TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Javorac, Dragana
AU  - Čolaković, Nataša
AU  - Oprić, Svetlana
AU  - Petričević, Simona
AU  - Granić, Miroslav
AU  - Kotur-Stevuljević, Jelena
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3915
AB  - Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.
PB  - Elsevier
T2  - Environmental Research
T1  - Cadmium tissue level in women diagnosed with breast cancer – A case control study
VL  - 199
DO  - 10.1016/j.envres.2021.111300
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Javorac, Dragana and Čolaković, Nataša and Oprić, Svetlana and Petričević, Simona and Granić, Miroslav and Kotur-Stevuljević, Jelena and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Cadmium tissue level in women diagnosed with breast cancer – A case control study",
volume = "199",
doi = "10.1016/j.envres.2021.111300"
}

Anđelković, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Javorac, D., Čolaković, N., Oprić, S., Petričević, S., Granić, M., Kotur-Stevuljević, J., Antonijević, B.,& Bulat, Z.. (2021). Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research
Elsevier., 199.
https://doi.org/10.1016/j.envres.2021.111300

Anđelković M, Buha-Đorđević A, Antonijević-Miljaković E, Javorac D, Čolaković N, Oprić S, Petričević S, Granić M, Kotur-Stevuljević J, Antonijević B, Bulat Z. Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research. 2021;199.
doi:10.1016/j.envres.2021.111300 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Javorac, Dragana, Čolaković, Nataša, Oprić, Svetlana, Petričević, Simona, Granić, Miroslav, Kotur-Stevuljević, Jelena, Antonijević, Biljana, Bulat, Zorica, "Cadmium tissue level in women diagnosed with breast cancer – A case control study" in Environmental Research, 199 (2021),
https://doi.org/10.1016/j.envres.2021.111300 . .