TY  - JOUR
AU  - Ivanovska, Aleksandra
AU  - Lađarević, Jelena
AU  - Asanović, Koviljka
AU  - Pavun, Leposava
AU  - Kostić, Mirjana
AU  - Mangovska, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4475
AB  - The present paper demonstrates a simple way for revalorization of differently softened cotton and cotton/elastane knitted fabric waste collected from the textile industry. Such waste was used as an adsorbent for Congo Red (CR) dye, whereby up to 96% removal efficiency was reached. The CR adsorption process onto cationic and silicone softened fabrics is in conformity with Langmuir (with maximum adsorption capacity of 12.533 mg/g) and Freundlich isotherms, respectively. Different adsorption of CR onto cationic and silicone softened fabrics is ascribed to the different softeners’ fixation to them, while the adsorption of CR operates in the same manner, via hydrophobic interactions. The adsorption kinetic data follow the pseudo-second-order model, while the equilibrium was reached after 90 min. Additionally, this study proposed a new circular economy solution for the disposal of fabric waste with adsorbed CR generating additional revenues. The volume electrical resistivity measurements confirmed that the knitted fabric wastes with adsorbed CR have 169–737 times lower resistivities (0.008–0.037 GΩ·cm) than before the adsorption. The inversely proportional correlation between fabrics’ adsorption efficiencies and their volume electrical resistivities after CR adsorption was found. Such knitted fabric waste with adsorbed CR could be defined as dissipative materials and could be used for providing antistatic protection.
PB  - Springer
T2  - Fibers and Polymers
T1  - Revalorization of Cotton and Cotton/Elastane Knitted Fabric Waste
VL  - 24
IS  - 2
SP  - 749
EP  - 758
DO  - 10.1007/s12221-023-00045-7
ER  - 

@article{
author = "Ivanovska, Aleksandra and Lađarević, Jelena and Asanović, Koviljka and Pavun, Leposava and Kostić, Mirjana and Mangovska, Biljana",
year = "2023",
abstract = "The present paper demonstrates a simple way for revalorization of differently softened cotton and cotton/elastane knitted fabric waste collected from the textile industry. Such waste was used as an adsorbent for Congo Red (CR) dye, whereby up to 96% removal efficiency was reached. The CR adsorption process onto cationic and silicone softened fabrics is in conformity with Langmuir (with maximum adsorption capacity of 12.533 mg/g) and Freundlich isotherms, respectively. Different adsorption of CR onto cationic and silicone softened fabrics is ascribed to the different softeners’ fixation to them, while the adsorption of CR operates in the same manner, via hydrophobic interactions. The adsorption kinetic data follow the pseudo-second-order model, while the equilibrium was reached after 90 min. Additionally, this study proposed a new circular economy solution for the disposal of fabric waste with adsorbed CR generating additional revenues. The volume electrical resistivity measurements confirmed that the knitted fabric wastes with adsorbed CR have 169–737 times lower resistivities (0.008–0.037 GΩ·cm) than before the adsorption. The inversely proportional correlation between fabrics’ adsorption efficiencies and their volume electrical resistivities after CR adsorption was found. Such knitted fabric waste with adsorbed CR could be defined as dissipative materials and could be used for providing antistatic protection.",
publisher = "Springer",
journal = "Fibers and Polymers",
title = "Revalorization of Cotton and Cotton/Elastane Knitted Fabric Waste",
volume = "24",
number = "2",
pages = "749-758",
doi = "10.1007/s12221-023-00045-7"
}

Ivanovska, A., Lađarević, J., Asanović, K., Pavun, L., Kostić, M.,& Mangovska, B.. (2023). Revalorization of Cotton and Cotton/Elastane Knitted Fabric Waste. in Fibers and Polymers
Springer., 24(2), 749-758.
https://doi.org/10.1007/s12221-023-00045-7

Ivanovska A, Lađarević J, Asanović K, Pavun L, Kostić M, Mangovska B. Revalorization of Cotton and Cotton/Elastane Knitted Fabric Waste. in Fibers and Polymers. 2023;24(2):749-758.
doi:10.1007/s12221-023-00045-7 .

Ivanovska, Aleksandra, Lađarević, Jelena, Asanović, Koviljka, Pavun, Leposava, Kostić, Mirjana, Mangovska, Biljana, "Revalorization of Cotton and Cotton/Elastane Knitted Fabric Waste" in Fibers and Polymers, 24, no. 2 (2023):749-758,
https://doi.org/10.1007/s12221-023-00045-7 . .

TY  - JOUR
AU  - Ivanovska, Aleksandra
AU  - Dojčinović, Biljana
AU  - Lađarević, Jelena
AU  - Pavun, Leposava
AU  - Mijin, Dušan
AU  - Kostić, Mirjana
AU  - Svetozarević, Milica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4519
AB  - This study is aimed at extending the soybean hulls' lifetime by their utilization as an adsorbent for metal ions (Cd2+ and Cu2+) and dyes (Reactive Yellow 39 (RY 39) and Acid Blue 225 (AB 225)). ATR-FTIR spectroscopy, FE-SEM microscopy, and zeta potential measurements were used for adsorbent characterization. The effect of the solution's pH, peroxidase extraction, adsorbent particle size, contact time, the pollutant's initial concentration, and temperature on the soybean hulls' adsorption potential was studied. Before peroxidase extraction, soybean hulls were capable of removing 72% Cd2+, 71% Cu2+ (at a pH of 5.00) or 81% RY 39, and 73% AB 225 (at a pH of 3.00). For further experiments, soybean hulls without peroxidase were used for several reasons: (1) due to their observed higher metal ion removal, (2) in order to reduce the waste disposal cost after the peroxidase (usually used for wastewater decolorization) extraction, and (3) since the soybean hulls without peroxidase possessed significantly lower secondary pollution than those with peroxidase. Cd2+ and Cu2+ removal was slightly increased when the smaller adsorbent fraction (710-1000 μm) was used, while the adsorbent particle size did not have an impact on dye removal. After 30 min of contact time, 92% and 88% of RY 39 and AB 225 were removed, respectively, while after the same contact time, 80% and 69% of Cd2+ and Cu2+ were removed, respectively. Adsorption of all tested pollutants follows a pseudo-second-order reaction through the fast adsorption, intraparticle diffusion, and final equilibrium stage. The maximal adsorption capacities determined by the Langmuir model were 21.10, 20.54, 16.54, and 17.23 mg/g for Cd2+, Cu2+, RY 39, and AB 225, respectively. Calculated thermodynamic parameters suggested that the adsorption of all pollutants is spontaneous and of endothermic character. Moreover, different binary mixtures were prepared, and the competitive adsorptions revealed that the soybean hulls are the most efficient adsorbent for the mixture of AB 225 and Cu2+. The findings of this study contribute to the soybean hulls' recovery after the peroxidase extraction and bring them into the circular economy concept.
PB  - Hindawi
T2  - Adsorption Science and Technology
T1  - Recovering the Soybean Hulls after Peroxidase Extraction and Their Application as Adsorbent for Metal Ions and Dyes
VL  - 2023
DO  - 10.1155/2023/8532316
ER  - 

@article{
author = "Ivanovska, Aleksandra and Dojčinović, Biljana and Lađarević, Jelena and Pavun, Leposava and Mijin, Dušan and Kostić, Mirjana and Svetozarević, Milica",
year = "2023",
abstract = "This study is aimed at extending the soybean hulls' lifetime by their utilization as an adsorbent for metal ions (Cd2+ and Cu2+) and dyes (Reactive Yellow 39 (RY 39) and Acid Blue 225 (AB 225)). ATR-FTIR spectroscopy, FE-SEM microscopy, and zeta potential measurements were used for adsorbent characterization. The effect of the solution's pH, peroxidase extraction, adsorbent particle size, contact time, the pollutant's initial concentration, and temperature on the soybean hulls' adsorption potential was studied. Before peroxidase extraction, soybean hulls were capable of removing 72% Cd2+, 71% Cu2+ (at a pH of 5.00) or 81% RY 39, and 73% AB 225 (at a pH of 3.00). For further experiments, soybean hulls without peroxidase were used for several reasons: (1) due to their observed higher metal ion removal, (2) in order to reduce the waste disposal cost after the peroxidase (usually used for wastewater decolorization) extraction, and (3) since the soybean hulls without peroxidase possessed significantly lower secondary pollution than those with peroxidase. Cd2+ and Cu2+ removal was slightly increased when the smaller adsorbent fraction (710-1000 μm) was used, while the adsorbent particle size did not have an impact on dye removal. After 30 min of contact time, 92% and 88% of RY 39 and AB 225 were removed, respectively, while after the same contact time, 80% and 69% of Cd2+ and Cu2+ were removed, respectively. Adsorption of all tested pollutants follows a pseudo-second-order reaction through the fast adsorption, intraparticle diffusion, and final equilibrium stage. The maximal adsorption capacities determined by the Langmuir model were 21.10, 20.54, 16.54, and 17.23 mg/g for Cd2+, Cu2+, RY 39, and AB 225, respectively. Calculated thermodynamic parameters suggested that the adsorption of all pollutants is spontaneous and of endothermic character. Moreover, different binary mixtures were prepared, and the competitive adsorptions revealed that the soybean hulls are the most efficient adsorbent for the mixture of AB 225 and Cu2+. The findings of this study contribute to the soybean hulls' recovery after the peroxidase extraction and bring them into the circular economy concept.",
publisher = "Hindawi",
journal = "Adsorption Science and Technology",
title = "Recovering the Soybean Hulls after Peroxidase Extraction and Their Application as Adsorbent for Metal Ions and Dyes",
volume = "2023",
doi = "10.1155/2023/8532316"
}

