TY  - JOUR
AU  - Simić, Milena
AU  - Paunović, Nikola
AU  - Borić, Ivan
AU  - Ranđelović, Jelena
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Pekmezović, Marina
AU  - Savić, Vladimir
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2580
AB  - A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic & Medicinal Chemistry Letters
T1  - Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies
VL  - 26
IS  - 1
SP  - 235
EP  - 239
DO  - 10.1016/j.bmcl.2015.08.086
ER  - 

@article{
author = "Simić, Milena and Paunović, Nikola and Borić, Ivan and Ranđelović, Jelena and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Pekmezović, Marina and Savić, Vladimir",
year = "2016",
abstract = "A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic & Medicinal Chemistry Letters",
title = "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies",
volume = "26",
number = "1",
pages = "235-239",
doi = "10.1016/j.bmcl.2015.08.086"
}

Simić, M., Paunović, N., Borić, I., Ranđelović, J., Vojnović, S., Nikodinović-Runić, J., Pekmezović, M.,& Savić, V.. (2016). Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic & Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 26(1), 235-239.
https://doi.org/10.1016/j.bmcl.2015.08.086

Simić M, Paunović N, Borić I, Ranđelović J, Vojnović S, Nikodinović-Runić J, Pekmezović M, Savić V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic & Medicinal Chemistry Letters. 2016;26(1):235-239.
doi:10.1016/j.bmcl.2015.08.086 .

Simić, Milena, Paunović, Nikola, Borić, Ivan, Ranđelović, Jelena, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Pekmezović, Marina, Savić, Vladimir, "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies" in Bioorganic & Medicinal Chemistry Letters, 26, no. 1 (2016):235-239,
https://doi.org/10.1016/j.bmcl.2015.08.086 . .

TY  - JOUR
AU  - Ranđelović, Jelena
AU  - Simić, Milena
AU  - Tasić, Gordana
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2090
AB  - Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and have become an indispensable tool in synthesis of pyrrolidines and pyrrolidine derived natural products. Amongst many methods for generating azomethine ylides, various processes involving imines derived from amino acid esters have been the most frequently studied. The use of Lewis acids to promote imine-ylide-cycloaddition sequence under mild conditions, in recent years, has led to the development of highly stereoselective metal catalysed methodologies for the preparation of pyrrolidine derivatives. In the last few years, the concept of organocatalysis has been incorporated in cycloaddition reactions of azomethine ylides providing an alternative access to chiral pyrrolidines. Several classes of typical organocatalysts such as prolines, phosphoric acids, thioureas, guanidines and sulphuric acid derivatives have been used for these purposes. Various mechanistic pathways have been proposed, based on either the activation of only one reacting partner, 1,3-dipole (imine) or dipolarophile (alkene), or both of them simultaneously. While the first three classes of organocatalysts appear to afford pyrrolidines, generally, in good yields and with high levels of stereoselectivity, guanidines and sulphuric acid derivatives are less efficient, but also the least studied catalyst group. A whole range of electron deficient dipolarophiles (alkenes) have been used in these cycloaddition processes, while, regarding the dipole precursor imine, aromatic aldimines seem to be more efficient than their aliphatic equivalents. There is no doubt that the recent progress in organocatalytic cycloadditions of azomethine ylides created new possibilities for synthesis of pyrrolidine derivatives and enriched this useful synthetic methodology.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Organic Chemistry
T1  - Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides
VL  - 18
IS  - 9
SP  - 1073
EP  - 1096
DO  - 10.2174/1385272819999140404130229
ER  - 

