TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
AU  - Spasić, Slavica
AU  - Stefanović, Aleksandra
AU  - Paripović, Dušan
AU  - Kostić, Mirjana
AU  - Vasić, Dragan
AU  - Vujović, Ana
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kornić-Ristovski, Danijela
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1943
AB  - The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p  lt  0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p  lt  0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease
VL  - 28
IS  - 2
SP  - 295
EP  - 303
DO  - 10.1007/s00467-012-2323-5
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Spasić, Slavica and Stefanović, Aleksandra and Paripović, Dušan and Kostić, Mirjana and Vasić, Dragan and Vujović, Ana and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kornić-Ristovski, Danijela",
year = "2013",
abstract = "The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p  lt  0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p  lt  0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease",
volume = "28",
number = "2",
pages = "295-303",
doi = "10.1007/s00467-012-2323-5"
}

Kotur-Stevuljević, J., Peco-Antić, A., Spasić, S., Stefanović, A., Paripović, D., Kostić, M., Vasić, D., Vujović, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kornić-Ristovski, D.. (2013). Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease. in Pediatric Nephrology
Springer, New York., 28(2), 295-303.
https://doi.org/10.1007/s00467-012-2323-5

Kotur-Stevuljević J, Peco-Antić A, Spasić S, Stefanović A, Paripović D, Kostić M, Vasić D, Vujović A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kornić-Ristovski D. Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease. in Pediatric Nephrology. 2013;28(2):295-303.
doi:10.1007/s00467-012-2323-5 .

Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Spasić, Slavica, Stefanović, Aleksandra, Paripović, Dušan, Kostić, Mirjana, Vasić, Dragan, Vujović, Ana, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kornić-Ristovski, Danijela, "Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease" in Pediatric Nephrology, 28, no. 2 (2013):295-303,
https://doi.org/10.1007/s00467-012-2323-5 . .

TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Lakić, Dragana
AU  - Vasić, Dragan
AU  - Petrova, Guenka
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1952
AB  - Introduction: We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. Material and methods: In the group of 192 patients with clinically suspected acute DVT, we examined the three different D-dimer measurements (Innovance D-dimer, Hemosil D-dimer HS and Vidas D-dimer Exclusion II) in combination with and without PTP assessment. Results: The diagnostic alternative employing Vidas D-dimer Exclusion II assay without and with PTP calculation gave lower incremental cost-effectiveness ratio (ICER) than the alternative employing Hemosil D-dimer HS assay (0.187 Euros vs. 0.998 Euros per one additional DVT positive patient selected for CUS in model without PTP assessment and 0.450 vs. 0.753 Euros per one DVT positive patient selected for CUS in model with PTP assessment). According to sensitivity analysis, the Hemosil D-dimer HS assay was the most cost effective alternative when one patient was admitted to the vascular ambulance per day. Vidas D-dimer Exclusion II assay was the most cost effective alternative when more than one patient were admitted to the vascular ambulance per day. Cost minimisation analysis indicated that selection of patients according to PTP score followed by D-dimer analysis decreases the cost of DVT diagnosis. Conclusions: ICER analysis enables laboratories to choose optimal laboratory tests according to number of patients admitted to laboratory. Results support the feasibility of using PTP scoring and D-dimer measurement before CUS examination in DVT screening.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis
VL  - 23
IS  - 1
SP  - 96
EP  - 106
DO  - 10.11613/BM.2013.012
ER  - 

@article{
author = "Bogavac-Stanojević, Nataša and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Lakić, Dragana and Vasić, Dragan and Petrova, Guenka",
year = "2013",
abstract = "Introduction: We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. Material and methods: In the group of 192 patients with clinically suspected acute DVT, we examined the three different D-dimer measurements (Innovance D-dimer, Hemosil D-dimer HS and Vidas D-dimer Exclusion II) in combination with and without PTP assessment. Results: The diagnostic alternative employing Vidas D-dimer Exclusion II assay without and with PTP calculation gave lower incremental cost-effectiveness ratio (ICER) than the alternative employing Hemosil D-dimer HS assay (0.187 Euros vs. 0.998 Euros per one additional DVT positive patient selected for CUS in model without PTP assessment and 0.450 vs. 0.753 Euros per one DVT positive patient selected for CUS in model with PTP assessment). According to sensitivity analysis, the Hemosil D-dimer HS assay was the most cost effective alternative when one patient was admitted to the vascular ambulance per day. Vidas D-dimer Exclusion II assay was the most cost effective alternative when more than one patient were admitted to the vascular ambulance per day. Cost minimisation analysis indicated that selection of patients according to PTP score followed by D-dimer analysis decreases the cost of DVT diagnosis. Conclusions: ICER analysis enables laboratories to choose optimal laboratory tests according to number of patients admitted to laboratory. Results support the feasibility of using PTP scoring and D-dimer measurement before CUS examination in DVT screening.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis",
volume = "23",
number = "1",
pages = "96-106",
doi = "10.11613/BM.2013.012"
}

