TY  - JOUR
AU  - Antonijević, Nebojša
AU  - Mitrović, Predrag
AU  - Gošnjić, Nikola
AU  - Orlić, Dejan
AU  - Kadija, Saša
AU  - Ilić Mostić, Tanja
AU  - Savić, Nebojša
AU  - Birovljev, Ljubica
AU  - Leković, Žaklina
AU  - Matić, Dragan
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5079
AB  - Caesarean section is a challenging intervention in patients treated with dual antiplatelet therapy. We present a case of a 32-year-old pregnant woman experiencing large acute myocardial infarction (MI) of the anterolateral wall, complicated by cardiogenic shock in the 38th week of pregnancy, and treated with drug-eluting stent implantation and dual antiplatelet therapy (DAPT) consisting of aspirin and ticagrelor. Less than 24 h after the MI delivery started, an urgent Caesarean section was indicated. As multiplate aggregometry testing showed a relatively insufficient level of ticagrelor platelet inhibition and a moderate level of aspirin platelet inhibition, a Caesarean section was performed without discontinuation of ticagrelor, which was decided due to the need for emergency surgery. Local hemostatic measures including administration of tranexamic acid were applied. The patient did not experience excessive bleeding. A healthy male baby was born. To the best of our knowledge, this is the first reported case of surgery in pregnant women treated with DAPT without ticagrelor discontinuation.
PB  - MDPI
T2  - Journal of Personalized Medicine
T1  - Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention
VL  - 13
IS  - 9
DO  - 10.3390/jpm13091344
ER  - 

@article{
author = "Antonijević, Nebojša and Mitrović, Predrag and Gošnjić, Nikola and Orlić, Dejan and Kadija, Saša and Ilić Mostić, Tanja and Savić, Nebojša and Birovljev, Ljubica and Leković, Žaklina and Matić, Dragan",
year = "2023",
abstract = "Caesarean section is a challenging intervention in patients treated with dual antiplatelet therapy. We present a case of a 32-year-old pregnant woman experiencing large acute myocardial infarction (MI) of the anterolateral wall, complicated by cardiogenic shock in the 38th week of pregnancy, and treated with drug-eluting stent implantation and dual antiplatelet therapy (DAPT) consisting of aspirin and ticagrelor. Less than 24 h after the MI delivery started, an urgent Caesarean section was indicated. As multiplate aggregometry testing showed a relatively insufficient level of ticagrelor platelet inhibition and a moderate level of aspirin platelet inhibition, a Caesarean section was performed without discontinuation of ticagrelor, which was decided due to the need for emergency surgery. Local hemostatic measures including administration of tranexamic acid were applied. The patient did not experience excessive bleeding. A healthy male baby was born. To the best of our knowledge, this is the first reported case of surgery in pregnant women treated with DAPT without ticagrelor discontinuation.",
publisher = "MDPI",
journal = "Journal of Personalized Medicine",
title = "Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention",
volume = "13",
number = "9",
doi = "10.3390/jpm13091344"
}

Antonijević, N., Mitrović, P., Gošnjić, N., Orlić, D., Kadija, S., Ilić Mostić, T., Savić, N., Birovljev, L., Leković, Ž.,& Matić, D.. (2023). Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention. in Journal of Personalized Medicine
MDPI., 13(9).
https://doi.org/10.3390/jpm13091344

Antonijević N, Mitrović P, Gošnjić N, Orlić D, Kadija S, Ilić Mostić T, Savić N, Birovljev L, Leković Ž, Matić D. Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention. in Journal of Personalized Medicine. 2023;13(9).
doi:10.3390/jpm13091344 .

Antonijević, Nebojša, Mitrović, Predrag, Gošnjić, Nikola, Orlić, Dejan, Kadija, Saša, Ilić Mostić, Tanja, Savić, Nebojša, Birovljev, Ljubica, Leković, Žaklina, Matić, Dragan, "Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention" in Journal of Personalized Medicine, 13, no. 9 (2023),
https://doi.org/10.3390/jpm13091344 . .

TY  - JOUR
AU  - Đunić, Irena
AU  - Dopsaj, Violeta
AU  - Miljić, Predrag
AU  - Savić, Nebojša
AU  - Milić, Nataša
AU  - Mitrović, Mirjana
AU  - Suvajdžić-Vuković, Nada
AU  - Tomin, Dragica
AU  - Elezović, Ivo
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082
AB  - Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
VL  - 60
IS  - 8
SP  - 1325
EP  - 1331
DO  - 10.7754/Clin.Lab.2013.130817
ER  - 

@article{
author = "Đunić, Irena and Dopsaj, Violeta and Miljić, Predrag and Savić, Nebojša and Milić, Nataša and Mitrović, Mirjana and Suvajdžić-Vuković, Nada and Tomin, Dragica and Elezović, Ivo",
year = "2014",
abstract = "Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia",
volume = "60",
number = "8",
pages = "1325-1331",
doi = "10.7754/Clin.Lab.2013.130817"
}

Đunić, I., Dopsaj, V., Miljić, P., Savić, N., Milić, N., Mitrović, M., Suvajdžić-Vuković, N., Tomin, D.,& Elezović, I.. (2014). Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 60(8), 1325-1331.
https://doi.org/10.7754/Clin.Lab.2013.130817

Đunić I, Dopsaj V, Miljić P, Savić N, Milić N, Mitrović M, Suvajdžić-Vuković N, Tomin D, Elezović I. Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory. 2014;60(8):1325-1331.
doi:10.7754/Clin.Lab.2013.130817 .

Đunić, Irena, Dopsaj, Violeta, Miljić, Predrag, Savić, Nebojša, Milić, Nataša, Mitrović, Mirjana, Suvajdžić-Vuković, Nada, Tomin, