TY  - JOUR
AU  - Rupar, Jelena
AU  - Dobričić, Vladimir
AU  - Grahovac, Jelena
AU  - Radulović, Siniša
AU  - Skok, Žiga
AU  - Ilaš, Janez
AU  - Aleksić, Mara
AU  - Brborić, Jasmina
AU  - Čudina, Olivera
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3606
AB  - A series of eleven 9-acridinyl amino acid derivatives were synthesized using a two-step procedure. Cytotoxicity was tested on the K562 and A549 cancer cell lines and normal diploid cell line MRC5 using the MTT assay. Compounds 6, 7, 8 and 9 were the most active, with IC50 values comparable to or lower than that of chemotherapeutic agent amsacrine. 8 and 9 were especially effective in the A549 cell line (IC50 ≈ 6 μM), which is of special interest since amsacrine is not sufficiently active in lung cancer patients. Cell cycle analysis revealed that 7 and 9 caused G2/M block, amsacrine caused arrest in the S phase, while 6 and 8 induced apoptotic cell death independently of the cell cycle regulation. In comparison to amsacrine, 6, 7, 8, and 9 showed similar inhibitory potential towards topoisomerase II, whereas only 7 showed DNA intercalation properties. In contrast to amsacrine, 6, 7, 8 and 9 showed a lack of toxicity towards unstimulated normal human leucocytes.
PB  - Royal Society of Chemistry
T2  - RSC Medicinal Chemistry
T1  - Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives
VL  - 11
IS  - 3
SP  - 378
EP  - 386
DO  - 10.1039/c9md00597h
DO  - 2-s2.0-85083014447
ER  - 

@article{
author = "Rupar, Jelena and Dobričić, Vladimir and Grahovac, Jelena and Radulović, Siniša and Skok, Žiga and Ilaš, Janez and Aleksić, Mara and Brborić, Jasmina and Čudina, Olivera",
year = "2020",
abstract = "A series of eleven 9-acridinyl amino acid derivatives were synthesized using a two-step procedure. Cytotoxicity was tested on the K562 and A549 cancer cell lines and normal diploid cell line MRC5 using the MTT assay. Compounds 6, 7, 8 and 9 were the most active, with IC50 values comparable to or lower than that of chemotherapeutic agent amsacrine. 8 and 9 were especially effective in the A549 cell line (IC50 ≈ 6 μM), which is of special interest since amsacrine is not sufficiently active in lung cancer patients. Cell cycle analysis revealed that 7 and 9 caused G2/M block, amsacrine caused arrest in the S phase, while 6 and 8 induced apoptotic cell death independently of the cell cycle regulation. In comparison to amsacrine, 6, 7, 8, and 9 showed similar inhibitory potential towards topoisomerase II, whereas only 7 showed DNA intercalation properties. In contrast to amsacrine, 6, 7, 8 and 9 showed a lack of toxicity towards unstimulated normal human leucocytes.",
publisher = "Royal Society of Chemistry",
journal = "RSC Medicinal Chemistry",
title = "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives",
volume = "11",
number = "3",
pages = "378-386",
doi = "10.1039/c9md00597h, 2-s2.0-85083014447"
}

Rupar, J., Dobričić, V., Grahovac, J., Radulović, S., Skok, Ž., Ilaš, J., Aleksić, M., Brborić, J.,& Čudina, O.. (2020). Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives. in RSC Medicinal Chemistry
Royal Society of Chemistry., 11(3), 378-386.
https://doi.org/10.1039/c9md00597h

Rupar J, Dobričić V, Grahovac J, Radulović S, Skok Ž, Ilaš J, Aleksić M, Brborić J, Čudina O. Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives. in RSC Medicinal Chemistry. 2020;11(3):378-386.
doi:10.1039/c9md00597h .

Rupar, Jelena, Dobričić, Vladimir, Grahovac, Jelena, Radulović, Siniša, Skok, Žiga, Ilaš, Janez, Aleksić, Mara, Brborić, Jasmina, Čudina, Olivera, "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives" in RSC Medicinal Chemistry, 11, no. 3 (2020):378-386,
https://doi.org/10.1039/c9md00597h . .