Ivanovska, A., Dojčinović, B., Lađarević, J., Pavun, L., Mijin, D., Kostić, M.,& Svetozarević, M.. (2023). Recovering the Soybean Hulls after Peroxidase Extraction and Their Application as Adsorbent for Metal Ions and Dyes. in Adsorption Science and Technology
Hindawi., 2023.
https://doi.org/10.1155/2023/8532316

Ivanovska A, Dojčinović B, Lađarević J, Pavun L, Mijin D, Kostić M, Svetozarević M. Recovering the Soybean Hulls after Peroxidase Extraction and Their Application as Adsorbent for Metal Ions and Dyes. in Adsorption Science and Technology. 2023;2023.
doi:10.1155/2023/8532316 .

Ivanovska, Aleksandra, Dojčinović, Biljana, Lađarević, Jelena, Pavun, Leposava, Mijin, Dušan, Kostić, Mirjana, Svetozarević, Milica, "Recovering the Soybean Hulls after Peroxidase Extraction and Their Application as Adsorbent for Metal Ions and Dyes" in Adsorption Science and Technology, 2023 (2023),
https://doi.org/10.1155/2023/8532316 . .

TY  - JOUR
AU  - Ivanovska, Aleksandra
AU  - Milošević, Marija
AU  - Lađarević, Jelena
AU  - Pavun, Leposava
AU  - Svirčev, Zorica
AU  - Kostić, Mirjana
AU  - Meriluoto, Juss
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4514
AB  - Featured Application: This work has a potential application in biocarpet engineering, which involves the use of cyanobacterial crusts either in the rehabilitation of damaged land surfaces or to combat desertification. Attempts to apply cyanobacterial crusts have not been completely successful so far because the growth of the initial inoculum requires more moisture than arid and semiarid environments can provide. To accelerate the development of the inoculum, it is necessary to provide additional moisture for the growth of cyanobacterial cells. Controlled water delivery could be achieved by using moisture-retentive material that is applied together with the inoculum in the treatment of damaged surfaces. Biocarpet engineering has the potential to solve not only some problems of damaged surfaces and desertification but also reduce and prevent air and water pollution caused by erosion. Raw jute fabric was treated with 0.5, 1.0, or 2.0% chitosan solution to improve its sorption properties (evaluated through the moisture sorption and adsorption of textile dye Reactive Orange 16 (RO 16)), which are essential for fabric utilization as geo-prebiotic polysaccharide support that should provide the necessary water for the growth of cyanobacterial communities in biocarpet engineering. Chitosan-treated fabrics possessed 39–78% higher moisture sorption values than the untreated ones. Concerning the dye adsorption, with the increase in its initial concentration, the adsorption potential of raw and fabrics treated with 0.5 or 1.0% chitosan solution was increased up to 1.9 times. The dye adsorption onto these fabrics was exothermic and enthalpy driven. By increasing the chitosan solution percentage up to 1.0%, fabric adsorption potential increased up to 2.2 times. An inverse relationship was observed in the case of the fabric treated with 2.0% chitosan solution, its adsorption potential decreased with increasing the initial dye concentration and temperature due to the different dominant binding interactions. Concerning the contact time, dye adsorption onto fabric treated with 1.0% chitosan solution was rapid in the first 2 h, while the equilibrium was attained after 4.5 h. The isotherm and kinetic data were represented by the Langmuir model and the pseudo-second-order kinetic model, respectively.
PB  - MDPI
T2  - Applied Sciences
T1  - Obtaining Polysaccharide-Based Fabrics with Improved Moisture Sorption and Dye Adsorption Properties
VL  - 13
IS  - 4
DO  - 10.3390/app13042512
ER  - 

@article{
author = "Ivanovska, Aleksandra and Milošević, Marija and Lađarević, Jelena and Pavun, Leposava and Svirčev, Zorica and Kostić, Mirjana and Meriluoto, Juss",
year = "2023",
abstract = "Featured Application: This work has a potential application in biocarpet engineering, which involves the use of cyanobacterial crusts either in the rehabilitation of damaged land surfaces or to combat desertification. Attempts to apply cyanobacterial crusts have not been completely successful so far because the growth of the initial inoculum requires more moisture than arid and semiarid environments can provide. To accelerate the development of the inoculum, it is necessary to provide additional moisture for the growth of cyanobacterial cells. Controlled water delivery could be achieved by using moisture-retentive material that is applied together with the inoculum in the treatment of damaged surfaces. Biocarpet engineering has the potential to solve not only some problems of damaged surfaces and desertification but also reduce and prevent air and water pollution caused by erosion. Raw jute fabric was treated with 0.5, 1.0, or 2.0% chitosan solution to improve its sorption properties (evaluated through the moisture sorption and adsorption of textile dye Reactive Orange 16 (RO 16)), which are essential for fabric utilization as geo-prebiotic polysaccharide support that should provide the necessary water for the growth of cyanobacterial communities in biocarpet engineering. Chitosan-treated fabrics possessed 39–78% higher moisture sorption values than the untreated ones. Concerning the dye adsorption, with the increase in its initial concentration, the adsorption potential of raw and fabrics treated with 0.5 or 1.0% chitosan solution was increased up to 1.9 times. The dye adsorption onto these fabrics was exothermic and enthalpy driven. By increasing the chitosan solution percentage up to 1.0%, fabric adsorption potential increased up to 2.2 times. An inverse relationship was observed in the case of the fabric treated with 2.0% chitosan solution, its adsorption potential decreased with increasing the initial dye concentration and temperature due to the different dominant binding interactions. Concerning the contact time, dye adsorption onto fabric treated with 1.0% chitosan solution was rapid in the first 2 h, while the equilibrium was attained after 4.5 h. The isotherm and kinetic data were represented by the Langmuir model and the pseudo-second-order kinetic model, respectively.",
publisher = "MDPI",
journal = "Applied Sciences",
title = "Obtaining Polysaccharide-Based Fabrics with Improved Moisture Sorption and Dye Adsorption Properties",
volume = "13",
number = "4",
doi = "10.3390/app13042512"
}

Ivanovska, A., Milošević, M., Lađarević, J., Pavun, L., Svirčev, Z., Kostić, M.,& Meriluoto, J.. (2023). Obtaining Polysaccharide-Based Fabrics with Improved Moisture Sorption and Dye Adsorption Properties. in Applied Sciences
MDPI., 13(4).
https://doi.org/10.3390/app13042512

Ivanovska A, Milošević M, Lađarević J, Pavun L, Svirčev Z, Kostić M, Meriluoto J. Obtaining Polysaccharide-Based Fabrics with Improved Moisture Sorption and Dye Adsorption Properties. in Applied Sciences. 2023;13(4).
doi:10.3390/app13042512 .

Ivanovska, Aleksandra, Milošević, Marija, Lađarević, Jelena, Pavun, Leposava, Svirčev, Zorica, Kostić, Mirjana, Meriluoto, Juss, "Obtaining Polysaccharide-Based Fabrics with Improved Moisture Sorption and Dye Adsorption Properties" in Applied Sciences, 13, no. 4 (2023),
https://doi.org/10.3390/app13042512 . .

