TY  - JOUR
AU  - Krnjeta, Tijana
AU  - Mirković, Ljiljana
AU  - Ignjatović, Svetlana
AU  - Tomasević, Dragana
AU  - Lukić, Jelena
AU  - Topalov, Drina
AU  - Majkić-Singh, Nada
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2848
AB  - Background/Aim. Preeclampsia (PE) belongs to the group of hypertensive disorders in pregnancy with the global average incidence of 2.16%. It is considered as one of the leading causes of maternal and neonatal morbidity and mortality worldwide. The goal of this study was to assess the potential association between Val158Met catechol-o-methyltransferase (COMT), tumor necrosis factor-alpha (TNF-alpha) -857 C>T, tumor necrosis factor receptor 1 (TNFR1) 36 A>G, interleukin-1alpha (IL-1 alpha) 4845 G>T and interleukin-10 (IL-10) -1082 A>G polymorphisms and risk of early-onset preeclampsia (PE) and its complications. Methods. The study included 47 early-onset PE patients, which were grouped by disease severity and by size for gestational age and 47 control cases. The Val158Met polymorphism was genotyped by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analysis and inflammatory cytokine polymorphisms by the Sanger sequencing method. Results. The COMT Met allele as well as IL-1 alpha T showed a protective role, decreasing the risk of early-onset PE after age and body mass index (BMI) adjustments. The detected interactions between the COMT Met and IL-10 A alleles, as well as between the COMT Met and TNF-alpha T alleles were insignificant after age and BMI adjustments. Conclusion. COMT and IL-1 alpha may be used as candidate genes for early-onset PE and its severe form and small for gestational age (SGA) complications.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications
VL  - 74
IS  - 12
SP  - 1155
EP  - 1161
DO  - 10.2298/VSP160329313K
ER  - 

@article{
author = "Krnjeta, Tijana and Mirković, Ljiljana and Ignjatović, Svetlana and Tomasević, Dragana and Lukić, Jelena and Topalov, Drina and Majkić-Singh, Nada",
year = "2017",
abstract = "Background/Aim. Preeclampsia (PE) belongs to the group of hypertensive disorders in pregnancy with the global average incidence of 2.16%. It is considered as one of the leading causes of maternal and neonatal morbidity and mortality worldwide. The goal of this study was to assess the potential association between Val158Met catechol-o-methyltransferase (COMT), tumor necrosis factor-alpha (TNF-alpha) -857 C>T, tumor necrosis factor receptor 1 (TNFR1) 36 A>G, interleukin-1alpha (IL-1 alpha) 4845 G>T and interleukin-10 (IL-10) -1082 A>G polymorphisms and risk of early-onset preeclampsia (PE) and its complications. Methods. The study included 47 early-onset PE patients, which were grouped by disease severity and by size for gestational age and 47 control cases. The Val158Met polymorphism was genotyped by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analysis and inflammatory cytokine polymorphisms by the Sanger sequencing method. Results. The COMT Met allele as well as IL-1 alpha T showed a protective role, decreasing the risk of early-onset PE after age and body mass index (BMI) adjustments. The detected interactions between the COMT Met and IL-10 A alleles, as well as between the COMT Met and TNF-alpha T alleles were insignificant after age and BMI adjustments. Conclusion. COMT and IL-1 alpha may be used as candidate genes for early-onset PE and its severe form and small for gestational age (SGA) complications.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications",
volume = "74",
number = "12",
pages = "1155-1161",
doi = "10.2298/VSP160329313K"
}

Krnjeta, T., Mirković, L., Ignjatović, S., Tomasević, D., Lukić, J., Topalov, D.,& Majkić-Singh, N.. (2017). Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(12), 1155-1161.
https://doi.org/10.2298/VSP160329313K

Krnjeta T, Mirković L, Ignjatović S, Tomasević D, Lukić J, Topalov D, Majkić-Singh N. Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications. in Vojnosanitetski pregled. 2017;74(12):1155-1161.
doi:10.2298/VSP160329313K .

Krnjeta, Tijana, Mirković, Ljiljana, Ignjatović, Svetlana, Tomasević, Dragana, Lukić, Jelena, Topalov, Drina, Majkić-Singh, Nada, "Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications" in Vojnosanitetski pregled, 74, no. 12 (2017):1155-1161,
https://doi.org/10.2298/VSP160329313K . .

TY  - JOUR
AU  - Krnjeta, Tijana
AU  - Mirković, Ljiljana
AU  - Ignjatović, Svetlana
AU  - Tomasević, Dragana
AU  - Lukić, Jelena
AU  - Topalov, Drina
AU  - Soldatović, Ivan
AU  - Majkić-Singh, Nada
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2638
AB  - Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications
VL  - 35
IS  - 3
SP  - 312
EP  - 318
DO  - 10.1515/jomb-2016-0013
ER  - 

@article{
author = "Krnjeta, Tijana and Mirković, Ljiljana and Ignjatović, Svetlana and Tomasević, Dragana and Lukić, Jelena and Topalov, Drina and Soldatović, Ivan and Majkić-Singh, Nada",
year = "2016",
abstract = "Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications",
volume = "35",
number = "3",
pages = "312-318",
doi = "10.1515/jomb-2016-0013"
}

Krnjeta, T., Mirković, L., Ignjatović, S., Tomasević, D., Lukić, J., Topalov, D., Soldatović, I.,& Majkić-Singh, N.. (2016). Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(3), 312-318.
https://doi.org/10.1515/jomb-2016-0013

Krnjeta T, Mirković L, Ignjatović S, Tomasević D, Lukić J, Topalov D, Soldatović I, Majkić-Singh N. Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications. in Journal of Medical Biochemistry. 2016;35(3):312-318.
doi:10.1515/jomb-2016-0013 .

Krnjeta, Tijana, Mirković, Ljiljana, Ignjatović, Svetlana, Tomasević, Dragana, Lukić, Jelena, Topalov, Drina, Soldatović, Ivan, Majkić-Singh, Nada, "Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications" in Journal of Medical Biochemistry, 35, no. 3 (2016):312-318,
https://doi.org/10.1515/jomb-2016-0013 . .