@article{
author = "Ranđelović, Jelena and Simić, Milena and Tasić, Gordana and Husinec, Suren and Savić, Vladimir",
year = "2014",
abstract = "Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and have become an indispensable tool in synthesis of pyrrolidines and pyrrolidine derived natural products. Amongst many methods for generating azomethine ylides, various processes involving imines derived from amino acid esters have been the most frequently studied. The use of Lewis acids to promote imine-ylide-cycloaddition sequence under mild conditions, in recent years, has led to the development of highly stereoselective metal catalysed methodologies for the preparation of pyrrolidine derivatives. In the last few years, the concept of organocatalysis has been incorporated in cycloaddition reactions of azomethine ylides providing an alternative access to chiral pyrrolidines. Several classes of typical organocatalysts such as prolines, phosphoric acids, thioureas, guanidines and sulphuric acid derivatives have been used for these purposes. Various mechanistic pathways have been proposed, based on either the activation of only one reacting partner, 1,3-dipole (imine) or dipolarophile (alkene), or both of them simultaneously. While the first three classes of organocatalysts appear to afford pyrrolidines, generally, in good yields and with high levels of stereoselectivity, guanidines and sulphuric acid derivatives are less efficient, but also the least studied catalyst group. A whole range of electron deficient dipolarophiles (alkenes) have been used in these cycloaddition processes, while, regarding the dipole precursor imine, aromatic aldimines seem to be more efficient than their aliphatic equivalents. There is no doubt that the recent progress in organocatalytic cycloadditions of azomethine ylides created new possibilities for synthesis of pyrrolidine derivatives and enriched this useful synthetic methodology.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Organic Chemistry",
title = "Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides",
volume = "18",
number = "9",
pages = "1073-1096",
doi = "10.2174/1385272819999140404130229"
}

Ranđelović, J., Simić, M., Tasić, G., Husinec, S.,& Savić, V.. (2014). Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides. in Current Organic Chemistry
Bentham Science Publ Ltd, Sharjah., 18(9), 1073-1096.
https://doi.org/10.2174/1385272819999140404130229

Ranđelović J, Simić M, Tasić G, Husinec S, Savić V. Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides. in Current Organic Chemistry. 2014;18(9):1073-1096.
doi:10.2174/1385272819999140404130229 .

Ranđelović, Jelena, Simić, Milena, Tasić, Gordana, Husinec, Suren, Savić, Vladimir, "Organocatalysis in Synthesis of Pyrrolidine Derivatives via Cycloaddition Reactions of Azomethine Ylides" in Current Organic Chemistry, 18, no. 9 (2014):1073-1096,
https://doi.org/10.2174/1385272819999140404130229 . .

TY  - JOUR
AU  - Ranđelović, Jelena
AU  - Erić, Slavica
AU  - Savić, Vladimir
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2222
AB  - In order to design a small molecule which potentially may interfere with CDK9/cyclin T1 complex formation and therefore influence its physiological role, a computational study of dynamics and druggability of CDK9 binding surface was conducted. Druggability estimates and pocket opening analyses indicated binding regions of cyclin T1 residues, Phe 146 and Lys 6, as starting points for the design of small molecules with the potential to inhibit the CDK9/cyclin T1 association. A pharmacophore model was created, based on these two residues and used to select potential inhibitor structures. Binding energies of the inhibitors were estimated with MM-GBSA. A good correlation of MM-GBSA energies and FTMap druggability predictions was observed. Amongst studied compounds a derivative of 2-amino-8-hydroxyquinoline was identified as the best potential candidate to inhibit CDK9/cyclin T1 interactions. 2014 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Molecular Graphics & Modelling
T1  - In silico design of small molecule inhibitors of CDK9/cyclin T1 interaction
VL  - 50
SP  - 100
EP  - 112
DO  - 10.1016/j.jmgm.2014.04.002
ER  - 

@article{
author = "Ranđelović, Jelena and Erić, Slavica and Savić, Vladimir",
year = "2014",
abstract = "In order to design a small molecule which potentially may interfere with CDK9/cyclin T1 complex formation and therefore influence its physiological role, a computational study of dynamics and druggability of CDK9 binding surface was conducted. Druggability estimates and pocket opening analyses indicated binding regions of cyclin T1 residues, Phe 146 and Lys 6, as starting points for the design of small molecules with the potential to inhibit the CDK9/cyclin T1 association. A pharmacophore model was created, based on these two residues and used to select potential inhibitor structures. Binding energies of the inhibitors were estimated with MM-GBSA. A good correlation of MM-GBSA energies and FTMap druggability predictions was observed. Amongst studied compounds a derivative of 2-amino-8-hydroxyquinoline was identified as the best potential candidate to inhibit CDK9/cyclin T1 interactions. 2014 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Molecular Graphics & Modelling",
title = "In silico design of small molecule inhibitors of CDK9/cyclin T1 interaction",
volume = "50",
pages = "100-112",
doi = "10.1016/j.jmgm.2014.04.002"
}