TY  - JOUR
AU  - Milenković, Milica
AU  - Pevec, Andrej
AU  - Turel, Iztok
AU  - Vujcić, Miroslava
AU  - Milenković, Marina
AU  - Jovanović, Katarina
AU  - Gligorijević, Nevenka
AU  - Radulović, Siniša
AU  - Swart, Marcel
AU  - Gruden-Pavlović, Maja
AU  - Adaila, Kawther
AU  - Cobeljić, Božidar
AU  - Anđelković, Katarina
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2118
AB  - Three square-planar complexes of Ni(II) with condensation derivative of 2-(diphenylphosphino)benzaldehyde and 4-phenylsemicarbazide and monodentate pseudohalides have been synthesized and characterized on the basis of the results of X-ray. NMR and IR spectroscopy and elemental analysis. Investigated complexes exhibited moderate antibacterial and cytotoxic activity. The most pronounced cytotoxic activity (in the range of cisplatin) to HeLa cell line was observed for ligand and all the complexes. Azido complex and ligand induced concentration dependent cell cycle arrest in the S phase, as well as decrease of percentage of cells in G1 phase, without significant increase of apoptotic fraction of cells. The interaction of the azido complex and ligand with CT-DNA results in changes in UV-Vis spectra typical for non-covalent bonding. The observed intrinsic binding constant of azido complex CT-DNA and ligand-CT-DNA were 3.22 x 10(5) M-1 and 2.79 x 10(5) M-1. The results of DNA cleavage experiments showed that azido complex nicked supercoiled plasmid DNA.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II
VL  - 87
SP  - 284
EP  - 297
DO  - 10.1016/j.ejmech.2014.06.079
ER  - 

@article{
author = "Milenković, Milica and Pevec, Andrej and Turel, Iztok and Vujcić, Miroslava and Milenković, Marina and Jovanović, Katarina and Gligorijević, Nevenka and Radulović, Siniša and Swart, Marcel and Gruden-Pavlović, Maja and Adaila, Kawther and Cobeljić, Božidar and Anđelković, Katarina",
year = "2014",
abstract = "Three square-planar complexes of Ni(II) with condensation derivative of 2-(diphenylphosphino)benzaldehyde and 4-phenylsemicarbazide and monodentate pseudohalides have been synthesized and characterized on the basis of the results of X-ray. NMR and IR spectroscopy and elemental analysis. Investigated complexes exhibited moderate antibacterial and cytotoxic activity. The most pronounced cytotoxic activity (in the range of cisplatin) to HeLa cell line was observed for ligand and all the complexes. Azido complex and ligand induced concentration dependent cell cycle arrest in the S phase, as well as decrease of percentage of cells in G1 phase, without significant increase of apoptotic fraction of cells. The interaction of the azido complex and ligand with CT-DNA results in changes in UV-Vis spectra typical for non-covalent bonding. The observed intrinsic binding constant of azido complex CT-DNA and ligand-CT-DNA were 3.22 x 10(5) M-1 and 2.79 x 10(5) M-1. The results of DNA cleavage experiments showed that azido complex nicked supercoiled plasmid DNA.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II",
volume = "87",
pages = "284-297",
doi = "10.1016/j.ejmech.2014.06.079"
}

Milenković, M., Pevec, A., Turel, I., Vujcić, M., Milenković, M., Jovanović, K., Gligorijević, N., Radulović, S., Swart, M., Gruden-Pavlović, M., Adaila, K., Cobeljić, B.,& Anđelković, K.. (2014). Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 87, 284-297.
https://doi.org/10.1016/j.ejmech.2014.06.079

Milenković M, Pevec A, Turel I, Vujcić M, Milenković M, Jovanović K, Gligorijević N, Radulović S, Swart M, Gruden-Pavlović M, Adaila K, Cobeljić B, Anđelković K. Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II. in European Journal of Medicinal Chemistry. 2014;87:284-297.
doi:10.1016/j.ejmech.2014.06.079 .

Milenković, Milica, Pevec, Andrej, Turel, Iztok, Vujcić, Miroslava, Milenković, Marina, Jovanović, Katarina, Gligorijević, Nevenka, Radulović, Siniša, Swart, Marcel, Gruden-Pavlović, Maja, Adaila, Kawther, Cobeljić, Božidar, Anđelković, Katarina, "Synthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part II" in European Journal of Medicinal Chemistry, 87 (2014):284-297,
https://doi.org/10.1016/j.ejmech.2014.06.079 . .

TY  - JOUR
AU  - Marčetić, Mirjana
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Malesević, Nevenka
AU  - Radulović, Siniša
AU  - Kovačević, Nada
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1913
AB  - In this study, we investigated the antimicrobial activity of the young shoots of the smoke tree, Cotinus coggygria Scop., Anacardiaceae. The acetone extract and the derived ethyl acetate fraction effectively inhibited the growth of Gram-positive and Gram-negative bacteria (MIC 25-200 mu g/ml), while the chloroform fraction showed pronounced activity against the yeast Candida albicans (MIC 3.12 mu g/ml). The ethyl acetate fraction exhibited a significant ferric-reducing ability (10.7mmol Fe2+/g extract), a very high DPPH radical scavenging activity (SC50=1.7 mu g/ml) and inhibition of lipid peroxidation (IC50=41.8 mu g/ml). High amounts of total phenolics (929.8mg/g), tannins (833.8mg/g) and flavonoids (35.5mg/g) were determined in the ethyl acetate fraction, which also exerted significant anti-inflammatory (76.7%) and cytotoxic effects (IC50=15.6 mu g/ml). Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Phytotherapy Research
T1  - Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop
VL  - 27
IS  - 11
SP  - 1658
EP  - 1663
DO  - 10.1002/ptr.4919
ER  - 

