TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kravljača, Milica
AU  - Stošović, Milan
AU  - Savić, Jasna
AU  - Gojković, Tamara
AU  - Stefanović, Aleksan
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2121
AB  - Dyslipidemia is a common metabolic disorder in chronic kidney disease (CKD) and is largely responsible for development of cardiovascular complications in these patients. It has been noticed that characteristics of lipid disorders vary according to the degree of renal failure. In this study, we investigated concentrations of cholesterol and apolipoprotein B in small, dense low-density lipoproteins (sdLDL-C and sdLDL-apoB) in pre-dialysis (PD) and hemodialysis (HD) stage of CKD. In addition, we explored independent contribution of sdLDL-C and sdLDL-apoB to progression of CKD. We recruited 38 PD and 41 HD patients in this study. Concentrations of sdLDL-C and sdLDL-apoB were determined by heparin-magnesium precipitation method. Other biochemical parameters were measured by routine laboratory methods. Concentrations of sdLDL-C and sdLDL-apoB were significantly higher in PD than in HD patients (P lt 0,001). SdLDL-C (OR=0,122; P lt 0,001) and sdLDL-apoB (OR=0,109; P lt 0,001) were identified as predictors of progression of CKD towards HD stage. Both of examined parameters were independently associated with the disease progression after adjustment for other lipid and non-lipid risk markers, with an exception for adjustment for urea concentration. Assessment of sdLDL-C and sdLDL-apoB in different stages of CKD could be beneficial in term of prediction of risk for cardiovascular disease development and prediction of progression of CKD itself.
AB  - Dislipidemija je uobičajen metabolički poremećaj u hroničnoj bubrežnoj bolesti (HBB) i u velikoj meri je odgovorna za nastanak kasnijih kardiovaskularnih komplikacija kod ovih pacijenata. Uočeno je da karakteristike dislipidemije variraju u zavisnosti od stadijuma HBB. U ovom radu ispitivali smo koncentracije holesterola i apolipoproteina B u malim, gustim česticama lipoproteina niske gustine (sdLDL-h i sdLDL-apoB) u predijaliznom (PD) i hemodijaliznom (HD) stadijumu HBB, kao i njihov nezavisni potencijal u predviđanju progresije HBB. U studiji je učestvovalo 38 PD i 41 HD pacijent. Koncentracije sdLDL-h i sdLDL-apoB određene su nakon selektivne precipitacije sa heparinom i Mg-solima, a koncentracije ostalih biohemijskih parametara rutinskim metodama. Koncentracije sdLDL-h i sdLDL-apoB bile su značajno više kod PD u odnosu na HD pacijente (P lt 0,001). SdLDL-h (OR=0,122; P lt 0,001) i sdLDL-apoB (OR=0,109; P lt 0,001) identifikovani su kao značajni prediktori progresije bolesti od PD do HD stadijuma, a nezavisan prediktivni potencijal zadržali su i u prisustvu drugih lipidnih i nelipidnih faktora rizika, osim uree. Određivanje sdLDL-h i sdLDL-apoB kod pacijenata u različitim stadijumima HBB može biti korisno u smislu predviđanja rizika za nastanak aterosklerotskih promena, kao i predviđanja progresije same HBB.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - The role of small, dense LDL cholesterol in progression of chronic kidney disease
T1  - Uloga holesterola u malim, gustim LDL česticama u progresiji hronične bubrežne bolesti
VL  - 6
IS  - 3
SP  - 253
EP  - 257
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2121
ER  - 