Ranđelović, J., Erić, S.,& Savić, V.. (2014). In silico design of small molecule inhibitors of CDK9/cyclin T1 interaction. in Journal of Molecular Graphics & Modelling
Elsevier Science Inc, New York., 50, 100-112.
https://doi.org/10.1016/j.jmgm.2014.04.002

Ranđelović J, Erić S, Savić V. In silico design of small molecule inhibitors of CDK9/cyclin T1 interaction. in Journal of Molecular Graphics & Modelling. 2014;50:100-112.
doi:10.1016/j.jmgm.2014.04.002 .

Ranđelović, Jelena, Erić, Slavica, Savić, Vladimir, "In silico design of small molecule inhibitors of CDK9/cyclin T1 interaction" in Journal of Molecular Graphics & Modelling, 50 (2014):100-112,
https://doi.org/10.1016/j.jmgm.2014.04.002 . .

TY  - JOUR
AU  - Jovanović, Predrag
AU  - Ranđelović, Jelena
AU  - Ivković, Branka
AU  - Suteu, Cristina
AU  - Tokić-Vujošević, Zorana
AU  - Savić, Vladimir
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2098
AB  - Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, were studied as organocatalysts in the Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10 mol % of the catalyst in wet CH2Cl2, the yields of the products were generally good while the enantioselectivity varied, reaching up to 52 %.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Substituted proline derivatives as organocatalysts in the Michael reaction
VL  - 79
IS  - 7
SP  - 767
EP  - 778
DO  - 10.2298/JSC131015002J
ER  - 

@article{
author = "Jovanović, Predrag and Ranđelović, Jelena and Ivković, Branka and Suteu, Cristina and Tokić-Vujošević, Zorana and Savić, Vladimir",
year = "2014",
abstract = "Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, were studied as organocatalysts in the Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10 mol % of the catalyst in wet CH2Cl2, the yields of the products were generally good while the enantioselectivity varied, reaching up to 52 %.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Substituted proline derivatives as organocatalysts in the Michael reaction",
volume = "79",
number = "7",
pages = "767-778",
doi = "10.2298/JSC131015002J"
}

Jovanović, P., Ranđelović, J., Ivković, B., Suteu, C., Tokić-Vujošević, Z.,& Savić, V.. (2014). Substituted proline derivatives as organocatalysts in the Michael reaction. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(7), 767-778.
https://doi.org/10.2298/JSC131015002J

Jovanović P, Ranđelović J, Ivković B, Suteu C, Tokić-Vujošević Z, Savić V. Substituted proline derivatives as organocatalysts in the Michael reaction. in Journal of the Serbian Chemical Society. 2014;79(7):767-778.
doi:10.2298/JSC131015002J .

Jovanović, Predrag, Ranđelović, Jelena, Ivković, Branka, Suteu, Cristina, Tokić-Vujošević, Zorana, Savić, Vladimir, "Substituted proline derivatives as organocatalysts in the Michael reaction" in Journal of the Serbian Chemical Society, 79, no. 7 (2014):767-778,
https://doi.org/10.2298/JSC131015002J . .

