TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Savić, V.
AU  - Prokić, Vera
AU  - Stojanov, Marina
AU  - Černak, Ibolja
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/660
AB  - Lung trauma has been considered to be one of the vital injuries induced by explosion-generated blast overpressure. Conflicting evidence exists as to whether nitric oxide plays a crucial role in acute lung injury induced by blast. Data presented in this study demonstrate that local exposure of midthoracic region to moderate-level blast overpressure significantly enhanced lipid peroxidation product malondialdehyde and superoxide anion generation in rabbit's lungs 30 minutes after exposure, whereas the activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) activity showed parallel increase. NG-nitro-L-arginine methyl ester, a non-specific inhibitor of nitric oxide synthase (NOS), had no effects on the measured parameters suggesting that oxidative stress induced by blast exposure might be independent from NOS.
AB  - Smatra se da je povreda pluća jedna od najvažnijih povreda do kojih dolazi delovanjem blast talasa generisanog na mestu eksplozije. Do danas ne postoji definitivan stav da li azot-monoksid ima bitnu ulogu u akutnoj blast povredi pluća. Rezultati ove studije pokazuju da lokalno delovanje blast nadpritiska srednje jačine na središnji deo toraksa dovodi do povećanog stvaranja malondialdehida, produkta lipidne peroksidacije kao i povećanog generisanja superoksidnog anjona, 30 minuta posle traume. Istovremeno, dolazi do smanjenja aktivnosti antioksidativnih enzima (superoksid-dizmutaze i glutation-peroksidaze) u plućnom tkivu kunića. NG-nitro-L-arginin-metil estar (L-NAME), nespecifični inhibitor enzima azot-monoksid sintaze (NOS) nije imao efekta na određivane parametere, što ukazuje daje oskidativni stres indukovan blast povredom verovatno nezavisan od aktivnosti enzima NOS.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production
T1  - Oksidativni stres u akutnoj blast povredi pluća je nezavisan od enzimske sinteze azot-monoksida
VL  - 55
IS  - 5-6
SP  - 385
EP  - 394
DO  - 10.2298/AVB0506385K
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Savić, V. and Prokić, Vera and Stojanov, Marina and Černak, Ibolja",
year = "2005",
abstract = "Lung trauma has been considered to be one of the vital injuries induced by explosion-generated blast overpressure. Conflicting evidence exists as to whether nitric oxide plays a crucial role in acute lung injury induced by blast. Data presented in this study demonstrate that local exposure of midthoracic region to moderate-level blast overpressure significantly enhanced lipid peroxidation product malondialdehyde and superoxide anion generation in rabbit's lungs 30 minutes after exposure, whereas the activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) activity showed parallel increase. NG-nitro-L-arginine methyl ester, a non-specific inhibitor of nitric oxide synthase (NOS), had no effects on the measured parameters suggesting that oxidative stress induced by blast exposure might be independent from NOS., Smatra se da je povreda pluća jedna od najvažnijih povreda do kojih dolazi delovanjem blast talasa generisanog na mestu eksplozije. Do danas ne postoji definitivan stav da li azot-monoksid ima bitnu ulogu u akutnoj blast povredi pluća. Rezultati ove studije pokazuju da lokalno delovanje blast nadpritiska srednje jačine na središnji deo toraksa dovodi do povećanog stvaranja malondialdehida, produkta lipidne peroksidacije kao i povećanog generisanja superoksidnog anjona, 30 minuta posle traume. Istovremeno, dolazi do smanjenja aktivnosti antioksidativnih enzima (superoksid-dizmutaze i glutation-peroksidaze) u plućnom tkivu kunića. NG-nitro-L-arginin-metil estar (L-NAME), nespecifični inhibitor enzima azot-monoksid sintaze (NOS) nije imao efekta na određivane parametere, što ukazuje daje oskidativni stres indukovan blast povredom verovatno nezavisan od aktivnosti enzima NOS.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production, Oksidativni stres u akutnoj blast povredi pluća je nezavisan od enzimske sinteze azot-monoksida",
volume = "55",
number = "5-6",
pages = "385-394",
doi = "10.2298/AVB0506385K"
}

Kotur-Stevuljević, J., Savić, V., Prokić, V., Stojanov, M.,& Černak, I.. (2005). Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 55(5-6), 385-394.
https://doi.org/10.2298/AVB0506385K

Kotur-Stevuljević J, Savić V, Prokić V, Stojanov M, Černak I. Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production. in Acta veterinaria. 2005;55(5-6):385-394.
doi:10.2298/AVB0506385K .

