TY  - CONF
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
AU  - Zlatković, M.
AU  - Đorđević, D.
AU  - Jovanović, M.
AU  - Ćurčić, Marijana
AU  - Kilibarda, Vesna
AU  - Bokonjić, Dubravko
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1469
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - How have the latest trends in toxicology of organophosphates affected our clinical practice?
VL  - 205
IS  - Supplement
SP  - S56
EP  - S56
DO  - 10.1016/j.toxlet.2011.05.215
ER  - 

@conference{
author = "Vučinić, Slavica and Antonijević, Biljana and Zlatković, M. and Đorđević, D. and Jovanović, M. and Ćurčić, Marijana and Kilibarda, Vesna and Bokonjić, Dubravko",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "How have the latest trends in toxicology of organophosphates affected our clinical practice?",
volume = "205",
number = "Supplement",
pages = "S56-S56",
doi = "10.1016/j.toxlet.2011.05.215"
}

Vučinić, S., Antonijević, B., Zlatković, M., Đorđević, D., Jovanović, M., Ćurčić, M., Kilibarda, V.,& Bokonjić, D.. (2011). How have the latest trends in toxicology of organophosphates affected our clinical practice?. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S56-S56.
https://doi.org/10.1016/j.toxlet.2011.05.215

Vučinić S, Antonijević B, Zlatković M, Đorđević D, Jovanović M, Ćurčić M, Kilibarda V, Bokonjić D. How have the latest trends in toxicology of organophosphates affected our clinical practice?. in Toxicology Letters. 2011;205(Supplement):S56-S56.
doi:10.1016/j.toxlet.2011.05.215 .

Vučinić, Slavica, Antonijević, Biljana, Zlatković, M., Đorđević, D., Jovanović, M., Ćurčić, Marijana, Kilibarda, Vesna, Bokonjić, Dubravko, "How have the latest trends in toxicology of organophosphates affected our clinical practice?" in Toxicology Letters, 205, no. Supplement (2011):S56-S56,
https://doi.org/10.1016/j.toxlet.2011.05.215 . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Stojiljković, Miloš P.
AU  - Bokonjić, Dubravko
AU  - Vučinić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1602
AB  - Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. Methods. Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy - ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously - sc). Results. Coadministration of memantine induced a significant decrease in median effective dose in null time of both HI-6 (7.96 vs 1.79 mmoL/kg in soman poisoning) and obidoxime (16.80 vs 2.75 mmoL/kg in dichlorvos poisoning; 21.56 vs 6.63 mmoL/kg in heptenophos poisoning). Memantine and midazolam succeeded to counteract the soman-induced proconvulsive activity. Conclusion. Memantine potentiated the antidotal effect of HI-6 against a lethal dose of soman, as well as the ability of obidoxime to antagonize the toxic effects of dichlorvos and heptenophos probably partly due to its anticonvulsive properties.
AB  - Uvod/Cilj. Poseban problem pri trovanju organofosfornim jedinjenjima predstavljaju mišićne fascikulacije i konvulzije, koje se ne mogu u potpunosti antagonizovati primenom atropina i oksima. Cilj ovog rada bio je ispitivanje antidotskog efekta kombinacije memantina i oksima HI-6 kod trovanja somanom, kao i kombinacije memantina sa obidoksimom kod trovanja dihlorvosom i heptenofosom. Metode. Albino miševima, mužjacima, u repnu venu date su rastuće doze oksima i/ili memantina (10 mg/kg) u različitim vremenskim intervalima pre intravenskog (iv) davanja 1,3 LD-50 somana, dihlorvosa ili heptenofosa. Praćenjem stepena preživljanja, izračunate su srednje efektivne doze i poluvreme efikasnosti. U odvojenom eksperimentu praćena je cerebralna ekstravazacija boje Evans plavo (40 mg/kg iv) nakon primene memantina (10 mg/kg iv), midazolama (2,5 mg/kg intraoperitonealno - ip) i ketamina (20 mg/kg ip) 5 min pre davanja somana (1 LD-50 supkutano - sc). Rezultati. Primenom kombinacija sa memantinom srednje efektivne doze u nultom vremenu i HI-6 (7,96 vs 1,79 mmoL/kg kod trovanja somanom) i obidoksima (16,80 vs 2,75 mmoL/kg kod trovanja dihlorvosom; 21,56 vs 6,63 mmoL/kg kod trovanja heptenofosom) bile su višestruko niže u odnosu na dozu samog oksima. Memantin i midazolam uspešno su suprimirali prokonvulzivni efekat somana. Zaključak. Rezultati ove studije pokazuju da primena memantina u kombinaciji sa oksimima obezbeđuje bolji zaštitni efekat nego sam oksim, a u osnovi ovog efekta verovatno leži i njegov antikonvulzivni potencijal.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos
T1  - Antidotski efekat kombinacija obidoksim/HI-6 i memantina kod miševa trovanih somanom, dihlorvosom ili heptenofosom
VL  - 68
IS  - 12
SP  - 1033
EP  - 1040
DO  - 10.2298/VSP1112033A
ER  - 

