TY  - JOUR
AU  - Perić, Aleksandar
AU  - Gaćeša, Dejan
AU  - Vezmar-Kovačević, Sandra
AU  - Perić, Aneta V.
AU  - Vojvodić, Danilo
AU  - Georgiou, Stella
AU  - Protopapadakis, Evdokia
AU  - Alevizopoulos, Konstantinos
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5346
AB  - Objective. To investigate epidermal growth factor (EGF), transforming growth factor (TGF)- a and interleukin (IL)-8 production in nasal mucosa irrigated with hypertonic 2.3% solution with algae extracts, in comparison to 0.9% NaCl during the first two weeks after surgery for nasal polyposis (NP), in relation to symptoms and local findings. Methods. This prospective study included 20 NP patients postoperatively irrigated with hypertonic and 20 with isotonic solution. We evaluated symptoms (NSS), endoscopic findings (ES) and mediator levels in nasal secretions before and after irrigation. Results. Following treatment, NSS and ES were significantly lower in the hypertonic solution group (p = 0.023; p < 0.001, respectively). The increase in the EGF and the decrease in the TGF-a and IL-8 concentration were higher in the hypertonic group (p < 0.001 for all mediators). Conclusion. Irrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.
PB  - Cambridge University Press
T2  - Journal of Laryngology and Otology
T1  - The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment
DO  - 10.1017/S0022215123001974
ER  - 

@article{
author = "Perić, Aleksandar and Gaćeša, Dejan and Vezmar-Kovačević, Sandra and Perić, Aneta V. and Vojvodić, Danilo and Georgiou, Stella and Protopapadakis, Evdokia and Alevizopoulos, Konstantinos",
year = "2023",
abstract = "Objective. To investigate epidermal growth factor (EGF), transforming growth factor (TGF)- a and interleukin (IL)-8 production in nasal mucosa irrigated with hypertonic 2.3% solution with algae extracts, in comparison to 0.9% NaCl during the first two weeks after surgery for nasal polyposis (NP), in relation to symptoms and local findings. Methods. This prospective study included 20 NP patients postoperatively irrigated with hypertonic and 20 with isotonic solution. We evaluated symptoms (NSS), endoscopic findings (ES) and mediator levels in nasal secretions before and after irrigation. Results. Following treatment, NSS and ES were significantly lower in the hypertonic solution group (p = 0.023; p < 0.001, respectively). The increase in the EGF and the decrease in the TGF-a and IL-8 concentration were higher in the hypertonic group (p < 0.001 for all mediators). Conclusion. Irrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.",
publisher = "Cambridge University Press",
journal = "Journal of Laryngology and Otology",
title = "The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment",
doi = "10.1017/S0022215123001974"
}

Perić, A., Gaćeša, D., Vezmar-Kovačević, S., Perić, A. V., Vojvodić, D., Georgiou, S., Protopapadakis, E.,& Alevizopoulos, K.. (2023). The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment. in Journal of Laryngology and Otology
Cambridge University Press..
https://doi.org/10.1017/S0022215123001974

Perić A, Gaćeša D, Vezmar-Kovačević S, Perić AV, Vojvodić D, Georgiou S, Protopapadakis E, Alevizopoulos K. The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment. in Journal of Laryngology and Otology. 2023;.
doi:10.1017/S0022215123001974 .

Perić, Aleksandar, Gaćeša, Dejan, Vezmar-Kovačević, Sandra, Perić, Aneta V., Vojvodić, Danilo, Georgiou, Stella, Protopapadakis, Evdokia, Alevizopoulos, Konstantinos, "The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment" in Journal of Laryngology and Otology (2023),
https://doi.org/10.1017/S0022215123001974 . .

