TY  - JOUR
AU  - Cvetković, Dragan J.
AU  - Stanojević, Ljiljana P.
AU  - Kundaković, Tatjana
AU  - Zlatković, Saša Ž.
AU  - Nikolić, Goran
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2315
AB  - Antioxidant and antimicrobial activities of a new phyto-gel were studied in this work. The formulated gel is composed of propilene glycol extracts of St. John's worth (H. perforatum L.), comfrey (S. officinale L.), yarrow (A. millefolium L.), horsetail (E. arvense L.) and Na-usniate. The antioxidant activity was determined for the gel and each investigated extract of the gel separately by the DPPH test. The total phenols and flavonoids content was determined spectrophotometrically, for the gel and each investigated extracts. The antimicrobial activity of the gel and each compound separately was tested in vitro on the following microorganisms: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antioxidant activity of the investigated samples decreases in the series: H. perforatum (EC50 = 1.04 mg/mL) > Na-usniate (EC50 = 4.16 mg/mL) > A. millefolium (EC50 = 7.60 mg/mL) > gel (EC50 = 23.47 mg/mL) > S. officinale (EC50 = 30.10 mg/mL) > E. arvense (EC50 = 44.70 mg/mL). The formulated phyto-gel showed the antimicrobial activity. The results suggest that the obtained phyto-gel is a good source of natural antioxidants and antimicrobial agents, and it has potential as an alternative to synthetic products in pharmaceutical and cosmetic industries.
AB  - U radu je ispitivana antioksidativna i antimikrobna aktivnost fitogela - formulacija gela sa propilen-glikolnim ekstraktima H. perforatum, S. officinale, A. millefolium, E. arvense i Na-usninatom. Primenom DPPH testa određena je antioksidativna aktivnost svih ispitivanih ekstrakata, Na-usninata i gela. Primenom spektrofotometrijskih metoda određen je sadržaj ukupnih fenola i flavonoida u ekstraktima i formulisanom gelu. Antimikrobna aktivnost gela, kao i njegovih pojedinačnih komponenata, je ispitivana in vitro na sledećim mikroorganizmima: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans i Aspergillus niger. Antioksidativna aktivnost ispitivanih uzoraka opada u nizu: H. perforatum (EC50=1,04 mg/ml) > Na-usnate (EC50=4,16 mg/ml) > A. millefolium (EC50=7,60 mg/ml) > gel (EC50=23,47 mg/ml) > S. officinale (EC50=30,10 mg/ml) > E. arvense (EC50 44,70 mg/ml). Formulisani fitogel je pokazao i antimikrobnu aktivnost. Dobijeni rezultati pokazuju da ispitivani fitogel predstavlja izvor prirodnih antioksidanasa i antimikrobnih agenasa, sa mogućom primenom u farmaceutsko-kozmetičkoj industriji kao alternativa sintetičkim proizvodima.
PB  - Univerzitet u Nišu - Tehnološki fakultet, Leskovac
T2  - Advanced Technologies
T1  - Antioxidant and antimicrobial activity of a new generation phyto-gel
T1  - Antioksidativna i antimikrobna aktivnost fitogela novije generacije
VL  - 4
IS  - 2
SP  - 11
EP  - 18
DO  - 10.5937/savteh1502011C
ER  - 

@article{
author = "Cvetković, Dragan J. and Stanojević, Ljiljana P. and Kundaković, Tatjana and Zlatković, Saša Ž. and Nikolić, Goran",
year = "2015",
abstract = "Antioxidant and antimicrobial activities of a new phyto-gel were studied in this work. The formulated gel is composed of propilene glycol extracts of St. John's worth (H. perforatum L.), comfrey (S. officinale L.), yarrow (A. millefolium L.), horsetail (E. arvense L.) and Na-usniate. The antioxidant activity was determined for the gel and each investigated extract of the gel separately by the DPPH test. The total phenols and flavonoids content was determined spectrophotometrically, for the gel and each investigated extracts. The antimicrobial activity of the gel and each compound separately was tested in vitro on the following microorganisms: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antioxidant activity of the investigated samples decreases in the series: H. perforatum (EC50 = 1.04 mg/mL) > Na-usniate (EC50 = 4.16 mg/mL) > A. millefolium (EC50 = 7.60 mg/mL) > gel (EC50 = 23.47 mg/mL) > S. officinale (EC50 = 30.10 mg/mL) > E. arvense (EC50 = 44.70 mg/mL). The formulated phyto-gel showed the antimicrobial activity. The results suggest that the obtained phyto-gel is a good source of natural antioxidants and antimicrobial agents, and it has potential as an alternative to synthetic products in pharmaceutical and cosmetic industries., U radu je ispitivana antioksidativna i antimikrobna aktivnost fitogela - formulacija gela sa propilen-glikolnim ekstraktima H. perforatum, S. officinale, A. millefolium, E. arvense i Na-usninatom. Primenom DPPH testa određena je antioksidativna aktivnost svih ispitivanih ekstrakata, Na-usninata i gela. Primenom spektrofotometrijskih metoda određen je sadržaj ukupnih fenola i flavonoida u ekstraktima i formulisanom gelu. Antimikrobna aktivnost gela, kao i njegovih pojedinačnih komponenata, je ispitivana in vitro na sledećim mikroorganizmima: Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans i Aspergillus niger. Antioksidativna aktivnost ispitivanih uzoraka opada u nizu: H. perforatum (EC50=1,04 mg/ml) > Na-usnate (EC50=4,16 mg/ml) > A. millefolium (EC50=7,60 mg/ml) > gel (EC50=23,47 mg/ml) > S. officinale (EC50=30,10 mg/ml) > E. arvense (EC50 44,70 mg/ml). Formulisani fitogel je pokazao i antimikrobnu aktivnost. Dobijeni rezultati pokazuju da ispitivani fitogel predstavlja izvor prirodnih antioksidanasa i antimikrobnih agenasa, sa mogućom primenom u farmaceutsko-kozmetičkoj industriji kao alternativa sintetičkim proizvodima.",
publisher = "Univerzitet u Nišu - Tehnološki fakultet, Leskovac",
journal = "Advanced Technologies",
title = "Antioxidant and antimicrobial activity of a new generation phyto-gel, Antioksidativna i antimikrobna aktivnost fitogela novije generacije",
volume = "4",
number = "2",
pages = "11-18",
doi = "10.5937/savteh1502011C"
}

