TY  - JOUR
AU  - Vujković, Branko
AU  - Brković, Voin
AU  - Pajičić, Ana
AU  - Pavlović, Vedrana
AU  - Stanisavljević, Dejana
AU  - Krajnović, Dušanka
AU  - Jović Vraneš, Aleksandra
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5652
AB  - Background: As digital health services are increasingly developing and becoming more interactive in Serbia, a comprehensive instrument for measuring eHealth literacy (EHL) is needed. Objective: This study aimed to translate, culturally adapt, and investigate the psychometric properties of the Serbian version of the eHealth Literacy Questionnaire (eHLQ); to evaluate EHL in the population of primary health care (PHC) users in Serbia; and to explore factors associated with their EHL. Methods: The validation study was conducted in 8 PHC centers in the territory of the Mačva district in Western Serbia. A stratified sampling method was used to obtain a representative sample. The Translation Integrity Procedure was followed to adapt the questionnaire to the Serbian language. The psychometric properties of the Serbian version of the eHLQ were analyzed through the examination of factorial structure, internal consistency, and test-retest reliability. Descriptive statistics were calculated to determine participant characteristics. Differences between groups were tested by the 2-tailed Students t test and ANOVA. Univariable and multivariable linear regression analyses were used to determine factors related to EHL. Results: A total of 475 PHC users were enrolled. The mean age was 51.0 (SD 17.3; range 19-94) years, and most participants were female (328/475, 69.1%). Confirmatory factor analysis validated the 7-factor structure of the questionnaire. Values for incremental fit index (0.96) and comparative fit index (0.95) were above the cutoff of ≥0.95. The root mean square error of approximation value of 0.05 was below the suggested value of ≤0.06. Cronbach α of the entire scale was 0.95, indicating excellent scale reliability, with Cronbach α ranging from 0.81 to 0.90 for domains. The intraclass correlation coefficient ranged from 0.63 to 0.82, indicating moderate to good test-retest reliability. The highest EHL mean scores were obtained for the understanding of health concepts and language (mean 2.86, SD 0.32) and feel safe and in control (mean 2.89, SD 0.33) domains. Statistically significant differences (all P<.05) for all 7 eHLQ scores were observed for age, education, perceived material status, perceived health status, searching for health information on the internet, and occupation (except domain 4). In multivariable regression models, searching for health information on the internet and being aged younger than 65 years were associated with higher values of all domain scores except the domain feel safe and in control for variable age. Conclusions: This study demonstrates that the Serbian version of the eHLQ can be a useful tool in the measurement of EHL and in the planning of digital health interventions at the population and individual level due to its strong psychometric properties in the Serbian context.
PB  - JMIR Publications Inc.
T2  - Journal of Medical Internet Research
T1  - Serbian Version of the eHealth Literacy Questionnaire (eHLQ): Translation, Cultural Adaptation, and Validation Study Among Primary Health Care Users
VL  - 26
SP  - e57963
DO  - 10.2196/57963
ER  - 

@article{
author = "Vujković, Branko and Brković, Voin and Pajičić, Ana and Pavlović, Vedrana and Stanisavljević, Dejana and Krajnović, Dušanka and Jović Vraneš, Aleksandra",
year = "2024",
abstract = "Background: As digital health services are increasingly developing and becoming more interactive in Serbia, a comprehensive instrument for measuring eHealth literacy (EHL) is needed. Objective: This study aimed to translate, culturally adapt, and investigate the psychometric properties of the Serbian version of the eHealth Literacy Questionnaire (eHLQ); to evaluate EHL in the population of primary health care (PHC) users in Serbia; and to explore factors associated with their EHL. Methods: The validation study was conducted in 8 PHC centers in the territory of the Mačva district in Western Serbia. A stratified sampling method was used to obtain a representative sample. The Translation Integrity Procedure was followed to adapt the questionnaire to the Serbian language. The psychometric properties of the Serbian version of the eHLQ were analyzed through the examination of factorial structure, internal consistency, and test-retest reliability. Descriptive statistics were calculated to determine participant characteristics. Differences between groups were tested by the 2-tailed Students t test and ANOVA. Univariable and multivariable linear regression analyses were used to determine factors related to EHL. Results: A total of 475 PHC users were enrolled. The mean age was 51.0 (SD 17.3; range 19-94) years, and most participants were female (328/475, 69.1%). Confirmatory factor analysis validated the 7-factor structure of the questionnaire. Values for incremental fit index (0.96) and comparative fit index (0.95) were above the cutoff of ≥0.95. The root mean square error of approximation value of 0.05 was below the suggested value of ≤0.06. Cronbach α of the entire scale was 0.95, indicating excellent scale reliability, with Cronbach α ranging from 0.81 to 0.90 for domains. The intraclass correlation coefficient ranged from 0.63 to 0.82, indicating moderate to good test-retest reliability. The highest EHL mean scores were obtained for the understanding of health concepts and language (mean 2.86, SD 0.32) and feel safe and in control (mean 2.89, SD 0.33) domains. Statistically significant differences (all P<.05) for all 7 eHLQ scores were observed for age, education, perceived material status, perceived health status, searching for health information on the internet, and occupation (except domain 4). In multivariable regression models, searching for health information on the internet and being aged younger than 65 years were associated with higher values of all domain scores except the domain feel safe and in control for variable age. Conclusions: This study demonstrates that the Serbian version of the eHLQ can be a useful tool in the measurement of EHL and in the planning of digital health interventions at the population and individual level due to its strong psychometric properties in the Serbian context.",
publisher = "JMIR Publications Inc.",
journal = "Journal of Medical Internet Research",
title = "Serbian Version of the eHealth Literacy Questionnaire (eHLQ): Translation, Cultural Adaptation, and Validation Study Among Primary Health Care Users",
volume = "26",
pages = "e57963",
doi = "10.2196/57963"
}

