni deo molekula propafenona utiče na promenu njegovih farmakoloških osobina. U ovoj studiji je ispitivan uticaj novog orto-hloro derivata (5OCl) propafenona na vaskularni tonus prekontrahovane aorte pacova. Orto hlorni derivat (5OCl) je izazvao endotel-nezavisnu relaksaciju aortnih prstenova. Da bi se ispitala uloga različitih jonskih kanala u ovoj relaksaciji, korišćeni su lidokain, (antagonist Na+ kanala), 4-aminopiridin (antagonist Kv kanala) i nifedipin (antagonist Ca2+ kanala L-tipa). Testirani antagonisti jonskih kanala nisu uticali na relaksaciju aorte pacova izazvanu visokom koncentracijom 5OCl (≥10 μM), ali su zato antagonizovali relaksaciju aorte koncentracijama 5OCl koje su bile manje od 10 μM. Prema tome, 5OCl derivat ima sličnu jačinu i efikasnost kao propafenon. Prema njegovoj interakciji sa lidokainom, 4-AP i nifedipinom može se reći da je mehanizam dejstva 5OCl sličan propafenonu. Mehanizam vazodilatacije 5OCl derivata u koncentracijama većim od 10 μM nije definisan i za to su potrebna dalja istraživanja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta, Relaksacija aorte pacova indukovana novosintetisanim orto-hlornim derivatom propafenona",
volume = "63",
number = "4",
pages = "363-371",
doi = "10.2298/AVB1304363I"
}

Ivković, B., Gojković-Bukarica, L., Vladimirov, S., Novaković, R., Ćupić, V., Lešić, A., Bumbaširević, M.,& Šćepanović, R.. (2013). The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(4), 363-371.
https://doi.org/10.2298/AVB1304363I

Ivković B, Gojković-Bukarica L, Vladimirov S, Novaković R, Ćupić V, Lešić A, Bumbaširević M, Šćepanović R. The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta. in Acta veterinaria. 2013;63(4):363-371.
doi:10.2298/AVB1304363I .

Ivković, Branka, Gojković-Bukarica, Ljiljana, Vladimirov, S., Novaković, Radmila, Ćupić, Vitomir, Lešić, A., Bumbaširević, M., Šćepanović, Radisav, "The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta" in Acta veterinaria, 63, no. 4 (2013):363-371,
https://doi.org/10.2298/AVB1304363I . .

TY  - JOUR
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Buha, Aleksandra
AU  - Ćupić, Vitomir
AU  - Pavlović, Zoran
AU  - Matović, Vesna
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1820
AB  - Cadmium (Cd) is today one of the most significant metal poisons, both in the area of professional as well as of eco toxicology. In the organism, cadmium has a harmful effect on the kidneys, liver, bones, testicles, etc., and, based on evidence in humans that it causes lung carcinoma, it has been placed in the first group of carcinogens. In spite of numerous data in literature on the harmful effects of cadmium, the interactions between cadmium and bioelements as a significant mechanism for cadmium toxicity have still not been sufficiently explained. Since the data so far point to a positive effect of supplementation with certain bioelements regarding toxicity and cadmium content in the organism, the objective of this work was to investigate the effect of increased simultaneous intake of magnesium, zinc and copper on urinary elimination of cadmium in rabbits exposed to cadmium. Rabbits were divided into two groups: Cd group - for a period of 28 days the animals received per os 10 mg Cd/kg b.m/day and Cd+(Mg+Zn+Cu) group - 10 mg Cd/kg b.m. + 40 mg Mg/kg b.m, 20 mg Zn/kg b.m. and 10 mg Cu/kg b.m/day. Daily urine was collected on days 0, 10, 15, 17, 19, 21, 23, 25, and 28 of the experiment. Following decomposition of urine samples with the help of concentrated HNO3 and HClO4 (4:1), the metal concentration was determined using the method of atomic absorption spectrophotometry. Supplementation with magnesium, zinc and copper did not result in significant changes in the elimination of cadmium through urine in animals poisoned with cadmium, in comparison with the animals that were administered only cadmium, while the concentration of all three applied bioelements in urine was significantly increased. It can be concluded that the simultaneous administration of increased doses of zinc, copper and magnesium does not have a positive effect on the elimination of cadmium in conditions when rabbits are poisoned with cadmium.
AB  - Kadmijum (Cd) je danas jedan od najznačajnijih metalnih otrova, kako u oblasti profesionalne tako i ekotoksikologije. U organizmu, Cd štetno deluje na bubrege, jetru, kosti, testise itd., a na osnovu dokaza da na ljudima izaziva karcinom pluća svrstan je i u I grupu karcinogena. I pored brojnih literaturnih podataka o štetnim efektima Cd, interakcije kadmijuma i bioelemenata kao značajnog mehanizma toksičnosti kadmijuma, još uvek nisu dovoljno razjašnjene. S obzirom na to da dosadašnji podaci ukazuju na pozitivan efekat suplementacije pojedinim bioelementima na toksičnost i sadržaj kadmijuma u organizmu, cilj ovog rada je bio da se ispita uticaj povećanog istovremenog unosa magnezijuma, cinka i bakra na urinarnu eliminaciju kadmijuma kod kunića izloženih kadmijumu. Kunići su bili podeljeni u dve grupe: I Cd grupa - životinje su 28 dana primale per os 10 mg Cd/kg t.m/dan i II grupa - Cd+ (Mg+Zn+Cu): 10 mg Cd/kg t.m. + 40 mg Mg/kg t.m, 20 mg Zn/kg t.m. i 10 mg Cu/kg t.m/dan. Dnevni urin je sakupljan 0, 10, 15, 17, 19, 21, 23, 25. i 28. dana eksperimenta. Nakon razaranja uzoraka urina uz pomoć koncentrovanih HNO3 i HClO4 (4:1), koncentracija metala je određena metodom atomske apsorpcione spektrofotometrije. Suplementacija magnezijumom, cinkom i bakrom nije dovela do značajne promene u eliminaciji kadmijuma urinom kod životinja trovanih kadmijumom u poređenju sa životinjama koje su primale samo kadmijum, dok je koncentracija sva tri primenjena bioelementa u urinu bila značajno povećana. Može se zaključiti da istovremeno davanje povećanih doza cinka, bakra i magnezijuma ne ispoljava pozitivan efekat na eliminaciju kadmijuma u uslovima trovanja kunića kadmijumom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits
T1  - Ispitivanje uticaja magnezijuma, cinka i bakra na izlučivanje kadmijuma kod kunića
VL  - 66
IS  - 5-6
SP  - 395
EP  - 406
DO  - 10.2298/VETGL1206395B
ER  - 

