TY  - JOUR
AU  - Popović, Dejana
AU  - Bjelobrk, Marija
AU  - Tesić, Milorad
AU  - Seman, Stefan
AU  - Jayasinghe, Sisitha
AU  - Hills, Andrew
AU  - Samuel Babu, Abraham
AU  - Jakovljević, Đorđe.
AU  - Stoner, Lee
AU  - Ozemek, Cemal
AU  - Bond, Samantha
AU  - Faghy, Mark
AU  - Pronk, Nicolaas
AU  - Lavie, Carl
AU  - Arena, Ross
AU  - On behalf of the HL - PIVOT Network
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4064
AB  - Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.
PB  - W.B. Saunders
T2  - Progress in Cardiovascular Diseases
T1  - Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise
DO  - 10.1016/j.pcad.2022.01.008
ER  - 

@article{
author = "Popović, Dejana and Bjelobrk, Marija and Tesić, Milorad and Seman, Stefan and Jayasinghe, Sisitha and Hills, Andrew and Samuel Babu, Abraham and Jakovljević, Đorđe. and Stoner, Lee and Ozemek, Cemal and Bond, Samantha and Faghy, Mark and Pronk, Nicolaas and Lavie, Carl and Arena, Ross and On behalf of the HL - PIVOT Network",
year = "2022",
abstract = "Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.",
publisher = "W.B. Saunders",
journal = "Progress in Cardiovascular Diseases",
title = "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise",
doi = "10.1016/j.pcad.2022.01.008"
}

Popović, D., Bjelobrk, M., Tesić, M., Seman, S., Jayasinghe, S., Hills, A., Samuel Babu, A., Jakovljević, Đorđe., Stoner, L., Ozemek, C., Bond, S., Faghy, M., Pronk, N., Lavie, C., Arena, R.,& On behalf of the HL - PIVOT Network. (2022). Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases
W.B. Saunders..
https://doi.org/10.1016/j.pcad.2022.01.008

Popović D, Bjelobrk M, Tesić M, Seman S, Jayasinghe S, Hills A, Samuel Babu A, Jakovljević Đ, Stoner L, Ozemek C, Bond S, Faghy M, Pronk N, Lavie C, Arena R, On behalf of the HL - PIVOT Network. Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases. 2022;.
doi:10.1016/j.pcad.2022.01.008 .

Popović, Dejana, Bjelobrk, Marija, Tesić, Milorad, Seman, Stefan, Jayasinghe, Sisitha, Hills, Andrew, Samuel Babu, Abraham, Jakovljević, Đorđe., Stoner, Lee, Ozemek, Cemal, Bond, Samantha, Faghy, Mark, Pronk, Nicolaas, Lavie, Carl, Arena, Ross, On behalf of the HL - PIVOT Network, "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise" in Progress in Cardiovascular Diseases (2022),
https://doi.org/10.1016/j.pcad.2022.01.008 . .

TY  - JOUR
AU  - Bjelobrk, Marija
AU  - Lakočević, Milan
AU  - Damjanović, Svetozar
AU  - Petakov, Milan
AU  - Petrović, Milan
AU  - Bosnić, Zoran
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3930
AB  - Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1. Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32.6 ± 13.1 vs. C: 36.2 ± 10.6, p >.05) before the initiation of treatment. Standard echocardiography at rest was used to assess left ventricular ejection fraction (LVEF) and pulmonary artery systolic pressure (PASP). Cardiopulmonary exercise testing (CPET) was performed on a recumbent ergometer using a ramp protocol. Results: LVEF was similar in both groups (GD-S: 65.1 ± 5.2% vs. C: 65.2 ± 5.2%, p >.05), as well as PAPS (24.1 ± 4.2 mmHg vs. C: 25.5 ± 1.3 mmHg, p >.05). GD-S had lower weight (p <.05) and worse CPET responses compared to C, including peak values of heart rate, oxygen consumption, carbondioxide production (VCO2), end-tidal pressure of CO2, and O2 pulse, as well as HR reserve after 3 min of recovery and the minute ventilation/VCO2 slope. Conclusions: Patients with GD type I have an abnormal CPET response compared to healthy controls likely due to the complex pathophysiologic process in GD that impacts multiple systems integral to the physiologic response to exercise.
PB  - John Wiley and Sons Inc
T2  - Molecular Genetics and Genomic Medicine
T1  - Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I
VL  - 9
IS  - 8
DO  - 10.1002/mgg3.1757
ER  - 

@article{
author = "Bjelobrk, Marija and Lakočević, Milan and Damjanović, Svetozar and Petakov, Milan and Petrović, Milan and Bosnić, Zoran and Arena, Ross and Popović, Dejana",
year = "2021",
abstract = "Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1. Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32.6 ± 13.1 vs. C: 36.2 ± 10.6, p >.05) before the initiation of treatment. Standard echocardiography at rest was used to assess left ventricular ejection fraction (LVEF) and pulmonary artery systolic pressure (PASP). Cardiopulmonary exercise testing (CPET) was performed on a recumbent ergometer using a ramp protocol. Results: LVEF was similar in both groups (GD-S: 65.1 ± 5.2% vs. C: 65.2 ± 5.2%, p >.05), as well as PAPS (24.1 ± 4.2 mmHg vs. C: 25.5 ± 1.3 mmHg, p >.05). GD-S had lower weight (p <.05) and worse CPET responses compared to C, including peak values of heart rate, oxygen consumption, carbondioxide production (VCO2), end-tidal pressure of CO2, and O2 pulse, as well as HR reserve after 3 min of recovery and the minute ventilation/VCO2 slope. Conclusions: Patients with GD type I have an abnormal CPET response compared to healthy controls likely due to the complex pathophysiologic process in GD that impacts multiple systems integral to the physiologic response to exercise.",
publisher = "John Wiley and Sons Inc",
journal = "Molecular Genetics and Genomic Medicine",
title = "Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I",
volume = "9",
number = "8",
doi = "10.1002/mgg3.1757"
}

Bjelobrk, M., Lakočević, M., Damjanović, S., Petakov, M., Petrović, M., Bosnić, Z., Arena, R.,& Popović, D.. (2021). Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I. in Molecular Genetics and Genomic Medicine
John Wiley and Sons Inc., 9(8).
https://doi.org/10.1002/mgg3.1757

Bjelobrk M, Lakočević M, Damjanović S, Petakov M, Petrović M, Bosnić Z, Arena R, Popović D. Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I. in Molecular Genetics and Genomic Medicine. 2021;9(8).
doi:10.1002/mgg3.1757 .

Bjelobrk, Marija, Lakočević, Milan, Damjanović, Svetozar, Petakov, Milan, Petrović, Milan, Bosnić, Zoran, Arena, Ross, Popović, Dejana, "Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I" in Molecular Genetics and Genomic Medicine, 9, no. 8 (2021),
https://doi.org/10.1002/mgg3.1757 . .