TY  - JOUR
AU  - Dimitrijević, Marija
AU  - Mitić, Violeta
AU  - Đorđević, Dragan
AU  - Popović, Gordana
AU  - Krstić, Nenad
AU  - Nikolić, Jelena
AU  - Stankov Jovanović, Vesna
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3988
AB  - Three edible mushrooms of the Russulacea family (Lactarius deliciosus, Lactarius sanguifluus and Lactarius semisanguifluus), most frequently consumed in Serbia, were analyzed using the ICP-OES technique to evaluate the content of K, P, Ca, Mg, Na, Al, As, Cd and Pb, both in cap and stipe. Corresponding soils were analyzed, too. Based on the obtained values for the elemental composition of the mushrooms and the soil, bioaccumulation and translocation factors were calculated. All the examined mushrooms species were recognized as bioexclusors of analyzed toxic elements, but bioaccumulators of K, P and Ca. The studied mushrooms are good sources of macroelements. One portion of 300 g of fresh mushrooms had a significant contribution of K and P, exceeding 15 % of the recommended daily intake for the elements. On the contrary, mushrooms had a low potential to bioaccumulate toxic elements, and presented results indicated the regular consumption of wild edible mushrooms is safe for human health. Correlation analysis was applied to determine phosphorus’s influence on the elements’ content in the mushrooms and corresponding soils, demonstrating the most remarkable mushrooms' tendency to accumulate phosphorus.
AB  - Циљ овог рада било је одређивање садржаја K, P, Ca, Mg, Na, Al, As, Cd и Pb у три
јестиве, самоникле печурке (Lactarius deliciosus, Lactarius sanguifluus и Lactarius semisanguifluus)
које припадају породици Russulacea. Такође, одређен је и садржај поменутих
елемената у земљишту на коме су расле анализиране печурке. На основу добијених
резултата, за сваки елемент је израчунат биоакумулациони и транслокациони фактор.
Будући да је утврђено да печурке акумулирају одговарајуће макроелементе, резултати
су приказани и као унос (%) одговарајућих елемената на основу препоручене дневне
дозе, прерачунато на порцију од 300 g свежих печурака. За токсичне елементе израчунат
је садржај уноса елемената на основу прихватљивог недељног уноса. Корелациона ана-
лиза је коришћена како би се утврдио утицај фосфора на садржај елемената у печур-
кама и одговарајућим земљиштима, обзиром да је фосфор показао најзначајнију тен-
денцију акумулације.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Macroelements versus toxic elements in selected wild edible mushrooms of the Russulacea family from Serbia
VL  - 86
IS  - 10
SP  - 927
EP  - 940
DO  - 10.2298/JSC210410038D
ER  - 

@article{
author = "Dimitrijević, Marija and Mitić, Violeta and Đorđević, Dragan and Popović, Gordana and Krstić, Nenad and Nikolić, Jelena and Stankov Jovanović, Vesna",
year = "2021",
abstract = "Three edible mushrooms of the Russulacea family (Lactarius deliciosus, Lactarius sanguifluus and Lactarius semisanguifluus), most frequently consumed in Serbia, were analyzed using the ICP-OES technique to evaluate the content of K, P, Ca, Mg, Na, Al, As, Cd and Pb, both in cap and stipe. Corresponding soils were analyzed, too. Based on the obtained values for the elemental composition of the mushrooms and the soil, bioaccumulation and translocation factors were calculated. All the examined mushrooms species were recognized as bioexclusors of analyzed toxic elements, but bioaccumulators of K, P and Ca. The studied mushrooms are good sources of macroelements. One portion of 300 g of fresh mushrooms had a significant contribution of K and P, exceeding 15 % of the recommended daily intake for the elements. On the contrary, mushrooms had a low potential to bioaccumulate toxic elements, and presented results indicated the regular consumption of wild edible mushrooms is safe for human health. Correlation analysis was applied to determine phosphorus’s influence on the elements’ content in the mushrooms and corresponding soils, demonstrating the most remarkable mushrooms' tendency to accumulate phosphorus., Циљ овог рада било је одређивање садржаја K, P, Ca, Mg, Na, Al, As, Cd и Pb у три
јестиве, самоникле печурке (Lactarius deliciosus, Lactarius sanguifluus и Lactarius semisanguifluus)
које припадају породици Russulacea. Такође, одређен је и садржај поменутих
елемената у земљишту на коме су расле анализиране печурке. На основу добијених
резултата, за сваки елемент је израчунат биоакумулациони и транслокациони фактор.
Будући да је утврђено да печурке акумулирају одговарајуће макроелементе, резултати
су приказани и као унос (%) одговарајућих елемената на основу препоручене дневне
дозе, прерачунато на порцију од 300 g свежих печурака. За токсичне елементе израчунат
је садржај уноса елемената на основу прихватљивог недељног уноса. Корелациона ана-
лиза је коришћена како би се утврдио утицај фосфора на садржај елемената у печур-
кама и одговарајућим земљиштима, обзиром да је фосфор показао најзначајнију тен-
денцију акумулације.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Macroelements versus toxic elements in selected wild edible mushrooms of the Russulacea family from Serbia",
volume = "86",
number = "10",
pages = "927-940",
doi = "10.2298/JSC210410038D"
}