@article{
author = "Antonijević, Biljana and Stojiljković, Miloš P. and Bokonjić, Dubravko and Vučinić, Slavica",
year = "2011",
abstract = "Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. Methods. Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy - ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously - sc). Results. Coadministration of memantine induced a significant decrease in median effective dose in null time of both HI-6 (7.96 vs 1.79 mmoL/kg in soman poisoning) and obidoxime (16.80 vs 2.75 mmoL/kg in dichlorvos poisoning; 21.56 vs 6.63 mmoL/kg in heptenophos poisoning). Memantine and midazolam succeeded to counteract the soman-induced proconvulsive activity. Conclusion. Memantine potentiated the antidotal effect of HI-6 against a lethal dose of soman, as well as the ability of obidoxime to antagonize the toxic effects of dichlorvos and heptenophos probably partly due to its anticonvulsive properties., Uvod/Cilj. Poseban problem pri trovanju organofosfornim jedinjenjima predstavljaju mišićne fascikulacije i konvulzije, koje se ne mogu u potpunosti antagonizovati primenom atropina i oksima. Cilj ovog rada bio je ispitivanje antidotskog efekta kombinacije memantina i oksima HI-6 kod trovanja somanom, kao i kombinacije memantina sa obidoksimom kod trovanja dihlorvosom i heptenofosom. Metode. Albino miševima, mužjacima, u repnu venu date su rastuće doze oksima i/ili memantina (10 mg/kg) u različitim vremenskim intervalima pre intravenskog (iv) davanja 1,3 LD-50 somana, dihlorvosa ili heptenofosa. Praćenjem stepena preživljanja, izračunate su srednje efektivne doze i poluvreme efikasnosti. U odvojenom eksperimentu praćena je cerebralna ekstravazacija boje Evans plavo (40 mg/kg iv) nakon primene memantina (10 mg/kg iv), midazolama (2,5 mg/kg intraoperitonealno - ip) i ketamina (20 mg/kg ip) 5 min pre davanja somana (1 LD-50 supkutano - sc). Rezultati. Primenom kombinacija sa memantinom srednje efektivne doze u nultom vremenu i HI-6 (7,96 vs 1,79 mmoL/kg kod trovanja somanom) i obidoksima (16,80 vs 2,75 mmoL/kg kod trovanja dihlorvosom; 21,56 vs 6,63 mmoL/kg kod trovanja heptenofosom) bile su višestruko niže u odnosu na dozu samog oksima. Memantin i midazolam uspešno su suprimirali prokonvulzivni efekat somana. Zaključak. Rezultati ove studije pokazuju da primena memantina u kombinaciji sa oksimima obezbeđuje bolji zaštitni efekat nego sam oksim, a u osnovi ovog efekta verovatno leži i njegov antikonvulzivni potencijal.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos, Antidotski efekat kombinacija obidoksim/HI-6 i memantina kod miševa trovanih somanom, dihlorvosom ili heptenofosom",
volume = "68",
number = "12",
pages = "1033-1040",
doi = "10.2298/VSP1112033A"
}

Antonijević, B., Stojiljković, M. P., Bokonjić, D.,& Vučinić, S.. (2011). Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 68(12), 1033-1040.
https://doi.org/10.2298/VSP1112033A

Antonijević B, Stojiljković MP, Bokonjić D, Vučinić S. Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos. in Vojnosanitetski pregled. 2011;68(12):1033-1040.
doi:10.2298/VSP1112033A .

Antonijević, Biljana, Stojiljković, Miloš P., Bokonjić, Dubravko, Vučinić, Slavica, "Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos" in Vojnosanitetski pregled, 68, no. 12 (2011):1033-1040,
https://doi.org/10.2298/VSP1112033A . .

TY  - CONF
AU  - Joksimović, Srđan
AU  - Savić, Miroslav
AU  - Clayton, Terry
AU  - Huang, Shengming
AU  - Ara, S.
AU  - van Linn, Michael
AU  - Milinković, Marija M.
AU  - Bokonjić, Dubravko
AU  - Sieghart, Werner
AU  - Cook, James M.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1079
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Relative contribution of the alpha2-, 3-and 5-containing GABAA receptors to benzodiazepine effects in the water maze
VL  - 18
IS  - Supplement 4
SP  - S282
EP  - S282
DO  - 10.1016/S0924-977X(08)70372-9
ER  - 

@conference{
author = "Joksimović, Srđan and Savić, Miroslav and Clayton, Terry and Huang, Shengming and Ara, S. and van Linn, Michael and Milinković, Marija M. and Bokonjić, Dubravko and Sieghart, Werner and Cook, James M.",
year = "2008",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Relative contribution of the alpha2-, 3-and 5-containing GABAA receptors to benzodiazepine effects in the water maze",
volume = "18",
number = "Supplement 4",
pages = "S282-S282",
doi = "10.1016/S0924-977X(08)70372-9"
}

Joksimović, S., Savić, M., Clayton, T., Huang, S., Ara, S., van Linn, M., Milinković, M. M., Bokonjić, D., Sieghart, W.,& Cook, J. M.. (2008). Relative contribution of the alpha2-, 3-and 5-containing GABAA receptors to benzodiazepine effects in the water maze. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 18(Supplement 4), S282-S282.
https://doi.org/10.1016/S0924-977X(08)70372-9

Joksimović S, Savić M, Clayton T, Huang S, Ara S, van Linn M, Milinković MM, Bokonjić D, Sieghart W, Cook JM. Relative contribution of the alpha2-, 3-and 5-containing GABAA receptors to benzodiazepine effects in the water maze. in European Neuropsychopharmacology. 2008;18(Supplement 4):S282-S282.
doi:10.1016/S0924-977X(08)70372-9 .

Joksimović, Srđan, Savić, Miroslav, Clayton, Terry, Huang, Shengming, Ara, S., van Linn, Michael, Milinković, Marija M., Bokonjić, Dubravko, Sieghart, Werner, Cook, James M., "Relative contribution of the alpha2-, 3-and 5-containing GABAA receptors to benzodiazepine effects in the water maze" in European Neuropsychopharmacology, 18, no. Supplement 4 (2008):S282-S282,
https://doi.org/10.1016/S0924-977X(08)70372-9 . .