Bogavac-Stanojević, N., Dopsaj, V., Jelić-Ivanović, Z., Lakić, D., Vasić, D.,& Petrova, G.. (2013). Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 23(1), 96-106.
https://doi.org/10.11613/BM.2013.012

Bogavac-Stanojević N, Dopsaj V, Jelić-Ivanović Z, Lakić D, Vasić D, Petrova G. Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis. in Biochemia Medica. 2013;23(1):96-106.
doi:10.11613/BM.2013.012 .

Bogavac-Stanojević, Nataša, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Lakić, Dragana, Vasić, Dragan, Petrova, Guenka, "Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis" in Biochemia Medica, 23, no. 1 (2013):96-106,
https://doi.org/10.11613/BM.2013.012 . .

TY  - CONF
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Peco-Antić, Amira
AU  - Kostić, Mirjana
AU  - Vasić, Dragan
AU  - Spasić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1460
PB  - Elsevier Science BV, Amsterdam
C3  - European Journal of Pharmaceutical Sciences
T1  - Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients
VL  - 44
IS  - Supplement 1
SP  - 191
EP  - 191
DO  - 10.1016/j.ejps.2011.08.002
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1460
ER  - 

@conference{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Peco-Antić, Amira and Kostić, Mirjana and Vasić, Dragan and Spasić, Slavica",
year = "2011",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients",
volume = "44",
number = "Supplement 1",
pages = "191-191",
doi = "10.1016/j.ejps.2011.08.002",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1460"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Peco-Antić, A., Kostić, M., Vasić, D.,& Spasić, S.. (2011). Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 44(Supplement 1), 191-191.
https://doi.org/10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1460

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Peco-Antić A, Kostić M, Vasić D, Spasić S. Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in European Journal of Pharmaceutical Sciences. 2011;44(Supplement 1):191-191.
doi:10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1460 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Peco-Antić, Amira, Kostić, Mirjana, Vasić, Dragan, Spasić, Slavica, "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients" in European Journal of Pharmaceutical Sciences, 44, no. Supplement 1 (2011):191-191,
https://doi.org/10.1016/j.ejps.2011.08.002 .,
https://hdl.handle.net/21.15107/rcub_farfar_1460 .

TY  - CONF
AU  - Spasić, S.
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
AU  - Kostić, M.
AU  - Vasić, Dragan
AU  - Stefanović, Aleksandra
AU  - Vujović, Ana
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kornić, D.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1486
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease
VL  - 12
IS  - 1
SP  - 22
EP  - 22
DO  - 10.1016/S1567-5688(11)70094-0
ER  - 

@conference{
author = "Spasić, S. and Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Kostić, M. and Vasić, Dragan and Stefanović, Aleksandra and Vujović, Ana and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kornić, D.",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease",
volume = "12",
number = "1",
pages = "22-22",
doi = "10.1016/S1567-5688(11)70094-0"
}

Spasić, S., Kotur-Stevuljević, J., Peco-Antić, A., Kostić, M., Vasić, D., Stefanović, A., Vujović, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kornić, D.. (2011). Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 12(1), 22-22.
https://doi.org/10.1016/S1567-5688(11)70094-0

Spasić S, Kotur-Stevuljević J, Peco-Antić A, Kostić M, Vasić D, Stefanović A, Vujović A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kornić D. Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease. in Atherosclerosis Supplements. 2011;12(1):22-22.
doi:10.1016/S1567-5688(11)70094-0 .