TY  - JOUR
AU  - Ranđelović, Jelena
AU  - Erić, Slavica
AU  - Savić, Vladimir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1929
AB  - Cyclin dependent kinase 9 (CDK9) is a protein that belongs to the cyclin-dependent kinases family, and its main role is in the regulation of the cell transcription processes. Since the increased activity of CDK9 is connected with the development of pathological processes such as tumor growth and survival and HIV-1 replication, inhibition of the CDK9 could be of particular interest for treating such diseases. The activation of CDK9 is initiated by the formation of CDK9/cyclin T1 complex, therefore disruption of its formation could be a promising strategy for the design of CDK9 inhibitors. In order to assist in the design of potential inhibitors of CDK9/cyclin T1 complex formation, a computational study of the CDK9/cyclin T1 interface was conducted. Ten peptides were designed using the information from the analysis of the complex, hot spot residues and fragment based design. The designed peptides were docked to CDK9 structures obtained by molecular dynamics simulations of CDK9/cyclin T1 complex and the CDK9 alone and their binding affinities were evaluated using molecular mechanics Poisson Boltzman surface area (MM-PBSA) method and steered molecular dynamics (SMD). Designed peptide sequences LQTLGF and ESIILQ, both derived from the surface of cyclin T1, as well as the peptide sequence PRWPE, derived from fragment based design, showed the most favorable binding properties and were selected for our further studies.
PB  - Springer, New York
T2  - Journal of Molecular Modeling
T1  - Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex
VL  - 19
IS  - 4
SP  - 1711
EP  - 1725
DO  - 10.1007/s00894-012-1735-2
ER  - 

@article{
author = "Ranđelović, Jelena and Erić, Slavica and Savić, Vladimir",
year = "2013",
abstract = "Cyclin dependent kinase 9 (CDK9) is a protein that belongs to the cyclin-dependent kinases family, and its main role is in the regulation of the cell transcription processes. Since the increased activity of CDK9 is connected with the development of pathological processes such as tumor growth and survival and HIV-1 replication, inhibition of the CDK9 could be of particular interest for treating such diseases. The activation of CDK9 is initiated by the formation of CDK9/cyclin T1 complex, therefore disruption of its formation could be a promising strategy for the design of CDK9 inhibitors. In order to assist in the design of potential inhibitors of CDK9/cyclin T1 complex formation, a computational study of the CDK9/cyclin T1 interface was conducted. Ten peptides were designed using the information from the analysis of the complex, hot spot residues and fragment based design. The designed peptides were docked to CDK9 structures obtained by molecular dynamics simulations of CDK9/cyclin T1 complex and the CDK9 alone and their binding affinities were evaluated using molecular mechanics Poisson Boltzman surface area (MM-PBSA) method and steered molecular dynamics (SMD). Designed peptide sequences LQTLGF and ESIILQ, both derived from the surface of cyclin T1, as well as the peptide sequence PRWPE, derived from fragment based design, showed the most favorable binding properties and were selected for our further studies.",
publisher = "Springer, New York",
journal = "Journal of Molecular Modeling",
title = "Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex",
volume = "19",
number = "4",
pages = "1711-1725",
doi = "10.1007/s00894-012-1735-2"
}

Ranđelović, J., Erić, S.,& Savić, V.. (2013). Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex. in Journal of Molecular Modeling
Springer, New York., 19(4), 1711-1725.
https://doi.org/10.1007/s00894-012-1735-2

Ranđelović J, Erić S, Savić V. Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex. in Journal of Molecular Modeling. 2013;19(4):1711-1725.
doi:10.1007/s00894-012-1735-2 .

Ranđelović, Jelena, Erić, Slavica, Savić, Vladimir, "Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex" in Journal of Molecular Modeling, 19, no. 4 (2013):1711-1725,
https://doi.org/10.1007/s00894-012-1735-2 . .

TY  - JOUR
AU  - Tasić, Gordana
AU  - Ranđelović, Jelena
AU  - Vusurović, Nikola
AU  - Maslak, Veselin
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1924
AB  - Intramolecular Pd-catalysed cyclisation reactions for the preparation of bicyclic compounds have been studied as a model system towards the synthesis of corialstonine and corialstonidine. Significant differences in reactivity have been observed for the cyclic allyl alcohols possessing O-protected and free OH functionalities. Cyclisation via the intramolecular Heck reaction, for both derivatives, proved to be highly regioselective and while the O-protected compound favoured the exo mode of cyclisation, the unprotected alcohol preferred the endo cyclisation pathway. Brief computational studies were carried out in order to obtain further insight into these processes.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron-Asymmetry
T1  - A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations
VL  - 54
IS  - 18
SP  - 2243
EP  - 2246
DO  - 10.1016/j.tetlet.2013.02.068
ER  - 