@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Buha, Aleksandra and Ćupić, Vitomir and Pavlović, Zoran and Matović, Vesna",
year = "2012",
abstract = "Cadmium (Cd) is today one of the most significant metal poisons, both in the area of professional as well as of eco toxicology. In the organism, cadmium has a harmful effect on the kidneys, liver, bones, testicles, etc., and, based on evidence in humans that it causes lung carcinoma, it has been placed in the first group of carcinogens. In spite of numerous data in literature on the harmful effects of cadmium, the interactions between cadmium and bioelements as a significant mechanism for cadmium toxicity have still not been sufficiently explained. Since the data so far point to a positive effect of supplementation with certain bioelements regarding toxicity and cadmium content in the organism, the objective of this work was to investigate the effect of increased simultaneous intake of magnesium, zinc and copper on urinary elimination of cadmium in rabbits exposed to cadmium. Rabbits were divided into two groups: Cd group - for a period of 28 days the animals received per os 10 mg Cd/kg b.m/day and Cd+(Mg+Zn+Cu) group - 10 mg Cd/kg b.m. + 40 mg Mg/kg b.m, 20 mg Zn/kg b.m. and 10 mg Cu/kg b.m/day. Daily urine was collected on days 0, 10, 15, 17, 19, 21, 23, 25, and 28 of the experiment. Following decomposition of urine samples with the help of concentrated HNO3 and HClO4 (4:1), the metal concentration was determined using the method of atomic absorption spectrophotometry. Supplementation with magnesium, zinc and copper did not result in significant changes in the elimination of cadmium through urine in animals poisoned with cadmium, in comparison with the animals that were administered only cadmium, while the concentration of all three applied bioelements in urine was significantly increased. It can be concluded that the simultaneous administration of increased doses of zinc, copper and magnesium does not have a positive effect on the elimination of cadmium in conditions when rabbits are poisoned with cadmium., Kadmijum (Cd) je danas jedan od najznačajnijih metalnih otrova, kako u oblasti profesionalne tako i ekotoksikologije. U organizmu, Cd štetno deluje na bubrege, jetru, kosti, testise itd., a na osnovu dokaza da na ljudima izaziva karcinom pluća svrstan je i u I grupu karcinogena. I pored brojnih literaturnih podataka o štetnim efektima Cd, interakcije kadmijuma i bioelemenata kao značajnog mehanizma toksičnosti kadmijuma, još uvek nisu dovoljno razjašnjene. S obzirom na to da dosadašnji podaci ukazuju na pozitivan efekat suplementacije pojedinim bioelementima na toksičnost i sadržaj kadmijuma u organizmu, cilj ovog rada je bio da se ispita uticaj povećanog istovremenog unosa magnezijuma, cinka i bakra na urinarnu eliminaciju kadmijuma kod kunića izloženih kadmijumu. Kunići su bili podeljeni u dve grupe: I Cd grupa - životinje su 28 dana primale per os 10 mg Cd/kg t.m/dan i II grupa - Cd+ (Mg+Zn+Cu): 10 mg Cd/kg t.m. + 40 mg Mg/kg t.m, 20 mg Zn/kg t.m. i 10 mg Cu/kg t.m/dan. Dnevni urin je sakupljan 0, 10, 15, 17, 19, 21, 23, 25. i 28. dana eksperimenta. Nakon razaranja uzoraka urina uz pomoć koncentrovanih HNO3 i HClO4 (4:1), koncentracija metala je određena metodom atomske apsorpcione spektrofotometrije. Suplementacija magnezijumom, cinkom i bakrom nije dovela do značajne promene u eliminaciji kadmijuma urinom kod životinja trovanih kadmijumom u poređenju sa životinjama koje su primale samo kadmijum, dok je koncentracija sva tri primenjena bioelementa u urinu bila značajno povećana. Može se zaključiti da istovremeno davanje povećanih doza cinka, bakra i magnezijuma ne ispoljava pozitivan efekat na eliminaciju kadmijuma u uslovima trovanja kunića kadmijumom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits, Ispitivanje uticaja magnezijuma, cinka i bakra na izlučivanje kadmijuma kod kunića",
volume = "66",
number = "5-6",
pages = "395-406",
doi = "10.2298/VETGL1206395B"
}

Bulat, Z., Đukić-Ćosić, D., Buha, A., Ćupić, V., Pavlović, Z.,& Matović, V.. (2012). Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(5-6), 395-406.
https://doi.org/10.2298/VETGL1206395B

Bulat Z, Đukić-Ćosić D, Buha A, Ćupić V, Pavlović Z, Matović V. Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits. in Veterinarski glasnik. 2012;66(5-6):395-406.
doi:10.2298/VETGL1206395B .