Cvetković, D. J., Stanojević, L. P., Kundaković, T., Zlatković, S. Ž.,& Nikolić, G.. (2015). Antioxidant and antimicrobial activity of a new generation phyto-gel. in Advanced Technologies
Univerzitet u Nišu - Tehnološki fakultet, Leskovac., 4(2), 11-18.
https://doi.org/10.5937/savteh1502011C

Cvetković DJ, Stanojević LP, Kundaković T, Zlatković SŽ, Nikolić G. Antioxidant and antimicrobial activity of a new generation phyto-gel. in Advanced Technologies. 2015;4(2):11-18.
doi:10.5937/savteh1502011C .

Cvetković, Dragan J., Stanojević, Ljiljana P., Kundaković, Tatjana, Zlatković, Saša Ž., Nikolić, Goran, "Antioxidant and antimicrobial activity of a new generation phyto-gel" in Advanced Technologies, 4, no. 2 (2015):11-18,
https://doi.org/10.5937/savteh1502011C . .

TY  - JOUR
AU  - Savić, Ivana
AU  - Nikolić, Katarina
AU  - Nikolić, Goran
AU  - Savić, Ivan
AU  - Agbaba, Danica
AU  - Cakić, Milorad
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1970
AB  - New formulation for treatment a copper deficiency in human organism was developed and optimized by application of mathematical modeling. This formulation contained copper (II) complex with polysaccharide pullulan, as active substance. The binder concentration [polyvinyl pyrrolidone (PVP %)], the disintegrant concentration (corn starch %) and the resistance to crushing (hardness) were taken as independent variables. In vitro measured drug release characteristics of the tablets at pH 1.20 and 7.56 were studied as response variables. Initially, the created full factorial 2(3) model showed that the resistance to crushing has the most significant effect on copper (II) complex release from the formulation. Optimal tablet formulation F2, with lower Hardness (50 N), lower Starch (20.0%) and higher PVP (2.7%) concentrations, is selected using the partial least squares (PLS) regression modeling. The selected formulation F2 has expressed the best drug release profile at both pH (98.66% pH = 1.20; 93.35% pH = 7.56), and the lowest variation of tablets weight. The presented theoretical approach and created PLS model can be readily applied in future copper complexes studies and formulation design.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Application of mathematical modeling for the development and optimization formulation with bioactive copper complex
VL  - 39
IS  - 7
SP  - 1084
EP  - 1090
DO  - 10.3109/03639045.2012.707208
ER  - 

@article{
author = "Savić, Ivana and Nikolić, Katarina and Nikolić, Goran and Savić, Ivan and Agbaba, Danica and Cakić, Milorad",
year = "2013",
abstract = "New formulation for treatment a copper deficiency in human organism was developed and optimized by application of mathematical modeling. This formulation contained copper (II) complex with polysaccharide pullulan, as active substance. The binder concentration [polyvinyl pyrrolidone (PVP %)], the disintegrant concentration (corn starch %) and the resistance to crushing (hardness) were taken as independent variables. In vitro measured drug release characteristics of the tablets at pH 1.20 and 7.56 were studied as response variables. Initially, the created full factorial 2(3) model showed that the resistance to crushing has the most significant effect on copper (II) complex release from the formulation. Optimal tablet formulation F2, with lower Hardness (50 N), lower Starch (20.0%) and higher PVP (2.7%) concentrations, is selected using the partial least squares (PLS) regression modeling. The selected formulation F2 has expressed the best drug release profile at both pH (98.66% pH = 1.20; 93.35% pH = 7.56), and the lowest variation of tablets weight. The presented theoretical approach and created PLS model can be readily applied in future copper complexes studies and formulation design.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Application of mathematical modeling for the development and optimization formulation with bioactive copper complex",
volume = "39",
number = "7",
pages = "1084-1090",
doi = "10.3109/03639045.2012.707208"
}

