TY  - JOUR
AU  - Jančić-Stojanović, Biljana
AU  - Vemić, Sava
AU  - Elezović, Valentina
AU  - Petrović, Ana
AU  - Sinadinović, Zoran
AU  - Ivanović, Darko
AU  - Damjanović, Svetozar S.
AU  - Miljković, Branislava
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2438
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3432
AB  - A simple and reliable new HPLC method with UV detection has been developed and validated for simultaneous determination of mitotane and its two metabolites DDA and DDE. Method development was carried out utilizing systematical approach of the design of experiments (DoE) methodology. For estimation of factors influence on selected chromatographic responses and definition of the optimal chromatographic conditions, Box-Behnken experimental design was applied. The defined optimal separation conditions were: column Restek Ultra Aqua C-18 with pre-column Restek Ultra Aqua C-18 operating at temperature 35 degrees C; mixture of acetonitrile and 0.5% formic acid as mobile phase with 1.2mL min(-1) flow rate and detection at 230nm. As sample preparation method, liquid-liquid extraction was chosen. Method was fully validated and LOQ and LOD were experimentally determined. Finally, method was successfully applied for determination of mitotane and its metabolites in plasma samples of patients with adrenocortical carcinoma.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology
VL  - 38
IS  - 14
SP  - 1371
EP  - 1378
DO  - 10.1080/10826076.2015.1057645
ER  - 

@article{
author = "Jančić-Stojanović, Biljana and Vemić, Sava and Elezović, Valentina and Petrović, Ana and Sinadinović, Zoran and Ivanović, Darko and Damjanović, Svetozar S. and Miljković, Branislava",
year = "2015",
abstract = "A simple and reliable new HPLC method with UV detection has been developed and validated for simultaneous determination of mitotane and its two metabolites DDA and DDE. Method development was carried out utilizing systematical approach of the design of experiments (DoE) methodology. For estimation of factors influence on selected chromatographic responses and definition of the optimal chromatographic conditions, Box-Behnken experimental design was applied. The defined optimal separation conditions were: column Restek Ultra Aqua C-18 with pre-column Restek Ultra Aqua C-18 operating at temperature 35 degrees C; mixture of acetonitrile and 0.5% formic acid as mobile phase with 1.2mL min(-1) flow rate and detection at 230nm. As sample preparation method, liquid-liquid extraction was chosen. Method was fully validated and LOQ and LOD were experimentally determined. Finally, method was successfully applied for determination of mitotane and its metabolites in plasma samples of patients with adrenocortical carcinoma.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology",
volume = "38",
number = "14",
pages = "1371-1378",
doi = "10.1080/10826076.2015.1057645"
}

Jančić-Stojanović, B., Vemić, S., Elezović, V., Petrović, A., Sinadinović, Z., Ivanović, D., Damjanović, S. S.,& Miljković, B.. (2015). Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 38(14), 1371-1378.
https://doi.org/10.1080/10826076.2015.1057645

Jančić-Stojanović B, Vemić S, Elezović V, Petrović A, Sinadinović Z, Ivanović D, Damjanović SS, Miljković B. Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology. in Journal of Liquid Chromatography & Related Technologies. 2015;38(14):1371-1378.
doi:10.1080/10826076.2015.1057645 .

Jančić-Stojanović, Biljana, Vemić, Sava, Elezović, Valentina, Petrović, Ana, Sinadinović, Zoran, Ivanović, Darko, Damjanović, Svetozar S., Miljković, Branislava, "Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology" in Journal of Liquid Chromatography & Related Technologies, 38, no. 14 (2015):1371-1378,
https://doi.org/10.1080/10826076.2015.1057645 . .