Bulat, Zorica, Đukić-Ćosić, Danijela, Buha, Aleksandra, Ćupić, Vitomir, Pavlović, Zoran, Matović, Vesna, "Investigations of effects of magnesium, zinc and copper on cadmium excretion in rabbits" in Veterinarski glasnik, 66, no. 5-6 (2012):395-406,
https://doi.org/10.2298/VETGL1206395B . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Vučinić, Slavica
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1791
AB  - The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect experimental animals against either dichlorvos, heptenophos or tabun. Trimedoxime was very effective against all three OPs. The ED-500 doses of trimedoxime necessary to protect 50% of animals after the simultaneous administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of efficacy in the tabun protocol was approximately three and two times longer than in the protocol for heptenophos and dichlorvos, respectively indicating also that trimedoxime is very potent in counteracting tabun toxicity. Addition of trimedoxime significantly improved the protective effect of HI-6 in acute tabun poisoning. When dichlorvos or heptenophos were used, addition of trimedoxime generally improved the antidotal effect of HI-6, but still lower protection was obtained than in the case when trimedoxime alone was administered. The investigations of different oxime combinations have indicated that application of a mixture of two oximes represents a promising antidotal approach.
AB  - Cilj ovog rada je bio da se uporedi zaštitni efekat pojedinačnih oksima HI-6 i trimedoksima sa zaštitnim efektom njihove kombinacije u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom. Oksim HI-6 nije štitio eksperimentalne životinje od trovanja, ali je trimedoksim bio veoma efikasan u antagonitovanju toksičnih efekata sva tri organofosforna jedinjenja. ED-500 doze trimedoksima potrebne da zaštite 50% životinja pri istovremenoj primeni organofosfata i oksima iznosile su 42,18, 14,97 i 32,08 μmol/kg kod trovanja dihlorvosom, heptenofosom odnosno tabunom. Poluvreme efikasnosti trimedoksima u tretmanu sa tabunom bilo je dva odnosno tri puta duže od poluvremena izračunatih kod trovanja heptenofosom odnosno dihlorvosom. Dodatak trimedoksima doveo je do značajnog poboljšanja zaštitnog efekta HI-6 kod trovanja tabunom. Dodatak trimedoksima takođe je poboljšao zaštitni efekat HI-6 i kod ostala dva otrova, ali je zaštita i dalje bila najbolja kada je primenjen sam trimedoksim. Ispitivanja različitih kombinacija oksima ukazuju da je primena smeše dva oksima opravdani pristup u prevazilaženju problema nejednake efikasnosti oksima.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos
T1  - Zaštitni efekat kombinacije HI-6 i trimedoksima u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom
VL  - 62
IS  - 2-3
SP  - 123
EP  - 135
DO  - 10.2298/AVB1203123A
ER  - 

@article{
author = "Antonijević, Biljana and Vučinić, Slavica and Ćupić, Vitomir",
year = "2012",
abstract = "The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. Oxime HI-6 did not protect experimental animals against either dichlorvos, heptenophos or tabun. Trimedoxime was very effective against all three OPs. The ED-500 doses of trimedoxime necessary to protect 50% of animals after the simultaneous administration of OPs and oxime were 42.18, 14.97 and 32.08 μmol/kg in dichlorvos, heptenophos and tabun poisoning, respectively. Half-time of efficacy in the tabun protocol was approximately three and two times longer than in the protocol for heptenophos and dichlorvos, respectively indicating also that trimedoxime is very potent in counteracting tabun toxicity. Addition of trimedoxime significantly improved the protective effect of HI-6 in acute tabun poisoning. When dichlorvos or heptenophos were used, addition of trimedoxime generally improved the antidotal effect of HI-6, but still lower protection was obtained than in the case when trimedoxime alone was administered. The investigations of different oxime combinations have indicated that application of a mixture of two oximes represents a promising antidotal approach., Cilj ovog rada je bio da se uporedi zaštitni efekat pojedinačnih oksima HI-6 i trimedoksima sa zaštitnim efektom njihove kombinacije u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom. Oksim HI-6 nije štitio eksperimentalne životinje od trovanja, ali je trimedoksim bio veoma efikasan u antagonitovanju toksičnih efekata sva tri organofosforna jedinjenja. ED-500 doze trimedoksima potrebne da zaštite 50% životinja pri istovremenoj primeni organofosfata i oksima iznosile su 42,18, 14,97 i 32,08 μmol/kg kod trovanja dihlorvosom, heptenofosom odnosno tabunom. Poluvreme efikasnosti trimedoksima u tretmanu sa tabunom bilo je dva odnosno tri puta duže od poluvremena izračunatih kod trovanja heptenofosom odnosno dihlorvosom. Dodatak trimedoksima doveo je do značajnog poboljšanja zaštitnog efekta HI-6 kod trovanja tabunom. Dodatak trimedoksima takođe je poboljšao zaštitni efekat HI-6 i kod ostala dva otrova, ali je zaštita i dalje bila najbolja kada je primenjen sam trimedoksim. Ispitivanja različitih kombinacija oksima ukazuju da je primena smeše dva oksima opravdani pristup u prevazilaženju problema nejednake efikasnosti oksima.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos, Zaštitni efekat kombinacije HI-6 i trimedoksima u miševa akutno trovanih tabunom, dihlorvosom ili heptenofosom",
volume = "62",
number = "2-3",
pages = "123-135",
doi = "10.2298/AVB1203123A"
}

Antonijević, B., Vučinić, S.,& Ćupić, V.. (2012). Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(2-3), 123-135.
https://doi.org/10.2298/AVB1203123A

Antonijević B, Vučinić S, Ćupić V. Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos. in Acta veterinaria. 2012;62(2-3):123-135.
doi:10.2298/AVB1203123A .