TY  - CONF
AU  - Ivanovska, Aleksandra
AU  - Milenković, Jovana
AU  - Lađarević, Jelena
AU  - Pavun, Leposava
AU  - Kostić, Mirjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5234
AB  - Abstract
Green tea aqueous extract was prepared and characterized regarding total flavonoids and total
phenolic contents as well as antioxidant activity (assessed by ABTS method). The characterized
aqueous extract was used for dyeing and functionalization of 100% cotton and cotton/linen
(47%/53% and 70%/30%) fabrics. Fabric color strength (K/S) values and their antioxidant
activities before and after washing were compared. The obtained results revealed that 100%
cotton (GTI), 47%/53% cotton/linen (GTII), and 70%/30% cotton/linen (GTIII) fabrics have
K/S values ranging between 8.33 and 10.85. After one washing cycle, these values decreased
significantly. On the other hand, dyed fabrics showed excellent (100 %) ABTS radical
scavenging ability which remained excellent (GTII) or decreased to medium (GTI and GTIII)
levels after one washing cycle. Based on the obtained results, it can be concluded that 47%/53%
cotton/linen fabric is the most suitable for functional clothing capable of trapping the free radial
of oxygen species. The current paper represents a step towards a more sustainable textile
industry that could undoubtedly contribute to overcoming the environmental problems caused
by the textile industry
PB  - University of Szeged, Hungary
C3  - 29th International Symposium on Analytical and Environmental Problems, November 13-14, 2023, Szeged, Hungary, Proceedings
T1  - Obtaining colored antioxidant cotton and cotton/linen fabrics using green tea aqueous extract
SP  - 163
EP  - 166
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5234
ER  - 

@conference{
author = "Ivanovska, Aleksandra and Milenković, Jovana and Lađarević, Jelena and Pavun, Leposava and Kostić, Mirjana",
year = "2023",
abstract = "Abstract
Green tea aqueous extract was prepared and characterized regarding total flavonoids and total
phenolic contents as well as antioxidant activity (assessed by ABTS method). The characterized
aqueous extract was used for dyeing and functionalization of 100% cotton and cotton/linen
(47%/53% and 70%/30%) fabrics. Fabric color strength (K/S) values and their antioxidant
activities before and after washing were compared. The obtained results revealed that 100%
cotton (GTI), 47%/53% cotton/linen (GTII), and 70%/30% cotton/linen (GTIII) fabrics have
K/S values ranging between 8.33 and 10.85. After one washing cycle, these values decreased
significantly. On the other hand, dyed fabrics showed excellent (100 %) ABTS radical
scavenging ability which remained excellent (GTII) or decreased to medium (GTI and GTIII)
levels after one washing cycle. Based on the obtained results, it can be concluded that 47%/53%
cotton/linen fabric is the most suitable for functional clothing capable of trapping the free radial
of oxygen species. The current paper represents a step towards a more sustainable textile
industry that could undoubtedly contribute to overcoming the environmental problems caused
by the textile industry",
publisher = "University of Szeged, Hungary",
journal = "29th International Symposium on Analytical and Environmental Problems, November 13-14, 2023, Szeged, Hungary, Proceedings",
title = "Obtaining colored antioxidant cotton and cotton/linen fabrics using green tea aqueous extract",
pages = "163-166",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5234"
}

Ivanovska, A., Milenković, J., Lađarević, J., Pavun, L.,& Kostić, M.. (2023). Obtaining colored antioxidant cotton and cotton/linen fabrics using green tea aqueous extract. in 29th International Symposium on Analytical and Environmental Problems, November 13-14, 2023, Szeged, Hungary, Proceedings
University of Szeged, Hungary., 163-166.
https://hdl.handle.net/21.15107/rcub_farfar_5234

Ivanovska A, Milenković J, Lađarević J, Pavun L, Kostić M. Obtaining colored antioxidant cotton and cotton/linen fabrics using green tea aqueous extract. in 29th International Symposium on Analytical and Environmental Problems, November 13-14, 2023, Szeged, Hungary, Proceedings. 2023;:163-166.
https://hdl.handle.net/21.15107/rcub_farfar_5234 .

Ivanovska, Aleksandra, Milenković, Jovana, Lađarević, Jelena, Pavun, Leposava, Kostić, Mirjana, "Obtaining colored antioxidant cotton and cotton/linen fabrics using green tea aqueous extract" in 29th International Symposium on Analytical and Environmental Problems, November 13-14, 2023, Szeged, Hungary, Proceedings (2023):163-166,
https://hdl.handle.net/21.15107/rcub_farfar_5234 .

TY  - JOUR
AU  - Ivanovska, Aleksandra
AU  - Veljović, Sonja
AU  - Reljić, Mirjana
AU  - Lađarević, Jelena
AU  - Pavun, Leposava
AU  - Natić, Maja
AU  - Kostić, Mirjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5059
AB  - ABSTRACT
This study reports the successful transformation of mulberry wood waste
into natural textile dye and adsorbent for Pb2+ ions from an aqueous solution. Fabrics of different chemical compositions were dyed using mulberry
wood extract, whereas wool possessed the best appearance and color fastness to washing. Among differently dyed wool fabrics, those dyed with 15%
extract for 5 h has the highest color strength (K/S = 11.24) and antioxidant
activity (83.5%), and the best color and antioxidant activity fastness to
washing, making it appropriate for protecting the skin from diverse damages
by decelerating the effect of free radical. Moreover, it could be suggested
that the binding mechanism proceeds via strong hydrogen bonds between
wool surface carboxylate groups and characteristic phenolics found in the
extract (dominantly taxifolin, oxyresveratrol, ellagic acid, and tannins). The
mulberry wood solid parts separated after the extraction were further evaluated as adsorbents for Pb2+ ions. The highest lead removal was achieved at
a solution pH of 5.5, while the equilibrium removal was reached after 4 h of
contact time. At 20 mg/l initial lead concentration, the mulberry wood waste
removal efficiency was 98.8%. The results of this study represent a step
forward to a healthier, cleaner, and more sustainable society
AB  - 摘要
本研究报告了将桑木废料成功转化为天然纺织染料和水溶液中Pb2+ 离子
的吸附剂. 不同化学成分的织物用桑木提取物染色, 而羊毛的外观和耐洗色
牢度最好. 在不同染色的羊毛织物中, 用15%提取物染色5小时的羊毛织物
具有最高的颜色强度 (K/S = 11.24) 和抗氧化活性 (83.5%), 并且具有最佳的
颜色和抗氧化活性耐洗牢度, 因此适合通过减缓自由基的作用来保护皮肤
免受各种损伤. 此外, 可以认为, 结合机制是通过羊毛表面羧基和提取物中
的特征酚类 (主要是紫杉醇, 白藜芦醇, 鞣花酸和单宁) 之间的强氢键进行
的. 提取后分离的桑木固体部分被进一步评估为Pb2+ 离子的吸附剂. 在溶
液pH值为5.5时, 铅的去除率最高, 而接触时间为4小时后, 铅的去除率达到
平衡. 在20mg/l的初始铅浓度下, 桑木废弃物的去除率为98.8%. 这项研究的
结果代表着朝着一个更健康, 更清洁, 更可持续的社会迈进了一步.
PB  - Taylor & Francis
T2  - Journal of Natural Fibers
T1  - Closing the Loop: Dyeing and Adsorption Potential of Mulberry Wood Waste
VL  - 19
IS  - 15
SP  - 11050
EP  - 11063
DO  - 10.1080/15440478.2021.2009398
ER  - 

