TY  - JOUR
AU  - Sopić, Miron
AU  - Karaduzovic-Hadziabdic, Kanita
AU  - Kardassis, Dimitris
AU  - Maegdefessel, Lars
AU  - Martelli, Fabio
AU  - Meerson, Ari
AU  - Munjas, Jelena
AU  - Niculescu, Loredan S.
AU  - Stoll, Monika
AU  - Magni, Paolo
AU  - Devaux, Yvan
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5616
AB  - Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research.
PB  - Elsevier Ltd.
T2  - Journal of Molecular and Cellular Cardiology Plus
T1  - Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges
VL  - 6
SP  - 100048
DO  - 10.1016/j.jmccpl.2023.100048
ER  - 

@article{
author = "Sopić, Miron and Karaduzovic-Hadziabdic, Kanita and Kardassis, Dimitris and Maegdefessel, Lars and Martelli, Fabio and Meerson, Ari and Munjas, Jelena and Niculescu, Loredan S. and Stoll, Monika and Magni, Paolo and Devaux, Yvan",
year = "2023",
abstract = "Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research.",
publisher = "Elsevier Ltd.",
journal = "Journal of Molecular and Cellular Cardiology Plus",
title = "Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges",
volume = "6",
pages = "100048",
doi = "10.1016/j.jmccpl.2023.100048"
}

Sopić, M., Karaduzovic-Hadziabdic, K., Kardassis, D., Maegdefessel, L., Martelli, F., Meerson, A., Munjas, J., Niculescu, L. S., Stoll, M., Magni, P.,& Devaux, Y.. (2023). Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges. in Journal of Molecular and Cellular Cardiology Plus
Elsevier Ltd.., 6, 100048.
https://doi.org/10.1016/j.jmccpl.2023.100048

Sopić M, Karaduzovic-Hadziabdic K, Kardassis D, Maegdefessel L, Martelli F, Meerson A, Munjas J, Niculescu LS, Stoll M, Magni P, Devaux Y. Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges. in Journal of Molecular and Cellular Cardiology Plus. 2023;6:100048.
doi:10.1016/j.jmccpl.2023.100048 .

Sopić, Miron, Karaduzovic-Hadziabdic, Kanita, Kardassis, Dimitris, Maegdefessel, Lars, Martelli, Fabio, Meerson, Ari, Munjas, Jelena, Niculescu, Loredan S., Stoll, Monika, Magni, Paolo, Devaux, Yvan, "Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges" in Journal of Molecular and Cellular Cardiology Plus, 6 (2023):100048,
https://doi.org/10.1016/j.jmccpl.2023.100048 . .