Savić, I., Nikolić, K., Nikolić, G., Savić, I., Agbaba, D.,& Cakić, M.. (2013). Application of mathematical modeling for the development and optimization formulation with bioactive copper complex. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 39(7), 1084-1090.
https://doi.org/10.3109/03639045.2012.707208

Savić I, Nikolić K, Nikolić G, Savić I, Agbaba D, Cakić M. Application of mathematical modeling for the development and optimization formulation with bioactive copper complex. in Drug Development and Industrial Pharmacy. 2013;39(7):1084-1090.
doi:10.3109/03639045.2012.707208 .

Savić, Ivana, Nikolić, Katarina, Nikolić, Goran, Savić, Ivan, Agbaba, Danica, Cakić, Milorad, "Application of mathematical modeling for the development and optimization formulation with bioactive copper complex" in Drug Development and Industrial Pharmacy, 39, no. 7 (2013):1084-1090,
https://doi.org/10.3109/03639045.2012.707208 . .

TY  - JOUR
AU  - Nikolić, Vesna D.
AU  - Stanković, Mihajlo
AU  - Nikolić, Ljubiša
AU  - Nikolić, Goran
AU  - Ilić-Stojanović, Snežana
AU  - Popsavin, Mirjana
AU  - Zlatković, Sasa
AU  - Kundaković, Tatjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1992
AB  - Molecular inclusion complexes of usnic acid (UA) with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclodextrin (HP beta-CD) were prepared by the co-precipitation method in the solid state in the molar ratio of 1:1. Structural complexes characterization was based on different methods, FTIR, H-1 NMR, XRD and DSC. Parallel to the complex by the above methods, corresponding physical mixtures of UA with cyclodextrins and complexing agents (beta-CD, HP beta-CD and UA) were analyzed. The results of DSC analysis showed that, at around 200 A degrees C, the endothermal peak in the complexes with cyclodextrins originating from the UA melting has disappeared. Complex diffractogram patterns do not contain peaks characteristic for the pure UA. They are more appropriate to cyclodextrin diffractogram. This fact points to the molecular encapsulation of UA in the cyclodextrin cavity. Chemical shifts in H-1 NMR spectra after the inclusion of UA into the cyclodextrin cavity, especially H-3 protons (0.0012 and 0.0102 ppm in the beta-CD and HP beta-CD, respectively) and H-5 and H-6 (0.0134 ppm) and hydrogen from CH3 (0.0073 ppm) HP beta-CD also points to the formation of molecular inclusion complexes. The improved solubility of UA in water was achieved by molecular incapsulation. In the complex with beta-CD the solubility is 0.3 mg/cm(3), with HP beta-CD 4.2 mg/cm(3) while the uncomplexed UA solubility is 0.06 mg/cm(3). The microbial activity of UA and both complexes was tested against eight bacteria and two fungi and during the test no reduced activity of UA in the complexes was observed.
PB  - Springer, Dordrecht
T2  - Journal of Inclusion Phenomena and Macrocyclic Chemistry
T1  - Inclusion complexes with cyclodextrin and usnic acid
VL  - 76
IS  - 1-2
SP  - 173
EP  - 182
DO  - 10.1007/s10847-012-0187-8
ER  - 

@article{
author = "Nikolić, Vesna D. and Stanković, Mihajlo and Nikolić, Ljubiša and Nikolić, Goran and Ilić-Stojanović, Snežana and Popsavin, Mirjana and Zlatković, Sasa and Kundaković, Tatjana",
year = "2013",
abstract = "Molecular inclusion complexes of usnic acid (UA) with beta-cyclodextrin (beta-CD) and 2-hydroxypropyl beta-cyclodextrin (HP beta-CD) were prepared by the co-precipitation method in the solid state in the molar ratio of 1:1. Structural complexes characterization was based on different methods, FTIR, H-1 NMR, XRD and DSC. Parallel to the complex by the above methods, corresponding physical mixtures of UA with cyclodextrins and complexing agents (beta-CD, HP beta-CD and UA) were analyzed. The results of DSC analysis showed that, at around 200 A degrees C, the endothermal peak in the complexes with cyclodextrins originating from the UA melting has disappeared. Complex diffractogram patterns do not contain peaks characteristic for the pure UA. They are more appropriate to cyclodextrin diffractogram. This fact points to the molecular encapsulation of UA in the cyclodextrin cavity. Chemical shifts in H-1 NMR spectra after the inclusion of UA into the cyclodextrin cavity, especially H-3 protons (0.0012 and 0.0102 ppm in the beta-CD and HP beta-CD, respectively) and H-5 and H-6 (0.0134 ppm) and hydrogen from CH3 (0.0073 ppm) HP beta-CD also points to the formation of molecular inclusion complexes. The improved solubility of UA in water was achieved by molecular incapsulation. In the complex with beta-CD the solubility is 0.3 mg/cm(3), with HP beta-CD 4.2 mg/cm(3) while the uncomplexed UA solubility is 0.06 mg/cm(3). The microbial activity of UA and both complexes was tested against eight bacteria and two fungi and during the test no reduced activity of UA in the complexes was observed.",
publisher = "Springer, Dordrecht",
journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
title = "Inclusion complexes with cyclodextrin and usnic acid",
volume = "76",
number = "1-2",
pages = "173-182",
doi = "10.1007/s10847-012-0187-8"
}

