@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Jorgovanović, Dragica and Živančević, Katarina and Javorac, Dragana and Stojilković, Nikola and Radović, Biljana and Marić, Đurđica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević-Miljaković, Evica and Antonijević, Biljana",
year = "2021",
abstract = "While experimental animal investigation has historically been the most conventional
approach conducted to assess drug safety and is currently considered the main method for
determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over
the last 20 years, there have been significant advances in computational sciences and computer
data processing, while knowledge of alternative techniques and their application has developed
into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety
assessment is constantly increasing. They are very complex and are grounded on accumulated
knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as
molecular biology. This review will summarize current state-of-the-art scientific data on the use
of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting
the strategies that should deliver consistent results, while covering the applications of in silico
methods in preclinical trials and drug impurities toxicity testing., Ispitivanja na eksperimentalnim životinjama ne samo da su u prošlosti bila smatrana najkonvencionalnijim pristupom za procenu bezbednosti lekova, već su i trenutno osnovna metoda za utvrđivanje njihove toksičnosti. Međutim, ova ispitivanja su skupa, vremenski zahtevna i za njihovo sprovođenje neophodne su etičke dozvole. Tokom poslednjih 20 godina došlo je do napretka u računarskoj nauci i kompjuterskoj obradi podataka, dok se znanje o alternativnim tehnikama i njihovoj primeni razvilo u dragocenu veštinu u toksikologiji. Stoga, primena in silico metoda u proceni bezbednosti lekova neprestano raste. Ove metode su veoma složene i zasnivaju se na saznanjima iz toksikologije, bioinformatike, biohemije, statistike, matematike i molekularne biologije. Ovaj pregledni rad će rezimirati trenutna naučna saznanja koja se tiču upotrebe in silico metoda u ispitivanju toksičnosti lekova, uzimajući u obzir njihova ograničenja i ističući strategije pomoću kojih se mogu dobiti konzistentni rezultati, sa posebnim osvrtom na primenu in silico metoda u pretkliničkim ispitivanjima i ispitivanjima toksičnosti nečistoća u lekovima.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "In silico toxicology methods in drug safety assessment, "In silico" metode u toksikologiji za procenu bezbednosti lekova",
volume = "71",
number = "4",
pages = "257-278",
doi = "10.5937/arhfarm71-32966"
}