TY  - JOUR
AU  - Jančić-Stojanović, Biljana
AU  - Vemić, Sava
AU  - Elezović, Valentina
AU  - Petrović, Ana
AU  - Sinadinović, Zoran
AU  - Ivanović, Darko
AU  - Damjanović, Svetozar S.
AU  - Miljković, Branislava
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2438
AB  - A simple and reliable new HPLC method with UV detection has been developed and validated for simultaneous determination of mitotane and its two metabolites DDA and DDE. Method development was carried out utilizing systematical approach of the design of experiments (DoE) methodology. For estimation of factors influence on selected chromatographic responses and definition of the optimal chromatographic conditions, Box-Behnken experimental design was applied. The defined optimal separation conditions were: column Restek Ultra Aqua C-18 with pre-column Restek Ultra Aqua C-18 operating at temperature 35 degrees C; mixture of acetonitrile and 0.5% formic acid as mobile phase with 1.2mL min(-1) flow rate and detection at 230nm. As sample preparation method, liquid-liquid extraction was chosen. Method was fully validated and LOQ and LOD were experimentally determined. Finally, method was successfully applied for determination of mitotane and its metabolites in plasma samples of patients with adrenocortical carcinoma.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology
VL  - 38
IS  - 14
SP  - 1371
EP  - 1378
DO  - 10.1080/10826076.2015.1057645
ER  - 

@article{
author = "Jančić-Stojanović, Biljana and Vemić, Sava and Elezović, Valentina and Petrović, Ana and Sinadinović, Zoran and Ivanović, Darko and Damjanović, Svetozar S. and Miljković, Branislava",
year = "2015",
abstract = "A simple and reliable new HPLC method with UV detection has been developed and validated for simultaneous determination of mitotane and its two metabolites DDA and DDE. Method development was carried out utilizing systematical approach of the design of experiments (DoE) methodology. For estimation of factors influence on selected chromatographic responses and definition of the optimal chromatographic conditions, Box-Behnken experimental design was applied. The defined optimal separation conditions were: column Restek Ultra Aqua C-18 with pre-column Restek Ultra Aqua C-18 operating at temperature 35 degrees C; mixture of acetonitrile and 0.5% formic acid as mobile phase with 1.2mL min(-1) flow rate and detection at 230nm. As sample preparation method, liquid-liquid extraction was chosen. Method was fully validated and LOQ and LOD were experimentally determined. Finally, method was successfully applied for determination of mitotane and its metabolites in plasma samples of patients with adrenocortical carcinoma.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology",
volume = "38",
number = "14",
pages = "1371-1378",
doi = "10.1080/10826076.2015.1057645"
}

Jančić-Stojanović, B., Vemić, S., Elezović, V., Petrović, A., Sinadinović, Z., Ivanović, D., Damjanović, S. S.,& Miljković, B.. (2015). Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 38(14), 1371-1378.
https://doi.org/10.1080/10826076.2015.1057645

Jančić-Stojanović B, Vemić S, Elezović V, Petrović A, Sinadinović Z, Ivanović D, Damjanović SS, Miljković B. Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology. in Journal of Liquid Chromatography & Related Technologies. 2015;38(14):1371-1378.
doi:10.1080/10826076.2015.1057645 .

Jančić-Stojanović, Biljana, Vemić, Sava, Elezović, Valentina, Petrović, Ana, Sinadinović, Zoran, Ivanović, Darko, Damjanović, Svetozar S., Miljković, Branislava, "Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology" in Journal of Liquid Chromatography & Related Technologies, 38, no. 14 (2015):1371-1378,
https://doi.org/10.1080/10826076.2015.1057645 . .

TY  - JOUR
AU  - Rakić, Tijana
AU  - Vemić, Sava
AU  - Jančić-Stojanović, Biljana
AU  - Medenica, Mirjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1947
AB  - This paper proposes an innovative concept for robustness evaluation guided by two crucial aims: indubitable identification of the factors that significantly affect the LC method and avoidance of unnecessary time and money wasting. The first phase of the proposed strategy includes robustness screening during the method optimization. Initial assumptions of the method robustness can be tracked as the rate of the response change while the factors deviate within the expected range. Therefore, partial and total robustness criteria are calculated. If the results obtained are not satisfactory, re-optimization of the method should be considered. Otherwise, extensive robustness testing defined by experimental design and multi-level factors estimation should be performed to confirm the method robustness. Firstly, the important factors are investigated by the standard graphical (normal probability plots) and statistical (algorithm of Dong and error estimation based on a priori declared negligible effects) procedures. Since these approaches have several drawbacks, they can result in the appearance of false negative or false positive results. Thus, the modification of the statistical tests is advised in order to make the final conclusions. Special attention was dedicated to the advantages of the adapted algorithm of Dong (so-called 75 % approach) in the absence of the effect sparsity. The new approach is presented on the optimization and robustness testing of LC method for determination of ramipril and its five impurities. It is proved that the proposed strategy can perform an overall robustness estimation and successfully reveal all important factors.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong
VL  - 76
IS  - 5-6
SP  - 267
EP  - 277
DO  - 10.1007/s10337-012-2317-2
ER  - 