@article{
author = "Ivanovska, Aleksandra and Veljović, Sonja and Reljić, Mirjana and Lađarević, Jelena and Pavun, Leposava and Natić, Maja and Kostić, Mirjana",
year = "2022",
abstract = "ABSTRACT
This study reports the successful transformation of mulberry wood waste
into natural textile dye and adsorbent for Pb2+ ions from an aqueous solution. Fabrics of different chemical compositions were dyed using mulberry
wood extract, whereas wool possessed the best appearance and color fastness to washing. Among differently dyed wool fabrics, those dyed with 15%
extract for 5 h has the highest color strength (K/S = 11.24) and antioxidant
activity (83.5%), and the best color and antioxidant activity fastness to
washing, making it appropriate for protecting the skin from diverse damages
by decelerating the effect of free radical. Moreover, it could be suggested
that the binding mechanism proceeds via strong hydrogen bonds between
wool surface carboxylate groups and characteristic phenolics found in the
extract (dominantly taxifolin, oxyresveratrol, ellagic acid, and tannins). The
mulberry wood solid parts separated after the extraction were further evaluated as adsorbents for Pb2+ ions. The highest lead removal was achieved at
a solution pH of 5.5, while the equilibrium removal was reached after 4 h of
contact time. At 20 mg/l initial lead concentration, the mulberry wood waste
removal efficiency was 98.8%. The results of this study represent a step
forward to a healthier, cleaner, and more sustainable society, 摘要
本研究报告了将桑木废料成功转化为天然纺织染料和水溶液中Pb2+ 离子
的吸附剂. 不同化学成分的织物用桑木提取物染色, 而羊毛的外观和耐洗色
牢度最好. 在不同染色的羊毛织物中, 用15%提取物染色5小时的羊毛织物
具有最高的颜色强度 (K/S = 11.24) 和抗氧化活性 (83.5%), 并且具有最佳的
颜色和抗氧化活性耐洗牢度, 因此适合通过减缓自由基的作用来保护皮肤
免受各种损伤. 此外, 可以认为, 结合机制是通过羊毛表面羧基和提取物中
的特征酚类 (主要是紫杉醇, 白藜芦醇, 鞣花酸和单宁) 之间的强氢键进行
的. 提取后分离的桑木固体部分被进一步评估为Pb2+ 离子的吸附剂. 在溶
液pH值为5.5时, 铅的去除率最高, 而接触时间为4小时后, 铅的去除率达到
平衡. 在20mg/l的初始铅浓度下, 桑木废弃物的去除率为98.8%. 这项研究的
结果代表着朝着一个更健康, 更清洁, 更可持续的社会迈进了一步.",
publisher = "Taylor & Francis",
journal = "Journal of Natural Fibers",
title = "Closing the Loop: Dyeing and Adsorption Potential of Mulberry Wood Waste",
volume = "19",
number = "15",
pages = "11050-11063",
doi = "10.1080/15440478.2021.2009398"
}

Ivanovska, A., Veljović, S., Reljić, M., Lađarević, J., Pavun, L., Natić, M.,& Kostić, M.. (2022). Closing the Loop: Dyeing and Adsorption Potential of Mulberry Wood Waste. in Journal of Natural Fibers
Taylor & Francis., 19(15), 11050-11063.
https://doi.org/10.1080/15440478.2021.2009398

Ivanovska A, Veljović S, Reljić M, Lađarević J, Pavun L, Natić M, Kostić M. Closing the Loop: Dyeing and Adsorption Potential of Mulberry Wood Waste. in Journal of Natural Fibers. 2022;19(15):11050-11063.
doi:10.1080/15440478.2021.2009398 .

Ivanovska, Aleksandra, Veljović, Sonja, Reljić, Mirjana, Lađarević, Jelena, Pavun, Leposava, Natić, Maja, Kostić, Mirjana, "Closing the Loop: Dyeing and Adsorption Potential of Mulberry Wood Waste" in Journal of Natural Fibers, 19, no. 15 (2022):11050-11063,
https://doi.org/10.1080/15440478.2021.2009398 . .

TY  - CONF
AU  - Roganović, Maša
AU  - Cvetković, Mirjana
AU  - Gojković, Ivana
AU  - Spasojević, Brankica
AU  - Kostić, Mirjana
AU  - Miljković, Branislava
AU  - Vučićević, Katarina
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4532
AB  - Cyclosporin A (CyA) is an immunosuppressant used as part of a post-transplant
therapeutic protocol to prevent graft rejection. Due to the large pharmacokinetic variability
that characterizes it, it is necessary to conduct therapeutic drug monitoring (TDM). The aim
of the conducted research is to assess the exposure of CyA in the period of up to 3 months
after transplantation (early post-transplantation period) with the identification of factors
that influence the values of the pharmacokinetic parameters of CyA. From pediatric patients
with kidney transplants, at the University Children ́s Hospital Tiršova, data about dosage
regimens, cotherapy, and measured CyA concentrations (C0 - immediately before the next
dose and C2 - 2 hours after the morning dose) were collected retrospectively. Data were
analysed in NONMEM® (version 7.4). Twenty six patients (up to 12 years old) were
included in the analysis. The pharmacokinetic model that best described the data is a one-
compartment model with first-order absorption. Haematocrit, serum creatinine and body
mass were identified as the main factors of variability. In further analysis, it is necessary to
include data about genetic polymorphism, which is expected to have the greatest impact on
drug exposure and change the power ratio of factors that influence CyA parameter values
and concentrations.The obtained results are expected considering the characteristics of CyA.
In addition to identification, quantification of the influence of the mentioned factors is crucial
for establishing an optimal dosing regimen in the early post-transplantation period in
children, when the risk of graft rejection is the highest.
AB  - Ciklosporin A (CyA) je imunosupresiv koji se koristi kao deo posttransplantacionog
terapijskog protokola u cilju prevencije odbacivanja grafta. Zbog velike farmakokinetičke
varijabilnosti koja ga karakteriše, neophodno je sprovođenje terapijskog monitoringa
(therapeutic drug monitoring, TDM). Cilj sprovedenog istraživanja je procena izloženosti CyA
u periodu do 3 meseca nakon transplantacije (rani posttransplantacioni period) uz
identifikaciju faktora koji utiču na vrednosti farmakokinetičkih parametara CyA. Od
pedijatrijskih pacijenata sa transplantiranim bubregom, u Univerzitetskoj klinici Tiršova,
retrospektivno su prikupljani podaci o primenjenoj dozi CyA, koterapiji, izmerenim
koncentracijama CyA (C0 – neposredno pred davanje naredne doze i C2 – 2 sata nakon
jutarnje doze) i vrednostima laboratorijskih parametara od značaja. Podaci su obrađivani
upotrebom populacione farmakokinetičke analize u programu NONMEM® (verzija 7.4). U
analizu je uključeno 26 pacijenata starosti do 12 godina. Farmakokinetički model koji
najbolje opisuje dostupne podatke je jednoprostorni model sa apsorpcijom prvog reda. Kao
glavni faktori varijabilnosti identifikovani su hematokrit, serumski kreatinin i telesna masa.
U daljoj analizi, neophodno je uključiti podatke o genetskom polimorfizmu, za koje se
očekuje da će imati najveći uticaj na izloženost leku i promeniti odnos snaga faktora koji
utiču na vrednosti parametara CyA i koncentraciju. Dobijeni rezultati su očekivani imajući u
vidu karakteristike CyA. Pored identifikacije, i kvantifikacija uticaja navedenih faktora je
ključna za uspostavljanje optimalnog režima doziranja u ranom posttransplantacionom
periodu kod dece, kada je rizik od odbacivanja grafta najveći.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Assessment of cyclosporin A exposure and identification of variability factors in the early posttransplantation period
T1  - Procena izloženosti ciklosporinu a i identifikacija faktora varijabilnosti u ranom posttransplantacionom periodu
VL  - 72
IS  - 4 suplement
SP  - S304
EP  - S305
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4532
ER  - 