Kotur-Stevuljević, Jelena, Savić, V., Prokić, Vera, Stojanov, Marina, Černak, Ibolja, "Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production" in Acta veterinaria, 55, no. 5-6 (2005):385-394,
https://doi.org/10.2298/AVB0506385K . .

TY  - CONF
AU  - Kotur-Stevuljević, Jelena
AU  - Černak, Ibolja
AU  - Stojanov, Marina
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/314
AB  - At present, the mechanisms of many diseases (cardiovascular diseases, cancer diabetes, rheumatoid arthritis, hepatitis, atherosclerosis, haemorrhagic shock, AIDS etc) are explained through interaction of oxidative stress (OS) mediators and antioxidative defence (AOD) sistem factors. It is important to develop new and evaluate existing analytical procedures for determination of OS mediators and methods for evaluation of antioxidative status. More frequent use of these tests will be very useful for evaluating organism status in health and disease, for monitoring the effects of therapies. These tests will be beneficial for judgment if antioxidant supplementation is necessary or therapy with vitamin E or selenium. All cells normally generate superoxide anion radical (O2 -), hydrogen peroxide (H2O2), hydroxyl anion radical (OH -), nitric oxide (NO), peroxynitrite anion (ONOO -). In cellular injury, during hypoxia and following reperfusion, increased amounts of free radicals can generate. This event can aggravate tissue injury. AOD system (albumin, uric acid, glutathione, vitamin E, vitamin C, SOD, GPx catalase, selenium, caeruloplasmin, transferrin) is very important physiological regulator in health and disease.
AB  - Danas se mehanizmi velikog broja bolesti (kardiovaskularne bolesti, kancer dijabetes, reumatoidni artritis, hepatitis, ateroskleroza, hemoragijski šok AIDS i dr) objašnjavaju interakcijom činilaca oksidativnog stresa (OS) i antioksidativne (AO) zaštite. Zbog toga je značajno razvijati nove i evaluirati postojeće metode za merenje pokazatelja oksidativnog stresa i to slobodnih radikala, njihovih reaktivnih intermedijera i produkata peroksidacije lipida, kao i metode za procenu antioksidativnog statusa organizma. Šira primena ovih testova bi bila značajna za procenu stanja kako već obolelog, tako i zdravog organizma u cilju prevencije potencijalnih bolesti, za praćenje efikasnosti primenjene terapije kao i procene da li je potrebna suplementacija ishrane antioksidansima ili uvođenje terapije vitaminom E ili selenom. U toku normalnog metabolizma u ćeliji se stvaraju superoksidni anjon (O2.-), vodonik peroksid (H2O2), hidroksilni anjon radikal (OH -), azot monoksid (NO), peroksinitritni anjon (ONOO -). U slučaju oštećenja/povrede ćelije, usled hipoksije i posledične reperfuzije dolazi do povećanog stvaranja slobodnih radikala, koji sami ili preko svojih reaktivnih produkata, produbljuju oštećenje tkiva. Sistem AO zaštite organizma (albumin, mokraćna kiselina, glutation; vitamini E i C; enzimi SOD, GPx, katalaza, selen; ceruloplazmin i transferin) je zbog toga značajan fiziološki regulator kako u toku normalnih metaboličkih procesa tako i u patološkim stanjima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Parameters of oxidative stress and antioxidative defence
T1  - Parametri oksidativnog stresa i antioksidativne zaštite
VL  - 52
IS  - 3
SP  - 287
EP  - 294
UR  - https://hdl.handle.net/21.15107/rcub_farfar_314
ER  - 