Antonijević, Biljana, Vučinić, Slavica, Ćupić, Vitomir, "Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos" in Acta veterinaria, 62, no. 2-3 (2012):123-135,
https://doi.org/10.2298/AVB1203123A . .

TY  - JOUR
AU  - Janković, Saša
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Radičević, Tatjana
AU  - Stefanović, Srđan
AU  - Nikolić, Dragica
AU  - Ćupić, Vitomir
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1790
AB  - Nutritional benefits of fish can be attributed primarily to the content of high-quality proteins, vitamins, elements and omega-3 polyunsaturated fatty acids. On the other hand, fish and fishery products are susceptible to contamination by chemicals that have been recognized as ubiquitous environmental pollutants such as toxic elements and polychlorinated organic compounds. Fish consumption could be therefore considered as one of the major sources of human exposure to all above-mentioned environmental contaminants. This paper is focused on mercury (Hg) that enters the environment by both, natural means (such as volcanic activity, erosions and weathering, factors which contribute to the presence of Hg in water, soil and the atmosphere) and human activities - mining, fossil fuels combustion, industrial emissions, direct application of fertilizers and fungicides as well as disposal of solid waste. Total concentrations of Hg were measured in fish muscle and canned fish products available on Serbian market. Total of 651 samples were analyzed: 350 samples of marine fish (hake, mackerel, sprat, scorpanea, gilthead, salmon), 34 samples of freshwater fish (trout and carp) and 267 samples of canned fish products (tuna and sardines). Data were collected during 2011. For the purpose of intake assessment, we used the data obtained from the GEMS/Food Consumption Cluster Diets database. According to this source, estimated average weekly consumption of marine fish is 106.4 g/week, while freshwater fish and canned fish contribute to the consumption with 29.4 g and 18.2 g/week respectively. Mercury concentrations in marine fish were in the range of 0.005-0.208 μgg-1 (mean 0.040 μgg-1); in freshwater fish 0.005- 0.099 μgg-1 (mean 0.020 μgg-1) and in canned products they were in the range of 0.005-0.642 μgg-1 (mean 0.064 μgg-1). All analyzed samples contained mercury below the maximum level laid down by the European Union and Serbian regulation. The estimated weekly intake for total mercury, based on mean mercury value in fish and average body mass of 70 kg, was 0.095 μg/kg b.w./week. Based on FAO/WHO recommended safe limit and on obtained results, we can conclude that the intake of mercury in the case of consuming fish and canned fish products is lower than the safe limit.
AB  - Nutritivna korist od konzumacije ribe ogleda se, pre svega u sadržaju visoko vrednih proteina, vitamina, makro i mikroelemenata i omega-3 polinezasićenih masnih kiselina. Sa druge strane, riba i proizvodi od ribe su u značajnoj meri podložni hemijskoj kontaminaciji ubikvitarnim zagađivačima kao što su teški metal i polihlorovana organska jedinjenja. Zbog svega ovoga, konzumacija ribe se smatra jednim od najznačajnijih izvora izloženosti navedenim kontaminentima. U radu je ispitivana kontaminacija živom koja se u spoljašnjoj sredini može naći kao posledica prirodnih procesa (vulkanska aktivnost, erozija tla i klimatska dešavanja koja doprinose prisustvu žive u vodi, zemljištu i atmosferi), kao i aktivnosti čoveka - eksploatacija ruda, sagorevanje fosilnih goriva, emisija industrijskih gasova, direktna primena veštačkih đubriva i fungicida, kao i neadekvatno odlaganje čvrstog otpada. Sadržaj ukupne žive je određivan u svežoj i konzervisanoj ribi sa srpskog tržišta. Ispitan je 651 uzorak: 350 uzoraka morske ribe (oslić, skuša, sardela, škarpina, orada i losos), 34 uzorka slatkovodne ribe (šaran i pastrmka) i 267 uzoraka konzervisane ribe (tuna i sardela). Svi uzorci su analizirani tokom 2011. godine. Za procenu unosa korišćeni su podaci iz 'GEMS/Food Consumption Cluster Diets database'. Prema ovom izvoru, procenjena prosečna nedeljna konzumacija morske ribe iznosi 106,4 g, slatkovodne 29,4 g dok je ova vrednost za konzervisane proizvode od ribe 18,2 g. Sardžaj žive u morskoj ribi se kretao u opsegu od 0,005 do 0,208 μgg-1 (srednja vrednost 0,040 μgg-1); u slatkovodnoj ribi 0,005-0,099 μgg-1 (srednja vrednost 0,020 μgg-1), dok se u konzervisanim ribljim proizvodima sadržaj žive kretao od 0,005 do 0,642 μgg-1 (srednja vrednost 0,064 μgg-1). Nivo žive u svim ispitanim uzorcima je bio ispod maksimalno dozvoljenih vrednosti propisanih relevantnom legislativom EU kao i domaćim propisima. Procenjeni nedeljni unos žive baziran na srednjoj vrednosti žive u konzumiranoj ribi i prosečnoj telesnoj težini od 70 kg, bio je 0,095 μg/kg telesne mase nedeljno. Na osnovu preporuka FAO/WHO i dobijenih rezultata, može se zaključiti da je unos žive pri konzumaciji morske i slatkovodne ribe i konzervisanih ribljih proizvoda, niži od preporučenih graničnih vrednosti.
PB  - Institut za higijenu i tehnologiju mesa, Beograd
T2  - Tehnologija mesa
T1  - Assessment of mercury intake associated with fish consumption in Serbia
T1  - Procena unosa žive kroz konzumaciju ribe u Srbiji
VL  - 53
IS  - 1
SP  - 56
EP  - 61
DO  - 10.5937/tehmesa1201056J
ER  - 