Dimitrijević, M., Mitić, V., Đorđević, D., Popović, G., Krstić, N., Nikolić, J.,& Stankov Jovanović, V.. (2021). Macroelements versus toxic elements in selected wild edible mushrooms of the Russulacea family from Serbia. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 86(10), 927-940.
https://doi.org/10.2298/JSC210410038D

Dimitrijević M, Mitić V, Đorđević D, Popović G, Krstić N, Nikolić J, Stankov Jovanović V. Macroelements versus toxic elements in selected wild edible mushrooms of the Russulacea family from Serbia. in Journal of the Serbian Chemical Society. 2021;86(10):927-940.
doi:10.2298/JSC210410038D .

Dimitrijević, Marija, Mitić, Violeta, Đorđević, Dragan, Popović, Gordana, Krstić, Nenad, Nikolić, Jelena, Stankov Jovanović, Vesna, "Macroelements versus toxic elements in selected wild edible mushrooms of the Russulacea family from Serbia" in Journal of the Serbian Chemical Society, 86, no. 10 (2021):927-940,
https://doi.org/10.2298/JSC210410038D . .

TY  - JOUR
AU  - Perić, Aneta
AU  - Šurbatović, Maja
AU  - Vezmar-Kovačević, Sandra
AU  - Antunović, Mirjana
AU  - Veljović, Milić
AU  - Krstić-Lečić, Ivana
AU  - Đorđević, Dragan
AU  - Kilibarda, Vesna
AU  - Zeba, Snježana
AU  - Dobrić, Silva
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2473
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach
T1  - Upotreba beta-laktamskih antibiotika u jedinicama intenzivne terapije - patofiziološki, farmakokinetički, farmakodinamički i farmakoekonomski pristup
VL  - 72
IS  - 2
SP  - 175
EP  - 180
DO  - 10.2298/VSP1502175P
ER  - 

@article{
author = "Perić, Aneta and Šurbatović, Maja and Vezmar-Kovačević, Sandra and Antunović, Mirjana and Veljović, Milić and Krstić-Lečić, Ivana and Đorđević, Dragan and Kilibarda, Vesna and Zeba, Snježana and Dobrić, Silva",
year = "2015",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach, Upotreba beta-laktamskih antibiotika u jedinicama intenzivne terapije - patofiziološki, farmakokinetički, farmakodinamički i farmakoekonomski pristup",
volume = "72",
number = "2",
pages = "175-180",
doi = "10.2298/VSP1502175P"
}

Perić, A., Šurbatović, M., Vezmar-Kovačević, S., Antunović, M., Veljović, M., Krstić-Lečić, I., Đorđević, D., Kilibarda, V., Zeba, S.,& Dobrić, S.. (2015). Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(2), 175-180.
https://doi.org/10.2298/VSP1502175P

Perić A, Šurbatović M, Vezmar-Kovačević S, Antunović M, Veljović M, Krstić-Lečić I, Đorđević D, Kilibarda V, Zeba S, Dobrić S. Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach. in Vojnosanitetski pregled. 2015;72(2):175-180.
doi:10.2298/VSP1502175P .

Perić, Aneta, Šurbatović, Maja, Vezmar-Kovačević, Sandra, Antunović, Mirjana, Veljović, Milić, Krstić-Lečić, Ivana, Đorđević, Dragan, Kilibarda, Vesna, Zeba, Snježana, Dobrić, Silva, "Beta-lactam antibiotics use in intensive care units: The pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach" in Vojnosanitetski pregled, 72, no. 2 (2015):175-180,
https://doi.org/10.2298/VSP1502175P . .