Vujković, B., Brković, V., Pajičić, A., Pavlović, V., Stanisavljević, D., Krajnović, D.,& Jović Vraneš, A.. (2024). Serbian Version of the eHealth Literacy Questionnaire (eHLQ): Translation, Cultural Adaptation, and Validation Study Among Primary Health Care Users. in Journal of Medical Internet Research
JMIR Publications Inc.., 26, e57963.
https://doi.org/10.2196/57963

Vujković B, Brković V, Pajičić A, Pavlović V, Stanisavljević D, Krajnović D, Jović Vraneš A. Serbian Version of the eHealth Literacy Questionnaire (eHLQ): Translation, Cultural Adaptation, and Validation Study Among Primary Health Care Users. in Journal of Medical Internet Research. 2024;26:e57963.
doi:10.2196/57963 .

Vujković, Branko, Brković, Voin, Pajičić, Ana, Pavlović, Vedrana, Stanisavljević, Dejana, Krajnović, Dušanka, Jović Vraneš, Aleksandra, "Serbian Version of the eHealth Literacy Questionnaire (eHLQ): Translation, Cultural Adaptation, and Validation Study Among Primary Health Care Users" in Journal of Medical Internet Research, 26 (2024):e57963,
https://doi.org/10.2196/57963 . .

TY  - JOUR
AU  - Radojević, Branislava
AU  - Dragašević-Mišković, Nataša T.
AU  - Milovanović, Andona
AU  - Svetel, Marina
AU  - Petrović, Igor
AU  - Pešić, Maja
AU  - Tomić, Aleksandra
AU  - Stanisavljević, Dejana
AU  - Savić, Miroslav
AU  - Kostić, Vladimir S.
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4329
AB  - Objectives: Adherence to medication is an important factor that can influence Parkinson's disease (PD) control. We aimed to explore patients' adherence to antiparkinsonian medication and determine factors that might affect adherence to medications among PD patients. Methods: A cross-sectional, exploratory survey of PD patients treated with at least one antiparkinsonian drug and with a total score of MoCA (Montreal Cognitive Assessment) ≥26 was conducted. The final sample included 112 PD patients. A patient's adherence was assessed through ARMS (Adherence to Refills and Medications Scale). ARMS scores higher than 12 were assumed lower adherence. In addition, each patient underwent neurological examination, assessment of depression, anxiety, and evaluation of the presence of PD nonmotor symptoms. Results: The mean ARDS value in our cohort was 14.9 ± 2.5. Most PD patients (74.1%) reported lower adherence to their medication. Participants in the lower adherence group were younger at PD onset, had significantly higher UPDRS (Unified PD Rating Scale) scores, as well as UPDRS III and UPDRS IV subscores, HARS (Hamilton Anxiety Rating Scale), and NMSQuest (Non-Motor Symptoms Questionnaire for PD) scores compared to the fully adherent group (p=0.013, p=0.017, p=0.041, p=0.043, and p=0.023, respectively). Among nonmotor PD symptoms, the presence of cardiovascular, apathy/attention-deficit/memory disorders, hallucinations/delusions, and problems regarding changes in weight, diplopia, or sweating were associated with lower adherence. Multivariate regression analysis revealed depression as the strongest independent predictor of lower adherence. Conclusion: Depressed PD patients compared to PD patients without clinical depression had a three times higher risk for lower adherence to pharmacotherapy. Recognition and adequate treatment of depression might result in improved adherence.
PB  - Hindawi
T2  - International journal of clinical practice
T1  - Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale
VL  - 2022
DO  - 10.1155/2022/6741280
ER  - 