@conference{
author = "Kotur-Stevuljević, Jelena and Černak, Ibolja and Stojanov, Marina",
year = "2002",
abstract = "At present, the mechanisms of many diseases (cardiovascular diseases, cancer diabetes, rheumatoid arthritis, hepatitis, atherosclerosis, haemorrhagic shock, AIDS etc) are explained through interaction of oxidative stress (OS) mediators and antioxidative defence (AOD) sistem factors. It is important to develop new and evaluate existing analytical procedures for determination of OS mediators and methods for evaluation of antioxidative status. More frequent use of these tests will be very useful for evaluating organism status in health and disease, for monitoring the effects of therapies. These tests will be beneficial for judgment if antioxidant supplementation is necessary or therapy with vitamin E or selenium. All cells normally generate superoxide anion radical (O2 -), hydrogen peroxide (H2O2), hydroxyl anion radical (OH -), nitric oxide (NO), peroxynitrite anion (ONOO -). In cellular injury, during hypoxia and following reperfusion, increased amounts of free radicals can generate. This event can aggravate tissue injury. AOD system (albumin, uric acid, glutathione, vitamin E, vitamin C, SOD, GPx catalase, selenium, caeruloplasmin, transferrin) is very important physiological regulator in health and disease., Danas se mehanizmi velikog broja bolesti (kardiovaskularne bolesti, kancer dijabetes, reumatoidni artritis, hepatitis, ateroskleroza, hemoragijski šok AIDS i dr) objašnjavaju interakcijom činilaca oksidativnog stresa (OS) i antioksidativne (AO) zaštite. Zbog toga je značajno razvijati nove i evaluirati postojeće metode za merenje pokazatelja oksidativnog stresa i to slobodnih radikala, njihovih reaktivnih intermedijera i produkata peroksidacije lipida, kao i metode za procenu antioksidativnog statusa organizma. Šira primena ovih testova bi bila značajna za procenu stanja kako već obolelog, tako i zdravog organizma u cilju prevencije potencijalnih bolesti, za praćenje efikasnosti primenjene terapije kao i procene da li je potrebna suplementacija ishrane antioksidansima ili uvođenje terapije vitaminom E ili selenom. U toku normalnog metabolizma u ćeliji se stvaraju superoksidni anjon (O2.-), vodonik peroksid (H2O2), hidroksilni anjon radikal (OH -), azot monoksid (NO), peroksinitritni anjon (ONOO -). U slučaju oštećenja/povrede ćelije, usled hipoksije i posledične reperfuzije dolazi do povećanog stvaranja slobodnih radikala, koji sami ili preko svojih reaktivnih produkata, produbljuju oštećenje tkiva. Sistem AO zaštite organizma (albumin, mokraćna kiselina, glutation; vitamini E i C; enzimi SOD, GPx, katalaza, selen; ceruloplazmin i transferin) je zbog toga značajan fiziološki regulator kako u toku normalnih metaboličkih procesa tako i u patološkim stanjima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Parameters of oxidative stress and antioxidative defence, Parametri oksidativnog stresa i antioksidativne zaštite",
volume = "52",
number = "3",
pages = "287-294",
url = "https://hdl.handle.net/21.15107/rcub_farfar_314"
}

Kotur-Stevuljević, J., Černak, I.,& Stojanov, M.. (2002). Parameters of oxidative stress and antioxidative defence. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(3), 287-294.
https://hdl.handle.net/21.15107/rcub_farfar_314

Kotur-Stevuljević J, Černak I, Stojanov M. Parameters of oxidative stress and antioxidative defence. in Arhiv za farmaciju. 2002;52(3):287-294.
https://hdl.handle.net/21.15107/rcub_farfar_314 .

Kotur-Stevuljević, Jelena, Černak, Ibolja, Stojanov, Marina, "Parameters of oxidative stress and antioxidative defence" in Arhiv za farmaciju, 52, no. 3 (2002):287-294,
https://hdl.handle.net/21.15107/rcub_farfar_314 .

