TY  - JOUR
AU  - Terzić, Jelena
AU  - Popović, Igor
AU  - Tumpa, Anja
AU  - Stajić, Ana
AU  - Jančić-Stojanović, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3022
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016)
VL  - 138
SP  - 386
EP  - 386
DO  - 10.1016/j.jpba.2017.02.016
ER  - 

@article{
author = "Terzić, Jelena and Popović, Igor and Tumpa, Anja and Stajić, Ana and Jančić-Stojanović, Biljana",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016)",
volume = "138",
pages = "386-386",
doi = "10.1016/j.jpba.2017.02.016"
}

Terzić, J., Popović, I., Tumpa, A., Stajić, A.,& Jančić-Stojanović, B.. (2017). Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016). in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 138, 386-386.
https://doi.org/10.1016/j.jpba.2017.02.016

Terzić J, Popović I, Tumpa A, Stajić A, Jančić-Stojanović B. Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016). in Journal of Pharmaceutical and Biomedical Analysis. 2017;138:386-386.
doi:10.1016/j.jpba.2017.02.016 .

Terzić, Jelena, Popović, Igor, Tumpa, Anja, Stajić, Ana, Jančić-Stojanović, Biljana, "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method (vol 125, pg 385, 2016)" in Journal of Pharmaceutical and Biomedical Analysis, 138 (2017):386-386,
https://doi.org/10.1016/j.jpba.2017.02.016 . .

TY  - JOUR
AU  - Terzić, Jelena
AU  - Popović, Igor
AU  - Stajić, Ana
AU  - Tumpa, Anja
AU  - Jančić-Stojanović, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2548
AB  - This paper deals with the development of hydrophilic interaction liquid chromatographic (HILIC) method for the analysis of bilastine and its degradation impurities following Analytical Quality by Design approach. It is the first time that the method for bilastine and its impurities is proposed. The main objective was to identify the conditions where an adequate separation in minimal analysis duration could be achieved within a robust region. Critical process parameters which have the most influence on method performance were defined as acetonitrile content in the mobile phase, pH of the aqueous phase and ammonium acetate concentration in the aqueous phase. Box-Behnken design was applied for establishing a relationship between critical process parameters and critical quality attributes. The defined mathematical models and Monte Carlo simulations were used to identify the design space. Fractional factorial design was applied for experimental robustness testing and the method is validated to verify the adequacy of selected optimal conditions: the analytical column Luna (R) HILIC (100 mm x 4.6 mm, 5 mu m particle size); mobile phase consisted of acetonitrile aqueous phase (50 mM ammonium acetate, pH adjusted to 5.3 with glacial acetic acid) (90.5:9.5, v/v); column temperature 30 degrees C, mobile phase flow rate 1 mL min(-1), wavelength of detection 275 nm.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method
VL  - 125
SP  - 385
EP  - 393
DO  - 10.1016/j.jpba.2016.04.022
ER  - 

@article{
author = "Terzić, Jelena and Popović, Igor and Stajić, Ana and Tumpa, Anja and Jančić-Stojanović, Biljana",
year = "2016",
abstract = "This paper deals with the development of hydrophilic interaction liquid chromatographic (HILIC) method for the analysis of bilastine and its degradation impurities following Analytical Quality by Design approach. It is the first time that the method for bilastine and its impurities is proposed. The main objective was to identify the conditions where an adequate separation in minimal analysis duration could be achieved within a robust region. Critical process parameters which have the most influence on method performance were defined as acetonitrile content in the mobile phase, pH of the aqueous phase and ammonium acetate concentration in the aqueous phase. Box-Behnken design was applied for establishing a relationship between critical process parameters and critical quality attributes. The defined mathematical models and Monte Carlo simulations were used to identify the design space. Fractional factorial design was applied for experimental robustness testing and the method is validated to verify the adequacy of selected optimal conditions: the analytical column Luna (R) HILIC (100 mm x 4.6 mm, 5 mu m particle size); mobile phase consisted of acetonitrile aqueous phase (50 mM ammonium acetate, pH adjusted to 5.3 with glacial acetic acid) (90.5:9.5, v/v); column temperature 30 degrees C, mobile phase flow rate 1 mL min(-1), wavelength of detection 275 nm.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method",
volume = "125",
pages = "385-393",
doi = "10.1016/j.jpba.2016.04.022"
}

Terzić, J., Popović, I., Stajić, A., Tumpa, A.,& Jančić-Stojanović, B.. (2016). Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 125, 385-393.
https://doi.org/10.1016/j.jpba.2016.04.022

Terzić J, Popović I, Stajić A, Tumpa A, Jančić-Stojanović B. Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method. in Journal of Pharmaceutical and Biomedical Analysis. 2016;125:385-393.
doi:10.1016/j.jpba.2016.04.022 .

Terzić, Jelena, Popović, Igor, Stajić, Ana, Tumpa, Anja, Jančić-Stojanović, Biljana, "Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method" in Journal of Pharmaceutical and Biomedical Analysis, 125 (2016):385-393,
https://doi.org/10.1016/j.jpba.2016.04.022 . .