@article{
author = "Radojević, Branislava and Dragašević-Mišković, Nataša T. and Milovanović, Andona and Svetel, Marina and Petrović, Igor and Pešić, Maja and Tomić, Aleksandra and Stanisavljević, Dejana and Savić, Miroslav and Kostić, Vladimir S.",
year = "2022",
abstract = "Objectives: Adherence to medication is an important factor that can influence Parkinson's disease (PD) control. We aimed to explore patients' adherence to antiparkinsonian medication and determine factors that might affect adherence to medications among PD patients. Methods: A cross-sectional, exploratory survey of PD patients treated with at least one antiparkinsonian drug and with a total score of MoCA (Montreal Cognitive Assessment) ≥26 was conducted. The final sample included 112 PD patients. A patient's adherence was assessed through ARMS (Adherence to Refills and Medications Scale). ARMS scores higher than 12 were assumed lower adherence. In addition, each patient underwent neurological examination, assessment of depression, anxiety, and evaluation of the presence of PD nonmotor symptoms. Results: The mean ARDS value in our cohort was 14.9 ± 2.5. Most PD patients (74.1%) reported lower adherence to their medication. Participants in the lower adherence group were younger at PD onset, had significantly higher UPDRS (Unified PD Rating Scale) scores, as well as UPDRS III and UPDRS IV subscores, HARS (Hamilton Anxiety Rating Scale), and NMSQuest (Non-Motor Symptoms Questionnaire for PD) scores compared to the fully adherent group (p=0.013, p=0.017, p=0.041, p=0.043, and p=0.023, respectively). Among nonmotor PD symptoms, the presence of cardiovascular, apathy/attention-deficit/memory disorders, hallucinations/delusions, and problems regarding changes in weight, diplopia, or sweating were associated with lower adherence. Multivariate regression analysis revealed depression as the strongest independent predictor of lower adherence. Conclusion: Depressed PD patients compared to PD patients without clinical depression had a three times higher risk for lower adherence to pharmacotherapy. Recognition and adequate treatment of depression might result in improved adherence.",
publisher = "Hindawi",
journal = "International journal of clinical practice",
title = "Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale",
volume = "2022",
doi = "10.1155/2022/6741280"
}

Radojević, B., Dragašević-Mišković, N. T., Milovanović, A., Svetel, M., Petrović, I., Pešić, M., Tomić, A., Stanisavljević, D., Savić, M.,& Kostić, V. S.. (2022). Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale. in International journal of clinical practice
Hindawi., 2022.
https://doi.org/10.1155/2022/6741280

Radojević B, Dragašević-Mišković NT, Milovanović A, Svetel M, Petrović I, Pešić M, Tomić A, Stanisavljević D, Savić M, Kostić VS. Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale. in International journal of clinical practice. 2022;2022.
doi:10.1155/2022/6741280 .

Radojević, Branislava, Dragašević-Mišković, Nataša T., Milovanović, Andona, Svetel, Marina, Petrović, Igor, Pešić, Maja, Tomić, Aleksandra, Stanisavljević, Dejana, Savić, Miroslav, Kostić, Vladimir S., "Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale" in International journal of clinical practice, 2022 (2022),
https://doi.org/10.1155/2022/6741280 . .

TY  - JOUR
AU  - Radojević, Branislava
AU  - Dragašević-Mišković, Nataša
AU  - Marjanović, Ana
AU  - Branković, Marija
AU  - Milovanović, Andona
AU  - Petrović, Igor
AU  - Svetel, Marina
AU  - Jančić, Ivan
AU  - Stanisavljević, Dejana
AU  - Milićević, Ognjen
AU  - Savić, Miroslav
AU  - Kostić, Vladimir
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4082
AB  - Background: Clinical-related risk factors to freezing of gait (FOG) in Parkinson’s disease (PD) have been iden- tified. Still, the influence of genetic variations on the FOG occurrence has been poorly studied thus far. Aim: We aimed to evaluate the association of six selected polymorphisms of DRD2, ANKK1, and COMT genes with the FOG occurrence and explore the influence of ANNK1/DRD2 haplotypes on the onset of FOG in the group of PD patients. Method: PD patients (n = 234), treated with levodopa for at least two years, were genotyped for the rs4680 in COMT, rs6277, rs1076560, and rs2283265 in DRD2, and rs1800497 and rs2734849 polymorphisms in ANKK1 genes. FOG was evaluated by posing a direct question. In addition, a comprehensive set of clinical scales was applied to all patients. Results: FOG occurred in 132 (56.4%) PD patients in our cohort. Freezers were younger at PD onset, had longer disease duration, used higher levodopa daily doses and dopaminergic agents, and had higher motor and non- motor scales scores than non-freezers. FOG was more frequent among AA rs4680 COMT carriers than AG and GG rs4680 COMT carriers. Independent predictors of FOG were: disease duration of more than ten years, levodopa daily dose higher than 500 mg/day, motor status, and COMT AA genotype. AGGAA and GGAAA haplotypes were revealed as protective and vulnerability factors for FOG occurrence. Conclusion: In addition to previously identified disease- and therapy-related risk factors, our results suggested a possible contribution of dopamine-related genes to the FOG occurrence.
PB  - Elsevier Ltd
T2  - Parkinsonism and Related Disorders
T1  - The correlation between genetic factors and freezing of gait in patients with Parkinson's disease
VL  - 98
SP  - 7
EP  - 12
DO  - 10.1016/j.parkreldis.2022.03.018
ER  - 

