TY  - JOUR
AU  - Bajdik, J
AU  - Pintye-Hodi, K
AU  - Planinsek, Odon
AU  - Tuske, Z
AU  - Tasić, Ljiljana
AU  - Regdon, G
AU  - Srcić, S
AU  - Eros, I
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/482
AB  - Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Surface treatment of indomethacin agglomerates with Eudragit
VL  - 30
IS  - 4
SP  - 381
EP  - 388
DO  - 10.1081/DDC-120030932
ER  - 

@article{
author = "Bajdik, J and Pintye-Hodi, K and Planinsek, Odon and Tuske, Z and Tasić, Ljiljana and Regdon, G and Srcić, S and Eros, I",
year = "2004",
abstract = "Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Surface treatment of indomethacin agglomerates with Eudragit",
volume = "30",
number = "4",
pages = "381-388",
doi = "10.1081/DDC-120030932"
}

Bajdik, J., Pintye-Hodi, K., Planinsek, O., Tuske, Z., Tasić, L., Regdon, G., Srcić, S.,& Eros, I.. (2004). Surface treatment of indomethacin agglomerates with Eudragit. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 30(4), 381-388.
https://doi.org/10.1081/DDC-120030932

Bajdik J, Pintye-Hodi K, Planinsek O, Tuske Z, Tasić L, Regdon G, Srcić S, Eros I. Surface treatment of indomethacin agglomerates with Eudragit. in Drug Development and Industrial Pharmacy. 2004;30(4):381-388.
doi:10.1081/DDC-120030932 .

Bajdik, J, Pintye-Hodi, K, Planinsek, Odon, Tuske, Z, Tasić, Ljiljana, Regdon, G, Srcić, S, Eros, I, "Surface treatment of indomethacin agglomerates with Eudragit" in Drug Development and Industrial Pharmacy, 30, no. 4 (2004):381-388,
https://doi.org/10.1081/DDC-120030932 . .

TY  - JOUR
AU  - Tasić, Ljiljana
AU  - PintyeHodi, K
AU  - SzaboRevesz, P
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/150
AB  - The compression behaviour of three powder products of Paracetamol-beta-cyclodextrin solid dispersions (PAR-beta-CD SD) and PAR alone were evaluated using the method of scanning electron microscopy (SEM). The four powder products were: PAR, PAR-beta-CD physical mixture, kneaded solid dispersion of PAR-beta-CD and spray dried solid dispersion of PAR-beta-CD (PAR-beta-CD ratio of 1:1 w/w). By observing the surface, side and broken surface of each tablet sample under different magnifications the compression behaviour, mechanism of consolidation and deformability of particles were evaluated. PAR alone and the PAR-beta-CD physical mixture were compressed by the brittle fracture mechanism; the PAR-beta-CD kneaded solid dispersion showed a good plastical deformation. With PAR-beta-CD spray dried solid dispersion a good plastic deformation and mechanism of cool sintering were postulated. The influence of beta-CD on the compression behavior of the PAR was proved. The results obtained by the SEM method are well correlated with physicopharmaceutical parameters (crushing strength, disintegration time, friability, elastic recovery and tensile strength) of the tablets.
PB  - Kluwer Academic Publ, Dordrecht
T2  - Journal of Inclusion Phenomena and Molecular Recognition in Chemistry
T1  - Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets
VL  - 28
IS  - 4
SP  - 299
EP  - 314
DO  - 10.1023/A:1007924212334
ER  - 

@article{
author = "Tasić, Ljiljana and PintyeHodi, K and SzaboRevesz, P",
year = "1997",
abstract = "The compression behaviour of three powder products of Paracetamol-beta-cyclodextrin solid dispersions (PAR-beta-CD SD) and PAR alone were evaluated using the method of scanning electron microscopy (SEM). The four powder products were: PAR, PAR-beta-CD physical mixture, kneaded solid dispersion of PAR-beta-CD and spray dried solid dispersion of PAR-beta-CD (PAR-beta-CD ratio of 1:1 w/w). By observing the surface, side and broken surface of each tablet sample under different magnifications the compression behaviour, mechanism of consolidation and deformability of particles were evaluated. PAR alone and the PAR-beta-CD physical mixture were compressed by the brittle fracture mechanism; the PAR-beta-CD kneaded solid dispersion showed a good plastical deformation. With PAR-beta-CD spray dried solid dispersion a good plastic deformation and mechanism of cool sintering were postulated. The influence of beta-CD on the compression behavior of the PAR was proved. The results obtained by the SEM method are well correlated with physicopharmaceutical parameters (crushing strength, disintegration time, friability, elastic recovery and tensile strength) of the tablets.",
publisher = "Kluwer Academic Publ, Dordrecht",
journal = "Journal of Inclusion Phenomena and Molecular Recognition in Chemistry",
title = "Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets",
volume = "28",
number = "4",
pages = "299-314",
doi = "10.1023/A:1007924212334"
}

Tasić, L., PintyeHodi, K.,& SzaboRevesz, P.. (1997). Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets. in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry
Kluwer Academic Publ, Dordrecht., 28(4), 299-314.
https://doi.org/10.1023/A:1007924212334

Tasić L, PintyeHodi K, SzaboRevesz P. Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets. in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 1997;28(4):299-314.
doi:10.1023/A:1007924212334 .

Tasić, Ljiljana, PintyeHodi, K, SzaboRevesz, P, "Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets" in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 28, no. 4 (1997):299-314,
https://doi.org/10.1023/A:1007924212334 . .