TY  - JOUR
AU  - Perić, Aleksandar
AU  - Vezmar-Kovačević, Sandra
AU  - Barać, Aleksandra
AU  - Perić, Aneta
AU  - Vojvodić, Danilo
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3949
AB  - Background: Previous investigations suggest the use of extract from the roots of Pelargonium sidoides (EPs 7630) for the therapy of uncomplicated rhinosinusitis. The aim of this prospective study was to compare the effects of herbal drug EPs 7630 and antibiotic roxithromycin on chemokine production in nasal mucosa and clinical parameters in patients with uncomplicated acute bacterial rhinosinusitis (ABRS). Methods: Seventy-eight ABRS patients were divided into 26 patients receiving EPs 7630 tablets, 3 × 20 mg/day per os (group 1), 26 patients receiving roxithromycin tablets, 2 × 150 mg/day per os (group 2), both for 10 days, and 26 patients who received no therapy (Control group). We measured chemokine levels in nasal secretions by flow cytometry and assessed clinical parameters on day 0 and day 10 of investigation. Results: EPs 7630 increased concentrations of MCP-1 (P =.001) and IP-10 (P =.049) and decreased levels of MIP-1α (P <.001), ENA-78 (P <.001), and IL-8 (P <.001). Roxithromycin increased levels of IP-10 (P =.049) and decreased levels of MCP-1 (P <.001), MIP-1α (P <.016), ENA-78 (P <.001), and IL-8 (P <.001). Comparison of the non-treated patients' group with groups 1 and 2 revealed significant improvement of all clinical parameters in treated patients (P <.001), but therapy with roxithromycin resulted in better improvement in nasal symptoms and endoscopic findings than therapy with EPs 7630. Conclusion: Our results suggest the presence of similar modulatory effects of both therapies on production of chemokines that regulate the function of neutrophils and monocytes in nasal mucosa. Roxithromycin shows better clinical efficacy than EPs 7630 in patients with uncomplicated ABRS. Level of Evidence: 1b.
PB  - John Wiley and Sons Inc
T2  - Laryngoscope Investigative Otolaryngology
T1  - Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis
VL  - 6
IS  - 1
SP  - 25
EP  - 33
DO  - 10.1002/lio2.514
ER  - 

@article{
author = "Perić, Aleksandar and Vezmar-Kovačević, Sandra and Barać, Aleksandra and Perić, Aneta and Vojvodić, Danilo",
year = "2021",
abstract = "Background: Previous investigations suggest the use of extract from the roots of Pelargonium sidoides (EPs 7630) for the therapy of uncomplicated rhinosinusitis. The aim of this prospective study was to compare the effects of herbal drug EPs 7630 and antibiotic roxithromycin on chemokine production in nasal mucosa and clinical parameters in patients with uncomplicated acute bacterial rhinosinusitis (ABRS). Methods: Seventy-eight ABRS patients were divided into 26 patients receiving EPs 7630 tablets, 3 × 20 mg/day per os (group 1), 26 patients receiving roxithromycin tablets, 2 × 150 mg/day per os (group 2), both for 10 days, and 26 patients who received no therapy (Control group). We measured chemokine levels in nasal secretions by flow cytometry and assessed clinical parameters on day 0 and day 10 of investigation. Results: EPs 7630 increased concentrations of MCP-1 (P =.001) and IP-10 (P =.049) and decreased levels of MIP-1α (P <.001), ENA-78 (P <.001), and IL-8 (P <.001). Roxithromycin increased levels of IP-10 (P =.049) and decreased levels of MCP-1 (P <.001), MIP-1α (P <.016), ENA-78 (P <.001), and IL-8 (P <.001). Comparison of the non-treated patients' group with groups 1 and 2 revealed significant improvement of all clinical parameters in treated patients (P <.001), but therapy with roxithromycin resulted in better improvement in nasal symptoms and endoscopic findings than therapy with EPs 7630. Conclusion: Our results suggest the presence of similar modulatory effects of both therapies on production of chemokines that regulate the function of neutrophils and monocytes in nasal mucosa. Roxithromycin shows better clinical efficacy than EPs 7630 in patients with uncomplicated ABRS. Level of Evidence: 1b.",
publisher = "John Wiley and Sons Inc",
journal = "Laryngoscope Investigative Otolaryngology",
title = "Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis",
volume = "6",
number = "1",
pages = "25-33",
doi = "10.1002/lio2.514"
}

