TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Marković, Bojan
AU  - Lusiana
AU  - Hoffmann, Christine
AU  - Mueller-Goymann, Christel
AU  - Milić, Jela
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2194
AB  - Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance
VL  - 40
IS  - 7
SP  - 960
EP  - 971
DO  - 10.3109/03639045.2013.794827
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Marković, Bojan and Lusiana and Hoffmann, Christine and Mueller-Goymann, Christel and Milić, Jela and Daniels, Rolf and Savić, Snežana",
year = "2014",
abstract = "Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance",
volume = "40",
number = "7",
pages = "960-971",
doi = "10.3109/03639045.2013.794827"
}

Pantelić, I., Lukić, M., Marković, B., Lusiana, Hoffmann, C., Mueller-Goymann, C., Milić, J., Daniels, R.,& Savić, S.. (2014). Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 40(7), 960-971.
https://doi.org/10.3109/03639045.2013.794827

Pantelić I, Lukić M, Marković B, Lusiana, Hoffmann C, Mueller-Goymann C, Milić J, Daniels R, Savić S. Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance. in Drug Development and Industrial Pharmacy. 2014;40(7):960-971.
doi:10.3109/03639045.2013.794827 .

Pantelić, Ivana, Lukić, Milica, Marković, Bojan, Lusiana, Hoffmann, Christine, Mueller-Goymann, Christel, Milić, Jela, Daniels, Rolf, Savić, Snežana, "Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance" in Drug Development and Industrial Pharmacy, 40, no. 7 (2014):960-971,
https://doi.org/10.3109/03639045.2013.794827 . .

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Malenović, Anđelija
AU  - Reichl, Stephan
AU  - Hoffmann, Christine
AU  - Mueller-Goymann, Christel
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1721
AB  - Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutics and Biopharmaceutics
T1  - Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study
VL  - 80
IS  - 1
SP  - 164
EP  - 175
DO  - 10.1016/j.ejpb.2011.09.001
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Malenović, Anđelija and Reichl, Stephan and Hoffmann, Christine and Mueller-Goymann, Christel and Daniels, Rolf and Savić, Snežana",
year = "2012",
abstract = "Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
title = "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study",
volume = "80",
number = "1",
pages = "164-175",
doi = "10.1016/j.ejpb.2011.09.001"
}

Pantelić, I., Lukić, M., Malenović, A., Reichl, S., Hoffmann, C., Mueller-Goymann, C., Daniels, R.,& Savić, S.. (2012). Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics
Elsevier Science BV, Amsterdam., 80(1), 164-175.
https://doi.org/10.1016/j.ejpb.2011.09.001

Pantelić I, Lukić M, Malenović A, Reichl S, Hoffmann C, Mueller-Goymann C, Daniels R, Savić S. Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics. 2012;80(1):164-175.
doi:10.1016/j.ejpb.2011.09.001 .

Pantelić, Ivana, Lukić, Milica, Malenović, Anđelija, Reichl, Stephan, Hoffmann, Christine, Mueller-Goymann, Christel, Daniels, Rolf, Savić, Snežana, "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study" in European Journal of Pharmaceutics and Biopharmaceutics, 80, no. 1 (2012):164-175,
https://doi.org/10.1016/j.ejpb.2011.09.001 . .