TY  - JOUR
AU  - Savić, Miroslav
AU  - Huang, Shengming
AU  - Furtmueller, Roman
AU  - Clayton, Terry
AU  - Huck, Sigismund
AU  - Obradović, Dragan I.
AU  - Ugrešić, Nenad
AU  - Sieghart, Werner
AU  - Bokonjić, Dubravko
AU  - Cook, James M.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1048
AB  - Classical benzodiazepines (BZs) exert anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA(A) receptors containing alpha(1), alpha(2), alpha(3) or alpha(5) subunits. Genetic studies suggest that modulation at the alpha(1) subunit contributes to much of the adverse effects of BZs, most notably sedation, ataxia, and amnesia. Hence, BZ site ligands functionally inactive at GABAA receptors containing the alpha(1) subunit are considered to be promising leads for novel, anxioselective anxiolytics devoid of sedative properties. In pursuing this approach, we used two-electrode voltage clamp experiments in Xenopus oocytes expressing recombinant GABAA receptor subtypes to investigate functional selectivity of three newly synthesized BZ site ligands and also compared their in vivo behavioral profiles. The compounds were functionally selective for alpha(2)-, alpha(3)-, and alpha(5)-containing subtypes of GABA(A) receptors (SH-053-S-CH3 and SH-053-S-CH3-2'F) or essentially selective for alpha(5) subtypes (SH-053-R-CH3). Possible influences on behavioral measures were tested in the elevated plus maze, spontaneous locomotor activity, and rotarod test, which are considered primarily predictive of the anxiolytic, sedative, and ataxic influence of BZs, respectively. The results confirmed the substantially diminished ataxic potential of BZ site agonists devoid of alpha(1) subunit-mediated effects, with preserved anti-anxiety effects at 30 mg/kg of SH-053-S-CH3 and SH-053-S-CH3-2'F. However, all three ligands, dosed at 30 mg/kg, decreased spontaneous locomotor activity, suggesting that sedation may be partly dependent on activity mediated by alpha(5)-containing GABAA receptors. Hence, it could be of importance to avoid substantial agonist activity at alpha(5) receptors by candidate anxioselective anxiolytics, if clinical sedation is to be avoided.
PB  - Nature Publishing Group, London
T2  - Neuropsychopharmacology
T1  - Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?
VL  - 33
IS  - 2
SP  - 332
EP  - 339
DO  - 10.1038/sj.npp.1301403
ER  - 

@article{
author = "Savić, Miroslav and Huang, Shengming and Furtmueller, Roman and Clayton, Terry and Huck, Sigismund and Obradović, Dragan I. and Ugrešić, Nenad and Sieghart, Werner and Bokonjić, Dubravko and Cook, James M.",
year = "2008",
abstract = "Classical benzodiazepines (BZs) exert anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA(A) receptors containing alpha(1), alpha(2), alpha(3) or alpha(5) subunits. Genetic studies suggest that modulation at the alpha(1) subunit contributes to much of the adverse effects of BZs, most notably sedation, ataxia, and amnesia. Hence, BZ site ligands functionally inactive at GABAA receptors containing the alpha(1) subunit are considered to be promising leads for novel, anxioselective anxiolytics devoid of sedative properties. In pursuing this approach, we used two-electrode voltage clamp experiments in Xenopus oocytes expressing recombinant GABAA receptor subtypes to investigate functional selectivity of three newly synthesized BZ site ligands and also compared their in vivo behavioral profiles. The compounds were functionally selective for alpha(2)-, alpha(3)-, and alpha(5)-containing subtypes of GABA(A) receptors (SH-053-S-CH3 and SH-053-S-CH3-2'F) or essentially selective for alpha(5) subtypes (SH-053-R-CH3). Possible influences on behavioral measures were tested in the elevated plus maze, spontaneous locomotor activity, and rotarod test, which are considered primarily predictive of the anxiolytic, sedative, and ataxic influence of BZs, respectively. The results confirmed the substantially diminished ataxic potential of BZ site agonists devoid of alpha(1) subunit-mediated effects, with preserved anti-anxiety effects at 30 mg/kg of SH-053-S-CH3 and SH-053-S-CH3-2'F. However, all three ligands, dosed at 30 mg/kg, decreased spontaneous locomotor activity, suggesting that sedation may be partly dependent on activity mediated by alpha(5)-containing GABAA receptors. Hence, it could be of importance to avoid substantial agonist activity at alpha(5) receptors by candidate anxioselective anxiolytics, if clinical sedation is to be avoided.",
publisher = "Nature Publishing Group, London",
journal = "Neuropsychopharmacology",
title = "Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?",
volume = "33",
number = "2",
pages = "332-339",
doi = "10.1038/sj.npp.1301403"
}

Savić, M., Huang, S., Furtmueller, R., Clayton, T., Huck, S., Obradović, D. I., Ugrešić, N., Sieghart, W., Bokonjić, D.,& Cook, J. M.. (2008). Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?. in Neuropsychopharmacology
Nature Publishing Group, London., 33(2), 332-339.
https://doi.org/10.1038/sj.npp.1301403

Savić M, Huang S, Furtmueller R, Clayton T, Huck S, Obradović DI, Ugrešić N, Sieghart W, Bokonjić D, Cook JM. Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?. in Neuropsychopharmacology. 2008;33(2):332-339.
doi:10.1038/sj.npp.1301403 .

Savić, Miroslav, Huang, Shengming, Furtmueller, Roman, Clayton, Terry, Huck, Sigismund, Obradović, Dragan I., Ugrešić, Nenad, Sieghart, Werner, Bokonjić, Dubravko, Cook, James M., "Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?" in Neuropsychopharmacology, 33, no. 2 (2008):332-339,
https://doi.org/10.1038/sj.npp.1301403 . .

TY  - CONF
AU  - Stefanović, D.
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/866
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats
T1  - Primena modela pri evaluaciji efikasnosti trimedoksima, atropina i natrijum-hidrogenkarbonata kod trovanja dihlorvosom u pacova
VL  - 56
IS  - 4
SP  - 602
EP  - 603
UR  - https://hdl.handle.net/21.15107/rcub_farfar_866
ER  - 

@conference{
author = "Stefanović, D. and Antonijević, Biljana and Bokonjić, Dubravko and Milovanović, Zoran A. and Stojiljković, Miloš P. and Nedeljković, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats, Primena modela pri evaluaciji efikasnosti trimedoksima, atropina i natrijum-hidrogenkarbonata kod trovanja dihlorvosom u pacova",
volume = "56",
number = "4",
pages = "602-603",
url = "https://hdl.handle.net/21.15107/rcub_farfar_866"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Milovanović, Z. A., Stojiljković, M. P.,& Nedeljković, M.. (2006). Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 602-603.
https://hdl.handle.net/21.15107/rcub_farfar_866

Stefanović D, Antonijević B, Bokonjić D, Milovanović ZA, Stojiljković MP, Nedeljković M. Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Arhiv za farmaciju. 2006;56(4):602-603.
https://hdl.handle.net/21.15107/rcub_farfar_866 .

Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, M., "Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats" in Arhiv za farmaciju, 56, no. 4 (2006):602-603,
https://hdl.handle.net/21.15107/rcub_farfar_866 .

