TY  - JOUR
AU  - Kuburović, Vladimir
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Carrie, Alain
AU  - Kotur-Stevuljević, Jelena
AU  - Bojanin, Dragana
AU  - Kosutić, Jovan
AU  - Spasojević-Kalimanovska, Vesna
AU  - Miljković, Milica
AU  - Kuburović, Nina
AU  - Couvert, Philippe
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2840
AB  - Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report
VL  - 50
IS  - 18
SP  - 1323
EP  - 1325
DO  - 10.1016/j.clinbiochem.2017.06.007
ER  - 

@article{
author = "Kuburović, Vladimir and Vekić, Jelena and Zeljković, Aleksandra and Carrie, Alain and Kotur-Stevuljević, Jelena and Bojanin, Dragana and Kosutić, Jovan and Spasojević-Kalimanovska, Vesna and Miljković, Milica and Kuburović, Nina and Couvert, Philippe",
year = "2017",
abstract = "Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report",
volume = "50",
number = "18",
pages = "1323-1325",
doi = "10.1016/j.clinbiochem.2017.06.007"
}

Kuburović, V., Vekić, J., Zeljković, A., Carrie, A., Kotur-Stevuljević, J., Bojanin, D., Kosutić, J., Spasojević-Kalimanovska, V., Miljković, M., Kuburović, N.,& Couvert, P.. (2017). The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 50(18), 1323-1325.
https://doi.org/10.1016/j.clinbiochem.2017.06.007

Kuburović V, Vekić J, Zeljković A, Carrie A, Kotur-Stevuljević J, Bojanin D, Kosutić J, Spasojević-Kalimanovska V, Miljković M, Kuburović N, Couvert P. The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. in Clinical Biochemistry. 2017;50(18):1323-1325.
doi:10.1016/j.clinbiochem.2017.06.007 .

Kuburović, Vladimir, Vekić, Jelena, Zeljković, Aleksandra, Carrie, Alain, Kotur-Stevuljević, Jelena, Bojanin, Dragana, Kosutić, Jovan, Spasojević-Kalimanovska, Vesna, Miljković, Milica, Kuburović, Nina, Couvert, Philippe, "The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report" in Clinical Biochemistry, 50, no. 18 (2017):1323-1325,
https://doi.org/10.1016/j.clinbiochem.2017.06.007 . .