@article{
author = "Janković, Saša and Antonijević, Biljana and Ćurčić, Marijana and Radičević, Tatjana and Stefanović, Srđan and Nikolić, Dragica and Ćupić, Vitomir",
year = "2012",
abstract = "Nutritional benefits of fish can be attributed primarily to the content of high-quality proteins, vitamins, elements and omega-3 polyunsaturated fatty acids. On the other hand, fish and fishery products are susceptible to contamination by chemicals that have been recognized as ubiquitous environmental pollutants such as toxic elements and polychlorinated organic compounds. Fish consumption could be therefore considered as one of the major sources of human exposure to all above-mentioned environmental contaminants. This paper is focused on mercury (Hg) that enters the environment by both, natural means (such as volcanic activity, erosions and weathering, factors which contribute to the presence of Hg in water, soil and the atmosphere) and human activities - mining, fossil fuels combustion, industrial emissions, direct application of fertilizers and fungicides as well as disposal of solid waste. Total concentrations of Hg were measured in fish muscle and canned fish products available on Serbian market. Total of 651 samples were analyzed: 350 samples of marine fish (hake, mackerel, sprat, scorpanea, gilthead, salmon), 34 samples of freshwater fish (trout and carp) and 267 samples of canned fish products (tuna and sardines). Data were collected during 2011. For the purpose of intake assessment, we used the data obtained from the GEMS/Food Consumption Cluster Diets database. According to this source, estimated average weekly consumption of marine fish is 106.4 g/week, while freshwater fish and canned fish contribute to the consumption with 29.4 g and 18.2 g/week respectively. Mercury concentrations in marine fish were in the range of 0.005-0.208 μgg-1 (mean 0.040 μgg-1); in freshwater fish 0.005- 0.099 μgg-1 (mean 0.020 μgg-1) and in canned products they were in the range of 0.005-0.642 μgg-1 (mean 0.064 μgg-1). All analyzed samples contained mercury below the maximum level laid down by the European Union and Serbian regulation. The estimated weekly intake for total mercury, based on mean mercury value in fish and average body mass of 70 kg, was 0.095 μg/kg b.w./week. Based on FAO/WHO recommended safe limit and on obtained results, we can conclude that the intake of mercury in the case of consuming fish and canned fish products is lower than the safe limit., Nutritivna korist od konzumacije ribe ogleda se, pre svega u sadržaju visoko vrednih proteina, vitamina, makro i mikroelemenata i omega-3 polinezasićenih masnih kiselina. Sa druge strane, riba i proizvodi od ribe su u značajnoj meri podložni hemijskoj kontaminaciji ubikvitarnim zagađivačima kao što su teški metal i polihlorovana organska jedinjenja. Zbog svega ovoga, konzumacija ribe se smatra jednim od najznačajnijih izvora izloženosti navedenim kontaminentima. U radu je ispitivana kontaminacija živom koja se u spoljašnjoj sredini može naći kao posledica prirodnih procesa (vulkanska aktivnost, erozija tla i klimatska dešavanja koja doprinose prisustvu žive u vodi, zemljištu i atmosferi), kao i aktivnosti čoveka - eksploatacija ruda, sagorevanje fosilnih goriva, emisija industrijskih gasova, direktna primena veštačkih đubriva i fungicida, kao i neadekvatno odlaganje čvrstog otpada. Sadržaj ukupne žive je određivan u svežoj i konzervisanoj ribi sa srpskog tržišta. Ispitan je 651 uzorak: 350 uzoraka morske ribe (oslić, skuša, sardela, škarpina, orada i losos), 34 uzorka slatkovodne ribe (šaran i pastrmka) i 267 uzoraka konzervisane ribe (tuna i sardela). Svi uzorci su analizirani tokom 2011. godine. Za procenu unosa korišćeni su podaci iz 'GEMS/Food Consumption Cluster Diets database'. Prema ovom izvoru, procenjena prosečna nedeljna konzumacija morske ribe iznosi 106,4 g, slatkovodne 29,4 g dok je ova vrednost za konzervisane proizvode od ribe 18,2 g. Sardžaj žive u morskoj ribi se kretao u opsegu od 0,005 do 0,208 μgg-1 (srednja vrednost 0,040 μgg-1); u slatkovodnoj ribi 0,005-0,099 μgg-1 (srednja vrednost 0,020 μgg-1), dok se u konzervisanim ribljim proizvodima sadržaj žive kretao od 0,005 do 0,642 μgg-1 (srednja vrednost 0,064 μgg-1). Nivo žive u svim ispitanim uzorcima je bio ispod maksimalno dozvoljenih vrednosti propisanih relevantnom legislativom EU kao i domaćim propisima. Procenjeni nedeljni unos žive baziran na srednjoj vrednosti žive u konzumiranoj ribi i prosečnoj telesnoj težini od 70 kg, bio je 0,095 μg/kg telesne mase nedeljno. Na osnovu preporuka FAO/WHO i dobijenih rezultata, može se zaključiti da je unos žive pri konzumaciji morske i slatkovodne ribe i konzervisanih ribljih proizvoda, niži od preporučenih graničnih vrednosti.",
publisher = "Institut za higijenu i tehnologiju mesa, Beograd",
journal = "Tehnologija mesa",
title = "Assessment of mercury intake associated with fish consumption in Serbia, Procena unosa žive kroz konzumaciju ribe u Srbiji",
volume = "53",
number = "1",
pages = "56-61",
doi = "10.5937/tehmesa1201056J"
}