@conference{
author = "Roganović, Maša and Cvetković, Mirjana and Gojković, Ivana and Spasojević, Brankica and Kostić, Mirjana and Miljković, Branislava and Vučićević, Katarina",
year = "2022",
abstract = "Cyclosporin A (CyA) is an immunosuppressant used as part of a post-transplant
therapeutic protocol to prevent graft rejection. Due to the large pharmacokinetic variability
that characterizes it, it is necessary to conduct therapeutic drug monitoring (TDM). The aim
of the conducted research is to assess the exposure of CyA in the period of up to 3 months
after transplantation (early post-transplantation period) with the identification of factors
that influence the values of the pharmacokinetic parameters of CyA. From pediatric patients
with kidney transplants, at the University Children ́s Hospital Tiršova, data about dosage
regimens, cotherapy, and measured CyA concentrations (C0 - immediately before the next
dose and C2 - 2 hours after the morning dose) were collected retrospectively. Data were
analysed in NONMEM® (version 7.4). Twenty six patients (up to 12 years old) were
included in the analysis. The pharmacokinetic model that best described the data is a one-
compartment model with first-order absorption. Haematocrit, serum creatinine and body
mass were identified as the main factors of variability. In further analysis, it is necessary to
include data about genetic polymorphism, which is expected to have the greatest impact on
drug exposure and change the power ratio of factors that influence CyA parameter values
and concentrations.The obtained results are expected considering the characteristics of CyA.
In addition to identification, quantification of the influence of the mentioned factors is crucial
for establishing an optimal dosing regimen in the early post-transplantation period in
children, when the risk of graft rejection is the highest., Ciklosporin A (CyA) je imunosupresiv koji se koristi kao deo posttransplantacionog
terapijskog protokola u cilju prevencije odbacivanja grafta. Zbog velike farmakokinetičke
varijabilnosti koja ga karakteriše, neophodno je sprovođenje terapijskog monitoringa
(therapeutic drug monitoring, TDM). Cilj sprovedenog istraživanja je procena izloženosti CyA
u periodu do 3 meseca nakon transplantacije (rani posttransplantacioni period) uz
identifikaciju faktora koji utiču na vrednosti farmakokinetičkih parametara CyA. Od
pedijatrijskih pacijenata sa transplantiranim bubregom, u Univerzitetskoj klinici Tiršova,
retrospektivno su prikupljani podaci o primenjenoj dozi CyA, koterapiji, izmerenim
koncentracijama CyA (C0 – neposredno pred davanje naredne doze i C2 – 2 sata nakon
jutarnje doze) i vrednostima laboratorijskih parametara od značaja. Podaci su obrađivani
upotrebom populacione farmakokinetičke analize u programu NONMEM® (verzija 7.4). U
analizu je uključeno 26 pacijenata starosti do 12 godina. Farmakokinetički model koji
najbolje opisuje dostupne podatke je jednoprostorni model sa apsorpcijom prvog reda. Kao
glavni faktori varijabilnosti identifikovani su hematokrit, serumski kreatinin i telesna masa.
U daljoj analizi, neophodno je uključiti podatke o genetskom polimorfizmu, za koje se
očekuje da će imati najveći uticaj na izloženost leku i promeniti odnos snaga faktora koji
utiču na vrednosti parametara CyA i koncentraciju. Dobijeni rezultati su očekivani imajući u
vidu karakteristike CyA. Pored identifikacije, i kvantifikacija uticaja navedenih faktora je
ključna za uspostavljanje optimalnog režima doziranja u ranom posttransplantacionom
periodu kod dece, kada je rizik od odbacivanja grafta najveći.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Assessment of cyclosporin A exposure and identification of variability factors in the early posttransplantation period, Procena izloženosti ciklosporinu a i identifikacija faktora varijabilnosti u ranom posttransplantacionom periodu",
volume = "72",
number = "4 suplement",
pages = "S304-S305",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4532"
}

Roganović, M., Cvetković, M., Gojković, I., Spasojević, B., Kostić, M., Miljković, B.,& Vučićević, K.. (2022). Assessment of cyclosporin A exposure and identification of variability factors in the early posttransplantation period. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S304-S305.
https://hdl.handle.net/21.15107/rcub_farfar_4532

Roganović M, Cvetković M, Gojković I, Spasojević B, Kostić M, Miljković B, Vučićević K. Assessment of cyclosporin A exposure and identification of variability factors in the early posttransplantation period. in Arhiv za farmaciju. 2022;72(4 suplement):S304-S305.
https://hdl.handle.net/21.15107/rcub_farfar_4532 .

Roganović, Maša, Cvetković, Mirjana, Gojković, Ivana, Spasojević, Brankica, Kostić, Mirjana, Miljković, Branislava, Vučićević, Katarina, "Assessment of cyclosporin A exposure and identification of variability factors in the early posttransplantation period" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S304-S305,
https://hdl.handle.net/21.15107/rcub_farfar_4532 .

TY  - CONF
AU  - Ivanovska, Aleksandra
AU  - Asanović, Koviljka
AU  - Cerović, Dragana
AU  - Pavun, Leposava
AU  - Dojčinović, Biljana
AU  - Mihajlovski, Katarina
AU  - Kostić, Mirjana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5214
AB  - This study aims to obtain multifunctional jute fabrics by using simple alkali
and oxidative protocols. Performed chemical treatments contributed to obtaining jute fabrics
with enhanced electro-physical and sorption properties. Moreover, the jute fabrics were
functionalized by incorporation of Ag+ (resulted in decreased volume electrical resistivity
and excellent antibacterial activity) and in-situ synthesis of Cu-based nanoparticles (resulted
in 38-88 times higher energy storage from an external electric field). Following the increased
focus on the concept of circular economy, the possibility of jute fabric waste revalorization
for wastewater purification (from Cu2+, Zn2+, Ni2+) was examined.
AB  - Cilj ovog istraživanja je dobijanje multifunkcionalnih tkanina od jute
upotrebom jednostavnih alkalnih i oksidativnih postupaka. Ovi hemijski tretmani omogućili
su dobijanje tkanina od jute sa poboljšanim elektro-fizičkim i sorpcionim svojstvima.
Tkanine od jute su, takođe, bile funkcionalizovane jonima srebra (što je rezultovalo
smanjenom specifičnom zapreminskom električnom otpornošću i odličnom antibakterijskom
aktivnošću) i in-situ sintezom nanočestica na bazi bakra (što je rezultovalo 38-88 puta većim
skladištenjem energije iz spoljašnjeg električnog polja). U skladu sa načelima cirkularne
ekonomije, ispitana je mogućnost revalorizacije otpada tkanina od jute za prečišćavanje
otpadnih voda (od Cu2+, Zn2+, Ni2+- jona).
PB  - Union of Engineers and Textile Technicians of Serbia
C3  - IV International Scientific Conference "Contemporary Trends and Innovations in the Textile Industry", CT&ITI 2021, Belgrade, 16-17 th September, 2021, Proceedings
T1  - Simple protocols for obtaining multifunctional jute fabrics
T1  - Jednostavni postupci za dobijanje multifunkcionalnih tkanina od jute
SP  - 3
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5214
ER  - 

@conference{
author = "Ivanovska, Aleksandra and Asanović, Koviljka and Cerović, Dragana and Pavun, Leposava and Dojčinović, Biljana and Mihajlovski, Katarina and Kostić, Mirjana",
year = "2021",
abstract = "This study aims to obtain multifunctional jute fabrics by using simple alkali
and oxidative protocols. Performed chemical treatments contributed to obtaining jute fabrics
with enhanced electro-physical and sorption properties. Moreover, the jute fabrics were
functionalized by incorporation of Ag+ (resulted in decreased volume electrical resistivity
and excellent antibacterial activity) and in-situ synthesis of Cu-based nanoparticles (resulted
in 38-88 times higher energy storage from an external electric field). Following the increased
focus on the concept of circular economy, the possibility of jute fabric waste revalorization
for wastewater purification (from Cu2+, Zn2+, Ni2+) was examined., Cilj ovog istraživanja je dobijanje multifunkcionalnih tkanina od jute
upotrebom jednostavnih alkalnih i oksidativnih postupaka. Ovi hemijski tretmani omogućili
su dobijanje tkanina od jute sa poboljšanim elektro-fizičkim i sorpcionim svojstvima.
Tkanine od jute su, takođe, bile funkcionalizovane jonima srebra (što je rezultovalo
smanjenom specifičnom zapreminskom električnom otpornošću i odličnom antibakterijskom
aktivnošću) i in-situ sintezom nanočestica na bazi bakra (što je rezultovalo 38-88 puta većim
skladištenjem energije iz spoljašnjeg električnog polja). U skladu sa načelima cirkularne
ekonomije, ispitana je mogućnost revalorizacije otpada tkanina od jute za prečišćavanje
otpadnih voda (od Cu2+, Zn2+, Ni2+- jona).",
publisher = "Union of Engineers and Textile Technicians of Serbia",
journal = "IV International Scientific Conference "Contemporary Trends and Innovations in the Textile Industry", CT&ITI 2021, Belgrade, 16-17 th September, 2021, Proceedings",
title = "Simple protocols for obtaining multifunctional jute fabrics, Jednostavni postupci za dobijanje multifunkcionalnih tkanina od jute",
pages = "3-12",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5214"
}

Ivanovska, A., Asanović, K., Cerović, D., Pavun, L., Dojčinović, B., Mihajlovski, K.,& Kostić, M.. (2021). Simple protocols for obtaining multifunctional jute fabrics. in IV International Scientific Conference "Contemporary Trends and Innovations in the Textile Industry", CT&ITI 2021, Belgrade, 16-17 th September, 2021, Proceedings
Union of Engineers and Textile Technicians of Serbia., 3-12.
https://hdl.handle.net/21.15107/rcub_farfar_5214

Ivanovska A, Asanović K, Cerović D, Pavun L, Dojčinović B, Mihajlovski K, Kostić M. Simple protocols for obtaining multifunctional jute fabrics. in IV International Scientific Conference "Contemporary Trends and Innovations in the Textile Industry", CT&ITI 2021, Belgrade, 16-17 th September, 2021, Proceedings. 2021;:3-12.
https://hdl.handle.net/21.15107/rcub_farfar_5214 .