TY  - CONF
AU  - Stojanov, Marina
AU  - Kotur, Jelena
AU  - Černak, Ibolja
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/286
PB  - Amer Assoc Clinical Chemistry, Washington
C3  - Clinical Chemistry
T1  - Oxidative stress in the pathogenesis of indirect neurotrauma caused by lung blast injury.
VL  - 47
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_farfar_286
ER  - 

@conference{
author = "Stojanov, Marina and Kotur, Jelena and Černak, Ibolja",
year = "2001",
publisher = "Amer Assoc Clinical Chemistry, Washington",
journal = "Clinical Chemistry",
title = "Oxidative stress in the pathogenesis of indirect neurotrauma caused by lung blast injury.",
volume = "47",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_farfar_286"
}

Stojanov, M., Kotur, J.,& Černak, I.. (2001). Oxidative stress in the pathogenesis of indirect neurotrauma caused by lung blast injury.. in Clinical Chemistry
Amer Assoc Clinical Chemistry, Washington., 47(6).
https://hdl.handle.net/21.15107/rcub_farfar_286

Stojanov M, Kotur J, Černak I. Oxidative stress in the pathogenesis of indirect neurotrauma caused by lung blast injury.. in Clinical Chemistry. 2001;47(6).
https://hdl.handle.net/21.15107/rcub_farfar_286 .

Stojanov, Marina, Kotur, Jelena, Černak, Ibolja, "Oxidative stress in the pathogenesis of indirect neurotrauma caused by lung blast injury." in Clinical Chemistry, 47, no. 6 (2001),
https://hdl.handle.net/21.15107/rcub_farfar_286 .

TY  - JOUR
AU  - Prokić, Vera
AU  - Kotur, Jelena
AU  - Černak, Ibolja
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/271
AB  - The blast wave overpressure generated by explosive material detonations causes pulmonary pathological alterations which affect the general and cerebral response of the organism to the blast injury. The aim of this study was to evaluate the development of oxidative stress (lipid peroxidation and superoxide anion) and the action of the antioxidant protection (superoxide dismutase) in bronchial and alveolar regions of the lungs. Rabbits were divided into two groups - blast and control. The blast group was exposed to blast wave overpressure focused on to the thoracic region, that was generated in laboratory conditions using an air-driven shock tube. The pulmonary injury was moderate and defined as confluent ecchymoses involving 30 - 60 % of lung tissue.The animals were sacrificed by decapitation after the early posttraumatic period of 30 minutes following blast injury. On the basis of obtained results it was concluded that there were statistically significant differences between blast and control group considering the increased oxidative stress in injured animals and respectively, the impairment of the antioxidative protection. It is suggested that the increased generation of reactive oxygen species in lungs could be a marker of serious pulmonary injury.
AB  - Talas vazdušnog nadpritiska (² blast ²) koji nastaje kao posledica detonacije eksplozivnih materija izaziva patološke promene na plućima koje utiču na opšti i cerebralni odgovor organizma na ²blast² povredu. Cilj ovog istraživanja je bio da proceni razvoj oksidativnog stresa (lipidna peroksidacija i superoksidni anjon) i antioksidativnog sistema zaštite (superoksid dismutaza) u bronhijalnom i alveolarnom regionu pluća nakon ²blast² povrede. Životinje su bile podeljene u dve grupe - BLAST i KONTROLA. Blast grupa je bila izložena talasu vazdušnog nadpritiska generisanog u laboratorijskim uslovima. Umerena povreda pluća je izražavana kao postojanje konfluentne ekhimoze u obimu od 30-60 % od ukupnog plućnog tkiva. Životinje su žrtvovane dekapitacijom u ranom posttraumatskom periodu od 30 minuta nakon nanošenja povrede. Na osnovu dobijenih rezultata zaključeno je da postoje statistički značajne razlike između blast i kontrolne grupe u smislu povećanja vrednosti parametara oksidativnog stresa kod povređenih zečeva kao i slabljenje antioksidativne zaštite. Kao rezultat ovog rada nastala je pretpostavka da povećana proizvodnja reaktivnih oksidativnih radikala u plućima može biti znak teške povrede pluća.
PB  - Unija bioloških naučnih društava Jugoslavije, Beograd
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Parameters of oxidative stress in rabbits with pulmonary blast injury
T1  - Parametri oksidativnog stresa u blast povredi pluća kod zeca
VL  - 36
IS  - 1
SP  - 33
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_farfar_271
ER  - 