Nikolić, V. D., Stanković, M., Nikolić, L., Nikolić, G., Ilić-Stojanović, S., Popsavin, M., Zlatković, S.,& Kundaković, T.. (2013). Inclusion complexes with cyclodextrin and usnic acid. in Journal of Inclusion Phenomena and Macrocyclic Chemistry
Springer, Dordrecht., 76(1-2), 173-182.
https://doi.org/10.1007/s10847-012-0187-8

Nikolić VD, Stanković M, Nikolić L, Nikolić G, Ilić-Stojanović S, Popsavin M, Zlatković S, Kundaković T. Inclusion complexes with cyclodextrin and usnic acid. in Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2013;76(1-2):173-182.
doi:10.1007/s10847-012-0187-8 .

Nikolić, Vesna D., Stanković, Mihajlo, Nikolić, Ljubiša, Nikolić, Goran, Ilić-Stojanović, Snežana, Popsavin, Mirjana, Zlatković, Sasa, Kundaković, Tatjana, "Inclusion complexes with cyclodextrin and usnic acid" in Journal of Inclusion Phenomena and Macrocyclic Chemistry, 76, no. 1-2 (2013):173-182,
https://doi.org/10.1007/s10847-012-0187-8 . .

TY  - JOUR
AU  - Savić, Ivana
AU  - Nikolić, Goran
AU  - Savić, Ivan
AU  - Nikolić, Katarina
AU  - Agbaba, Danica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1744
AB  - The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation technique, are containg active substance, a copper(II) complex with polysaccharide pullulan. The binder concentration, the disintegrant concentration and the resistance to crushing were used as independent variables in the formulation; while in vitro measured drug release characteristics of the tablets was response variable in a full factorial design 2(3) modeling. A cubic model for data fitted was used to examine the obtained results. They showed that the resistance to crushing has the most significant effect on copper(II) complex release from the formulation, while the disintegrant concentration has smaller influence on dissolution profile of copper(II) complex and the binder concentration had minor impact in this study. Lower value of resistance to crushing has influence on better dissolution profile. Furthermore, physical characteristics of the tablets were evaluated, viz., drug content, hardness, thickness, friability, disintegration time, mass variation, particle size and size distribution.
PB  - Polskie Towarzystwo Farmaceutyczne, Warsaw
T2  - Acta Poloniae Pharmaceutica - Drug Research
T1  - Development and optimization of formulation for treatment of copper deficiency in human organism
VL  - 69
IS  - 4
SP  - 739
EP  - 749
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1744
ER  - 

@article{
author = "Savić, Ivana and Nikolić, Goran and Savić, Ivan and Nikolić, Katarina and Agbaba, Danica",
year = "2012",
abstract = "The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation technique, are containg active substance, a copper(II) complex with polysaccharide pullulan. The binder concentration, the disintegrant concentration and the resistance to crushing were used as independent variables in the formulation; while in vitro measured drug release characteristics of the tablets was response variable in a full factorial design 2(3) modeling. A cubic model for data fitted was used to examine the obtained results. They showed that the resistance to crushing has the most significant effect on copper(II) complex release from the formulation, while the disintegrant concentration has smaller influence on dissolution profile of copper(II) complex and the binder concentration had minor impact in this study. Lower value of resistance to crushing has influence on better dissolution profile. Furthermore, physical characteristics of the tablets were evaluated, viz., drug content, hardness, thickness, friability, disintegration time, mass variation, particle size and size distribution.",
publisher = "Polskie Towarzystwo Farmaceutyczne, Warsaw",
journal = "Acta Poloniae Pharmaceutica - Drug Research",
title = "Development and optimization of formulation for treatment of copper deficiency in human organism",
volume = "69",
number = "4",
pages = "739-749",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1744"
}

Savić, I., Nikolić, G., Savić, I., Nikolić, K.,& Agbaba, D.. (2012). Development and optimization of formulation for treatment of copper deficiency in human organism. in Acta Poloniae Pharmaceutica - Drug Research
Polskie Towarzystwo Farmaceutyczne, Warsaw., 69(4), 739-749.
https://hdl.handle.net/21.15107/rcub_farfar_1744

Savić I, Nikolić G, Savić I, Nikolić K, Agbaba D. Development and optimization of formulation for treatment of copper deficiency in human organism. in Acta Poloniae Pharmaceutica - Drug Research. 2012;69(4):739-749.
https://hdl.handle.net/21.15107/rcub_farfar_1744 .