Ivanovska, Aleksandra, Asanović, Koviljka, Cerović, Dragana, Pavun, Leposava, Dojčinović, Biljana, Mihajlovski, Katarina, Kostić, Mirjana, "Simple protocols for obtaining multifunctional jute fabrics" in IV International Scientific Conference "Contemporary Trends and Innovations in the Textile Industry", CT&ITI 2021, Belgrade, 16-17 th September, 2021, Proceedings (2021):3-12,
https://hdl.handle.net/21.15107/rcub_farfar_5214 .

TY  - CONF
AU  - Roganović, Maša
AU  - Cvetković, Mirjana
AU  - Gojković, Ivana
AU  - Spasojević, Brankica
AU  - Kostić, Mirjana
AU  - Miljković, Branislava
AU  - Vučićević, Katarina
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4819
AB  - Introduction: Cyclosporine (CyA), an immunosuppressive agent, is mandatory part of post-transplantation therapy protocols. CyA shows large interindividual and intraindividual pharmacokinetic (PK) variability, has a narrow therapeutic range and several factors has already been identified as sources of variability. Proactive dosing strategies to achieve and maintain predefined CyA levels, via therapeutic drug monitoring (TDM), may prevent graft rejection and minimize serious side effects [1,2]. Data obtained during TDM can be used for describing PK model on both population and individual level while taking into account individual characteristics. Furthermore, that model could inform optimal CyA dosing via Bayesian-TDM approach.

Objectives: We aimed in developing CyA population PK model and address sources of PK variabilities in order to explain observable differences in the concentrations of the drug. In addition, the objective of the study is to assess the effect of PK on the response to CyA therapy using modelling approach. 

Methods: Data regarding dosage regimens, CyA blood concentrations, concomitant medications and laboratory findings of significance in kidney transplant paediatric patients were collected from their medical history. Drug concentration was measured in whole blood samples, and the samples were drawn before (Ctrough) and 2 hours after the morning dose (C2). Population pharmacokinetic analyses was performed using nonlinear mixed effects modelling software – NONMEM® (version 7.4) with first-order conditional estimation method with interaction (FOCE-I). NONMEM outputs were handled in R software (graphical diagnostics). We tried fitting one- and two-compartment to concentration-time data. Covariate model building was performed using stepwise covariate procedure (SCM). Covariates that were tested are age, weight (WT), serum creatinine levels (CR) haematocrit (HCT) (continuous covariates). Influence of categorical covariates was also examined – gender (GEND) and type of transplanted graft - live or cadaveric transplantation (TRANS). Model appropriateness has been performed using numerical and visual approaches.

Results: : In total, 58 patients aged 2-25 years (mean± sd: 12.46±0.78), mainly paediatrics (79.31% up to 18 years) were included in the analysis. We have analysed 496 concentrations obtained during up to one year post-transplant period. Mean values of C0 and C2 are 126.1±4.37 ng/ml and 825.8±20.32 ng/ml, respectively. One-compartment model with first order absorption best described the data. Typical values of clearance (CL), volume (V), and absorption rate constant (Ka) from covariate model were 14.2 L/h, 1.94 L/kg, 1.3 1/h, respectively. Tested PK parameter-covariate relations that caused the significant drop in objective function value are influence of WT, CR and HCT on CL, and WT on volume V. Interindividual variability (IIV) on CL and V, after inclusion of covariates was 22.6 % and 25.3% (in the base model the IIV was 33.5% and 36.5%, respectively). In the further analyses, population pharmacokinetic/pharmacodynamic (popPK/PD) will be developed.

Conclusions: The results regarding PK parameters are in accordance with a published study in a similar population (paediatric transplant patients) [3]. Knowing individual parameters values can help maximize the benefits of drug therapy and minimize side effects, which is a cornerstone of safe and effective therapy.


References:
[1] Midtvedt K. Therapeutic drug monitoring of cyclosporine. Transplant Proc. 2004;36(2 Suppl):430S-433S. doi:10.1016/j.transproceed.2004.01.025.
[2] Kang JS, Lee MH. Overview of therapeutic drug monitoring. Korean J Intern Med. 2009;24(1):1-10. doi:10.3904/kjim.2009.24.1.1
[3] Fanta S, Jönsson S, Backman JT, Karlsson MO, Hoppu K. Developmental pharmacokinetics of ciclosporin-a population pharmacokinetic study in paediatric renal transplant candidates. Br J Clin Pharmacol. 2007;64(6):772-84. doi: 10.1111/j.1365-2125.2007.03003.x
C3  - Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe
T1  - Population pharmacokinetic modelling of cyclosporine in paediatric kidney transplant patients using routine TDM data
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4819
ER  - 

@conference{
author = "Roganović, Maša and Cvetković, Mirjana and Gojković, Ivana and Spasojević, Brankica and Kostić, Mirjana and Miljković, Branislava and Vučićević, Katarina",
year = "2021",
abstract = "Introduction: Cyclosporine (CyA), an immunosuppressive agent, is mandatory part of post-transplantation therapy protocols. CyA shows large interindividual and intraindividual pharmacokinetic (PK) variability, has a narrow therapeutic range and several factors has already been identified as sources of variability. Proactive dosing strategies to achieve and maintain predefined CyA levels, via therapeutic drug monitoring (TDM), may prevent graft rejection and minimize serious side effects [1,2]. Data obtained during TDM can be used for describing PK model on both population and individual level while taking into account individual characteristics. Furthermore, that model could inform optimal CyA dosing via Bayesian-TDM approach.

Objectives: We aimed in developing CyA population PK model and address sources of PK variabilities in order to explain observable differences in the concentrations of the drug. In addition, the objective of the study is to assess the effect of PK on the response to CyA therapy using modelling approach. 

Methods: Data regarding dosage regimens, CyA blood concentrations, concomitant medications and laboratory findings of significance in kidney transplant paediatric patients were collected from their medical history. Drug concentration was measured in whole blood samples, and the samples were drawn before (Ctrough) and 2 hours after the morning dose (C2). Population pharmacokinetic analyses was performed using nonlinear mixed effects modelling software – NONMEM® (version 7.4) with first-order conditional estimation method with interaction (FOCE-I). NONMEM outputs were handled in R software (graphical diagnostics). We tried fitting one- and two-compartment to concentration-time data. Covariate model building was performed using stepwise covariate procedure (SCM). Covariates that were tested are age, weight (WT), serum creatinine levels (CR) haematocrit (HCT) (continuous covariates). Influence of categorical covariates was also examined – gender (GEND) and type of transplanted graft - live or cadaveric transplantation (TRANS). Model appropriateness has been performed using numerical and visual approaches.

Results: : In total, 58 patients aged 2-25 years (mean± sd: 12.46±0.78), mainly paediatrics (79.31% up to 18 years) were included in the analysis. We have analysed 496 concentrations obtained during up to one year post-transplant period. Mean values of C0 and C2 are 126.1±4.37 ng/ml and 825.8±20.32 ng/ml, respectively. One-compartment model with first order absorption best described the data. Typical values of clearance (CL), volume (V), and absorption rate constant (Ka) from covariate model were 14.2 L/h, 1.94 L/kg, 1.3 1/h, respectively. Tested PK parameter-covariate relations that caused the significant drop in objective function value are influence of WT, CR and HCT on CL, and WT on volume V. Interindividual variability (IIV) on CL and V, after inclusion of covariates was 22.6 % and 25.3% (in the base model the IIV was 33.5% and 36.5%, respectively). In the further analyses, population pharmacokinetic/pharmacodynamic (popPK/PD) will be developed.

Conclusions: The results regarding PK parameters are in accordance with a published study in a similar population (paediatric transplant patients) [3]. Knowing individual parameters values can help maximize the benefits of drug therapy and minimize side effects, which is a cornerstone of safe and effective therapy.


References:
[1] Midtvedt K. Therapeutic drug monitoring of cyclosporine. Transplant Proc. 2004;36(2 Suppl):430S-433S. doi:10.1016/j.transproceed.2004.01.025.
[2] Kang JS, Lee MH. Overview of therapeutic drug monitoring. Korean J Intern Med. 2009;24(1):1-10. doi:10.3904/kjim.2009.24.1.1
[3] Fanta S, Jönsson S, Backman JT, Karlsson MO, Hoppu K. Developmental pharmacokinetics of ciclosporin-a population pharmacokinetic study in paediatric renal transplant candidates. Br J Clin Pharmacol. 2007;64(6):772-84. doi: 10.1111/j.1365-2125.2007.03003.x",
journal = "Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe",
title = "Population pharmacokinetic modelling of cyclosporine in paediatric kidney transplant patients using routine TDM data",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4819"
}

Roganović, M., Cvetković, M., Gojković, I., Spasojević, B., Kostić, M., Miljković, B.,& Vučićević, K.. (2021). Population pharmacokinetic modelling of cyclosporine in paediatric kidney transplant patients using routine TDM data. in Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe.
https://hdl.handle.net/21.15107/rcub_farfar_4819

Roganović M, Cvetković M, Gojković I, Spasojević B, Kostić M, Miljković B, Vučićević K. Population pharmacokinetic modelling of cyclosporine in paediatric kidney transplant patients using routine TDM data. in Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_4819 .

