TY  - JOUR
AU  - Milić, Jela
AU  - Radojković, Branko
AU  - Jančić-Stojanović, Biljana
AU  - Drašković, Jasmina
AU  - Mirašević, Slavica
AU  - Čalija, Bojan
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2943
AB  - In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C).
AB  - U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C).
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules
T1  - Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula
VL  - 67
IS  - 1
SP  - 14
EP  - 25
DO  - 10.5937/arhfarm1701014M
ER  - 

@article{
author = "Milić, Jela and Radojković, Branko and Jančić-Stojanović, Biljana and Drašković, Jasmina and Mirašević, Slavica and Čalija, Bojan",
year = "2017",
abstract = "In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C)., U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C).",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules, Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula",
volume = "67",
number = "1",
pages = "14-25",
doi = "10.5937/arhfarm1701014M"
}

Milić, J., Radojković, B., Jančić-Stojanović, B., Drašković, J., Mirašević, S.,& Čalija, B.. (2017). Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(1), 14-25.
https://doi.org/10.5937/arhfarm1701014M

Milić J, Radojković B, Jančić-Stojanović B, Drašković J, Mirašević S, Čalija B. Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in Arhiv za farmaciju. 2017;67(1):14-25.
doi:10.5937/arhfarm1701014M .

Milić, Jela, Radojković, Branko, Jančić-Stojanović, Biljana, Drašković, Jasmina, Mirašević, Slavica, Čalija, Bojan, "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules" in Arhiv za farmaciju, 67, no. 1 (2017):14-25,
https://doi.org/10.5937/arhfarm1701014M . .

TY  - CONF
AU  - Milić, Jela
AU  - Radojković, Branko
AU  - Stojanović, Biljana
AU  - Drašković, Jasmina
AU  - Mirašević, Slavica
AU  - Đorđević, Sanela
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2734
PB  - Elsevier Science BV, Amsterdam
C3  - International Journal of Pharmaceutics
T1  - Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules
VL  - 511
IS  - 2
SP  - 1147
EP  - 1148
DO  - 10.1016/j.ijpharm.2016.06.107
ER  - 

@conference{
author = "Milić, Jela and Radojković, Branko and Stojanović, Biljana and Drašković, Jasmina and Mirašević, Slavica and Đorđević, Sanela",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules",
volume = "511",
number = "2",
pages = "1147-1148",
doi = "10.1016/j.ijpharm.2016.06.107"
}

Milić, J., Radojković, B., Stojanović, B., Drašković, J., Mirašević, S.,& Đorđević, S.. (2016). Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 511(2), 1147-1148.
https://doi.org/10.1016/j.ijpharm.2016.06.107

Milić J, Radojković B, Stojanović B, Drašković J, Mirašević S, Đorđević S. Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in International Journal of Pharmaceutics. 2016;511(2):1147-1148.
doi:10.1016/j.ijpharm.2016.06.107 .

Milić, Jela, Radojković, Branko, Stojanović, Biljana, Drašković, Jasmina, Mirašević, Slavica, Đorđević, Sanela, "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules" in International Journal of Pharmaceutics, 511, no. 2 (2016):1147-1148,
https://doi.org/10.1016/j.ijpharm.2016.06.107 . .