Savić, Ivana, Nikolić, Goran, Savić, Ivan, Nikolić, Katarina, Agbaba, Danica, "Development and optimization of formulation for treatment of copper deficiency in human organism" in Acta Poloniae Pharmaceutica - Drug Research, 69, no. 4 (2012):739-749,
https://hdl.handle.net/21.15107/rcub_farfar_1744 .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Milenković, Marina
AU  - Zlatković, Sasa
AU  - Nikolić, Vesna D.
AU  - Nikolić, Goran
AU  - Binić, Ivana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1706
AB  - Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.
PB  - Karger, Basel
T2  - Forschende Komplementarmedizin
T1  - Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study
VL  - 19
IS  - 1
SP  - 26
EP  - 30
DO  - 10.1159/000335786
ER  - 

@article{
author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Nikolić, Vesna D. and Nikolić, Goran and Binić, Ivana",
year = "2012",
abstract = "Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.",
publisher = "Karger, Basel",
journal = "Forschende Komplementarmedizin",
title = "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study",
volume = "19",
number = "1",
pages = "26-30",
doi = "10.1159/000335786"
}

Kundaković, T., Milenković, M., Zlatković, S., Nikolić, V. D., Nikolić, G.,& Binić, I.. (2012). Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin
Karger, Basel., 19(1), 26-30.
https://doi.org/10.1159/000335786

Kundaković T, Milenković M, Zlatković S, Nikolić VD, Nikolić G, Binić I. Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin. 2012;19(1):26-30.
doi:10.1159/000335786 .

Kundaković, Tatjana, Milenković, Marina, Zlatković, Sasa, Nikolić, Vesna D., Nikolić, Goran, Binić, Ivana, "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study" in Forschende Komplementarmedizin, 19, no. 1 (2012):26-30,
https://doi.org/10.1159/000335786 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Ćirić, Ana D.
AU  - Soković, Marina
AU  - Milenković, Marina
AU  - Nikolić, Vesna D.
AU  - Nikolić, Goran
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1595
AB  - According to the tested antimicrobial activity of constituents and their chemical characteristics, a new formulation of oral antiseptic was made based on garlic bulb powder and its active principles with strong antimicrobial activity against a wide range of bacteria and fungi. The antimicrobial activity of garlic bulb powder, allicin and the lozenge with 15% of garlic powder was tested using broth microdilution method. The tested garlic powder, as well the lozenge, have shown very high antimicrobial activity with MIC 1.25-5.00 mg/ml, and 1.87-7.50 mg/ml, respectively. The major compound, allicin, was highly active at a very low concentration. The minimal inhibitory concentration of allicin was from 6.25-12.50 μg/ml for antibacterial activity and 0.4 μg/ml for antifungal activity. Those concentrations are comparable with concentrations of commercially available antibiotics and fungicides. The formulation of an antiseptic with herbal constituents, high antibacterial and antifungal activity and pleasant taste could be an alternative to classical pharmaceutical oral antiseptics.
AB  - Na osnovu ispitane antimikrobne aktivnosti komponenata i njihovih hemijskih karakteristika, napravljena je nova formulacija oralnog antiseptika koji kao aktivnu komponentu ima prašak belog luka čiji sastojci pokazuju veoma izraženu aktivnost protiv širokog spektra bakterija i gljive Candida albicans. Antimikrobna aktivnost praška belog luka, alicina i lozengi sa 15% praška belog luka je ispitivana bujon mikrodilucionom metodom. Testiran prašak belog luka, kao i lozenge imaju veoma jaku antimikrobnu aktivnost sa minimalnim inhibitornim koncentracijama (MIC) 1,25-5,00 mg/ml (prašak belog luka) i 1,87-7,50 mg/ml (lozenge). Glavna aktivna komponeta belog luka, alicin, pokazuje antimikrobnu aktivnost u veoma niskim koncentracijama. Minimalne inhibitorne koncentracije alicina se kreću od 6,25-12,5 μg/ml protiv bakterija i 0,4 μg/ml protiv gljivice Candida albicans. Ove koncentracije se mogu uporediti sa koncentracijama komercijalnih antibiotika i fungicida. Naši rezultati su u skladu sa prethodnim ispitivanjima alicina i različitih ekstrakta belog luka, i potvrđuju najvažniju ulogu alicina u antimikrobnoj aktivnosti. Veoma je važna visoka aktivnost ovako formulisanog oralnog preparata protiv gljivice C. albicans koja je čest uzročnik infekcija usne duplje. Formulisan proizvod sa antiseptičkim osobinama karakteriše stanje čvrstog rastvora gde su aktivne supstance molekularno-disperzno ugrađene u obliku dobro rastvornog polimernog matriksa (sorbitola) velike specifične površine. Dobra rastvorljivost polimernog matriksa i velika specifična površina omogućuju zadovoljavajuću brzinu otpuštanja aktivnih principa iz belog luka (alicin). Pored visoke antimikrobne aktivnosti, lozenge poseduju prijatan ukus i osvežavaju dah, pa se mogu koristiti kao prirodni antiseptik u prevenciji i terapiji infekcija sluzokože usta i ždrela. Formulacija antiseptika sa biljnim sastojcima i visokom antibakterijskom i antifungalnom aktivnošću može biti alternativa farmaceutskim oralnim antisepticima.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Antimicrobial activity of lozenge with garlic bulb powder
T1  - Antimikrobna aktivnost lozengi sa praškom belog luka
VL  - 65
IS  - 5
SP  - 607
EP  - 610
DO  - 10.2298/HEMIND110414048K
ER  - 

