TY  - JOUR
AU  - Đunić, Irena
AU  - Dopsaj, Violeta
AU  - Miljić, Predrag
AU  - Savić, Nebojša
AU  - Milić, Nataša
AU  - Mitrović, Mirjana
AU  - Suvajdžić-Vuković, Nada
AU  - Tomin, Dragica
AU  - Elezović, Ivo
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082
AB  - Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
VL  - 60
IS  - 8
SP  - 1325
EP  - 1331
DO  - 10.7754/Clin.Lab.2013.130817
ER  - 

@article{
author = "Đunić, Irena and Dopsaj, Violeta and Miljić, Predrag and Savić, Nebojša and Milić, Nataša and Mitrović, Mirjana and Suvajdžić-Vuković, Nada and Tomin, Dragica and Elezović, Ivo",
year = "2014",
abstract = "Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia",
volume = "60",
number = "8",
pages = "1325-1331",
doi = "10.7754/Clin.Lab.2013.130817"
}

Đunić, I., Dopsaj, V., Miljić, P., Savić, N., Milić, N., Mitrović, M., Suvajdžić-Vuković, N., Tomin, D.,& Elezović, I.. (2014). Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 60(8), 1325-1331.
https://doi.org/10.7754/Clin.Lab.2013.130817

Đunić I, Dopsaj V, Miljić P, Savić N, Milić N, Mitrović M, Suvajdžić-Vuković N, Tomin D, Elezović I. Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory. 2014;60(8):1325-1331.
doi:10.7754/Clin.Lab.2013.130817 .

Đunić, Irena, Dopsaj, Violeta, Miljić, Predrag, Savić, Nebojša, Milić, Nataša, Mitrović, Mirjana, Suvajdžić-Vuković, Nada, Tomin, Dragica, Elezović, Ivo, "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia" in Clinical Laboratory, 60, no. 8 (2014):1325-1331,
https://doi.org/10.7754/Clin.Lab.2013.130817 . .

TY  - JOUR
AU  - Mitrović, Mirjana
AU  - Šumarac, Zorica
AU  - Antić, Darko
AU  - Bogdanović, Andrija
AU  - Elezović, Ivo
AU  - Vukosavljević, Dragana
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Suvajdzić, Nada
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1754
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Blood Cells Molecules and Diseases
T1  - Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy
VL  - 49
IS  - 1
SP  - 58
EP  - 59
DO  - 10.1016/j.bcmd.2012.03.003
ER  - 

@article{
author = "Mitrović, Mirjana and Šumarac, Zorica and Antić, Darko and Bogdanović, Andrija and Elezović, Ivo and Vukosavljević, Dragana and Ignjatović, Svetlana and Majkić-Singh, Nada and Suvajdzić, Nada",
year = "2012",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Blood Cells Molecules and Diseases",
title = "Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy",
volume = "49",
number = "1",
pages = "58-59",
doi = "10.1016/j.bcmd.2012.03.003"
}

Mitrović, M., Šumarac, Z., Antić, D., Bogdanović, A., Elezović, I., Vukosavljević, D., Ignjatović, S., Majkić-Singh, N.,& Suvajdzić, N.. (2012). Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy. in Blood Cells Molecules and Diseases
Academic Press Inc Elsevier Science, San Diego., 49(1), 58-59.
https://doi.org/10.1016/j.bcmd.2012.03.003

Mitrović M, Šumarac Z, Antić D, Bogdanović A, Elezović I, Vukosavljević D, Ignjatović S, Majkić-Singh N, Suvajdzić N. Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy. in Blood Cells Molecules and Diseases. 2012;49(1):58-59.
doi:10.1016/j.bcmd.2012.03.003 .

Mitrović, Mirjana, Šumarac, Zorica, Antić, Darko, Bogdanović, Andrija, Elezović, Ivo, Vukosavljević, Dragana, Ignjatović, Svetlana, Majkić-Singh, Nada, Suvajdzić, Nada, "Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy" in Blood Cells Molecules and Diseases, 49, no. 1 (2012):58-59,
https://doi.org/10.1016/j.bcmd.2012.03.003 . .

TY  - JOUR
AU  - Šumarac, Zorica
AU  - Suvajdzić, Nada
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Janić, Dragana
AU  - Petakov, Milan
AU  - Đorđević, Maja
AU  - Mitrović, Mirjana
AU  - Dajak, Marijana
AU  - Golubović, Milka
AU  - Rodić, Predrag
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1553
AB  - Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers in Serbian patients with Gaucher disease
VL  - 44
IS  - 12
SP  - 950
EP  - 954
DO  - 10.1016/j.clinbiochem.2011.05.016
ER  - 

@article{
author = "Šumarac, Zorica and Suvajdzić, Nada and Ignjatović, Svetlana and Majkić-Singh, Nada and Janić, Dragana and Petakov, Milan and Đorđević, Maja and Mitrović, Mirjana and Dajak, Marijana and Golubović, Milka and Rodić, Predrag",
year = "2011",
abstract = "Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers in Serbian patients with Gaucher disease",
volume = "44",
number = "12",
pages = "950-954",
doi = "10.1016/j.clinbiochem.2011.05.016"
}

Šumarac, Z., Suvajdzić, N., Ignjatović, S., Majkić-Singh, N., Janić, D., Petakov, M., Đorđević, M., Mitrović, M., Dajak, M., Golubović, M.,& Rodić, P.. (2011). Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 44(12), 950-954.
https://doi.org/10.1016/j.clinbiochem.2011.05.016

Šumarac Z, Suvajdzić N, Ignjatović S, Majkić-Singh N, Janić D, Petakov M, Đorđević M, Mitrović M, Dajak M, Golubović M, Rodić P. Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry. 2011;44(12):950-954.
doi:10.1016/j.clinbiochem.2011.05.016 .

Šumarac, Zorica, Suvajdzić, Nada, Ignjatović, Svetlana, Majkić-Singh, Nada, Janić, Dragana, Petakov, Milan, Đorđević, Maja, Mitrović, Mirjana, Dajak, Marijana, Golubović, Milka, Rodić, Predrag, "Biomarkers in Serbian patients with Gaucher disease" in Clinical Biochemistry, 44, no. 12 (2011):950-954,
https://doi.org/10.1016/j.clinbiochem.2011.05.016 . .