TY  - JOUR
AU  - Madžarević, Marijana
AU  - Medarević, Đorđe
AU  - Pavlović, Stefan
AU  - Ivković, Branka
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5544
AB  - Selective laser sintering (SLS) is a rapid prototyping technique for the production of
three-dimensional objects through selectively sintering powder-based layer materials. The aim
of the study was to investigate the effect of energy density (ED) and formulation factors on the
printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors,
ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR
results revealed that there was no interaction between irbesartan and the applied excipients. DSC
results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a
significant influence on tablets’ physical, mechanical, and morphological characteristics. Adding
lactose monohydrate enabled faster drug release while reducing the possibility for printing with
different laser speeds. However, formulations with crospovidone were printable with a wider range
of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS
tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results
suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical
formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however,
it needs to be governed by the composition of the whole formulation.
PB  - MDPI
T2  - Pharmaceutics
T1  - Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model
VL  - 13
IS  - 11
SP  - 1969
DO  - 10.3390/pharmaceutics13111969
ER  - 

@article{
author = "Madžarević, Marijana and Medarević, Đorđe and Pavlović, Stefan and Ivković, Branka and Đuriš, Jelena and Ibrić, Svetlana",
year = "2021",
abstract = "Selective laser sintering (SLS) is a rapid prototyping technique for the production of
three-dimensional objects through selectively sintering powder-based layer materials. The aim
of the study was to investigate the effect of energy density (ED) and formulation factors on the
printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors,
ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR
results revealed that there was no interaction between irbesartan and the applied excipients. DSC
results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a
significant influence on tablets’ physical, mechanical, and morphological characteristics. Adding
lactose monohydrate enabled faster drug release while reducing the possibility for printing with
different laser speeds. However, formulations with crospovidone were printable with a wider range
of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS
tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results
suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical
formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however,
it needs to be governed by the composition of the whole formulation.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model",
volume = "13",
number = "11",
pages = "1969",
doi = "10.3390/pharmaceutics13111969"
}

Madžarević, M., Medarević, Đ., Pavlović, S., Ivković, B., Đuriš, J.,& Ibrić, S.. (2021). Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model. in Pharmaceutics
MDPI., 13(11), 1969.
https://doi.org/10.3390/pharmaceutics13111969

Madžarević M, Medarević Đ, Pavlović S, Ivković B, Đuriš J, Ibrić S. Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model. in Pharmaceutics. 2021;13(11):1969.
doi:10.3390/pharmaceutics13111969 .

Madžarević, Marijana, Medarević, Đorđe, Pavlović, Stefan, Ivković, Branka, Đuriš, Jelena, Ibrić, Svetlana, "Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model" in Pharmaceutics, 13, no. 11 (2021):1969,
https://doi.org/10.3390/pharmaceutics13111969 . .

TY  - JOUR
AU  - Milovanović, Stoja
AU  - Đuriš, Jelena
AU  - Dapčević, Aleksandra
AU  - Lučić-Škorić, Marija
AU  - Medarević, Đorđe
AU  - Pavlović, Stefan
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3782
AB  - This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
PB  - Springer Science and Business Media B.V.
T2  - Journal of Polymer Research
T1  - Preparation of floating polymer-valsartan delivery systems using supercritical CO2
VL  - 28
IS  - 3
DO  - 10.1007/s10965-021-02440-1
ER  - 

@article{
author = "Milovanović, Stoja and Đuriš, Jelena and Dapčević, Aleksandra and Lučić-Škorić, Marija and Medarević, Đorđe and Pavlović, Stefan and Ibrić, Svetlana",
year = "2021",
abstract = "This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.",
publisher = "Springer Science and Business Media B.V.",
journal = "Journal of Polymer Research",
title = "Preparation of floating polymer-valsartan delivery systems using supercritical CO2",
volume = "28",
number = "3",
doi = "10.1007/s10965-021-02440-1"
}

Milovanović, S., Đuriš, J., Dapčević, A., Lučić-Škorić, M., Medarević, Đ., Pavlović, S.,& Ibrić, S.. (2021). Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research
Springer Science and Business Media B.V.., 28(3).
https://doi.org/10.1007/s10965-021-02440-1

Milovanović S, Đuriš J, Dapčević A, Lučić-Škorić M, Medarević Đ, Pavlović S, Ibrić S. Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research. 2021;28(3).
doi:10.1007/s10965-021-02440-1 .

Milovanović, Stoja, Đuriš, Jelena, Dapčević, Aleksandra, Lučić-Škorić, Marija, Medarević, Đorđe, Pavlović, Stefan, Ibrić, Svetlana, "Preparation of floating polymer-valsartan delivery systems using supercritical CO2" in Journal of Polymer Research, 28, no. 3 (2021),
https://doi.org/10.1007/s10965-021-02440-1 . .

TY  - JOUR
AU  - Mudrić, Jelena
AU  - Šavikin, Katarina
AU  - Ðekić, Ljiljana
AU  - Pavlović, Stefan
AU  - Kurćubić, Ivana
AU  - Ibrić, Svetlana
AU  - Ðuriš, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4014
AB  - Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.
PB  - MDPI
T2  - Pharmaceutics
T1  - Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique
VL  - 13
IS  - 12
DO  - 10.3390/pharmaceutics13122095
ER  - 

@article{
author = "Mudrić, Jelena and Šavikin, Katarina and Ðekić, Ljiljana and Pavlović, Stefan and Kurćubić, Ivana and Ibrić, Svetlana and Ðuriš, Jelena",
year = "2021",
abstract = "Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique",
volume = "13",
number = "12",
doi = "10.3390/pharmaceutics13122095"
}

Mudrić, J., Šavikin, K., Ðekić, L., Pavlović, S., Kurćubić, I., Ibrić, S.,& Ðuriš, J.. (2021). Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique. in Pharmaceutics
MDPI., 13(12).
https://doi.org/10.3390/pharmaceutics13122095

Mudrić J, Šavikin K, Ðekić L, Pavlović S, Kurćubić I, Ibrić S, Ðuriš J. Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique. in Pharmaceutics. 2021;13(12).
doi:10.3390/pharmaceutics13122095 .

Mudrić, Jelena, Šavikin, Katarina, Ðekić, Ljiljana, Pavlović, Stefan, Kurćubić, Ivana, Ibrić, Svetlana, Ðuriš, Jelena, "Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique" in Pharmaceutics, 13, no. 12 (2021),
https://doi.org/10.3390/pharmaceutics13122095 . .