TY  - CONF
AU  - Stefanović, D.
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/711
PB  - Elsevier
C3  - Toxicology Letters
T1  - Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats
VL  - 164, Supplement
SP  - S244
EP  - S244
DO  - 10.1016/j.toxlet.2006.07.167
ER  - 

@conference{
author = "Stefanović, D. and Antonijević, Biljana and Bokonjić, Dubravko and Milovanović, Zoran A. and Stojiljković, Miloš P. and Nedeljković, Mirjana",
year = "2006",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats",
volume = "164, Supplement",
pages = "S244-S244",
doi = "10.1016/j.toxlet.2006.07.167"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Milovanović, Z. A., Stojiljković, M. P.,& Nedeljković, M.. (2006). Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Toxicology Letters
Elsevier., 164, Supplement, S244-S244.
https://doi.org/10.1016/j.toxlet.2006.07.167

Stefanović D, Antonijević B, Bokonjić D, Milovanović ZA, Stojiljković MP, Nedeljković M. Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Toxicology Letters. 2006;164, Supplement:S244-S244.
doi:10.1016/j.toxlet.2006.07.167 .

Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, Mirjana, "Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats" in Toxicology Letters, 164, Supplement (2006):S244-S244,
https://doi.org/10.1016/j.toxlet.2006.07.167 . .

TY  - JOUR
AU  - Savić, Miroslav
AU  - Obradović, Dragan I.
AU  - Ugrešić, Nenad
AU  - Cook, James M.
AU  - Yin, Wenyuan
AU  - van Linn, Michael
AU  - Bokonjić, Dubravko
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/828
AB  - Benzodiazepine site inverse agonists may increase or decrease locomotor activity in rodents, depending on the experimental settings. We have compared the behavioral responses to environmental novelty of rats treated with the non-selective inverse agonist DMCM (2 mg/kg) and the alpha(1)-subunit affinity-selective inverse agonist 3-EBC (15 mg/kg). The behavior in spontaneous locomotor assay (during 45 min) and elevated plus maze (EPM) was automatically recorded. In the EPM, general activity-related parameters were similarly decreased, whereas only DMCM inhibited open-arm activity. In the locomotor assay, both compounds depressed locomotion in the first 15 min and activity in the central zone of the chamber. However, the influence of 3-EBC was less pronounced. The alpha(1)-subunit selective antagonist beta-CCt (15 mg/kg) attenuated locomotor depression, but not the central-zone avoidance elicited by DMCM. When habituated to the chamber, DMCM-treated animals emitted a plateau phase of activity, which disappeared by adding beta-CCt. Hence, inhibition of activity in exposed areas may be mediated by non-alpha(1)-subunits, whereas both alpha(1) and non-alpha(1)-subunits may participate in suppression of activity in more protective areas of an apparatus. Hyperlocomotion in habituated animals may depend primarily on the alpha(1)-subunit. Moreover, the bimodal influence of inverse agonists on locomotion can be biphasic, observable in the same experiment.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Pharmacology Biochemistry and Behavior
T1  - Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence
VL  - 84
IS  - 1
SP  - 35
EP  - 42
DO  - 10.1016/j.pbb.2006.04.001
ER  - 

@article{
author = "Savić, Miroslav and Obradović, Dragan I. and Ugrešić, Nenad and Cook, James M. and Yin, Wenyuan and van Linn, Michael and Bokonjić, Dubravko",
year = "2006",
abstract = "Benzodiazepine site inverse agonists may increase or decrease locomotor activity in rodents, depending on the experimental settings. We have compared the behavioral responses to environmental novelty of rats treated with the non-selective inverse agonist DMCM (2 mg/kg) and the alpha(1)-subunit affinity-selective inverse agonist 3-EBC (15 mg/kg). The behavior in spontaneous locomotor assay (during 45 min) and elevated plus maze (EPM) was automatically recorded. In the EPM, general activity-related parameters were similarly decreased, whereas only DMCM inhibited open-arm activity. In the locomotor assay, both compounds depressed locomotion in the first 15 min and activity in the central zone of the chamber. However, the influence of 3-EBC was less pronounced. The alpha(1)-subunit selective antagonist beta-CCt (15 mg/kg) attenuated locomotor depression, but not the central-zone avoidance elicited by DMCM. When habituated to the chamber, DMCM-treated animals emitted a plateau phase of activity, which disappeared by adding beta-CCt. Hence, inhibition of activity in exposed areas may be mediated by non-alpha(1)-subunits, whereas both alpha(1) and non-alpha(1)-subunits may participate in suppression of activity in more protective areas of an apparatus. Hyperlocomotion in habituated animals may depend primarily on the alpha(1)-subunit. Moreover, the bimodal influence of inverse agonists on locomotion can be biphasic, observable in the same experiment.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Pharmacology Biochemistry and Behavior",
title = "Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence",
volume = "84",
number = "1",
pages = "35-42",
doi = "10.1016/j.pbb.2006.04.001"
}

Savić, M., Obradović, D. I., Ugrešić, N., Cook, J. M., Yin, W., van Linn, M.,& Bokonjić, D.. (2006). Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence. in Pharmacology Biochemistry and Behavior
Pergamon-Elsevier Science Ltd, Oxford., 84(1), 35-42.
https://doi.org/10.1016/j.pbb.2006.04.001

Savić M, Obradović DI, Ugrešić N, Cook JM, Yin W, van Linn M, Bokonjić D. Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence. in Pharmacology Biochemistry and Behavior. 2006;84(1):35-42.
doi:10.1016/j.pbb.2006.04.001 .

Savić, Miroslav, Obradović, Dragan I., Ugrešić, Nenad, Cook, James M., Yin, Wenyuan, van Linn, Michael, Bokonjić, Dubravko, "Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence" in Pharmacology Biochemistry and Behavior, 84, no. 1 (2006):35-42,
https://doi.org/10.1016/j.pbb.2006.04.001 . .

