TY  - JOUR
AU  - Nikolić, Ines
AU  - Simić, Mitar
AU  - Pantelić, Ivana
AU  - Stojanović, Goran
AU  - Antić-Stanković, Jelena
AU  - Marković, Bojan
AU  - Savić, Snežana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4328
AB  - So far, various approaches have been proposed to improve dermal drug delivery. The
use of chemical penetration enhancers has a long history of application, while methods based on
the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to
evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded
nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration
enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were
designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety
profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min
(continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and
5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the
total amount of curcumin that penetrated through the superficial skin layers ( in vivo tape stripping)
(Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly
more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions.
Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical
contribution in the field of dermal drug application.
PB  - MDPI
T2  - Pharmaceutics
T1  - Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis
VL  - 14
IS  - 6
DO  - 10.3390/pharmaceutics14061144
ER  - 

@article{
author = "Nikolić, Ines and Simić, Mitar and Pantelić, Ivana and Stojanović, Goran and Antić-Stanković, Jelena and Marković, Bojan and Savić, Snežana",
year = "2022",
abstract = "So far, various approaches have been proposed to improve dermal drug delivery. The
use of chemical penetration enhancers has a long history of application, while methods based on
the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to
evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded
nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration
enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were
designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety
profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min
(continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and
5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the
total amount of curcumin that penetrated through the superficial skin layers ( in vivo tape stripping)
(Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly
more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions.
Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical
contribution in the field of dermal drug application.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis",
volume = "14",
number = "6",
doi = "10.3390/pharmaceutics14061144"
}

Nikolić, I., Simić, M., Pantelić, I., Stojanović, G., Antić-Stanković, J., Marković, B.,& Savić, S.. (2022). Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. in Pharmaceutics
MDPI., 14(6).
https://doi.org/10.3390/pharmaceutics14061144

Nikolić I, Simić M, Pantelić I, Stojanović G, Antić-Stanković J, Marković B, Savić S. Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. in Pharmaceutics. 2022;14(6).
doi:10.3390/pharmaceutics14061144 .

Nikolić, Ines, Simić, Mitar, Pantelić, Ivana, Stojanović, Goran, Antić-Stanković, Jelena, Marković, Bojan, Savić, Snežana, "Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis" in Pharmaceutics, 14, no. 6 (2022),
https://doi.org/10.3390/pharmaceutics14061144 . .

TY  - JOUR
AU  - Stojanović, Goran
AU  - Vasiljević-Blagojević, Milica
AU  - Bahtijari, Zulfer
AU  - Stanković, Bratislav
AU  - Terzić-Marković, Dragana
AU  - Stojanović, Dušan
AU  - Marinković, Valentina
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3272
AB  - Background/Aim. Since the beginning of competitive sports, athletes have been trying to improve their abilities by taking various substances. The problem of using prohibited substances is not strictly tied to elite athletes; it is also present in the general population. The aim of this study was to test the knowledge and attitudes of the students regarding the use of stimulative substances and dietary supplements in sports. Methods. A cross-sectional study was performed among students at the College of Health and Professional Studies in Belgrade, Serbia. The data was collected by filling in an especially designed questionnaire. Results. Knowledge of prohibited substances and methods was characterized as 'good' with 24.2% of respondents, namely 8.09% of males and 16.1% of females; knowledge of the adverse effects of prohibited substances and methods on health was demonstrated by 17.7% (9.03% of male respondents and 8.72% of female respondents). Conclusion. Student population is not knowledgeable enough about the problems of prohibited substances use and their negative effects on one's health. The comparative analysis of our and European researches on knowledge, attitudes and uses of prohibited substances show a rather uniform prevalence rate. Not being aware of the adverse effects shows the need to further educate students.
AB  - Uvod/Cilj. Sportisti oduvek u takmičarskom sportu pokušavaju da poprave svoje sposobnosti uzimanjem različitih supstanci. Problem korišćenja nedozvoljenih supstanci nije vezan isključivo za elitne sportiste, već je prisutan i u opštoj populaciji. Cilj rada bio je ispitivanje znanja i stavova studenata u vezi sa upotrebom stimulativnih supstanci i dijetetskih suplemenata u sportu. Metode. Istraživanje je srovedeno kao studija preseka kod studentske populacije u Visokoj zdravstvenoj školi strukovnih studija u Beogradu. Podaci su prikupljani popunjavanjem posebno dizajniranog upitnika. Rezultati. Dobro znanje o nedozvoljenim supstancama i metodama, pokazalo je 24,2% ispitanika (8,09% muškog pola i 16,1% ženskog pola), a o neželjenim efektima zabranjenih supstanci i metoda na zdravlje, znanje je pokazalo 17,7% ispitanika (9,03% muškog pola i 8,72% ženskog pola). Zaključak. Populacija studenata nema dovoljno znanja o problemu upotrebe nedozvoljenih supstanci i njihovim negativnim posledicama po zdravlje. Komparativna analiza našeg i evropskih istraživanja znanja, stavova i upotrebe nedozvoljenih supstanci ukazuje na približno ujednačene stope prevalencije. Nepoznavanje neželjenih efekata ukazuje na potrebu za dodatnom edukacijom studenata.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Analysis of knowledge and attitudes of the students of health and professional studies regarding the use of stimulative substances in sports
T1  - Analiza znanja i stavova studenata zdravstvenih studija o upotrebi stimulativnih supstanci u sportu
VL  - 76
IS  - 2
SP  - 144
EP  - 151
DO  - 10.2298/VSP170214078S
ER  - 