@article{
author = "Prokić, Vera and Kotur, Jelena and Černak, Ibolja",
year = "2000",
abstract = "The blast wave overpressure generated by explosive material detonations causes pulmonary pathological alterations which affect the general and cerebral response of the organism to the blast injury. The aim of this study was to evaluate the development of oxidative stress (lipid peroxidation and superoxide anion) and the action of the antioxidant protection (superoxide dismutase) in bronchial and alveolar regions of the lungs. Rabbits were divided into two groups - blast and control. The blast group was exposed to blast wave overpressure focused on to the thoracic region, that was generated in laboratory conditions using an air-driven shock tube. The pulmonary injury was moderate and defined as confluent ecchymoses involving 30 - 60 % of lung tissue.The animals were sacrificed by decapitation after the early posttraumatic period of 30 minutes following blast injury. On the basis of obtained results it was concluded that there were statistically significant differences between blast and control group considering the increased oxidative stress in injured animals and respectively, the impairment of the antioxidative protection. It is suggested that the increased generation of reactive oxygen species in lungs could be a marker of serious pulmonary injury., Talas vazdušnog nadpritiska (² blast ²) koji nastaje kao posledica detonacije eksplozivnih materija izaziva patološke promene na plućima koje utiču na opšti i cerebralni odgovor organizma na ²blast² povredu. Cilj ovog istraživanja je bio da proceni razvoj oksidativnog stresa (lipidna peroksidacija i superoksidni anjon) i antioksidativnog sistema zaštite (superoksid dismutaza) u bronhijalnom i alveolarnom regionu pluća nakon ²blast² povrede. Životinje su bile podeljene u dve grupe - BLAST i KONTROLA. Blast grupa je bila izložena talasu vazdušnog nadpritiska generisanog u laboratorijskim uslovima. Umerena povreda pluća je izražavana kao postojanje konfluentne ekhimoze u obimu od 30-60 % od ukupnog plućnog tkiva. Životinje su žrtvovane dekapitacijom u ranom posttraumatskom periodu od 30 minuta nakon nanošenja povrede. Na osnovu dobijenih rezultata zaključeno je da postoje statistički značajne razlike između blast i kontrolne grupe u smislu povećanja vrednosti parametara oksidativnog stresa kod povređenih zečeva kao i slabljenje antioksidativne zaštite. Kao rezultat ovog rada nastala je pretpostavka da povećana proizvodnja reaktivnih oksidativnih radikala u plućima može biti znak teške povrede pluća.",
publisher = "Unija bioloških naučnih društava Jugoslavije, Beograd",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Parameters of oxidative stress in rabbits with pulmonary blast injury, Parametri oksidativnog stresa u blast povredi pluća kod zeca",
volume = "36",
number = "1",
pages = "33-42",
url = "https://hdl.handle.net/21.15107/rcub_farfar_271"
}

Prokić, V., Kotur, J.,& Černak, I.. (2000). Parameters of oxidative stress in rabbits with pulmonary blast injury. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
Unija bioloških naučnih društava Jugoslavije, Beograd., 36(1), 33-42.
https://hdl.handle.net/21.15107/rcub_farfar_271

Prokić V, Kotur J, Černak I. Parameters of oxidative stress in rabbits with pulmonary blast injury. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2000;36(1):33-42.
https://hdl.handle.net/21.15107/rcub_farfar_271 .

Prokić, Vera, Kotur, Jelena, Černak, Ibolja, "Parameters of oxidative stress in rabbits with pulmonary blast injury" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 36, no. 1 (2000):33-42,
https://hdl.handle.net/21.15107/rcub_farfar_271 .