TY  - JOUR
AU  - Stefanović, D
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Milovanović, Zoran A.
AU  - Nedeljković, M
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/773
AB  - The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos
VL  - 98
IS  - 2
SP  - 173
EP  - 180
DO  - 10.1111/j.1742-7843.2006.pto_68.x
ER  - 

@article{
author = "Stefanović, D and Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Milovanović, Zoran A. and Nedeljković, M",
year = "2006",
abstract = "The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos",
volume = "98",
number = "2",
pages = "173-180",
doi = "10.1111/j.1742-7843.2006.pto_68.x"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Stojiljković, M. P., Milovanović, Z. A.,& Nedeljković, M.. (2006). Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 98(2), 173-180.
https://doi.org/10.1111/j.1742-7843.2006.pto_68.x

Stefanović D, Antonijević B, Bokonjić D, Stojiljković MP, Milovanović ZA, Nedeljković M. Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. in Basic & Clinical Pharmacology & Toxicology. 2006;98(2):173-180.
doi:10.1111/j.1742-7843.2006.pto_68.x .

Stefanović, D, Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Milovanović, Zoran A., Nedeljković, M, "Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos" in Basic & Clinical Pharmacology & Toxicology, 98, no. 2 (2006):173-180,
https://doi.org/10.1111/j.1742-7843.2006.pto_68.x . .

TY  - JOUR
AU  - Savić, Miroslav
AU  - Obradović, Dragan I.
AU  - Ugrešić, Nenad
AU  - Bokonjić, Dubravko
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/644
AB  - Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.
PB  - Hindawi Limited
T2  - Neural Plasticity
T1  - Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes
VL  - 12
IS  - 4
SP  - 289
EP  - 298
DO  - 10.1155/NP.2005.289
ER  - 

@article{
author = "Savić, Miroslav and Obradović, Dragan I. and Ugrešić, Nenad and Bokonjić, Dubravko",
year = "2005",
abstract = "Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.",
publisher = "Hindawi Limited",
journal = "Neural Plasticity",
title = "Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes",
volume = "12",
number = "4",
pages = "289-298",
doi = "10.1155/NP.2005.289"
}

Savić, M., Obradović, D. I., Ugrešić, N.,& Bokonjić, D.. (2005). Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes. in Neural Plasticity
Hindawi Limited., 12(4), 289-298.
https://doi.org/10.1155/NP.2005.289

Savić M, Obradović DI, Ugrešić N, Bokonjić D. Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes. in Neural Plasticity. 2005;12(4):289-298.
doi:10.1155/NP.2005.289 .

Savić, Miroslav, Obradović, Dragan I., Ugrešić, Nenad, Bokonjić, Dubravko, "Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes" in Neural Plasticity, 12, no. 4 (2005):289-298,
https://doi.org/10.1155/NP.2005.289 . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Kilibarda, Vesna
AU  - Milovanović, Zoran A.
AU  - Nedeljković, M
AU  - Maksimović, M
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/632
AB  - The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos
VL  - 96
IS  - 2
SP  - 111
EP  - 117
DO  - 10.1111/j.1742-7843.2005.pto960204.x
ER  - 

@article{
author = "Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Kilibarda, Vesna and Milovanović, Zoran A. and Nedeljković, M and Maksimović, M",
year = "2005",
abstract = "The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos",
volume = "96",
number = "2",
pages = "111-117",
doi = "10.1111/j.1742-7843.2005.pto960204.x"
}

Antonijević, B., Bokonjić, D., Stojiljković, M. P., Kilibarda, V., Milovanović, Z. A., Nedeljković, M.,& Maksimović, M.. (2005). Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 96(2), 111-117.
https://doi.org/10.1111/j.1742-7843.2005.pto960204.x

Antonijević B, Bokonjić D, Stojiljković MP, Kilibarda V, Milovanović ZA, Nedeljković M, Maksimović M. Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. in Basic & Clinical Pharmacology & Toxicology. 2005;96(2):111-117.
doi:10.1111/j.1742-7843.2005.pto960204.x .

Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Kilibarda, Vesna, Milovanović, Zoran A., Nedeljković, M, Maksimović, M, "Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos" in Basic & Clinical Pharmacology & Toxicology, 96, no. 2 (2005):111-117,
https://doi.org/10.1111/j.1742-7843.2005.pto960204.x . .

TY  - JOUR
AU  - Stefanović, Danka
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Milovanović, Zoran A.
AU  - Nedeljković, Mirjana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/565
AB  - The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes.
AB  - Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos
T1  - Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom
VL  - 23
IS  - 2
SP  - 165
EP  - 170
DO  - 10.2298/JMH0402165S
ER  - 

@article{
author = "Stefanović, Danka and Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Milovanović, Zoran A. and Nedeljković, Mirjana",
year = "2004",
abstract = "The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes., Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos, Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom",
volume = "23",
number = "2",
pages = "165-170",
doi = "10.2298/JMH0402165S"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Stojiljković, M. P., Milovanović, Z. A.,& Nedeljković, M.. (2004). Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 23(2), 165-170.
https://doi.org/10.2298/JMH0402165S

Stefanović D, Antonijević B, Bokonjić D, Stojiljković MP, Milovanović ZA, Nedeljković M. Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos. in Jugoslovenska medicinska biohemija. 2004;23(2):165-170.
doi:10.2298/JMH0402165S .

Stefanović, Danka, Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Milovanović, Zoran A., Nedeljković, Mirjana, "Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos" in Jugoslovenska medicinska biohemija, 23, no. 2 (2004):165-170,
https://doi.org/10.2298/JMH0402165S . .

TY  - JOUR
AU  - Petrović, Silvana
AU  - Dobrić, Silva
AU  - Bokonjić, Dubravko
AU  - Niketić, Marjan
AU  - Garcia-Pineres, A
AU  - Merfort, I
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/443
AB  - Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.
PB  - Elsevier Ireland Ltd, Clare
T2  - Journal of Ethnopharmacology
T1  - Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats
VL  - 87
IS  - 1
SP  - 109
EP  - 113
DO  - 10.1016/S0378-8741(03)00118-1
ER  - 

@article{
author = "Petrović, Silvana and Dobrić, Silva and Bokonjić, Dubravko and Niketić, Marjan and Garcia-Pineres, A and Merfort, I",
year = "2003",
abstract = "Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Journal of Ethnopharmacology",
title = "Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats",
volume = "87",
number = "1",
pages = "109-113",
doi = "10.1016/S0378-8741(03)00118-1"
}

Petrović, S., Dobrić, S., Bokonjić, D., Niketić, M., Garcia-Pineres, A.,& Merfort, I.. (2003). Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. in Journal of Ethnopharmacology
Elsevier Ireland Ltd, Clare., 87(1), 109-113.
https://doi.org/10.1016/S0378-8741(03)00118-1

Petrović S, Dobrić S, Bokonjić D, Niketić M, Garcia-Pineres A, Merfort I. Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. in Journal of Ethnopharmacology. 2003;87(1):109-113.
doi:10.1016/S0378-8741(03)00118-1 .