@article{
author = "Stojanović, Goran and Vasiljević-Blagojević, Milica and Bahtijari, Zulfer and Stanković, Bratislav and Terzić-Marković, Dragana and Stojanović, Dušan and Marinković, Valentina",
year = "2019",
abstract = "Background/Aim. Since the beginning of competitive sports, athletes have been trying to improve their abilities by taking various substances. The problem of using prohibited substances is not strictly tied to elite athletes; it is also present in the general population. The aim of this study was to test the knowledge and attitudes of the students regarding the use of stimulative substances and dietary supplements in sports. Methods. A cross-sectional study was performed among students at the College of Health and Professional Studies in Belgrade, Serbia. The data was collected by filling in an especially designed questionnaire. Results. Knowledge of prohibited substances and methods was characterized as 'good' with 24.2% of respondents, namely 8.09% of males and 16.1% of females; knowledge of the adverse effects of prohibited substances and methods on health was demonstrated by 17.7% (9.03% of male respondents and 8.72% of female respondents). Conclusion. Student population is not knowledgeable enough about the problems of prohibited substances use and their negative effects on one's health. The comparative analysis of our and European researches on knowledge, attitudes and uses of prohibited substances show a rather uniform prevalence rate. Not being aware of the adverse effects shows the need to further educate students., Uvod/Cilj. Sportisti oduvek u takmičarskom sportu pokušavaju da poprave svoje sposobnosti uzimanjem različitih supstanci. Problem korišćenja nedozvoljenih supstanci nije vezan isključivo za elitne sportiste, već je prisutan i u opštoj populaciji. Cilj rada bio je ispitivanje znanja i stavova studenata u vezi sa upotrebom stimulativnih supstanci i dijetetskih suplemenata u sportu. Metode. Istraživanje je srovedeno kao studija preseka kod studentske populacije u Visokoj zdravstvenoj školi strukovnih studija u Beogradu. Podaci su prikupljani popunjavanjem posebno dizajniranog upitnika. Rezultati. Dobro znanje o nedozvoljenim supstancama i metodama, pokazalo je 24,2% ispitanika (8,09% muškog pola i 16,1% ženskog pola), a o neželjenim efektima zabranjenih supstanci i metoda na zdravlje, znanje je pokazalo 17,7% ispitanika (9,03% muškog pola i 8,72% ženskog pola). Zaključak. Populacija studenata nema dovoljno znanja o problemu upotrebe nedozvoljenih supstanci i njihovim negativnim posledicama po zdravlje. Komparativna analiza našeg i evropskih istraživanja znanja, stavova i upotrebe nedozvoljenih supstanci ukazuje na približno ujednačene stope prevalencije. Nepoznavanje neželjenih efekata ukazuje na potrebu za dodatnom edukacijom studenata.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Analysis of knowledge and attitudes of the students of health and professional studies regarding the use of stimulative substances in sports, Analiza znanja i stavova studenata zdravstvenih studija o upotrebi stimulativnih supstanci u sportu",
volume = "76",
number = "2",
pages = "144-151",
doi = "10.2298/VSP170214078S"
}

Stojanović, G., Vasiljević-Blagojević, M., Bahtijari, Z., Stanković, B., Terzić-Marković, D., Stojanović, D.,& Marinković, V.. (2019). Analysis of knowledge and attitudes of the students of health and professional studies regarding the use of stimulative substances in sports. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(2), 144-151.
https://doi.org/10.2298/VSP170214078S

Stojanović G, Vasiljević-Blagojević M, Bahtijari Z, Stanković B, Terzić-Marković D, Stojanović D, Marinković V. Analysis of knowledge and attitudes of the students of health and professional studies regarding the use of stimulative substances in sports. in Vojnosanitetski pregled. 2019;76(2):144-151.
doi:10.2298/VSP170214078S .

Stojanović, Goran, Vasiljević-Blagojević, Milica, Bahtijari, Zulfer, Stanković, Bratislav, Terzić-Marković, Dragana, Stojanović, Dušan, Marinković, Valentina, "Analysis of knowledge and attitudes of the students of health and professional studies regarding the use of stimulative substances in sports" in Vojnosanitetski pregled, 76, no. 2 (2019):144-151,
https://doi.org/10.2298/VSP170214078S . .