TY  - JOUR
AU  - Perić, Aneta
AU  - Šurbatović, Maja
AU  - Vezmar-Kovačević, Sandra
AU  - Antunović, Mirjana
AU  - Veljović, Milić
AU  - Đorđević, Dragan
AU  - Anđelić, Tamara
AU  - Zeba, Snježana
AU  - Dobrić, Silva
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2262
AB  - Background/Aim. Critically ill patients are at very high risk of developing severe infections in intensive care units (ICUs). Procalcitonin (PCT) levels are eleveted in the circulation in patients with bacterial sepsis and PCT might be useful in guiding antibiotic treatment. The aim of this study was to estimate factors influencing patients survival and treatment cost in ICU with special emphasis on the impact of PCT serum levels use in guiding antimicrobial therapy. Methods. The study was conducted from August 2010 to May 2012 in the Intensive Therapy Unit, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy (MMA), Belgrade, Serbia. All adult critically ill patients with sepsis and/or trauma admitted in the ICU were included in the study. This study included only the cost of antimicrobial therapy in the ICU and the cost for PCT analysis. We used prices valid in the MMA for the year 2012. PCT in serum was measured by homogeneous immunoassay on a Brahms Kryptor analyzer. Results. A total of 102 patients were enrolled. The mean patients age was 55 ± 19 years and 61.8% of patients were male. The mean length of stay (LOS) in the ICU was 12 ± 21 days. There was a statistically significant difference (p  lt  0.001) between the sepsis and trauma group regarding outcome (higher mortality rate was in the sepsis group, particularly in the patients with peritonitis who were mostly women). The patients younger than 70 years had better chance of survival. LOS, the use of carbapenems and PCT-measurement influenced the cost of therapy in the ICU. Conclusions. The obtained results show that age, the diagnosis and gender were the main predictors of survival of critically ill patients in the ICU. The cost of ICU stay was dependent on LOS, use of carbapenems and PCT measurement although the influence of these three factors on the outcome in the patients did not reach a statistical significance.
AB  - Uvod/Cilj. Kritično oboleli pacijenti imaju veliki rizik od razvoja teških infekcija u jedinicama intenzivne terapije (JIT). Nivo prokalcitonina (PCT) u cirkulaciji je povišen kod bolesnika sa bakterijskom sepsom, tako da PCT može biti koristan u praćenju antibiotske terapije. Cilj ove studije bio je da se ustanove faktori koji utiču na ishod i troškove lečenja u JIT u našoj ustanovi sa posebnim naglaskom na uticaj korišćenja serumskog nivoa PCT u vođenju antimikrobne terapije. Metode. Studija je sprovedena od avgusta 2010. godine do maja 2012. godine u Jedinici intenzivne terapije Klinike za anesteziologiju i intenzivnu terapiju Vojnomedicinske akademije (VMA) u Beogradu, Srbija. Svi kritično oboleli sa sepsom i/ili traumom koji su primljeni u JIT bili su uključeni u studiju. Studijom su obuhvaćeni samo troškovi antimikrobne terapije u JIT i troškovi PCT analize. Koristili smo cenovnik VMA za 2012. godinu. PCT u serumu je meren tehnikom homogenog imunoeseja na Brams Kriptor analizatoru. Rezultati. Studijom su bila obuhvaćena 102 bolesnika. Prosečna starost bolesnika iznosila je 55 ± 19 godina, a 61,8% bolesnika bili su muškarci. Prosečna dužina boravka u JIT (lenght of stay LOS) iznosila je 12 ± 21 dana. Postojala je statistički značajna razlika (p  lt  0.001) između ishoda lečenja u grupi sa sepsom u odnosu na grupu sa traumom. Bolesnici mlađi od 70 godina imali su bolju šansu da prežive. Dužina boravka, upotreba karbapenema i merenje PCT uticali su na cenu terapije u JIT. Zaključak. Dobijeni rezultati pokazuju da su godine života, dijagnoza i pol bili glavni prediktori preživljavanja kritično obolelih u JIT. Cena terapije zavisila je od dužine boravka u JIT, upotrebe karbapenema i merenja PCT, ali uticaj ovih faktora na ishod lečenja nije dostigao statističku značajnost.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study
T1  - Faktori koji utiču na cenu antibiotske terapije i ishod kod kritično obolelih pacijenata - 'real-life' studija
VL  - 71
IS  - 12
SP  - 1102
EP  - 1108
DO  - 10.2298/VSP1412102P
ER  - 