Petrović, Silvana, Dobrić, Silva, Bokonjić, Dubravko, Niketić, Marjan, Garcia-Pineres, A, Merfort, I, "Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats" in Journal of Ethnopharmacology, 87, no. 1 (2003):109-113,
https://doi.org/10.1016/S0378-8741(03)00118-1 . .

TY  - JOUR
AU  - Obradović, Dragan I.
AU  - Savić, Miroslav
AU  - Ugrešić, Nenad
AU  - Bokonjić, Dubravko
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/463
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - GABA-A receptors: molecular substrate for the development of new anxiolytic agents
T1  - GABAa receptori - molekulski supstrat za razvoj novih anksiolitika
VL  - 60
IS  - 3
SP  - 345
EP  - 352
DO  - 10.2298/VSP0303345O
ER  - 

@article{
author = "Obradović, Dragan I. and Savić, Miroslav and Ugrešić, Nenad and Bokonjić, Dubravko",
year = "2003",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "GABA-A receptors: molecular substrate for the development of new anxiolytic agents, GABAa receptori - molekulski supstrat za razvoj novih anksiolitika",
volume = "60",
number = "3",
pages = "345-352",
doi = "10.2298/VSP0303345O"
}

Obradović, D. I., Savić, M., Ugrešić, N.,& Bokonjić, D.. (2003). GABA-A receptors: molecular substrate for the development of new anxiolytic agents. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 60(3), 345-352.
https://doi.org/10.2298/VSP0303345O

Obradović DI, Savić M, Ugrešić N, Bokonjić D. GABA-A receptors: molecular substrate for the development of new anxiolytic agents. in Vojnosanitetski pregled. 2003;60(3):345-352.
doi:10.2298/VSP0303345O .

Obradović, Dragan I., Savić, Miroslav, Ugrešić, Nenad, Bokonjić, Dubravko, "GABA-A receptors: molecular substrate for the development of new anxiolytic agents" in Vojnosanitetski pregled, 60, no. 3 (2003):345-352,
https://doi.org/10.2298/VSP0303345O . .

TY  - JOUR
AU  - Petrović, RMS
AU  - Tokić-Vujošević, Zorana
AU  - Milovanov, S
AU  - Ceković, Z
AU  - Bokonjić, Dubravko
AU  - Dobrić, Silva
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/322
PB  - Govi-Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery
VL  - 57
IS  - 7
SP  - 507
EP  - 508
UR  - https://hdl.handle.net/21.15107/rcub_farfar_322
ER  - 

@article{
author = "Petrović, RMS and Tokić-Vujošević, Zorana and Milovanov, S and Ceković, Z and Bokonjić, Dubravko and Dobrić, Silva",
year = "2002",
publisher = "Govi-Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery",
volume = "57",
number = "7",
pages = "507-508",
url = "https://hdl.handle.net/21.15107/rcub_farfar_322"
}

Petrović, R., Tokić-Vujošević, Z., Milovanov, S., Ceković, Z., Bokonjić, D.,& Dobrić, S.. (2002). Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery. in Pharmazie
Govi-Verlag Gmbh, Eschborn., 57(7), 507-508.
https://hdl.handle.net/21.15107/rcub_farfar_322

Petrović R, Tokić-Vujošević Z, Milovanov S, Ceković Z, Bokonjić D, Dobrić S. Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery. in Pharmazie. 2002;57(7):507-508.
https://hdl.handle.net/21.15107/rcub_farfar_322 .

Petrović, RMS, Tokić-Vujošević, Zorana, Milovanov, S, Ceković, Z, Bokonjić, Dubravko, Dobrić, Silva, "Pharmacological evaluation of a novel oxime derived from isosorbide-5-mononitrate on isolated rat superior mesenteric artery" in Pharmazie, 57, no. 7 (2002):507-508,
https://hdl.handle.net/21.15107/rcub_farfar_322 .

TY  - CONF
AU  - Antonijević, Biljana
AU  - Stefanović, Danka
AU  - Nedeljković, Mirjana
AU  - Stojiljković, Miloš P.
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/368
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos
T1  - Zaštitni efekat standardnih antidota primenjenih sa natrijum bikarbonatom u pacova trovanih dihlorvosom
VL  - 52
IS  - 4
SP  - 762
EP  - 763
UR  - https://hdl.handle.net/21.15107/rcub_farfar_368
ER  - 

@conference{
author = "Antonijević, Biljana and Stefanović, Danka and Nedeljković, Mirjana and Stojiljković, Miloš P. and Bokonjić, Dubravko and Milovanović, Zoran A.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos, Zaštitni efekat standardnih antidota primenjenih sa natrijum bikarbonatom u pacova trovanih dihlorvosom",
volume = "52",
number = "4",
pages = "762-763",
url = "https://hdl.handle.net/21.15107/rcub_farfar_368"
}

Antonijević, B., Stefanović, D., Nedeljković, M., Stojiljković, M. P., Bokonjić, D.,& Milovanović, Z. A.. (2002). Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 762-763.
https://hdl.handle.net/21.15107/rcub_farfar_368

Antonijević B, Stefanović D, Nedeljković M, Stojiljković MP, Bokonjić D, Milovanović ZA. Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos. in Arhiv za farmaciju. 2002;52(4):762-763.
https://hdl.handle.net/21.15107/rcub_farfar_368 .

