TY  - JOUR
AU  - Suryanegara, Jose
AU  - Cassidy, Sophie
AU  - Ninković, Vladan
AU  - Popović, Dejana
AU  - Grbović, Miljan
AU  - Okwose, Nduka
AU  - Trenell, Michael I.
AU  - MacGowan, Guy G.
AU  - Jakovljević, Đorđe G.
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3303
AB  - AimThe present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes.MethodsTwenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention.ResultsAt baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.36.1 vs. 21.75.5ml/kg/min, p=0.21), and peak exercise heart rate (156.3 +/- 15.0 vs. 153.8 +/- 12.5 beats/min, p=0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 +/- 2.4 vs. 15.2 +/- 2.2ml/min/kg, p=0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 +/- 2.7-12.8 +/- 3.6L/min, p=0.03), but not in the control group (15.7 +/- 4.9-16.3 +/- 4.1L/min, p=0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p=0.03) and heart rate by 9% (p=0.04).Conclusion Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.Trial registration ISRCTN78698481. Registered 23 January 2013, retrospectively registered.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Acta Diabetologica
T1  - High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial
VL  - 56
IS  - 3
SP  - 321
EP  - 329
DO  - 10.1007/s00592-018-1245-5
ER  - 

@article{
author = "Suryanegara, Jose and Cassidy, Sophie and Ninković, Vladan and Popović, Dejana and Grbović, Miljan and Okwose, Nduka and Trenell, Michael I. and MacGowan, Guy G. and Jakovljević, Đorđe G.",
year = "2019",
abstract = "AimThe present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes.MethodsTwenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention.ResultsAt baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.36.1 vs. 21.75.5ml/kg/min, p=0.21), and peak exercise heart rate (156.3 +/- 15.0 vs. 153.8 +/- 12.5 beats/min, p=0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 +/- 2.4 vs. 15.2 +/- 2.2ml/min/kg, p=0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 +/- 2.7-12.8 +/- 3.6L/min, p=0.03), but not in the control group (15.7 +/- 4.9-16.3 +/- 4.1L/min, p=0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p=0.03) and heart rate by 9% (p=0.04).Conclusion Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.Trial registration ISRCTN78698481. Registered 23 January 2013, retrospectively registered.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Acta Diabetologica",
title = "High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial",
volume = "56",
number = "3",
pages = "321-329",
doi = "10.1007/s00592-018-1245-5"
}

Suryanegara, J., Cassidy, S., Ninković, V., Popović, D., Grbović, M., Okwose, N., Trenell, M. I., MacGowan, G. G.,& Jakovljević, Đ. G.. (2019). High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. in Acta Diabetologica
Springer-Verlag Italia Srl, Milan., 56(3), 321-329.
https://doi.org/10.1007/s00592-018-1245-5

Suryanegara J, Cassidy S, Ninković V, Popović D, Grbović M, Okwose N, Trenell MI, MacGowan GG, Jakovljević ĐG. High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. in Acta Diabetologica. 2019;56(3):321-329.
doi:10.1007/s00592-018-1245-5 .

Suryanegara, Jose, Cassidy, Sophie, Ninković, Vladan, Popović, Dejana, Grbović, Miljan, Okwose, Nduka, Trenell, Michael I., MacGowan, Guy G., Jakovljević, Đorđe G., "High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial" in Acta Diabetologica, 56, no. 3 (2019):321-329,
https://doi.org/10.1007/s00592-018-1245-5 . .