@article{
author = "Tasić, Gordana and Ranđelović, Jelena and Vusurović, Nikola and Maslak, Veselin and Husinec, Suren and Savić, Vladimir",
year = "2013",
abstract = "Intramolecular Pd-catalysed cyclisation reactions for the preparation of bicyclic compounds have been studied as a model system towards the synthesis of corialstonine and corialstonidine. Significant differences in reactivity have been observed for the cyclic allyl alcohols possessing O-protected and free OH functionalities. Cyclisation via the intramolecular Heck reaction, for both derivatives, proved to be highly regioselective and while the O-protected compound favoured the exo mode of cyclisation, the unprotected alcohol preferred the endo cyclisation pathway. Brief computational studies were carried out in order to obtain further insight into these processes.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron-Asymmetry",
title = "A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations",
volume = "54",
number = "18",
pages = "2243-2246",
doi = "10.1016/j.tetlet.2013.02.068"
}

Tasić, G., Ranđelović, J., Vusurović, N., Maslak, V., Husinec, S.,& Savić, V.. (2013). A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations. in Tetrahedron-Asymmetry
Pergamon-Elsevier Science Ltd, Oxford., 54(18), 2243-2246.
https://doi.org/10.1016/j.tetlet.2013.02.068

Tasić G, Ranđelović J, Vusurović N, Maslak V, Husinec S, Savić V. A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations. in Tetrahedron-Asymmetry. 2013;54(18):2243-2246.
doi:10.1016/j.tetlet.2013.02.068 .

Tasić, Gordana, Ranđelović, Jelena, Vusurović, Nikola, Maslak, Veselin, Husinec, Suren, Savić, Vladimir, "A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations" in Tetrahedron-Asymmetry, 54, no. 18 (2013):2243-2246,
https://doi.org/10.1016/j.tetlet.2013.02.068 . .

TY  - JOUR
AU  - Simić, Milena
AU  - Savić, Vladimir
AU  - Ranđelović, Jelena
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1618
AB  - Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures.
AB  - Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Annulation of isoquinoline and β-carboline using olefinic metathesis
T1  - Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze
VL  - 61
IS  - 3
SP  - 267
EP  - 278
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1618
ER  - 

@article{
author = "Simić, Milena and Savić, Vladimir and Ranđelović, Jelena",
year = "2011",
abstract = "Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures., Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Annulation of isoquinoline and β-carboline using olefinic metathesis, Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze",
volume = "61",
number = "3",
pages = "267-278",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1618"
}

Simić, M., Savić, V.,& Ranđelović, J.. (2011). Annulation of isoquinoline and β-carboline using olefinic metathesis. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 61(3), 267-278.
https://hdl.handle.net/21.15107/rcub_farfar_1618

Simić M, Savić V, Ranđelović J. Annulation of isoquinoline and β-carboline using olefinic metathesis. in Arhiv za farmaciju. 2011;61(3):267-278.
https://hdl.handle.net/21.15107/rcub_farfar_1618 .

Simić, Milena, Savić, Vladimir, Ranđelović, Jelena, "Annulation of isoquinoline and β-carboline using olefinic metathesis" in Arhiv za farmaciju, 61, no. 3 (2011):267-278,
https://hdl.handle.net/21.15107/rcub_farfar_1618 .

