TY  - JOUR
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Kotur-Stevuljević, Jelena
AU  - Dukić, Milan
AU  - Paripović, Dušan
AU  - Miloševski-Lomić, Gordana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Pavicević, Polina
AU  - Mitrović, Jadranka
AU  - Kostić, Mirjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2793
AB  - Background: New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function. Material/Methods: The first group (n=58) of patients included in the study were undergoing angiography with iopromide, and the second group (n=65) were undergoing magnetic resonance (MR) angiography/urography with Gd-DTPA administration. The concentrations of NGAL and KIM-1 were measured four times in the urine (pre-contrast, then at four hours, 24 hours, and 48 hours after contrast administration), and serum NGAL was measured at 0 (base-line), 24 hours, and 48 hours after contrast exposure. Results: After 24 hours, serum NGAL increase of >= 25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). In the Gd-DTPA group, we observed a statistically significant increase in urinary KIM-1 24 hours after the procedure. Normalized urinary KIM-1, 24 hours after contrast exposure, was a better predictive factor for CI-AKI than other biomarkers (AUC 0.757, cut off 214 pg/mg, sensitivity 83.3%, specificity 54.2%, p=0.035). Conclusions: In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1.
PB  - Int Scientific Information, Inc, Melville
T2  - Medical Science Monitor
T1  - Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio
VL  - 23
DO  - 10.12659/MSM.903255
ER  - 

@article{
author = "Spasojević-Dimitrijeva, Brankica and Kotur-Stevuljević, Jelena and Dukić, Milan and Paripović, Dušan and Miloševski-Lomić, Gordana and Spasojević-Kalimanovska, Vesna and Pavicević, Polina and Mitrović, Jadranka and Kostić, Mirjana",
year = "2017",
abstract = "Background: New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function. Material/Methods: The first group (n=58) of patients included in the study were undergoing angiography with iopromide, and the second group (n=65) were undergoing magnetic resonance (MR) angiography/urography with Gd-DTPA administration. The concentrations of NGAL and KIM-1 were measured four times in the urine (pre-contrast, then at four hours, 24 hours, and 48 hours after contrast administration), and serum NGAL was measured at 0 (base-line), 24 hours, and 48 hours after contrast exposure. Results: After 24 hours, serum NGAL increase of >= 25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). In the Gd-DTPA group, we observed a statistically significant increase in urinary KIM-1 24 hours after the procedure. Normalized urinary KIM-1, 24 hours after contrast exposure, was a better predictive factor for CI-AKI than other biomarkers (AUC 0.757, cut off 214 pg/mg, sensitivity 83.3%, specificity 54.2%, p=0.035). Conclusions: In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1.",
publisher = "Int Scientific Information, Inc, Melville",
journal = "Medical Science Monitor",
title = "Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio",
volume = "23",
doi = "10.12659/MSM.903255"
}

Spasojević-Dimitrijeva, B., Kotur-Stevuljević, J., Dukić, M., Paripović, D., Miloševski-Lomić, G., Spasojević-Kalimanovska, V., Pavicević, P., Mitrović, J.,& Kostić, M.. (2017). Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio. in Medical Science Monitor
Int Scientific Information, Inc, Melville., 23.
https://doi.org/10.12659/MSM.903255

Spasojević-Dimitrijeva B, Kotur-Stevuljević J, Dukić M, Paripović D, Miloševski-Lomić G, Spasojević-Kalimanovska V, Pavicević P, Mitrović J, Kostić M. Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio. in Medical Science Monitor. 2017;23.
doi:10.12659/MSM.903255 .

Spasojević-Dimitrijeva, Brankica, Kotur-Stevuljević, Jelena, Dukić, Milan, Paripović, Dušan, Miloševski-Lomić, Gordana, Spasojević-Kalimanovska, Vesna, Pavicević, Polina, Mitrović, Jadranka, Kostić, Mirjana, "Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio" in Medical Science Monitor, 23 (2017),
https://doi.org/10.12659/MSM.903255 . .