@article{
author = "Kundaković, Tatjana and Ćirić, Ana D. and Soković, Marina and Milenković, Marina and Nikolić, Vesna D. and Nikolić, Goran",
year = "2011",
abstract = "According to the tested antimicrobial activity of constituents and their chemical characteristics, a new formulation of oral antiseptic was made based on garlic bulb powder and its active principles with strong antimicrobial activity against a wide range of bacteria and fungi. The antimicrobial activity of garlic bulb powder, allicin and the lozenge with 15% of garlic powder was tested using broth microdilution method. The tested garlic powder, as well the lozenge, have shown very high antimicrobial activity with MIC 1.25-5.00 mg/ml, and 1.87-7.50 mg/ml, respectively. The major compound, allicin, was highly active at a very low concentration. The minimal inhibitory concentration of allicin was from 6.25-12.50 μg/ml for antibacterial activity and 0.4 μg/ml for antifungal activity. Those concentrations are comparable with concentrations of commercially available antibiotics and fungicides. The formulation of an antiseptic with herbal constituents, high antibacterial and antifungal activity and pleasant taste could be an alternative to classical pharmaceutical oral antiseptics., Na osnovu ispitane antimikrobne aktivnosti komponenata i njihovih hemijskih karakteristika, napravljena je nova formulacija oralnog antiseptika koji kao aktivnu komponentu ima prašak belog luka čiji sastojci pokazuju veoma izraženu aktivnost protiv širokog spektra bakterija i gljive Candida albicans. Antimikrobna aktivnost praška belog luka, alicina i lozengi sa 15% praška belog luka je ispitivana bujon mikrodilucionom metodom. Testiran prašak belog luka, kao i lozenge imaju veoma jaku antimikrobnu aktivnost sa minimalnim inhibitornim koncentracijama (MIC) 1,25-5,00 mg/ml (prašak belog luka) i 1,87-7,50 mg/ml (lozenge). Glavna aktivna komponeta belog luka, alicin, pokazuje antimikrobnu aktivnost u veoma niskim koncentracijama. Minimalne inhibitorne koncentracije alicina se kreću od 6,25-12,5 μg/ml protiv bakterija i 0,4 μg/ml protiv gljivice Candida albicans. Ove koncentracije se mogu uporediti sa koncentracijama komercijalnih antibiotika i fungicida. Naši rezultati su u skladu sa prethodnim ispitivanjima alicina i različitih ekstrakta belog luka, i potvrđuju najvažniju ulogu alicina u antimikrobnoj aktivnosti. Veoma je važna visoka aktivnost ovako formulisanog oralnog preparata protiv gljivice C. albicans koja je čest uzročnik infekcija usne duplje. Formulisan proizvod sa antiseptičkim osobinama karakteriše stanje čvrstog rastvora gde su aktivne supstance molekularno-disperzno ugrađene u obliku dobro rastvornog polimernog matriksa (sorbitola) velike specifične površine. Dobra rastvorljivost polimernog matriksa i velika specifična površina omogućuju zadovoljavajuću brzinu otpuštanja aktivnih principa iz belog luka (alicin). Pored visoke antimikrobne aktivnosti, lozenge poseduju prijatan ukus i osvežavaju dah, pa se mogu koristiti kao prirodni antiseptik u prevenciji i terapiji infekcija sluzokože usta i ždrela. Formulacija antiseptika sa biljnim sastojcima i visokom antibakterijskom i antifungalnom aktivnošću može biti alternativa farmaceutskim oralnim antisepticima.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Antimicrobial activity of lozenge with garlic bulb powder, Antimikrobna aktivnost lozengi sa praškom belog luka",
volume = "65",
number = "5",
pages = "607-610",
doi = "10.2298/HEMIND110414048K"
}

