TY  - DATA
AU  - Kotur-Stevuljević, Jelena
AU  - Roksandić-Milenković, Marina
AU  - Dimić, Nemanja
AU  - Dimić, Dejan
AU  - Ćujić, Danica
AU  - Vekić, Jelena
AU  - Guzonjić, Azra
AU  - Gagić, Jelena
AU  - Timotijević, Ljiljana
AU  - Žujović, Dejan
AU  - Gnjatović, Marija
AU  - Todorović, Aleksandra
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5108
AB  - Background A three-year COVID-19 pandemic revealed a spectrum of disease severity and clinical manifestations. The most intriguing part of this phenomenon lays in interindividual variability in COVID-19 course among patients, which is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to assess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of inflammation, oxidative stress (OS), pulmonary involvement and implemented therapy on the course of the disease.

Material and methods Routine biochemical/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin D, IgM and IgG antibodies level and relative length of leukocyte telomeres (rLTL) were measured at three time-points (at diagnosis, after 14 and 21 days from the disease onset) in blood samples of 31 consecutive COVID-19 patients, with a mild (n=16) and moderate (n=15) form of the disease, treated on an outpatient basis.

Results Although the patients had reduced rLTL at baseline (median: 0.592; 25th – 75th percentiles: 0.518-0.724), it significantly increased during the follow-up (median: 0.773; 25th – 75th percentiles: 0.615-0.923; P<0.01). The rate of telomere attrition was associated with the extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidative defence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was associated with telomere lengthening.

Conclusion Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation.
PB  - Hindawi
T1  - Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5108
ER  - 

@misc{
author = "Kotur-Stevuljević, Jelena and Roksandić-Milenković, Marina and Dimić, Nemanja and Dimić, Dejan and Ćujić, Danica and Vekić, Jelena and Guzonjić, Azra and Gagić, Jelena and Timotijević, Ljiljana and Žujović, Dejan and Gnjatović, Marija and Todorović, Aleksandra and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "Background A three-year COVID-19 pandemic revealed a spectrum of disease severity and clinical manifestations. The most intriguing part of this phenomenon lays in interindividual variability in COVID-19 course among patients, which is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to assess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of inflammation, oxidative stress (OS), pulmonary involvement and implemented therapy on the course of the disease.

Material and methods Routine biochemical/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin D, IgM and IgG antibodies level and relative length of leukocyte telomeres (rLTL) were measured at three time-points (at diagnosis, after 14 and 21 days from the disease onset) in blood samples of 31 consecutive COVID-19 patients, with a mild (n=16) and moderate (n=15) form of the disease, treated on an outpatient basis.

Results Although the patients had reduced rLTL at baseline (median: 0.592; 25th – 75th percentiles: 0.518-0.724), it significantly increased during the follow-up (median: 0.773; 25th – 75th percentiles: 0.615-0.923; P<0.01). The rate of telomere attrition was associated with the extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidative defence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was associated with telomere lengthening.

Conclusion Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation.",
publisher = "Hindawi",
title = "Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5108"
}

Kotur-Stevuljević, J., Roksandić-Milenković, M., Dimić, N., Dimić, D., Ćujić, D., Vekić, J., Guzonjić, A., Gagić, J., Timotijević, L., Žujović, D., Gnjatović, M., Todorović, A.,& Bogavac-Stanojević, N.. (2023). Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy. 
Hindawi..
https://hdl.handle.net/21.15107/rcub_farfar_5108

Kotur-Stevuljević J, Roksandić-Milenković M, Dimić N, Dimić D, Ćujić D, Vekić J, Guzonjić A, Gagić J, Timotijević L, Žujović D, Gnjatović M, Todorović A, Bogavac-Stanojević N. Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_5108 .

Kotur-Stevuljević, Jelena, Roksandić-Milenković, Marina, Dimić, Nemanja, Dimić, Dejan, Ćujić, Danica, Vekić, Jelena, Guzonjić, Azra, Gagić, Jelena, Timotijević, Ljiljana, Žujović, Dejan, Gnjatović, Marija, Todorović, Aleksandra, Bogavac-Stanojević, Nataša, "Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy" (2023),
https://hdl.handle.net/21.15107/rcub_farfar_5108 .