TY  - JOUR
AU  - Ranđelović, Jelena
AU  - Savić, Vladimir
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1587
AB  - Protein-protein interactions form the basics of both physiological and pathological processes, which makes them important targets for drug discovery. Structural characteristics of protein complexes, features of their binding interfaces and theoretical foundations relevant to the design of small molecules modulators of protein interactions have been briefly described in this text. Several experimental methods applicable to the design of drugs acting on protein-protein interactions are listed. The research progress achieved so far is illustrated through several examples of successfully designed modulator molecules. Due to the extraordinary significance of protein-protein interactions in living systems and our improved understanding of them, protein-protein interactions are becoming an increasingly important part of drug discovery research projects. Drugs modulating protein-protein interactions are likely going to represent an increasing percentage of therapeutically active compounds.
AB  - Interakcije među proteinima nalaze se u osnovi kako fizioloških, tako i patoloških procesa, što ih čini važnim metama za razvoj novih lekova. U ovom radu su ukratko prikazane strukturne karakteristike kompleksa nastalih interakcijom proteina, osobine njihovih vezivnih površina i teorijske postavke na kojima se zasniva dizajn malih molekula modulatora proteinskih interakcija. Navedeno je nekoliko eksperimentalnih metoda primenjivih u razvoju organskih molekula koji deluju na protein-protein interakcije. Dosadašnji razvoj istraživanja u ovoj oblasti ilustrovan je kroz više primera uspešno dizajniranih modulatorskih jedinjenja. Zbog izuzetnog značaja u živim sistemima, a zahvaljujući sve boljem razumevanju protein-protein interakcija, one postaju sve važniji deo istraživačkih programa za razvoj novih lekova. Lekovi koji deluju kao modulatori proteinskih interakcija u budućnosti će verovatno predstavljati sve veći procenat terapijski aktivnih supstanci.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Protein-protein interactions in drug discovery
T1  - Protein-protein interakcije u razvoju novih lekova
VL  - 61
IS  - 5
SP  - 464
EP  - 477
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1587
ER  - 

@article{
author = "Ranđelović, Jelena and Savić, Vladimir",
year = "2011",
abstract = "Protein-protein interactions form the basics of both physiological and pathological processes, which makes them important targets for drug discovery. Structural characteristics of protein complexes, features of their binding interfaces and theoretical foundations relevant to the design of small molecules modulators of protein interactions have been briefly described in this text. Several experimental methods applicable to the design of drugs acting on protein-protein interactions are listed. The research progress achieved so far is illustrated through several examples of successfully designed modulator molecules. Due to the extraordinary significance of protein-protein interactions in living systems and our improved understanding of them, protein-protein interactions are becoming an increasingly important part of drug discovery research projects. Drugs modulating protein-protein interactions are likely going to represent an increasing percentage of therapeutically active compounds., Interakcije među proteinima nalaze se u osnovi kako fizioloških, tako i patoloških procesa, što ih čini važnim metama za razvoj novih lekova. U ovom radu su ukratko prikazane strukturne karakteristike kompleksa nastalih interakcijom proteina, osobine njihovih vezivnih površina i teorijske postavke na kojima se zasniva dizajn malih molekula modulatora proteinskih interakcija. Navedeno je nekoliko eksperimentalnih metoda primenjivih u razvoju organskih molekula koji deluju na protein-protein interakcije. Dosadašnji razvoj istraživanja u ovoj oblasti ilustrovan je kroz više primera uspešno dizajniranih modulatorskih jedinjenja. Zbog izuzetnog značaja u živim sistemima, a zahvaljujući sve boljem razumevanju protein-protein interakcija, one postaju sve važniji deo istraživačkih programa za razvoj novih lekova. Lekovi koji deluju kao modulatori proteinskih interakcija u budućnosti će verovatno predstavljati sve veći procenat terapijski aktivnih supstanci.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Protein-protein interactions in drug discovery, Protein-protein interakcije u razvoju novih lekova",
volume = "61",
number = "5",
pages = "464-477",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1587"
}

Ranđelović, J.,& Savić, V.. (2011). Protein-protein interactions in drug discovery. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 61(5), 464-477.
https://hdl.handle.net/21.15107/rcub_farfar_1587

Ranđelović J, Savić V. Protein-protein interactions in drug discovery. in Arhiv za farmaciju. 2011;61(5):464-477.
https://hdl.handle.net/21.15107/rcub_farfar_1587 .

Ranđelović, Jelena, Savić, Vladimir, "Protein-protein interactions in drug discovery" in Arhiv za farmaciju, 61, no. 5 (2011):464-477,
https://hdl.handle.net/21.15107/rcub_farfar_1587 .