Spasić, S., Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Kostić, M., Vasić, Dragan, Stefanović, Aleksandra, Vujović, Ana, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kornić, D., "Hyperlipidemia and oxidative stress are the main determinants of intima-media thickness in children with chronic kidney disease" in Atherosclerosis Supplements, 12, no. 1 (2011):22-22,
https://doi.org/10.1016/S1567-5688(11)70094-0 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Peco-Antić, Amira
AU  - Kostić, Mirjana
AU  - Vasić, Dragan
AU  - Spasić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1549
AB  - Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P  lt  0.001), but more HDL 3a (P  lt  0.01) and 3b (P  lt  0.001) subclasses. They also had increased sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05) levels. The proportion of the HDL 3b subclasses was a significant predictor of increased cIMT (P  lt  0.05). Patients treated with cyclosporine had significantly higher sdLDL-C and sdLDL-apoB concentrations (P  lt  0.05) when compared with those on tacrolimus therapy. Pediatric renal transplant recipients have impaired distribution of HDL and LDL particles. Changes in the proportion of small-sized HDL particles are significantly associated with cIMT. Advanced lipid testing might be useful in evaluating the effects of immunosuppressive therapy.
PB  - Wiley-Blackwell, Malden
T2  - Transplantation
T1  - Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients
VL  - 24
IS  - 11
SP  - 1094
EP  - 1102
DO  - 10.1111/j.1432-2277.2011.01313.x
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Peco-Antić, Amira and Kostić, Mirjana and Vasić, Dragan and Spasić, Slavica",
year = "2011",
abstract = "Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P  lt  0.001), but more HDL 3a (P  lt  0.01) and 3b (P  lt  0.001) subclasses. They also had increased sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05) levels. The proportion of the HDL 3b subclasses was a significant predictor of increased cIMT (P  lt  0.05). Patients treated with cyclosporine had significantly higher sdLDL-C and sdLDL-apoB concentrations (P  lt  0.05) when compared with those on tacrolimus therapy. Pediatric renal transplant recipients have impaired distribution of HDL and LDL particles. Changes in the proportion of small-sized HDL particles are significantly associated with cIMT. Advanced lipid testing might be useful in evaluating the effects of immunosuppressive therapy.",
publisher = "Wiley-Blackwell, Malden",
journal = "Transplantation",
title = "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients",
volume = "24",
number = "11",
pages = "1094-1102",
doi = "10.1111/j.1432-2277.2011.01313.x"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Peco-Antić, A., Kostić, M., Vasić, D.,& Spasić, S.. (2011). Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in Transplantation
Wiley-Blackwell, Malden., 24(11), 1094-1102.
https://doi.org/10.1111/j.1432-2277.2011.01313.x

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Peco-Antić A, Kostić M, Vasić D, Spasić S. Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. in Transplantation. 2011;24(11):1094-1102.
doi:10.1111/j.1432-2277.2011.01313.x .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Peco-Antić, Amira, Kostić, Mirjana, Vasić, Dragan, Spasić, Slavica, "Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients" in Transplantation, 24, no. 11 (2011):1094-1102,
https://doi.org/10.1111/j.1432-2277.2011.01313.x . .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Bogavac-Stanojević, Nataša
AU  - Vasić, Dragan
AU  - Vukosavljević, Dragana
AU  - Martinović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1180
AB  - Many studies have investigated the clinical accuracy of the D-dimer test in combination with pretest probability score for deep venous thrombosis (DVT) exclusion. However, few have evaluated its potential when combined with additional markers such as fibrin monomer. The aim of this study was to test the incremental usefulness of fibrin monomer for DVT screening in a bi-marker approach. This was achieved by adding the fibrin monomer to logistic models that included different D-dimer tests. Plasma concentrations of D-dimer and fibrin monomer were measured in 96 outpatients suspected of having DVT and in 76 patients selected from the total patient group according to pretest probability score (termed the DVT-unlikely group). We constructed receiver operating characteristic curves for three different D-dimer assays. Predictive probabilities from different logistic regression models and pair-wise comparisons of the areas under the receiver operating characteristic curve (AUCs) were calculated without and with fibrin monomer included in the models. For all three D-dimer assays, the AUCs were higher in the DVT-unlikely group compared with AUCs in the total patient group [but the differences were without statistical significance (P>0.05)]. The calculated fibrin monomer AUCs (0.724 in the total patient group and 0.683 in the DVT-unlikely group) were lower than the D-dimer tests' AUCs. The AUCs obtained from logistic regression models that included the three D-dimer tests in the total patient group and the DVT-unlikely group were significantly increased when fibrin monomer was included in the model to such an extent that the AUCs for one of them indicated outstanding discriminative abilities. Simultaneous D-dimer and fibrin monomer determination provides a more valuable approximation for DVT exclusion compared with just D-dimer analysis. Bearing in mind that the fibrin monomer assay is now both more practical and more suited for routine clinical use, fibrin monomer determination could be a more commonly used parameter together with D-dimer and pretest probability score for DVT diagnosis in the future. Blood Coagul Fibrinolysis 20:546-551
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Blood Coagulation & Fibrinolysis
T1  - Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?
VL  - 20
IS  - 7
SP  - 546
EP  - 551
DO  - 10.1097/MBC.0b013e32832e0605
ER  - 

