TY  - JOUR
AU  - Tanasković, Slađana
AU  - Antonijević-Nikolić, Mirjana
AU  - Hollo, Berta Barta
AU  - Dražić, Branka
AU  - Stanojković, Tatjana
AU  - Meszaros-Szecsenyi, Katalin
AU  - Vucković, Gordana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2131
AB  - Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes
VL  - 79
IS  - 10
SP  - 1235
EP  - 1247
DO  - 10.2298/JSC140404044T
ER  - 

@article{
author = "Tanasković, Slađana and Antonijević-Nikolić, Mirjana and Hollo, Berta Barta and Dražić, Branka and Stanojković, Tatjana and Meszaros-Szecsenyi, Katalin and Vucković, Gordana",
year = "2014",
abstract = "Seven macrocyclic dinuclear Cu(II) complexes with tpmc = = N,N ',N '',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane of coordination formulae [Cu(2)tpmc](ClO4)(4) (1), [Cu-2(X)tpmc](ClO4)(3)center dot nH(2)O, X= F-, n = 0 (2), X = Cl-, n = 1 (3), X = Br-, n = 0 (4), X= I-, n = 1 (5), X = = NO2-, n = 0 (6), [Cu-2(NCS)(2)tpmc](ClO4)(2) (7) were evaluated for their cytotoxic activity against human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The results were compared with the corresponding data for the cis-diamminedichloridoplafinum(H) (CDDP) as referent cytostatic, as well as with the free ligands and the solvent dimethyl sulfoxide (DMSO) as controls. The complexes showed considerable antiproliferative effect, although significantly less than CDDP. The thermal decomposition pattern of the complexes was determined by simultaneous TG/DSC measurements. The thermal stability of the compounds 2-7 followed the trend of their antiproliferative activity against the HeLa cell line, as well as their corresponding stability constants. The highest thermal stability and cytotoxicity belonged to complex [Cu(2)tpmc](ClO4)(4), with no anionic co-ligand. Complex [Cu-2(NO2)tpmc](ClO4)(3) exhibited a selective cytotoxicity against LS174 cells, at the level of the most active [Cu(2)tpmc](ClO4)(4).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes",
volume = "79",
number = "10",
pages = "1235-1247",
doi = "10.2298/JSC140404044T"
}

Tanasković, S., Antonijević-Nikolić, M., Hollo, B. B., Dražić, B., Stanojković, T., Meszaros-Szecsenyi, K.,& Vucković, G.. (2014). Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(10), 1235-1247.
https://doi.org/10.2298/JSC140404044T

Tanasković S, Antonijević-Nikolić M, Hollo BB, Dražić B, Stanojković T, Meszaros-Szecsenyi K, Vucković G. Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes. in Journal of the Serbian Chemical Society. 2014;79(10):1235-1247.
doi:10.2298/JSC140404044T .

Tanasković, Slađana, Antonijević-Nikolić, Mirjana, Hollo, Berta Barta, Dražić, Branka, Stanojković, Tatjana, Meszaros-Szecsenyi, Katalin, Vucković, Gordana, "Correlations between the in vitro antiproliferative activity, structure and thermal stability of some macrocyclic dinuclear Cu(II) complexes" in Journal of the Serbian Chemical Society, 79, no. 10 (2014):1235-1247,
https://doi.org/10.2298/JSC140404044T . .