Janković, S., Antonijević, B., Ćurčić, M., Radičević, T., Stefanović, S., Nikolić, D.,& Ćupić, V.. (2012). Assessment of mercury intake associated with fish consumption in Serbia. in Tehnologija mesa
Institut za higijenu i tehnologiju mesa, Beograd., 53(1), 56-61.
https://doi.org/10.5937/tehmesa1201056J

Janković S, Antonijević B, Ćurčić M, Radičević T, Stefanović S, Nikolić D, Ćupić V. Assessment of mercury intake associated with fish consumption in Serbia. in Tehnologija mesa. 2012;53(1):56-61.
doi:10.5937/tehmesa1201056J .

Janković, Saša, Antonijević, Biljana, Ćurčić, Marijana, Radičević, Tatjana, Stefanović, Srđan, Nikolić, Dragica, Ćupić, Vitomir, "Assessment of mercury intake associated with fish consumption in Serbia" in Tehnologija mesa, 53, no. 1 (2012):56-61,
https://doi.org/10.5937/tehmesa1201056J . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Vladimirov, Sote
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Heinle, Helmut
AU  - Gojković-Bukarica, Ljiljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1740
AB  - Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Arzneimittelforschung - Drug Research
T1  - The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta
VL  - 62
IS  - 7
SP  - 345
EP  - 350
DO  - 10.1055/s-0032-1312617
ER  - 

@article{
author = "Ivković, Branka and Vladimirov, Sote and Novaković, Radmila and Ćupić, Vitomir and Heinle, Helmut and Gojković-Bukarica, Ljiljana",
year = "2012",
abstract = "Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Arzneimittelforschung - Drug Research",
title = "The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta",
volume = "62",
number = "7",
pages = "345-350",
doi = "10.1055/s-0032-1312617"
}

Ivković, B., Vladimirov, S., Novaković, R., Ćupić, V., Heinle, H.,& Gojković-Bukarica, L.. (2012). The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta. in Arzneimittelforschung - Drug Research
Georg Thieme Verlag Kg, Stuttgart., 62(7), 345-350.
https://doi.org/10.1055/s-0032-1312617

Ivković B, Vladimirov S, Novaković R, Ćupić V, Heinle H, Gojković-Bukarica L. The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta. in Arzneimittelforschung - Drug Research. 2012;62(7):345-350.
doi:10.1055/s-0032-1312617 .

Ivković, Branka, Vladimirov, Sote, Novaković, Radmila, Ćupić, Vitomir, Heinle, Helmut, Gojković-Bukarica, Ljiljana, "The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta" in Arzneimittelforschung - Drug Research, 62, no. 7 (2012):345-350,
https://doi.org/10.1055/s-0032-1312617 . .

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Dobrić, Silva
AU  - Antonijević, Biljana
AU  - Čelebićanin, Sanja
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1581
AB  - Rational use of drugs in veterinary medicine has manifold significance. By using each drug, only when it is really necessary (indicated), in right dose and route of administration, the potential damage of their use is reduced, efficiency increased, and the risk of microorganisms resistance development (in case of antimicrobials) significantly decreased. All of this becomes more important when these drugs are used in food producing animals. Simultaneously with the intensifying of cattle breeding and exceptional increase of animal productivity, the number of used drugs is unavoidably increased. There are almost no animals today in intensive as well as in extensive production/rearing system, which haven't received at least one drug during their life. In poultry, cattle and pig production, which are main sectors for production of food stuffs of animal origin, the use of drugs has increased and reached the limits which are considered alarming for health of people. On the first place are antibiotics, or antimicrobial drugs, which are used very often in therapy or prevention of bacteria diseases, and also, very often, as growth stimulator. In addition to antibiotics, many other drugs are used, with proven numerous harmful effects, even with carcinogenic and teratogenic features, whose residues in food intended for human consumption can very seriously endanger the health of people, as potential consumers of this kind of food. Therefore, the control of use of antimicrobial, and other drugs in livestock production is exceptionally significant.
AB  - Racionalna primena lekova u veterinarskoj medicini ima višestruk značaj. Korišćenjem lekova samo kada su stvarno neophodni (indikovani), u pravoj dozi i na pravi način, smanjuje se potencijalna šteta od njihovog korišćenja, a ujedno se povećava delotvornost, i smanjuje rizik od nastanka rezistentnosti mikroorganizama (odnosi se na antimikrobne lekove). Sve navedeno postaje još važnije kada se veterinarski lekovi koriste u lečenju farmskih životinja, odnosno životinja čiji se proizvodi koriste za ishranu ljudi. Istovremeno sa intenziviranjem stočarske proizvodnje i povećanjem produktivnosti životinja, povećava se i broj lekova koji se koriste. Danas ne postoji skoro nijedna životinja, u intenzivnom, kao i ekstenzivnom uzgoju, koja nije primila barem jedan lek tokom svog života. U živinarstvu, govedarstvu i svinjarstvu, kao glavnim sektorima gde se proizvode prehrambeni proizvodi životinjskog porekla, upotreba lekova je dostigla granice koje se mogu smatrati alarmantnim za zdravlje ljudi. Na prvom mestu su antibiotici, ili antimikrobni lekovi, koji se veoma često koriste u terapiji ili prevenciji bakterijskih bolesti, a ne tako retko i kao promotori rasta. Osim antibiotika, koriste se i mnogi drugi lekovi, koji imaju dokazano štetno dejstvo, pa čak i kancerogene ili teratogene osobine/svojstva. Njihove rezidue u proizvodima životinjskog porekla koji se koriste u ljudskoj ishrani, mogu veoma ozbiljno da ugroze zdravlje ljudi, koji su potencijalni konzumenti ove vrste hrane. Zbog toga je kontrola primene antimikrobnih lekova, kao i ostalih lekova u stočarstvu, od izuzetne važnosti.
PB  - Institut za higijenu i tehnologiju mesa, Beograd
T2  - Tehnologija mesa
T1  - The significance of rational use of drugs in veterinary medicine for food safety
T1  - Značaj racionalne primene lekova u veterinarskoj medicini za bezbednost hrane
VL  - 52
IS  - 1
SP  - 74
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_778
ER  - 