TY  - JOUR
AU  - Žuža, Olivera
AU  - Minić, Rajna
AU  - Kotur-Stevuljević, Jelena
AU  - Žujović, Dejan
AU  - Đorđević, Brižita
AU  - Ilić, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4090
AB  - OBJECTIVE: The aim of this study was to determine any differences in ox- idative stress and inflammation parameters in COPD patients treated with either N-acetyl cys- teine (NAC) alone or with NAC in combination with propolis (NACP). PATIENTS AND METHODS: Forty COPD pa- tients in the exacerbation phase were enrolled into the study and were treated with either NAC (NAC group; n=20) or NACP (NACP group; n=20) twice daily for one month. Redox status was de - termined by measuring superoxide anion (O 2 .– ), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidative-anti- oxidant balance (PAB), malondialdehyde (MDA), ischemia modified albumin (IMA) and sever- al other antioxidant markers: superoxide dis- mutase (SOD), paraoxonase 1 (PON1), total sulf- hydryl groups (SHG) and total antioxidant status (TAS). Interleukins 6, 8 and 17 were measured as markers of inflammatory status. RESULTS: Both groups had similar socio-de - mographic and clinical characteristics. Af- ter treatment significantly higher SHG [0.446 (0.395-0.516) vs. 0.292 (0.270-0.325), p<0.001] and significantly lower TOS – 50.6 [49.7-53.4 vs. 73.2 (50.9-84.6), p<0.05] – and IMA [0.650 (0.629-0.682) vs. 0.709 (0.667-0.756), p<0.05] – were found in the NACP group compared to the NAC group. Factorial analysis indicated a larger oxidative stress-inflammatory load in the NAC group after treatment. CONCLUSIONS: From an oxidative stress and inflammatory status perspective, treatment with NACP was more successful than with NAC. The inclusion of propolis into therapy for COPD patients, especially those in the exacerbation phase, could prove beneficial.
PB  - Verduci Editore srl
T2  - European Review for Medical and Pharmacological Sciences
T1  - A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation
VL  - 26
IS  - 7
SP  - 2467
EP  - 2477
DO  - 10.26355/eurrev_202204_28481
ER  - 

@article{
author = "Žuža, Olivera and Minić, Rajna and Kotur-Stevuljević, Jelena and Žujović, Dejan and Đorđević, Brižita and Ilić, Aleksandra",
year = "2022",
abstract = "OBJECTIVE: The aim of this study was to determine any differences in ox- idative stress and inflammation parameters in COPD patients treated with either N-acetyl cys- teine (NAC) alone or with NAC in combination with propolis (NACP). PATIENTS AND METHODS: Forty COPD pa- tients in the exacerbation phase were enrolled into the study and were treated with either NAC (NAC group; n=20) or NACP (NACP group; n=20) twice daily for one month. Redox status was de - termined by measuring superoxide anion (O 2 .– ), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidative-anti- oxidant balance (PAB), malondialdehyde (MDA), ischemia modified albumin (IMA) and sever- al other antioxidant markers: superoxide dis- mutase (SOD), paraoxonase 1 (PON1), total sulf- hydryl groups (SHG) and total antioxidant status (TAS). Interleukins 6, 8 and 17 were measured as markers of inflammatory status. RESULTS: Both groups had similar socio-de - mographic and clinical characteristics. Af- ter treatment significantly higher SHG [0.446 (0.395-0.516) vs. 0.292 (0.270-0.325), p<0.001] and significantly lower TOS – 50.6 [49.7-53.4 vs. 73.2 (50.9-84.6), p<0.05] – and IMA [0.650 (0.629-0.682) vs. 0.709 (0.667-0.756), p<0.05] – were found in the NACP group compared to the NAC group. Factorial analysis indicated a larger oxidative stress-inflammatory load in the NAC group after treatment. CONCLUSIONS: From an oxidative stress and inflammatory status perspective, treatment with NACP was more successful than with NAC. The inclusion of propolis into therapy for COPD patients, especially those in the exacerbation phase, could prove beneficial.",
publisher = "Verduci Editore srl",
journal = "European Review for Medical and Pharmacological Sciences",
title = "A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation",
volume = "26",
number = "7",
pages = "2467-2477",
doi = "10.26355/eurrev_202204_28481"
}

Žuža, O., Minić, R., Kotur-Stevuljević, J., Žujović, D., Đorđević, B.,& Ilić, A.. (2022). A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation. in European Review for Medical and Pharmacological Sciences
Verduci Editore srl., 26(7), 2467-2477.
https://doi.org/10.26355/eurrev_202204_28481

Žuža O, Minić R, Kotur-Stevuljević J, Žujović D, Đorđević B, Ilić A. A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation. in European Review for Medical and Pharmacological Sciences. 2022;26(7):2467-2477.
doi:10.26355/eurrev_202204_28481 .

Žuža, Olivera, Minić, Rajna, Kotur-Stevuljević, Jelena, Žujović, Dejan, Đorđević, Brižita, Ilić, Aleksandra, "A combination of N-acetyl cysteine and propolis
attenuates oxidative-inflammatory parameters
during COPD exacerbation" in European Review for Medical and Pharmacological Sciences, 26, no. 7 (2022):2467-2477,
https://doi.org/10.26355/eurrev_202204_28481 . .