Kundaković, T., Ćirić, A. D., Soković, M., Milenković, M., Nikolić, V. D.,& Nikolić, G.. (2011). Antimicrobial activity of lozenge with garlic bulb powder. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 65(5), 607-610.
https://doi.org/10.2298/HEMIND110414048K

Kundaković T, Ćirić AD, Soković M, Milenković M, Nikolić VD, Nikolić G. Antimicrobial activity of lozenge with garlic bulb powder. in Hemijska industrija. 2011;65(5):607-610.
doi:10.2298/HEMIND110414048K .

Kundaković, Tatjana, Ćirić, Ana D., Soković, Marina, Milenković, Marina, Nikolić, Vesna D., Nikolić, Goran, "Antimicrobial activity of lozenge with garlic bulb powder" in Hemijska industrija, 65, no. 5 (2011):607-610,
https://doi.org/10.2298/HEMIND110414048K . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Milenković, Marina
AU  - Zlatković, Sasa
AU  - Kovačević, Nada
AU  - Nikolić, Goran
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1478
AB  - The composition of the essential oil obtained by hydrodistillation from the aerial parts of Satureja kitaibelii from Rtanj mountain (Serbia), collected during three years, was studied. Thirty-nine components were identified in each sample of S. kitaibelii essential oil, representing about 87% of the oils. p-Cymene was the most dominant compound in all three oils (27.9%, 14.7% and 24.4%, respectively). The simple formulation of a lozenge with 0.2% of S. kitaibelii essential oil was prepared and the antimicrobial activity of the essential oil and the lozenge with essential oil was tested using a broth microdilution assay. Both essential oil and lozenge possessed strong antimicrobial activity with MIC values of 0.10-25 mu g/mL, and 0.97-15.6 mg/mL, respectively.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity
VL  - 6
IS  - 9
SP  - 1353
EP  - 1356
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1478
ER  - 

@article{
author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Kovačević, Nada and Nikolić, Goran",
year = "2011",
abstract = "The composition of the essential oil obtained by hydrodistillation from the aerial parts of Satureja kitaibelii from Rtanj mountain (Serbia), collected during three years, was studied. Thirty-nine components were identified in each sample of S. kitaibelii essential oil, representing about 87% of the oils. p-Cymene was the most dominant compound in all three oils (27.9%, 14.7% and 24.4%, respectively). The simple formulation of a lozenge with 0.2% of S. kitaibelii essential oil was prepared and the antimicrobial activity of the essential oil and the lozenge with essential oil was tested using a broth microdilution assay. Both essential oil and lozenge possessed strong antimicrobial activity with MIC values of 0.10-25 mu g/mL, and 0.97-15.6 mg/mL, respectively.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity",
volume = "6",
number = "9",
pages = "1353-1356",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1478"
}

Kundaković, T., Milenković, M., Zlatković, S., Kovačević, N.,& Nikolić, G.. (2011). Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity. in Natural Product Communications
Natural Products Inc, Westerville., 6(9), 1353-1356.
https://hdl.handle.net/21.15107/rcub_farfar_1478

Kundaković T, Milenković M, Zlatković S, Kovačević N, Nikolić G. Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity. in Natural Product Communications. 2011;6(9):1353-1356.
https://hdl.handle.net/21.15107/rcub_farfar_1478 .

Kundaković, Tatjana, Milenković, Marina, Zlatković, Sasa, Kovačević, Nada, Nikolić, Goran, "Composition of Satureja kitaibelii Essential Oil and its Antimicrobial Activity" in Natural Product Communications, 6, no. 9 (2011):1353-1356,
https://hdl.handle.net/21.15107/rcub_farfar_1478 .

TY  - CONF
AU  - Kundaković, Tatjana
AU  - Binić, I
AU  - Milenković, Marina
AU  - Zlatković, S.
AU  - Nikolić, Goran
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1330
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Some therapeutic effects of herbal based ointment "Dermoplant G"on venous ulcers
VL  - 76
IS  - 12
SP  - 1355
EP  - 1355
DO  - 10.1055/s-0030-1264929
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1330
ER  - 

@conference{
author = "Kundaković, Tatjana and Binić, I and Milenković, Marina and Zlatković, S. and Nikolić, Goran",
year = "2010",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Some therapeutic effects of herbal based ointment "Dermoplant G"on venous ulcers",
volume = "76",
number = "12",
pages = "1355-1355",
doi = "10.1055/s-0030-1264929",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1330"
}

Kundaković, T., Binić, I., Milenković, M., Zlatković, S.,& Nikolić, G.. (2010). Some therapeutic effects of herbal based ointment "Dermoplant G"on venous ulcers. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 76(12), 1355-1355.
https://doi.org/10.1055/s-0030-1264929
https://hdl.handle.net/21.15107/rcub_farfar_1330

Kundaković T, Binić I, Milenković M, Zlatković S, Nikolić G. Some therapeutic effects of herbal based ointment "Dermoplant G"on venous ulcers. in Planta Medica. 2010;76(12):1355-1355.
doi:10.1055/s-0030-1264929
https://hdl.handle.net/21.15107/rcub_farfar_1330 .