@article{
author = "Marčetić, Mirjana and Božić, Dragana and Milenković, Marina and Malesević, Nevenka and Radulović, Siniša and Kovačević, Nada",
year = "2013",
abstract = "In this study, we investigated the antimicrobial activity of the young shoots of the smoke tree, Cotinus coggygria Scop., Anacardiaceae. The acetone extract and the derived ethyl acetate fraction effectively inhibited the growth of Gram-positive and Gram-negative bacteria (MIC 25-200 mu g/ml), while the chloroform fraction showed pronounced activity against the yeast Candida albicans (MIC 3.12 mu g/ml). The ethyl acetate fraction exhibited a significant ferric-reducing ability (10.7mmol Fe2+/g extract), a very high DPPH radical scavenging activity (SC50=1.7 mu g/ml) and inhibition of lipid peroxidation (IC50=41.8 mu g/ml). High amounts of total phenolics (929.8mg/g), tannins (833.8mg/g) and flavonoids (35.5mg/g) were determined in the ethyl acetate fraction, which also exerted significant anti-inflammatory (76.7%) and cytotoxic effects (IC50=15.6 mu g/ml). Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytotherapy Research",
title = "Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop",
volume = "27",
number = "11",
pages = "1658-1663",
doi = "10.1002/ptr.4919"
}

Marčetić, M., Božić, D., Milenković, M., Malesević, N., Radulović, S.,& Kovačević, N.. (2013). Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop. in Phytotherapy Research
Wiley-Blackwell, Hoboken., 27(11), 1658-1663.
https://doi.org/10.1002/ptr.4919

Marčetić M, Božić D, Milenković M, Malesević N, Radulović S, Kovačević N. Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop. in Phytotherapy Research. 2013;27(11):1658-1663.
doi:10.1002/ptr.4919 .

Marčetić, Mirjana, Božić, Dragana, Milenković, Marina, Malesević, Nevenka, Radulović, Siniša, Kovačević, Nada, "Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop" in Phytotherapy Research, 27, no. 11 (2013):1658-1663,
https://doi.org/10.1002/ptr.4919 . .

TY  - CONF
AU  - Tadić, Vanja M.
AU  - Đorđević, S.
AU  - Arsić, I
AU  - Nikolić, Katarina
AU  - Gligorijević, Nevenka
AU  - Radulović, Siniša
AU  - Marković, G.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1093
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Cytotoxic activity and antioxidative properties of Sideritis scardica extracts
VL  - 74
IS  - 9
SP  - 990
EP  - 990
DO  - 10.1055/s-0028-1084204
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1093
ER  - 

@conference{
author = "Tadić, Vanja M. and Đorđević, S. and Arsić, I and Nikolić, Katarina and Gligorijević, Nevenka and Radulović, Siniša and Marković, G.",
year = "2008",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Cytotoxic activity and antioxidative properties of Sideritis scardica extracts",
volume = "74",
number = "9",
pages = "990-990",
doi = "10.1055/s-0028-1084204",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1093"
}

Tadić, V. M., Đorđević, S., Arsić, I., Nikolić, K., Gligorijević, N., Radulović, S.,& Marković, G.. (2008). Cytotoxic activity and antioxidative properties of Sideritis scardica extracts. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 74(9), 990-990.
https://doi.org/10.1055/s-0028-1084204
https://hdl.handle.net/21.15107/rcub_farfar_1093

Tadić VM, Đorđević S, Arsić I, Nikolić K, Gligorijević N, Radulović S, Marković G. Cytotoxic activity and antioxidative properties of Sideritis scardica extracts. in Planta Medica. 2008;74(9):990-990.
doi:10.1055/s-0028-1084204
https://hdl.handle.net/21.15107/rcub_farfar_1093 .

Tadić, Vanja M., Đorđević, S., Arsić, I, Nikolić, Katarina, Gligorijević, Nevenka, Radulović, Siniša, Marković, G., "Cytotoxic activity and antioxidative properties of Sideritis scardica extracts" in Planta Medica, 74, no. 9 (2008):990-990,
https://doi.org/10.1055/s-0028-1084204 .,
https://hdl.handle.net/21.15107/rcub_farfar_1093 .