TY  - CONF
AU  - Suručić, Relja
AU  - Samardžić, Stevan
AU  - Radulović, Dragana
AU  - Lakić, Željko
AU  - Travar, Nikola
AU  - Antić, Marina
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4986
AB  - Geranium robertianum L. (Geraniaceae) has been traditionally used to treat a
range of ailments, including high blood pressure Recent in vitro studies have
shown that some traditional usages, such as antimicrobials, were scientifically
confirmed. Although the phytoconstituents of this plant species have been
extensively studied, some plant parts used in traditional medicine, such as
flowers, have not yet been chemically characterized. Given that the inhibition
of the angiotensin converting enzyme (ACE) is one of the most significant
mechanisms for decreasing blood pressure, we undertook this investigation to
find scientific support for G. robertianum anti-hypertensive traditional use.
Acetone was used to extract plant material since prior research revealed that it
had the highest total phenol and total flavonoid levels, which are considered to
be the primary sources of bioactive chemicals. The chemical composition of
G. robertianum collected in R. Srpska was determined using the LC MS
method, and the ACE inhibitory activity of acetone extract was measured
through the enzymatically cleaved 3-hydroxybutyric acid from 3-
hydryoxybutyryl-gly-gly-gly. Geraniin, a hydrolysable tannin with a Mr of
952.6, was the most abundant single chemical found in the extract. Derivatives
of galic and ellagic acids, as well as flavonoids like kaempferol and quercetine,
a were also present in significant amounts. G. robertianum acetonic floral
extract has been shown to be an effective natural ACE inhibitor with an IC50
of 22.14 μg/mL. To the best of our knowledge, this is the first report on the
chemical composition of G. robertianum floral acetonic extract and its ACE
inhibitory activity.
PB  - Faculty of Agriculture, University of Banja Luka
C3  - XI International Symposium of Agricultural Sciences "AgroReS 2022" - Book of Abstracts
T1  - Chemical characterization and ACE-inhibitory activity of acetone extract of Geranium robertianum L. flowers
SP  - 153
EP  - 154
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4986
ER  - 

@conference{
author = "Suručić, Relja and Samardžić, Stevan and Radulović, Dragana and Lakić, Željko and Travar, Nikola and Antić, Marina",
year = "2022",
abstract = "Geranium robertianum L. (Geraniaceae) has been traditionally used to treat a
range of ailments, including high blood pressure Recent in vitro studies have
shown that some traditional usages, such as antimicrobials, were scientifically
confirmed. Although the phytoconstituents of this plant species have been
extensively studied, some plant parts used in traditional medicine, such as
flowers, have not yet been chemically characterized. Given that the inhibition
of the angiotensin converting enzyme (ACE) is one of the most significant
mechanisms for decreasing blood pressure, we undertook this investigation to
find scientific support for G. robertianum anti-hypertensive traditional use.
Acetone was used to extract plant material since prior research revealed that it
had the highest total phenol and total flavonoid levels, which are considered to
be the primary sources of bioactive chemicals. The chemical composition of
G. robertianum collected in R. Srpska was determined using the LC MS
method, and the ACE inhibitory activity of acetone extract was measured
through the enzymatically cleaved 3-hydroxybutyric acid from 3-
hydryoxybutyryl-gly-gly-gly. Geraniin, a hydrolysable tannin with a Mr of
952.6, was the most abundant single chemical found in the extract. Derivatives
of galic and ellagic acids, as well as flavonoids like kaempferol and quercetine,
a were also present in significant amounts. G. robertianum acetonic floral
extract has been shown to be an effective natural ACE inhibitor with an IC50
of 22.14 μg/mL. To the best of our knowledge, this is the first report on the
chemical composition of G. robertianum floral acetonic extract and its ACE
inhibitory activity.",
publisher = "Faculty of Agriculture, University of Banja Luka",
journal = "XI International Symposium of Agricultural Sciences "AgroReS 2022" - Book of Abstracts",
title = "Chemical characterization and ACE-inhibitory activity of acetone extract of Geranium robertianum L. flowers",
pages = "153-154",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4986"
}

Suručić, R., Samardžić, S., Radulović, D., Lakić, Ž., Travar, N.,& Antić, M.. (2022). Chemical characterization and ACE-inhibitory activity of acetone extract of Geranium robertianum L. flowers. in XI International Symposium of Agricultural Sciences "AgroReS 2022" - Book of Abstracts
Faculty of Agriculture, University of Banja Luka., 153-154.
https://hdl.handle.net/21.15107/rcub_farfar_4986

Suručić R, Samardžić S, Radulović D, Lakić Ž, Travar N, Antić M. Chemical characterization and ACE-inhibitory activity of acetone extract of Geranium robertianum L. flowers. in XI International Symposium of Agricultural Sciences "AgroReS 2022" - Book of Abstracts. 2022;:153-154.
https://hdl.handle.net/21.15107/rcub_farfar_4986 .

Suručić, Relja, Samardžić, Stevan, Radulović, Dragana, Lakić, Željko, Travar, Nikola, Antić, Marina, "Chemical characterization and ACE-inhibitory activity of acetone extract of Geranium robertianum L. flowers" in XI International Symposium of Agricultural Sciences "AgroReS 2022" - Book of Abstracts (2022):153-154,
https://hdl.handle.net/21.15107/rcub_farfar_4986 .