@article{
author = "Ćupić, Vitomir and Dobrić, Silva and Antonijević, Biljana and Čelebićanin, Sanja",
year = "2011",
abstract = "Rational use of drugs in veterinary medicine has manifold significance. By using each drug, only when it is really necessary (indicated), in right dose and route of administration, the potential damage of their use is reduced, efficiency increased, and the risk of microorganisms resistance development (in case of antimicrobials) significantly decreased. All of this becomes more important when these drugs are used in food producing animals. Simultaneously with the intensifying of cattle breeding and exceptional increase of animal productivity, the number of used drugs is unavoidably increased. There are almost no animals today in intensive as well as in extensive production/rearing system, which haven't received at least one drug during their life. In poultry, cattle and pig production, which are main sectors for production of food stuffs of animal origin, the use of drugs has increased and reached the limits which are considered alarming for health of people. On the first place are antibiotics, or antimicrobial drugs, which are used very often in therapy or prevention of bacteria diseases, and also, very often, as growth stimulator. In addition to antibiotics, many other drugs are used, with proven numerous harmful effects, even with carcinogenic and teratogenic features, whose residues in food intended for human consumption can very seriously endanger the health of people, as potential consumers of this kind of food. Therefore, the control of use of antimicrobial, and other drugs in livestock production is exceptionally significant., Racionalna primena lekova u veterinarskoj medicini ima višestruk značaj. Korišćenjem lekova samo kada su stvarno neophodni (indikovani), u pravoj dozi i na pravi način, smanjuje se potencijalna šteta od njihovog korišćenja, a ujedno se povećava delotvornost, i smanjuje rizik od nastanka rezistentnosti mikroorganizama (odnosi se na antimikrobne lekove). Sve navedeno postaje još važnije kada se veterinarski lekovi koriste u lečenju farmskih životinja, odnosno životinja čiji se proizvodi koriste za ishranu ljudi. Istovremeno sa intenziviranjem stočarske proizvodnje i povećanjem produktivnosti životinja, povećava se i broj lekova koji se koriste. Danas ne postoji skoro nijedna životinja, u intenzivnom, kao i ekstenzivnom uzgoju, koja nije primila barem jedan lek tokom svog života. U živinarstvu, govedarstvu i svinjarstvu, kao glavnim sektorima gde se proizvode prehrambeni proizvodi životinjskog porekla, upotreba lekova je dostigla granice koje se mogu smatrati alarmantnim za zdravlje ljudi. Na prvom mestu su antibiotici, ili antimikrobni lekovi, koji se veoma često koriste u terapiji ili prevenciji bakterijskih bolesti, a ne tako retko i kao promotori rasta. Osim antibiotika, koriste se i mnogi drugi lekovi, koji imaju dokazano štetno dejstvo, pa čak i kancerogene ili teratogene osobine/svojstva. Njihove rezidue u proizvodima životinjskog porekla koji se koriste u ljudskoj ishrani, mogu veoma ozbiljno da ugroze zdravlje ljudi, koji su potencijalni konzumenti ove vrste hrane. Zbog toga je kontrola primene antimikrobnih lekova, kao i ostalih lekova u stočarstvu, od izuzetne važnosti.",
publisher = "Institut za higijenu i tehnologiju mesa, Beograd",
journal = "Tehnologija mesa",
title = "The significance of rational use of drugs in veterinary medicine for food safety, Značaj racionalne primene lekova u veterinarskoj medicini za bezbednost hrane",
volume = "52",
number = "1",
pages = "74-79",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_778"
}

Ćupić, V., Dobrić, S., Antonijević, B.,& Čelebićanin, S.. (2011). The significance of rational use of drugs in veterinary medicine for food safety. in Tehnologija mesa
Institut za higijenu i tehnologiju mesa, Beograd., 52(1), 74-79.
https://hdl.handle.net/21.15107/rcub_veterinar_778

Ćupić V, Dobrić S, Antonijević B, Čelebićanin S. The significance of rational use of drugs in veterinary medicine for food safety. in Tehnologija mesa. 2011;52(1):74-79.
https://hdl.handle.net/21.15107/rcub_veterinar_778 .