Antonijević, Biljana, Stefanović, Danka, Nedeljković, Mirjana, Stojiljković, Miloš P., Bokonjić, Dubravko, Milovanović, Zoran A., "Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos" in Arhiv za farmaciju, 52, no. 4 (2002):762-763,
https://hdl.handle.net/21.15107/rcub_farfar_368 .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Maksimović, Matej
AU  - Kilibarda, Vesna
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
AU  - Milovanović, Zoran A.
AU  - Bokonjić, Dubravko
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/305
AB  - The aim of this study was to investigate the efficacy of four pyridinium oximes - pralidoxime (PAM-2), trimedoxime (TMB-4), obidoxime (LuH-6) and HI-6 - alone or in combination with memantine and its principal metabolite 1-amino-3-hydroxymethyl-5-methyl adamantane (Mrz 2/373) against soman in mice. Male Albino mice were pretreated iv with oximes and adamantanes at various times before 1.3 LD-50 of soman iv in order to obtain their ED-50t. In a separate experiment, the brain, dia­phragmai and erythrocytic acetylcholinesterase and plasma carboxylesterase activities were determined after sacrificing mice 5 min after soman 0.75 LD-50. Oxime HI-6 (ED-50 value at 5 min before soman) and adamantanes were administered 5 min before soman. In the combination regimens and in the biochemical experiments the dose of memantine and Mrz 2/373 was fixed at 10 mg/kg iv. Along the tested time intervals, HI-6 afforded the best protection of experimental animals, and calculated EDSOo value of HI-6 was 7.96 µmol/kg. Memantine significantly (up to 9 times) de­creased ED-500 values of all the oximes used, with the exception of TMB-4. Among tested tis­sues, the highest recovery of inhibited acetylcholinesterase was obtained in the diaphragm. Co-administration of adamantanes (memantine, Mrz 2/373) produced a statistically significant in­crease in the erythrocyte acetylcholinesterase activity. It could be concluded that memantine antidotal efficacy could be ascribed to the protection of acetylcholinesterase activity. .
AB  - Pored činjenice daje oksim HI-6 najefikasniji u antagonizovanju toksičnih efekata somana, terapija trovanja ovim nervnim bojnim otrovom još nije u potpunosti zadovoljavajuća. Dosadašnji eksperimenti sa memantinom su pokazali da ovaj derivat adamantana potencira terapijski efekat standardnih antidota pri trovanju organofosfornim jedinjenjima. U ovom radu ispitivana je antidotska efikasnost piridinijumskih oksima - pralidoksima, trimedoksima, obidoksima i HI-6, kao i njihovih kombinacija sa memantinom ili njegovim aktivnim metabolitom Mrz 2/373 u miševa trovanih somanom. Radi dobijanja parametara zaštitne efikasnosti antidota, albino miševima mužjacima su iv aplikovane rastuće doze antidota u određenim vremenskim intervalima ( 1 -60 min) pre 1,3 LD-50 iv somana. Aktivnosti acetilholinesteraze mozga, dijafragme i eritrocita, kao i karboksilesteraza plazme, određivane su nakon iv primene adamantana (10 mg/kg) i/ili oksima HI-6 (3,1 mg/kg; 7,96 µmol/kg) datih 5 min pre 0,75 LD-50 iv somana. Primena oksima HI-6 je obezbedila najbolju zaštitu eksperimentalnih životinja, a srednja efektivna doza u nultom vremenu ED-500 iznosila je 7,96 µmol/kg. Kada je primenjen u kombinaciji sa oksimima, memantin je doveo do značajnog (oko 9 puta) smanjenja HD-500 vrednosti svih oksima, osim trimedoksima. ali je zato poluvreme efikasnosti trimedoksima povećano 4,82 puta. Značajan porast acetilholinesteraze dijafragme dobijen je primenom HI-6, memantina kao i njihove kombinacije. U odnosu na grupu koja je primila samo soman, aktivnost acetilholi­nesteraze eritrocita bila je značajno veća u grupama kojima su davani adamantani i/ili HI-6. Nijedan od primenjenih tretmana nije doveo do statistički značajnog povećanja aktivnosti acetilholinesteraze mozga i karboksilesteraza plazme. Bolji zaštitni efekt kombinacija oksima i memantina u odnosu na same oksime mogao bi se pripisati antikonvulzivnom potencijalu memantina, koji je nekompetitivni antagonista NMDA receptora, ali i izvesnoj zaštiti aktivnog centra acetilholinesteraze dijafragme.
PB  - Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd
T2  - Archives of Toxicology, Kinetics and Xenobiotic Metabolism
T1  - Potential beneficial action of adamantanes in mice poisoned with soman
T1  - Potencijalna uloga adamantana u trovanju miševa somanom
VL  - 9
IS  - 1-2
SP  - 13
EP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_farfar_305
ER  - 