Roganović, Maša, Cvetković, Mirjana, Gojković, Ivana, Spasojević, Brankica, Kostić, Mirjana, Miljković, Branislava, Vučićević, Katarina, "Population pharmacokinetic modelling of cyclosporine in paediatric kidney transplant patients using routine TDM data" in Page. Abstracts of the Annual Meeting of the Population Approach Group in Europe (2021),
https://hdl.handle.net/21.15107/rcub_farfar_4819 .

TY  - JOUR
AU  - Ivanovska, A.
AU  - Dojčinović, Biljana
AU  - Maletić, S.
AU  - Pavun, Leposava
AU  - Asanović, Koviljka
AU  - Kostić, Mirjana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3718
AB  - The influence of the chemical composition on the biosorption potential of waste jute fabric for Ni2+, Cu2+, and Zn2+ was investigated. The raw jute fabric was treated with sodium hydroxide or sodium chlorite to selectively remove hemicelluloses and lignin, respectively. All jute fabrics were characterized by determination of their chemical composition as well as functional group content. The effects of solution pH, contact time, and initial metal ion concentration on the biosorption from monometallic and polymetallic solution by jute fabrics were investigated. The maximum biosorption capacity for all heavy metal ions was observed at pH 5.5. Concerning the contact time, the raw jute fabric shows more than 72 % of the total uptake capacity of Ni2+, Cu2+, and Zn2+ within 1 h, while the jute fabrics with lower hemicelluloses and lignin content show between 72–85 % of the total uptake capacity within 3 h. Increased initial metal ion concentration from 10 to 20 mg/l in monometallic solution caused an increase in the total uptake capacity of jute fabrics with lower hemicelluloses and lignin content for 47–69 % (Ni2+), 42–63 % (Cu2+), and 22–37 % (Zn2+). The biosorption capacity of alkali treated jute fabrics was affected by the changes in the total amount of carboxyl and aldehyde groups that accompany the hemicelluloses removal. In the case of the oxidative treatment, the biosorption capacity was affected by the lignin content as well as the amount of introduced carboxyl groups. The best biosorption performance possesses jute fabric with 63.2 % lower lignin content as well as 81.1 % higher amount of carboxyl groups; biosorption capacity toward Ni2+, Cu2+, and Zn2+ in monometallic solution is about 2.4; 2.2 and 3.5 times higher compared to the raw jute fabric, respectively. All jute fabrics exhibited the same affinity order (which is independent on the initial metal ion concentrations) toward heavy metal ions: Ni2+ > Cu2+ > Zn2+ in the case of competitive biosorption. An increase in the initial metal ion concentration for two times in the polymetallic solution caused about a 35–59 % increase in the total uptake capacity of Ni2+, while the total uptake capacities of Cu2+ and Zn2+ increased for 19–38 % and 18–65 %, respectively.
PB  - Korean Fiber Society
T2  - Fibers and Polymers
T1  - Waste Jute Fabric as a Biosorbent for Heavy Metal Ions from Aqueous Solution
VL  - 21
IS  - 9
SP  - 1992
EP  - 2002
DO  - 10.1007/s12221-020-9639-8
ER  - 

@article{
author = "Ivanovska, A. and Dojčinović, Biljana and Maletić, S. and Pavun, Leposava and Asanović, Koviljka and Kostić, Mirjana",
year = "2020",
abstract = "The influence of the chemical composition on the biosorption potential of waste jute fabric for Ni2+, Cu2+, and Zn2+ was investigated. The raw jute fabric was treated with sodium hydroxide or sodium chlorite to selectively remove hemicelluloses and lignin, respectively. All jute fabrics were characterized by determination of their chemical composition as well as functional group content. The effects of solution pH, contact time, and initial metal ion concentration on the biosorption from monometallic and polymetallic solution by jute fabrics were investigated. The maximum biosorption capacity for all heavy metal ions was observed at pH 5.5. Concerning the contact time, the raw jute fabric shows more than 72 % of the total uptake capacity of Ni2+, Cu2+, and Zn2+ within 1 h, while the jute fabrics with lower hemicelluloses and lignin content show between 72–85 % of the total uptake capacity within 3 h. Increased initial metal ion concentration from 10 to 20 mg/l in monometallic solution caused an increase in the total uptake capacity of jute fabrics with lower hemicelluloses and lignin content for 47–69 % (Ni2+), 42–63 % (Cu2+), and 22–37 % (Zn2+). The biosorption capacity of alkali treated jute fabrics was affected by the changes in the total amount of carboxyl and aldehyde groups that accompany the hemicelluloses removal. In the case of the oxidative treatment, the biosorption capacity was affected by the lignin content as well as the amount of introduced carboxyl groups. The best biosorption performance possesses jute fabric with 63.2 % lower lignin content as well as 81.1 % higher amount of carboxyl groups; biosorption capacity toward Ni2+, Cu2+, and Zn2+ in monometallic solution is about 2.4; 2.2 and 3.5 times higher compared to the raw jute fabric, respectively. All jute fabrics exhibited the same affinity order (which is independent on the initial metal ion concentrations) toward heavy metal ions: Ni2+ > Cu2+ > Zn2+ in the case of competitive biosorption. An increase in the initial metal ion concentration for two times in the polymetallic solution caused about a 35–59 % increase in the total uptake capacity of Ni2+, while the total uptake capacities of Cu2+ and Zn2+ increased for 19–38 % and 18–65 %, respectively.",
publisher = "Korean Fiber Society",
journal = "Fibers and Polymers",
title = "Waste Jute Fabric as a Biosorbent for Heavy Metal Ions from Aqueous Solution",
volume = "21",
number = "9",
pages = "1992-2002",
doi = "10.1007/s12221-020-9639-8"
}

Ivanovska, A., Dojčinović, B., Maletić, S., Pavun, L., Asanović, K.,& Kostić, M.. (2020). Waste Jute Fabric as a Biosorbent for Heavy Metal Ions from Aqueous Solution. in Fibers and Polymers
Korean Fiber Society., 21(9), 1992-2002.
https://doi.org/10.1007/s12221-020-9639-8

Ivanovska A, Dojčinović B, Maletić S, Pavun L, Asanović K, Kostić M. Waste Jute Fabric as a Biosorbent for Heavy Metal Ions from Aqueous Solution. in Fibers and Polymers. 2020;21(9):1992-2002.
doi:10.1007/s12221-020-9639-8 .

Ivanovska, A., Dojčinović, Biljana, Maletić, S., Pavun, Leposava, Asanović, Koviljka, Kostić, Mirjana, "Waste Jute Fabric as a Biosorbent for Heavy Metal Ions from Aqueous Solution" in Fibers and Polymers, 21, no. 9 (2020):1992-2002,
https://doi.org/10.1007/s12221-020-9639-8 . .