@article{
author = "Perić, Aneta and Šurbatović, Maja and Vezmar-Kovačević, Sandra and Antunović, Mirjana and Veljović, Milić and Đorđević, Dragan and Anđelić, Tamara and Zeba, Snježana and Dobrić, Silva",
year = "2014",
abstract = "Background/Aim. Critically ill patients are at very high risk of developing severe infections in intensive care units (ICUs). Procalcitonin (PCT) levels are eleveted in the circulation in patients with bacterial sepsis and PCT might be useful in guiding antibiotic treatment. The aim of this study was to estimate factors influencing patients survival and treatment cost in ICU with special emphasis on the impact of PCT serum levels use in guiding antimicrobial therapy. Methods. The study was conducted from August 2010 to May 2012 in the Intensive Therapy Unit, Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy (MMA), Belgrade, Serbia. All adult critically ill patients with sepsis and/or trauma admitted in the ICU were included in the study. This study included only the cost of antimicrobial therapy in the ICU and the cost for PCT analysis. We used prices valid in the MMA for the year 2012. PCT in serum was measured by homogeneous immunoassay on a Brahms Kryptor analyzer. Results. A total of 102 patients were enrolled. The mean patients age was 55 ± 19 years and 61.8% of patients were male. The mean length of stay (LOS) in the ICU was 12 ± 21 days. There was a statistically significant difference (p  lt  0.001) between the sepsis and trauma group regarding outcome (higher mortality rate was in the sepsis group, particularly in the patients with peritonitis who were mostly women). The patients younger than 70 years had better chance of survival. LOS, the use of carbapenems and PCT-measurement influenced the cost of therapy in the ICU. Conclusions. The obtained results show that age, the diagnosis and gender were the main predictors of survival of critically ill patients in the ICU. The cost of ICU stay was dependent on LOS, use of carbapenems and PCT measurement although the influence of these three factors on the outcome in the patients did not reach a statistical significance., Uvod/Cilj. Kritično oboleli pacijenti imaju veliki rizik od razvoja teških infekcija u jedinicama intenzivne terapije (JIT). Nivo prokalcitonina (PCT) u cirkulaciji je povišen kod bolesnika sa bakterijskom sepsom, tako da PCT može biti koristan u praćenju antibiotske terapije. Cilj ove studije bio je da se ustanove faktori koji utiču na ishod i troškove lečenja u JIT u našoj ustanovi sa posebnim naglaskom na uticaj korišćenja serumskog nivoa PCT u vođenju antimikrobne terapije. Metode. Studija je sprovedena od avgusta 2010. godine do maja 2012. godine u Jedinici intenzivne terapije Klinike za anesteziologiju i intenzivnu terapiju Vojnomedicinske akademije (VMA) u Beogradu, Srbija. Svi kritično oboleli sa sepsom i/ili traumom koji su primljeni u JIT bili su uključeni u studiju. Studijom su obuhvaćeni samo troškovi antimikrobne terapije u JIT i troškovi PCT analize. Koristili smo cenovnik VMA za 2012. godinu. PCT u serumu je meren tehnikom homogenog imunoeseja na Brams Kriptor analizatoru. Rezultati. Studijom su bila obuhvaćena 102 bolesnika. Prosečna starost bolesnika iznosila je 55 ± 19 godina, a 61,8% bolesnika bili su muškarci. Prosečna dužina boravka u JIT (lenght of stay LOS) iznosila je 12 ± 21 dana. Postojala je statistički značajna razlika (p  lt  0.001) između ishoda lečenja u grupi sa sepsom u odnosu na grupu sa traumom. Bolesnici mlađi od 70 godina imali su bolju šansu da prežive. Dužina boravka, upotreba karbapenema i merenje PCT uticali su na cenu terapije u JIT. Zaključak. Dobijeni rezultati pokazuju da su godine života, dijagnoza i pol bili glavni prediktori preživljavanja kritično obolelih u JIT. Cena terapije zavisila je od dužine boravka u JIT, upotrebe karbapenema i merenja PCT, ali uticaj ovih faktora na ishod lečenja nije dostigao statističku značajnost.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study, Faktori koji utiču na cenu antibiotske terapije i ishod kod kritično obolelih pacijenata - 'real-life' studija",
volume = "71",
number = "12",
pages = "1102-1108",
doi = "10.2298/VSP1412102P"
}

Perić, A., Šurbatović, M., Vezmar-Kovačević, S., Antunović, M., Veljović, M., Đorđević, D., Anđelić, T., Zeba, S.,& Dobrić, S.. (2014). Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(12), 1102-1108.
https://doi.org/10.2298/VSP1412102P

Perić A, Šurbatović M, Vezmar-Kovačević S, Antunović M, Veljović M, Đorđević D, Anđelić T, Zeba S, Dobrić S. Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study. in Vojnosanitetski pregled. 2014;71(12):1102-1108.
doi:10.2298/VSP1412102P .

Perić, Aneta, Šurbatović, Maja, Vezmar-Kovačević, Sandra, Antunović, Mirjana, Veljović, Milić, Đorđević, Dragan, Anđelić, Tamara, Zeba, Snježana, Dobrić, Silva, "Factors influencing antibiotic treatment cost and outcome in critically ill patients: A 'real-life' study" in Vojnosanitetski pregled, 71, no. 12 (2014):1102-1108,
https://doi.org/10.2298/VSP1412102P . .