@article{
author = "Antonijević, Biljana and Maksimović, Matej and Kilibarda, Vesna and Stojiljković, Miloš P. and Nedeljković, Mirjana and Milovanović, Zoran A. and Bokonjić, Dubravko",
year = "2001",
abstract = "The aim of this study was to investigate the efficacy of four pyridinium oximes - pralidoxime (PAM-2), trimedoxime (TMB-4), obidoxime (LuH-6) and HI-6 - alone or in combination with memantine and its principal metabolite 1-amino-3-hydroxymethyl-5-methyl adamantane (Mrz 2/373) against soman in mice. Male Albino mice were pretreated iv with oximes and adamantanes at various times before 1.3 LD-50 of soman iv in order to obtain their ED-50t. In a separate experiment, the brain, dia­phragmai and erythrocytic acetylcholinesterase and plasma carboxylesterase activities were determined after sacrificing mice 5 min after soman 0.75 LD-50. Oxime HI-6 (ED-50 value at 5 min before soman) and adamantanes were administered 5 min before soman. In the combination regimens and in the biochemical experiments the dose of memantine and Mrz 2/373 was fixed at 10 mg/kg iv. Along the tested time intervals, HI-6 afforded the best protection of experimental animals, and calculated EDSOo value of HI-6 was 7.96 µmol/kg. Memantine significantly (up to 9 times) de­creased ED-500 values of all the oximes used, with the exception of TMB-4. Among tested tis­sues, the highest recovery of inhibited acetylcholinesterase was obtained in the diaphragm. Co-administration of adamantanes (memantine, Mrz 2/373) produced a statistically significant in­crease in the erythrocyte acetylcholinesterase activity. It could be concluded that memantine antidotal efficacy could be ascribed to the protection of acetylcholinesterase activity. ., Pored činjenice daje oksim HI-6 najefikasniji u antagonizovanju toksičnih efekata somana, terapija trovanja ovim nervnim bojnim otrovom još nije u potpunosti zadovoljavajuća. Dosadašnji eksperimenti sa memantinom su pokazali da ovaj derivat adamantana potencira terapijski efekat standardnih antidota pri trovanju organofosfornim jedinjenjima. U ovom radu ispitivana je antidotska efikasnost piridinijumskih oksima - pralidoksima, trimedoksima, obidoksima i HI-6, kao i njihovih kombinacija sa memantinom ili njegovim aktivnim metabolitom Mrz 2/373 u miševa trovanih somanom. Radi dobijanja parametara zaštitne efikasnosti antidota, albino miševima mužjacima su iv aplikovane rastuće doze antidota u određenim vremenskim intervalima ( 1 -60 min) pre 1,3 LD-50 iv somana. Aktivnosti acetilholinesteraze mozga, dijafragme i eritrocita, kao i karboksilesteraza plazme, određivane su nakon iv primene adamantana (10 mg/kg) i/ili oksima HI-6 (3,1 mg/kg; 7,96 µmol/kg) datih 5 min pre 0,75 LD-50 iv somana. Primena oksima HI-6 je obezbedila najbolju zaštitu eksperimentalnih životinja, a srednja efektivna doza u nultom vremenu ED-500 iznosila je 7,96 µmol/kg. Kada je primenjen u kombinaciji sa oksimima, memantin je doveo do značajnog (oko 9 puta) smanjenja HD-500 vrednosti svih oksima, osim trimedoksima. ali je zato poluvreme efikasnosti trimedoksima povećano 4,82 puta. Značajan porast acetilholinesteraze dijafragme dobijen je primenom HI-6, memantina kao i njihove kombinacije. U odnosu na grupu koja je primila samo soman, aktivnost acetilholi­nesteraze eritrocita bila je značajno veća u grupama kojima su davani adamantani i/ili HI-6. Nijedan od primenjenih tretmana nije doveo do statistički značajnog povećanja aktivnosti acetilholinesteraze mozga i karboksilesteraza plazme. Bolji zaštitni efekt kombinacija oksima i memantina u odnosu na same oksime mogao bi se pripisati antikonvulzivnom potencijalu memantina, koji je nekompetitivni antagonista NMDA receptora, ali i izvesnoj zaštiti aktivnog centra acetilholinesteraze dijafragme.",
publisher = "Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd",
journal = "Archives of Toxicology, Kinetics and Xenobiotic Metabolism",
title = "Potential beneficial action of adamantanes in mice poisoned with soman, Potencijalna uloga adamantana u trovanju miševa somanom",
volume = "9",
number = "1-2",
pages = "13-20",
url = "https://hdl.handle.net/21.15107/rcub_farfar_305"
}

Antonijević, B., Maksimović, M., Kilibarda, V., Stojiljković, M. P., Nedeljković, M., Milovanović, Z. A.,& Bokonjić, D.. (2001). Potential beneficial action of adamantanes in mice poisoned with soman. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism
Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd., 9(1-2), 13-20.
https://hdl.handle.net/21.15107/rcub_farfar_305

Antonijević B, Maksimović M, Kilibarda V, Stojiljković MP, Nedeljković M, Milovanović ZA, Bokonjić D. Potential beneficial action of adamantanes in mice poisoned with soman. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism. 2001;9(1-2):13-20.
https://hdl.handle.net/21.15107/rcub_farfar_305 .

Antonijević, Biljana, Maksimović, Matej, Kilibarda, Vesna, Stojiljković, Miloš P., Nedeljković, Mirjana, Milovanović, Zoran A., Bokonjić, Dubravko, "Potential beneficial action of adamantanes in mice poisoned with soman" in Archives of Toxicology, Kinetics and Xenobiotic Metabolism, 9, no. 1-2 (2001):13-20,
https://hdl.handle.net/21.15107/rcub_farfar_305 .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Dobrić, Silva
AU  - Bokonjić, Dubravko
AU  - Dragojević-Simić, Viktorija
AU  - Kilibarda, Vesna
AU  - Kovacević, N
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/238
PB  - Govi-Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Anti-inflammatory and anti-ulcer activity of Achillea alexandri-regis
VL  - 55
IS  - 11
SP  - 866
EP  - 867
UR  - https://hdl.handle.net/21.15107/rcub_farfar_238
ER  - 

@article{
author = "Kundaković, Tatjana and Dobrić, Silva and Bokonjić, Dubravko and Dragojević-Simić, Viktorija and Kilibarda, Vesna and Kovacević, N",
year = "2000",
publisher = "Govi-Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Anti-inflammatory and anti-ulcer activity of Achillea alexandri-regis",
volume = "55",
number = "11",
pages = "866-867",
url = "https://hdl.handle.net/21.15107/rcub_farfar_238"
}

Kundaković, T., Dobrić, S., Bokonjić, D., Dragojević-Simić, V., Kilibarda, V.,& Kovacević, N.. (2000). Anti-inflammatory and anti-ulcer activity of Achillea alexandri-regis. in Pharmazie
Govi-Verlag Gmbh, Eschborn., 55(11), 866-867.
https://hdl.handle.net/21.15107/rcub_farfar_238

Kundaković T, Dobrić S, Bokonjić D, Dragojević-Simić V, Kilibarda V, Kovacević N. Anti-inflammatory and anti-ulcer activity of Achillea alexandri-regis. in Pharmazie. 2000;55(11):866-867.
https://hdl.handle.net/21.15107/rcub_farfar_238 .

Kundaković, Tatjana, Dobrić, Silva, Bokonjić, Dubravko, Dragojević-Simić, Viktorija, Kilibarda, Vesna, Kovacević, N, "Anti-inflammatory and anti-ulcer activity of Achillea alexandri-regis" in Pharmazie, 55, no. 11 (2000):866-867,
https://hdl.handle.net/21.15107/rcub_farfar_238 .