Ćupić, Vitomir, Dobrić, Silva, Antonijević, Biljana, Čelebićanin, Sanja, "The significance of rational use of drugs in veterinary medicine for food safety" in Tehnologija mesa, 52, no. 1 (2011):74-79,
https://hdl.handle.net/21.15107/rcub_veterinar_778 .

TY  - CONF
AU  - Ćupić, Vitomir
AU  - Petricević, S.
AU  - Ristić, Slavica M.
AU  - Simić, Slobodanka
AU  - Petrović, S.
AU  - Vučićević, Katarina
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1271
PB  - Wiley-Blackwell Publishing, Inc, Malden
C3  - Journal of Veterinary Pharmacology and Therapeutics
T1  - Comparison between pharmacokinetic parameters of sustained-release aminophylline tablets in rabbits
VL  - 32
IS  - Suppl. 1
SP  - 243
EP  - 243
DO  - 10.1111/j.1365-2885.2009.01091.x
ER  - 

@conference{
author = "Ćupić, Vitomir and Petricević, S. and Ristić, Slavica M. and Simić, Slobodanka and Petrović, S. and Vučićević, Katarina",
year = "2009",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
title = "Comparison between pharmacokinetic parameters of sustained-release aminophylline tablets in rabbits",
volume = "32",
number = "Suppl. 1",
pages = "243-243",
doi = "10.1111/j.1365-2885.2009.01091.x"
}

Ćupić, V., Petricević, S., Ristić, S. M., Simić, S., Petrović, S.,& Vučićević, K.. (2009). Comparison between pharmacokinetic parameters of sustained-release aminophylline tablets in rabbits. in Journal of Veterinary Pharmacology and Therapeutics
Wiley-Blackwell Publishing, Inc, Malden., 32(Suppl. 1), 243-243.
https://doi.org/10.1111/j.1365-2885.2009.01091.x

Ćupić V, Petricević S, Ristić SM, Simić S, Petrović S, Vučićević K. Comparison between pharmacokinetic parameters of sustained-release aminophylline tablets in rabbits. in Journal of Veterinary Pharmacology and Therapeutics. 2009;32(Suppl. 1):243-243.
doi:10.1111/j.1365-2885.2009.01091.x .

Ćupić, Vitomir, Petricević, S., Ristić, Slavica M., Simić, Slobodanka, Petrović, S., Vučićević, Katarina, "Comparison between pharmacokinetic parameters of sustained-release aminophylline tablets in rabbits" in Journal of Veterinary Pharmacology and Therapeutics, 32, no. Suppl. 1 (2009):243-243,
https://doi.org/10.1111/j.1365-2885.2009.01091.x . .

TY  - CONF
AU  - Vasilev, S.
AU  - Majstorović, Ivana
AU  - Vucević, D.
AU  - Gašić, Sonja
AU  - Vasilijić, Saša
AU  - Bufan, Biljana
AU  - Ćupić, Vitomir
AU  - Čolić, Miodrag
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/637
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effect of NCX 4016 and NCX 4040, two nitric oxide-donating aspirin derivatives, on apoptosis of neutrophil granulocytes in vitro
VL  - 158
IS  - 1, Supplement
SP  - S229
EP  - S229
DO  - 10.1016/j.toxlet.2005.05.014
ER  - 

@conference{
author = "Vasilev, S. and Majstorović, Ivana and Vucević, D. and Gašić, Sonja and Vasilijić, Saša and Bufan, Biljana and Ćupić, Vitomir and Čolić, Miodrag",
year = "2005",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effect of NCX 4016 and NCX 4040, two nitric oxide-donating aspirin derivatives, on apoptosis of neutrophil granulocytes in vitro",
volume = "158",
number = "1, Supplement",
pages = "S229-S229",
doi = "10.1016/j.toxlet.2005.05.014"
}

Vasilev, S., Majstorović, I., Vucević, D., Gašić, S., Vasilijić, S., Bufan, B., Ćupić, V.,& Čolić, M.. (2005). The effect of NCX 4016 and NCX 4040, two nitric oxide-donating aspirin derivatives, on apoptosis of neutrophil granulocytes in vitro. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 158(1, Supplement), S229-S229.
https://doi.org/10.1016/j.toxlet.2005.05.014

Vasilev S, Majstorović I, Vucević D, Gašić S, Vasilijić S, Bufan B, Ćupić V, Čolić M. The effect of NCX 4016 and NCX 4040, two nitric oxide-donating aspirin derivatives, on apoptosis of neutrophil granulocytes in vitro. in Toxicology Letters. 2005;158(1, Supplement):S229-S229.
doi:10.1016/j.toxlet.2005.05.014 .

Vasilev, S., Majstorović, Ivana, Vucević, D., Gašić, Sonja, Vasilijić, Saša, Bufan, Biljana, Ćupić, Vitomir, Čolić, Miodrag, "The effect of NCX 4016 and NCX 4040, two nitric oxide-donating aspirin derivatives, on apoptosis of neutrophil granulocytes in vitro" in Toxicology Letters, 158, no. 1, Supplement (2005):S229-S229,
https://doi.org/10.1016/j.toxlet.2005.05.014 . .