@article{
author = "Dopsaj, Violeta and Bogavac-Stanojević, Nataša and Vasić, Dragan and Vukosavljević, Dragana and Martinović, Jelena and Kotur-Stevuljević, Jelena and Spasić, Slavica",
year = "2009",
abstract = "Many studies have investigated the clinical accuracy of the D-dimer test in combination with pretest probability score for deep venous thrombosis (DVT) exclusion. However, few have evaluated its potential when combined with additional markers such as fibrin monomer. The aim of this study was to test the incremental usefulness of fibrin monomer for DVT screening in a bi-marker approach. This was achieved by adding the fibrin monomer to logistic models that included different D-dimer tests. Plasma concentrations of D-dimer and fibrin monomer were measured in 96 outpatients suspected of having DVT and in 76 patients selected from the total patient group according to pretest probability score (termed the DVT-unlikely group). We constructed receiver operating characteristic curves for three different D-dimer assays. Predictive probabilities from different logistic regression models and pair-wise comparisons of the areas under the receiver operating characteristic curve (AUCs) were calculated without and with fibrin monomer included in the models. For all three D-dimer assays, the AUCs were higher in the DVT-unlikely group compared with AUCs in the total patient group [but the differences were without statistical significance (P>0.05)]. The calculated fibrin monomer AUCs (0.724 in the total patient group and 0.683 in the DVT-unlikely group) were lower than the D-dimer tests' AUCs. The AUCs obtained from logistic regression models that included the three D-dimer tests in the total patient group and the DVT-unlikely group were significantly increased when fibrin monomer was included in the model to such an extent that the AUCs for one of them indicated outstanding discriminative abilities. Simultaneous D-dimer and fibrin monomer determination provides a more valuable approximation for DVT exclusion compared with just D-dimer analysis. Bearing in mind that the fibrin monomer assay is now both more practical and more suited for routine clinical use, fibrin monomer determination could be a more commonly used parameter together with D-dimer and pretest probability score for DVT diagnosis in the future. Blood Coagul Fibrinolysis 20:546-551",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Blood Coagulation & Fibrinolysis",
title = "Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?",
volume = "20",
number = "7",
pages = "546-551",
doi = "10.1097/MBC.0b013e32832e0605"
}

Dopsaj, V., Bogavac-Stanojević, N., Vasić, D., Vukosavljević, D., Martinović, J., Kotur-Stevuljević, J.,& Spasić, S.. (2009). Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?. in Blood Coagulation & Fibrinolysis
Lippincott Williams & Wilkins, Philadelphia., 20(7), 546-551.
https://doi.org/10.1097/MBC.0b013e32832e0605

Dopsaj V, Bogavac-Stanojević N, Vasić D, Vukosavljević D, Martinović J, Kotur-Stevuljević J, Spasić S. Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?. in Blood Coagulation & Fibrinolysis. 2009;20(7):546-551.
doi:10.1097/MBC.0b013e32832e0605 .

Dopsaj, Violeta, Bogavac-Stanojević, Nataša, Vasić, Dragan, Vukosavljević, Dragana, Martinović, Jelena, Kotur-Stevuljević, Jelena, Spasić, Slavica, "Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?" in Blood Coagulation & Fibrinolysis, 20, no. 7 (2009):546-551,
https://doi.org/10.1097/MBC.0b013e32832e0605 . .