@article{
author = "Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Kravljača, Milica and Stošović, Milan and Savić, Jasna and Gojković, Tamara and Stefanović, Aleksan",
year = "2014",
abstract = "Dyslipidemia is a common metabolic disorder in chronic kidney disease (CKD) and is largely responsible for development of cardiovascular complications in these patients. It has been noticed that characteristics of lipid disorders vary according to the degree of renal failure. In this study, we investigated concentrations of cholesterol and apolipoprotein B in small, dense low-density lipoproteins (sdLDL-C and sdLDL-apoB) in pre-dialysis (PD) and hemodialysis (HD) stage of CKD. In addition, we explored independent contribution of sdLDL-C and sdLDL-apoB to progression of CKD. We recruited 38 PD and 41 HD patients in this study. Concentrations of sdLDL-C and sdLDL-apoB were determined by heparin-magnesium precipitation method. Other biochemical parameters were measured by routine laboratory methods. Concentrations of sdLDL-C and sdLDL-apoB were significantly higher in PD than in HD patients (P lt 0,001). SdLDL-C (OR=0,122; P lt 0,001) and sdLDL-apoB (OR=0,109; P lt 0,001) were identified as predictors of progression of CKD towards HD stage. Both of examined parameters were independently associated with the disease progression after adjustment for other lipid and non-lipid risk markers, with an exception for adjustment for urea concentration. Assessment of sdLDL-C and sdLDL-apoB in different stages of CKD could be beneficial in term of prediction of risk for cardiovascular disease development and prediction of progression of CKD itself., Dislipidemija je uobičajen metabolički poremećaj u hroničnoj bubrežnoj bolesti (HBB) i u velikoj meri je odgovorna za nastanak kasnijih kardiovaskularnih komplikacija kod ovih pacijenata. Uočeno je da karakteristike dislipidemije variraju u zavisnosti od stadijuma HBB. U ovom radu ispitivali smo koncentracije holesterola i apolipoproteina B u malim, gustim česticama lipoproteina niske gustine (sdLDL-h i sdLDL-apoB) u predijaliznom (PD) i hemodijaliznom (HD) stadijumu HBB, kao i njihov nezavisni potencijal u predviđanju progresije HBB. U studiji je učestvovalo 38 PD i 41 HD pacijent. Koncentracije sdLDL-h i sdLDL-apoB određene su nakon selektivne precipitacije sa heparinom i Mg-solima, a koncentracije ostalih biohemijskih parametara rutinskim metodama. Koncentracije sdLDL-h i sdLDL-apoB bile su značajno više kod PD u odnosu na HD pacijente (P lt 0,001). SdLDL-h (OR=0,122; P lt 0,001) i sdLDL-apoB (OR=0,109; P lt 0,001) identifikovani su kao značajni prediktori progresije bolesti od PD do HD stadijuma, a nezavisan prediktivni potencijal zadržali su i u prisustvu drugih lipidnih i nelipidnih faktora rizika, osim uree. Određivanje sdLDL-h i sdLDL-apoB kod pacijenata u različitim stadijumima HBB može biti korisno u smislu predviđanja rizika za nastanak aterosklerotskih promena, kao i predviđanja progresije same HBB.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "The role of small, dense LDL cholesterol in progression of chronic kidney disease, Uloga holesterola u malim, gustim LDL česticama u progresiji hronične bubrežne bolesti",
volume = "6",
number = "3",
pages = "253-257",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2121"
}

Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Vekić, J., Spasojević-Kalimanovska, V., Kravljača, M., Stošović, M., Savić, J., Gojković, T.,& Stefanović, A.. (2014). The role of small, dense LDL cholesterol in progression of chronic kidney disease. in MD - Medical data
Most Art doo, Beograd., 6(3), 253-257.
https://hdl.handle.net/21.15107/rcub_farfar_2121

Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Vekić J, Spasojević-Kalimanovska V, Kravljača M, Stošović M, Savić J, Gojković T, Stefanović A. The role of small, dense LDL cholesterol in progression of chronic kidney disease. in MD - Medical data. 2014;6(3):253-257.
https://hdl.handle.net/21.15107/rcub_farfar_2121 .

Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Kravljača, Milica, Stošović, Milan, Savić, Jasna, Gojković, Tamara, Stefanović, Aleksan, "The role of small, dense LDL cholesterol in progression of chronic kidney disease" in MD - Medical data, 6, no. 3 (2014):253-257,
https://hdl.handle.net/21.15107/rcub_farfar_2121 .

TY  - JOUR
AU  - Savić, Jasna
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Gojković, Tamara
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2126
AB  - Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.
PB  - Informa Healthcare, London
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease
VL  - 74
IS  - 7
SP  - 637
EP  - 643
DO  - 10.3109/00365513.2014.928944
ER  - 

@article{
author = "Savić, Jasna and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Stošović, Milan and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Gojković, Tamara and Spasić, Slavica",
year = "2014",
abstract = "Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.",
publisher = "Informa Healthcare, London",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease",
volume = "74",
number = "7",
pages = "637-643",
doi = "10.3109/00365513.2014.928944"
}

Savić, J., Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M., Stošović, M., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Gojković, T.,& Spasić, S.. (2014). Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation
Informa Healthcare, London., 74(7), 637-643.
https://doi.org/10.3109/00365513.2014.928944

Savić J, Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Stošović M, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Gojković T, Spasić S. Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(7):637-643.
doi:10.3109/00365513.2014.928944 .

Savić, Jasna, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Stošović, Milan, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Gojković, Tamara, Spasić, Slavica, "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 7 (2014):637-643,
https://doi.org/10.3109/00365513.2014.928944 . .