TY  - JOUR
AU  - Ivanovska, A.
AU  - Asanović, Koviljka
AU  - Jankoska, Maja
AU  - Mihajlovski, Katarina
AU  - Pavun, Leposava
AU  - Kostić, Mirjana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3646
AB  - Abstract: The aim of the present research is first to reduce the jute fabric non-cellulosic components by using different chemical modifications (i.e. alkali and oxidative) and then to analyze their influence on the jute fabric properties. For that purpose, the jute fabrics were characterized in terms of their chemical composition, structural parameters, mechanical properties, volume electrical resistivity, antibacterial activity and biosorption of Zn2+. Moreover, the jute fabrics were functionalized by incorporation of silver ions and the fabrics were evaluated as sorption material with a further perspective of reuse. After the alkali modifications, the hemicelluloses were selectively removed and the fabric structural parameters increased. Alkali modifications under mild conditions (1% NaOH for 30 min and 5% NaOH for 5 min) lead to a decrease, while the most intensive alkali modification (17.5% NaOH for 30 min) contributed to an increase in the volume electrical resistivity and fabric maximum force compared to unmodified fabric. A relationship between the jute fabric chemical composition, crystallinity index, conversion of cellulose I to cellulose II, fabric structural parameters and volume electrical resistivity was found. The oxidations lead to selective lignin removal, which consequently causes a decrease in the volume electrical resistivity and fabric maximum force. Ag+ incorporated in the selected samples decreased their electrical resistivity even further. Following the increased focus on the concept of circular economy and sustainable development goals, the biosorption potential of damaged and waste jute fabrics for Zn2+ was investigated. Jute fabrics with incorporated Ag+ and those obtained after the biosorption of Zn2+ provided maximum bacterial reduction (99.99%) for Escherichia coli and Staphylococcus aureus. The chemically modified jute fabrics can be utilized as carpet backing and protective clothing in environments sensitive to electrical discharges, but also as filters for water disinfection and biosorbents for Zn2+.Graphic abstract: [Figure not available: see fulltext.].
PB  - Springer Nature B.V.
T2  - Cellulose
T1  - Multifunctional jute fabrics obtained by different chemical modifications
VL  - 27
SP  - 8485
EP  - 8502
DO  - 10.1007/s10570-020-03360-x
ER  - 

@article{
author = "Ivanovska, A. and Asanović, Koviljka and Jankoska, Maja and Mihajlovski, Katarina and Pavun, Leposava and Kostić, Mirjana",
year = "2020",
abstract = "Abstract: The aim of the present research is first to reduce the jute fabric non-cellulosic components by using different chemical modifications (i.e. alkali and oxidative) and then to analyze their influence on the jute fabric properties. For that purpose, the jute fabrics were characterized in terms of their chemical composition, structural parameters, mechanical properties, volume electrical resistivity, antibacterial activity and biosorption of Zn2+. Moreover, the jute fabrics were functionalized by incorporation of silver ions and the fabrics were evaluated as sorption material with a further perspective of reuse. After the alkali modifications, the hemicelluloses were selectively removed and the fabric structural parameters increased. Alkali modifications under mild conditions (1% NaOH for 30 min and 5% NaOH for 5 min) lead to a decrease, while the most intensive alkali modification (17.5% NaOH for 30 min) contributed to an increase in the volume electrical resistivity and fabric maximum force compared to unmodified fabric. A relationship between the jute fabric chemical composition, crystallinity index, conversion of cellulose I to cellulose II, fabric structural parameters and volume electrical resistivity was found. The oxidations lead to selective lignin removal, which consequently causes a decrease in the volume electrical resistivity and fabric maximum force. Ag+ incorporated in the selected samples decreased their electrical resistivity even further. Following the increased focus on the concept of circular economy and sustainable development goals, the biosorption potential of damaged and waste jute fabrics for Zn2+ was investigated. Jute fabrics with incorporated Ag+ and those obtained after the biosorption of Zn2+ provided maximum bacterial reduction (99.99%) for Escherichia coli and Staphylococcus aureus. The chemically modified jute fabrics can be utilized as carpet backing and protective clothing in environments sensitive to electrical discharges, but also as filters for water disinfection and biosorbents for Zn2+.Graphic abstract: [Figure not available: see fulltext.].",
publisher = "Springer Nature B.V.",
journal = "Cellulose",
title = "Multifunctional jute fabrics obtained by different chemical modifications",
volume = "27",
pages = "8485-8502",
doi = "10.1007/s10570-020-03360-x"
}

Ivanovska, A., Asanović, K., Jankoska, M., Mihajlovski, K., Pavun, L.,& Kostić, M.. (2020). Multifunctional jute fabrics obtained by different chemical modifications. in Cellulose
Springer Nature B.V.., 27, 8485-8502.
https://doi.org/10.1007/s10570-020-03360-x

Ivanovska A, Asanović K, Jankoska M, Mihajlovski K, Pavun L, Kostić M. Multifunctional jute fabrics obtained by different chemical modifications. in Cellulose. 2020;27:8485-8502.
doi:10.1007/s10570-020-03360-x .

Ivanovska, A., Asanović, Koviljka, Jankoska, Maja, Mihajlovski, Katarina, Pavun, Leposava, Kostić, Mirjana, "Multifunctional jute fabrics obtained by different chemical modifications" in Cellulose, 27 (2020):8485-8502,
https://doi.org/10.1007/s10570-020-03360-x . .

TY  - JOUR
AU  - Kramar, Ana
AU  - Ilić-Tomić, Tatjana
AU  - Petković, Miloš
AU  - Radulović, Niko
AU  - Kostić, Mirjana
AU  - Jocić, Dragan
AU  - Nikodinović-Runić, Jasmina
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2214
AB  - Renewed demand for incorporation of natural dyes (bio-colorants) in textile industry could be met through biotechnological production of bacterial pigments. Two new Streptomyces strains (NP2 and NP4) were isolated for the remarkable ability to produce diffusible deep blue and deep red pigment into fermentation medium. Crude mycelial extracts of both strains were used as bio-colorants in conventional textile dyeing procedures avoiding downstream purification procedures. The yields of bio-colorants obtained in this way were 62 and 84 mg per g of mycelia for Streptomyces sp. NP2 and Streptomyces sp. NP4, respectively. Through nuclear magnetic resonance analysis of crude extracts before and after dyeing procedures, it was shown that both extracts contained prodigiosin-like family of compounds that exhibited different dyeing capabilities towards different textile fibers. Polyamide and acrylic fibers were colored to the deepest shade, polyester and triacetate fibers to a noticeable, but much lower shade depth, while cotton and cellulosic fibers stained weakly. These results confirmed that crude bacterial extracts had the characteristics similar to those of ionic and disperse dyes, which was consistent with the identified polypyrrolic prodigiosin-like structures.
PB  - Springer, New York
T2  - Yakugaku Zasshi - Journal of the Pharmaceutical Society of Japan
T1  - Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing
VL  - 30
IS  - 8
SP  - 2231
EP  - 2240
DO  - 10.1007/s11274-014-1644-x
ER  - 

@article{
author = "Kramar, Ana and Ilić-Tomić, Tatjana and Petković, Miloš and Radulović, Niko and Kostić, Mirjana and Jocić, Dragan and Nikodinović-Runić, Jasmina",
year = "2014",
abstract = "Renewed demand for incorporation of natural dyes (bio-colorants) in textile industry could be met through biotechnological production of bacterial pigments. Two new Streptomyces strains (NP2 and NP4) were isolated for the remarkable ability to produce diffusible deep blue and deep red pigment into fermentation medium. Crude mycelial extracts of both strains were used as bio-colorants in conventional textile dyeing procedures avoiding downstream purification procedures. The yields of bio-colorants obtained in this way were 62 and 84 mg per g of mycelia for Streptomyces sp. NP2 and Streptomyces sp. NP4, respectively. Through nuclear magnetic resonance analysis of crude extracts before and after dyeing procedures, it was shown that both extracts contained prodigiosin-like family of compounds that exhibited different dyeing capabilities towards different textile fibers. Polyamide and acrylic fibers were colored to the deepest shade, polyester and triacetate fibers to a noticeable, but much lower shade depth, while cotton and cellulosic fibers stained weakly. These results confirmed that crude bacterial extracts had the characteristics similar to those of ionic and disperse dyes, which was consistent with the identified polypyrrolic prodigiosin-like structures.",
publisher = "Springer, New York",
journal = "Yakugaku Zasshi - Journal of the Pharmaceutical Society of Japan",
title = "Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing",
volume = "30",
number = "8",
pages = "2231-2240",
doi = "10.1007/s11274-014-1644-x"
}

Kramar, A., Ilić-Tomić, T., Petković, M., Radulović, N., Kostić, M., Jocić, D.,& Nikodinović-Runić, J.. (2014). Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing. in Yakugaku Zasshi - Journal of the Pharmaceutical Society of Japan
Springer, New York., 30(8), 2231-2240.
https://doi.org/10.1007/s11274-014-1644-x

Kramar A, Ilić-Tomić T, Petković M, Radulović N, Kostić M, Jocić D, Nikodinović-Runić J. Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing. in Yakugaku Zasshi - Journal of the Pharmaceutical Society of Japan. 2014;30(8):2231-2240.
doi:10.1007/s11274-014-1644-x .

Kramar, Ana, Ilić-Tomić, Tatjana, Petković, Miloš, Radulović, Niko, Kostić, Mirjana, Jocić, Dragan, Nikodinović-Runić, Jasmina, "Crude bacterial extracts of two new Streptomyces sp isolates as bio-colorants for textile dyeing" in Yakugaku Zasshi - Journal of the Pharmaceutical Society of Japan, 30, no. 8 (2014):2231-2240,
https://doi.org/10.1007/s11274-014-1644-x . .