Perić, A., Vezmar-Kovačević, S., Barać, A., Perić, A.,& Vojvodić, D.. (2021). Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis. in Laryngoscope Investigative Otolaryngology
John Wiley and Sons Inc., 6(1), 25-33.
https://doi.org/10.1002/lio2.514

Perić A, Vezmar-Kovačević S, Barać A, Perić A, Vojvodić D. Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis. in Laryngoscope Investigative Otolaryngology. 2021;6(1):25-33.
doi:10.1002/lio2.514 .

Perić, Aleksandar, Vezmar-Kovačević, Sandra, Barać, Aleksandra, Perić, Aneta, Vojvodić, Danilo, "Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis" in Laryngoscope Investigative Otolaryngology, 6, no. 1 (2021):25-33,
https://doi.org/10.1002/lio2.514 . .

TY  - JOUR
AU  - Perić, Aleksandar
AU  - Vezmar-Kovačević, Sandra
AU  - Barac, Aleksandra
AU  - Gacesa, Dejan
AU  - Perić, Aneta
AU  - Matković-Jozin, Svjetlana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3352
AB  - Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. Results: We found significantly lower total symptom score (TSS) during the 7th (p= .009), 14th (p = .003), 21st (p  lt  .001) and the 28th day (p=.001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Oto-Laryngologica
T1  - Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery
VL  - 139
IS  - 6
SP  - 529
EP  - 535
DO  - 10.1080/00016489.2019.1605454
ER  - 

@article{
author = "Perić, Aleksandar and Vezmar-Kovačević, Sandra and Barac, Aleksandra and Gacesa, Dejan and Perić, Aneta and Matković-Jozin, Svjetlana",
year = "2019",
abstract = "Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. Results: We found significantly lower total symptom score (TSS) during the 7th (p= .009), 14th (p = .003), 21st (p  lt  .001) and the 28th day (p=.001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Oto-Laryngologica",
title = "Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery",
volume = "139",
number = "6",
pages = "529-535",
doi = "10.1080/00016489.2019.1605454"
}

Perić, A., Vezmar-Kovačević, S., Barac, A., Gacesa, D., Perić, A.,& Matković-Jozin, S.. (2019). Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery. in Acta Oto-Laryngologica
Taylor & Francis Ltd, Abingdon., 139(6), 529-535.
https://doi.org/10.1080/00016489.2019.1605454

Perić A, Vezmar-Kovačević S, Barac A, Gacesa D, Perić A, Matković-Jozin S. Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery. in Acta Oto-Laryngologica. 2019;139(6):529-535.
doi:10.1080/00016489.2019.1605454 .

Perić, Aleksandar, Vezmar-Kovačević, Sandra, Barac, Aleksandra, Gacesa, Dejan, Perić, Aneta, Matković-Jozin, Svjetlana, "Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery" in Acta Oto-Laryngologica, 139, no. 6 (2019):529-535,
https://doi.org/10.1080/00016489.2019.1605454 . .