TY  - JOUR
AU  - Terzić, Jelena
AU  - Popović, Igor
AU  - Jančić-Stojanović, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2292
AB  - In this review article, aspects of DryLab® software application in liquid chromatography are given. Literature survey shows wide application of software for chromatography method development, optimization, as well as for robustness testing. Earlier versions of DryLab®software enabled the simultaneous monitoring of the impact of two parameters on the selected system response, as an upgraded version of the software provides significantly more opportunities. Namely, the new DryLab®software version enables fulfilling requirements given by Quality by Design (QbD) concept through a systematic approach to the development of chromatographic methods, and the construction of a 3D cube which provides the visualization of a Design Space. In addition, when running liquid chromatography methods on a routine basis software can be a useful tool for optimization process in order to minimize retention times and run time, as well as facilitating the transfer of a method (DryLab® data can be sent electronically). Finally, DryLab®software provides useful information about the method and can be applied to training of young analysts without performing experiments, while saving time, money, and laboratory instruments.
AB  - U preglednom radu prikazani su aspekti primene DryLab® softvera u tečnoj hromatografiji. Literaturni pregled pokazuje široku primenu softvera u fazi postavljanja nove hromatografske metode, optimizaciji, kao i u proceni robusnosti metode. Ranije verzije DryLab® softvera omogućavale su istovremeno praćenje uticaja dva faktora na odabrani odgovor sistema, dok unapređene verzije softvera daju značajno veće mogućnosti. Novije verzije DryLab® softvera omogućavaju ispunjavanje zahteva određenih Quality by Design (QbD) konceptom kroz sistematičan prilaz razvoju hromatografske metode, kao i kroz konstruisanje 3D kocke kojom se omogućava vizuelni prikaz Design space-a. Pored toga, u rutinskoj primeni metoda tečne hromatografije softver može biti koristan 'alat' za optimizaciju u cilju skraćenja retencionih vremena i trajanja analize, kao i olakšavanja transfera metoda (podaci dobijeni uz pomoć DryLab®-a se mogu slati elektronskim putem). Na kraju, upotrebom DryLab® softvera dobijaju se korisne informacije o metodi, a uz to može služiti za obučavanje mladih analitičara bez izvođenja eksperimenata, uz istovremenu uštedu vremena, novca i laboratorijske opreme.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Aspects of DryLab® software application in chromatography methods optimization and robustness testing
T1  - Aspekti primene DryLab® softvera u optimizaciji i proceni robusnosti hromatografskih metoda
VL  - 64
IS  - 3
SP  - 205
EP  - 219
DO  - 10.5937/arhfarm1403205T
ER  - 

@article{
author = "Terzić, Jelena and Popović, Igor and Jančić-Stojanović, Biljana",
year = "2014",
abstract = "In this review article, aspects of DryLab® software application in liquid chromatography are given. Literature survey shows wide application of software for chromatography method development, optimization, as well as for robustness testing. Earlier versions of DryLab®software enabled the simultaneous monitoring of the impact of two parameters on the selected system response, as an upgraded version of the software provides significantly more opportunities. Namely, the new DryLab®software version enables fulfilling requirements given by Quality by Design (QbD) concept through a systematic approach to the development of chromatographic methods, and the construction of a 3D cube which provides the visualization of a Design Space. In addition, when running liquid chromatography methods on a routine basis software can be a useful tool for optimization process in order to minimize retention times and run time, as well as facilitating the transfer of a method (DryLab® data can be sent electronically). Finally, DryLab®software provides useful information about the method and can be applied to training of young analysts without performing experiments, while saving time, money, and laboratory instruments., U preglednom radu prikazani su aspekti primene DryLab® softvera u tečnoj hromatografiji. Literaturni pregled pokazuje široku primenu softvera u fazi postavljanja nove hromatografske metode, optimizaciji, kao i u proceni robusnosti metode. Ranije verzije DryLab® softvera omogućavale su istovremeno praćenje uticaja dva faktora na odabrani odgovor sistema, dok unapređene verzije softvera daju značajno veće mogućnosti. Novije verzije DryLab® softvera omogućavaju ispunjavanje zahteva određenih Quality by Design (QbD) konceptom kroz sistematičan prilaz razvoju hromatografske metode, kao i kroz konstruisanje 3D kocke kojom se omogućava vizuelni prikaz Design space-a. Pored toga, u rutinskoj primeni metoda tečne hromatografije softver može biti koristan 'alat' za optimizaciju u cilju skraćenja retencionih vremena i trajanja analize, kao i olakšavanja transfera metoda (podaci dobijeni uz pomoć DryLab®-a se mogu slati elektronskim putem). Na kraju, upotrebom DryLab® softvera dobijaju se korisne informacije o metodi, a uz to može služiti za obučavanje mladih analitičara bez izvođenja eksperimenata, uz istovremenu uštedu vremena, novca i laboratorijske opreme.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Aspects of DryLab® software application in chromatography methods optimization and robustness testing, Aspekti primene DryLab® softvera u optimizaciji i proceni robusnosti hromatografskih metoda",
volume = "64",
number = "3",
pages = "205-219",
doi = "10.5937/arhfarm1403205T"
}

Terzić, J., Popović, I.,& Jančić-Stojanović, B.. (2014). Aspects of DryLab® software application in chromatography methods optimization and robustness testing. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(3), 205-219.
https://doi.org/10.5937/arhfarm1403205T

Terzić J, Popović I, Jančić-Stojanović B. Aspects of DryLab® software application in chromatography methods optimization and robustness testing. in Arhiv za farmaciju. 2014;64(3):205-219.
doi:10.5937/arhfarm1403205T .

Terzić, Jelena, Popović, Igor, Jančić-Stojanović, Biljana, "Aspects of DryLab® software application in chromatography methods optimization and robustness testing" in Arhiv za farmaciju, 64, no. 3 (2014):205-219,
https://doi.org/10.5937/arhfarm1403205T . .