Kundaković, Tatjana, Binić, I, Milenković, Marina, Zlatković, S., Nikolić, Goran, "Some therapeutic effects of herbal based ointment "Dermoplant G"on venous ulcers" in Planta Medica, 76, no. 12 (2010):1355-1355,
https://doi.org/10.1055/s-0030-1264929 .,
https://hdl.handle.net/21.15107/rcub_farfar_1330 .

TY  - CONF
AU  - Živković, M.
AU  - Kukić-Marković, Jelena
AU  - Milenković, Marina
AU  - Nikolić, Goran
AU  - Savić, I
AU  - Zlatković, S.
AU  - Kundaković, Tatjana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1280
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - The antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff., Lamiaceae
VL  - 75
IS  - 9
SP  - 1049
EP  - 1049
DO  - 10.1055/s-0029-1234881
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1280
ER  - 

@conference{
author = "Živković, M. and Kukić-Marković, Jelena and Milenković, Marina and Nikolić, Goran and Savić, I and Zlatković, S. and Kundaković, Tatjana",
year = "2009",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "The antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff., Lamiaceae",
volume = "75",
number = "9",
pages = "1049-1049",
doi = "10.1055/s-0029-1234881",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1280"
}

Živković, M., Kukić-Marković, J., Milenković, M., Nikolić, G., Savić, I., Zlatković, S.,& Kundaković, T.. (2009). The antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff., Lamiaceae. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 75(9), 1049-1049.
https://doi.org/10.1055/s-0029-1234881
https://hdl.handle.net/21.15107/rcub_farfar_1280

Živković M, Kukić-Marković J, Milenković M, Nikolić G, Savić I, Zlatković S, Kundaković T. The antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff., Lamiaceae. in Planta Medica. 2009;75(9):1049-1049.
doi:10.1055/s-0029-1234881
https://hdl.handle.net/21.15107/rcub_farfar_1280 .

Živković, M., Kukić-Marković, Jelena, Milenković, Marina, Nikolić, Goran, Savić, I, Zlatković, S., Kundaković, Tatjana, "The antimicrobial activity of Satureja kitaibelii Wierzb. ex Heuff., Lamiaceae" in Planta Medica, 75, no. 9 (2009):1049-1049,
https://doi.org/10.1055/s-0029-1234881 .,
https://hdl.handle.net/21.15107/rcub_farfar_1280 .

TY  - CONF
AU  - Živković, M.
AU  - Kukić-Marković, Jelena
AU  - Milenković, Marina
AU  - Nikolić, Goran
AU  - Savić, I
AU  - Zlatković, S.
AU  - Kundaković, Tatjana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1279
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - The antimicrobial activity of Usnea barbata ethanol extract
VL  - 75
IS  - 9
SP  - 1049
EP  - 1049
DO  - 10.1055/s-0029-1234882
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1279
ER  - 

@conference{
author = "Živković, M. and Kukić-Marković, Jelena and Milenković, Marina and Nikolić, Goran and Savić, I and Zlatković, S. and Kundaković, Tatjana",
year = "2009",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "The antimicrobial activity of Usnea barbata ethanol extract",
volume = "75",
number = "9",
pages = "1049-1049",
doi = "10.1055/s-0029-1234882",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1279"
}

Živković, M., Kukić-Marković, J., Milenković, M., Nikolić, G., Savić, I., Zlatković, S.,& Kundaković, T.. (2009). The antimicrobial activity of Usnea barbata ethanol extract. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 75(9), 1049-1049.
https://doi.org/10.1055/s-0029-1234882
https://hdl.handle.net/21.15107/rcub_farfar_1279

Živković M, Kukić-Marković J, Milenković M, Nikolić G, Savić I, Zlatković S, Kundaković T. The antimicrobial activity of Usnea barbata ethanol extract. in Planta Medica. 2009;75(9):1049-1049.
doi:10.1055/s-0029-1234882
https://hdl.handle.net/21.15107/rcub_farfar_1279 .

Živković, M., Kukić-Marković, Jelena, Milenković, Marina, Nikolić, Goran, Savić, I, Zlatković, S., Kundaković, Tatjana, "The antimicrobial activity of Usnea barbata ethanol extract" in Planta Medica, 75, no. 9 (2009):1049-1049,
https://doi.org/10.1055/s-0029-1234882 .,
https://hdl.handle.net/21.15107/rcub_farfar_1279 .