@article{
author = "Radojević, Branislava and Dragašević-Mišković, Nataša and Marjanović, Ana and Branković, Marija and Milovanović, Andona and Petrović, Igor and Svetel, Marina and Jančić, Ivan and Stanisavljević, Dejana and Milićević, Ognjen and Savić, Miroslav and Kostić, Vladimir",
year = "2022",
abstract = "Background: Clinical-related risk factors to freezing of gait (FOG) in Parkinson’s disease (PD) have been iden- tified. Still, the influence of genetic variations on the FOG occurrence has been poorly studied thus far. Aim: We aimed to evaluate the association of six selected polymorphisms of DRD2, ANKK1, and COMT genes with the FOG occurrence and explore the influence of ANNK1/DRD2 haplotypes on the onset of FOG in the group of PD patients. Method: PD patients (n = 234), treated with levodopa for at least two years, were genotyped for the rs4680 in COMT, rs6277, rs1076560, and rs2283265 in DRD2, and rs1800497 and rs2734849 polymorphisms in ANKK1 genes. FOG was evaluated by posing a direct question. In addition, a comprehensive set of clinical scales was applied to all patients. Results: FOG occurred in 132 (56.4%) PD patients in our cohort. Freezers were younger at PD onset, had longer disease duration, used higher levodopa daily doses and dopaminergic agents, and had higher motor and non- motor scales scores than non-freezers. FOG was more frequent among AA rs4680 COMT carriers than AG and GG rs4680 COMT carriers. Independent predictors of FOG were: disease duration of more than ten years, levodopa daily dose higher than 500 mg/day, motor status, and COMT AA genotype. AGGAA and GGAAA haplotypes were revealed as protective and vulnerability factors for FOG occurrence. Conclusion: In addition to previously identified disease- and therapy-related risk factors, our results suggested a possible contribution of dopamine-related genes to the FOG occurrence.",
publisher = "Elsevier Ltd",
journal = "Parkinsonism and Related Disorders",
title = "The correlation between genetic factors and freezing of gait in patients with Parkinson's disease",
volume = "98",
pages = "7-12",
doi = "10.1016/j.parkreldis.2022.03.018"
}

Radojević, B., Dragašević-Mišković, N., Marjanović, A., Branković, M., Milovanović, A., Petrović, I., Svetel, M., Jančić, I., Stanisavljević, D., Milićević, O., Savić, M.,& Kostić, V.. (2022). The correlation between genetic factors and freezing of gait in patients with Parkinson's disease. in Parkinsonism and Related Disorders
Elsevier Ltd., 98, 7-12.
https://doi.org/10.1016/j.parkreldis.2022.03.018

Radojević B, Dragašević-Mišković N, Marjanović A, Branković M, Milovanović A, Petrović I, Svetel M, Jančić I, Stanisavljević D, Milićević O, Savić M, Kostić V. The correlation between genetic factors and freezing of gait in patients with Parkinson's disease. in Parkinsonism and Related Disorders. 2022;98:7-12.
doi:10.1016/j.parkreldis.2022.03.018 .

Radojević, Branislava, Dragašević-Mišković, Nataša, Marjanović, Ana, Branković, Marija, Milovanović, Andona, Petrović, Igor, Svetel, Marina, Jančić, Ivan, Stanisavljević, Dejana, Milićević, Ognjen, Savić, Miroslav, Kostić, Vladimir, "The correlation between genetic factors and freezing of gait in patients with Parkinson's disease" in Parkinsonism and Related Disorders, 98 (2022):7-12,
https://doi.org/10.1016/j.parkreldis.2022.03.018 . .