@article{
author = "Rakić, Tijana and Vemić, Sava and Jančić-Stojanović, Biljana and Medenica, Mirjana",
year = "2013",
abstract = "This paper proposes an innovative concept for robustness evaluation guided by two crucial aims: indubitable identification of the factors that significantly affect the LC method and avoidance of unnecessary time and money wasting. The first phase of the proposed strategy includes robustness screening during the method optimization. Initial assumptions of the method robustness can be tracked as the rate of the response change while the factors deviate within the expected range. Therefore, partial and total robustness criteria are calculated. If the results obtained are not satisfactory, re-optimization of the method should be considered. Otherwise, extensive robustness testing defined by experimental design and multi-level factors estimation should be performed to confirm the method robustness. Firstly, the important factors are investigated by the standard graphical (normal probability plots) and statistical (algorithm of Dong and error estimation based on a priori declared negligible effects) procedures. Since these approaches have several drawbacks, they can result in the appearance of false negative or false positive results. Thus, the modification of the statistical tests is advised in order to make the final conclusions. Special attention was dedicated to the advantages of the adapted algorithm of Dong (so-called 75 % approach) in the absence of the effect sparsity. The new approach is presented on the optimization and robustness testing of LC method for determination of ramipril and its five impurities. It is proved that the proposed strategy can perform an overall robustness estimation and successfully reveal all important factors.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong",
volume = "76",
number = "5-6",
pages = "267-277",
doi = "10.1007/s10337-012-2317-2"
}

Rakić, T., Vemić, S., Jančić-Stojanović, B.,& Medenica, M.. (2013). Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong. in Chromatographia
Springer Heidelberg, Heidelberg., 76(5-6), 267-277.
https://doi.org/10.1007/s10337-012-2317-2

Rakić T, Vemić S, Jančić-Stojanović B, Medenica M. Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong. in Chromatographia. 2013;76(5-6):267-277.
doi:10.1007/s10337-012-2317-2 .

Rakić, Tijana, Vemić, Sava, Jančić-Stojanović, Biljana, Medenica, Mirjana, "Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong" in Chromatographia, 76, no. 5-6 (2013):267-277,
https://doi.org/10.1007/s10337-012-2317-2 . .

TY  - CONF
AU  - Kotur-Stevuljević, Jelena
AU  - Vemić, Sava
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S.
AU  - Jelić-Ivanović, Zorana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1277
PB  - Taylor & Francis Ltd, Abingdon
C3  - Free Radical Research
T1  - Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients
VL  - 43
SP  - 96
EP  - 97
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1277
ER  - 

@conference{
author = "Kotur-Stevuljević, Jelena and Vemić, Sava and Spasojević-Kalimanovska, Vesna and Spasić, S. and Jelić-Ivanović, Zorana",
year = "2009",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Free Radical Research",
title = "Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients",
volume = "43",
pages = "96-97",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1277"
}

Kotur-Stevuljević, J., Vemić, S., Spasojević-Kalimanovska, V., Spasić, S.,& Jelić-Ivanović, Z.. (2009). Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients. in Free Radical Research
Taylor & Francis Ltd, Abingdon., 43, 96-97.
https://hdl.handle.net/21.15107/rcub_farfar_1277

Kotur-Stevuljević J, Vemić S, Spasojević-Kalimanovska V, Spasić S, Jelić-Ivanović Z. Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients. in Free Radical Research. 2009;43:96-97.
https://hdl.handle.net/21.15107/rcub_farfar_1277 .

Kotur-Stevuljević, Jelena, Vemić, Sava, Spasojević-Kalimanovska, Vesna, Spasić, S., Jelić-Ivanović, Zorana, "Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients" in Free Radical Research, 43 (2009):96-97,
https://hdl.handle.net/21.15107/rcub_farfar_1277 .