TY  - JOUR
AU  - Perić, Aleksandar
AU  - Vezmar-Kovačević, Sandra
AU  - Gacesa, Dejan
AU  - Perić, Aneta
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2868
AB  - Objective: Herbal medicinal products have a well-established role in therapy of upper airway inflammations. Current evidence supports the use of intranasal corticosteroids for improvement in clinical symptoms of uncomplicated acute rhinosinusitis (ARS). We aimed to evaluate efficacy and safety of combined therapy by mometasone furoate nasal spray (MFNS) and oral herbal medicinal product Sinupret in comparison to MFNS monotherapy when treating mild to moderate ARS. Methods: Forty-six ARS patients were divided into two groups. Group 1 (n=23) received herbal drug Sinupret, 160 mg per os, three times daily and MFNS 200 mu g twice daily for 7 days. Group 2 (n=23) received only MFNS 200 mu g twice daily for 7 days. We assessed total symptom score (TSS), individual symptom scores for each symptom (nasal obstruction, rhinorrhea, postnasal drip, facial pain/pressure, impaired sense of smell) and endoscopic findings (mucosal edema, mucopurulent secretion), before and after treatment. Results: Significant improvement of all clinical parameters was found after both treatment modalities (p lt 0.000). We observed lower post-treatment TSS (p=0.002), nasal obstruction (p=0.001), rhinorrhea (p=0.001), facial pain (p=0.001), impaired sense of smell (p=0.002), mucosal edema (p=0.003) and mucopurulent secretion (p=0.001) in MFNS/Sinupret group than in MFNS group. We found no adverse events in MFNS/Sinupret group, while only 1 patient reported mild epistaxis and 1 patient reported dryness in the nose in MFNS Group. Conclusion: Our results suggest better efficacy of combined MFNS/Sinupret therapy of ARS on nasal symptoms and endoscopic findings, with the absence of adverse events in comparison to MFNS monotherapy.
PB  - Deomed Publ, Istanbul, Istanbul
T2  - ENT Updates
T1  - Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray
VL  - 7
IS  - 2
SP  - 68
EP  - 74
DO  - 10.2399/jmu.2017002003
ER  - 

@article{
author = "Perić, Aleksandar and Vezmar-Kovačević, Sandra and Gacesa, Dejan and Perić, Aneta",
year = "2017",
abstract = "Objective: Herbal medicinal products have a well-established role in therapy of upper airway inflammations. Current evidence supports the use of intranasal corticosteroids for improvement in clinical symptoms of uncomplicated acute rhinosinusitis (ARS). We aimed to evaluate efficacy and safety of combined therapy by mometasone furoate nasal spray (MFNS) and oral herbal medicinal product Sinupret in comparison to MFNS monotherapy when treating mild to moderate ARS. Methods: Forty-six ARS patients were divided into two groups. Group 1 (n=23) received herbal drug Sinupret, 160 mg per os, three times daily and MFNS 200 mu g twice daily for 7 days. Group 2 (n=23) received only MFNS 200 mu g twice daily for 7 days. We assessed total symptom score (TSS), individual symptom scores for each symptom (nasal obstruction, rhinorrhea, postnasal drip, facial pain/pressure, impaired sense of smell) and endoscopic findings (mucosal edema, mucopurulent secretion), before and after treatment. Results: Significant improvement of all clinical parameters was found after both treatment modalities (p lt 0.000). We observed lower post-treatment TSS (p=0.002), nasal obstruction (p=0.001), rhinorrhea (p=0.001), facial pain (p=0.001), impaired sense of smell (p=0.002), mucosal edema (p=0.003) and mucopurulent secretion (p=0.001) in MFNS/Sinupret group than in MFNS group. We found no adverse events in MFNS/Sinupret group, while only 1 patient reported mild epistaxis and 1 patient reported dryness in the nose in MFNS Group. Conclusion: Our results suggest better efficacy of combined MFNS/Sinupret therapy of ARS on nasal symptoms and endoscopic findings, with the absence of adverse events in comparison to MFNS monotherapy.",
publisher = "Deomed Publ, Istanbul, Istanbul",
journal = "ENT Updates",
title = "Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray",
volume = "7",
number = "2",
pages = "68-74",
doi = "10.2399/jmu.2017002003"
}

Perić, A., Vezmar-Kovačević, S., Gacesa, D.,& Perić, A.. (2017). Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. in ENT Updates
Deomed Publ, Istanbul, Istanbul., 7(2), 68-74.
https://doi.org/10.2399/jmu.2017002003

Perić A, Vezmar-Kovačević S, Gacesa D, Perić A. Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. in ENT Updates. 2017;7(2):68-74.
doi:10.2399/jmu.2017002003 .

Perić, Aleksandar, Vezmar-Kovačević, Sandra, Gacesa, Dejan, Perić, Aneta, "Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray" in ENT Updates, 7, no. 2 (2017):68-74,
https://doi.org/10.2399/jmu.2017002003 . .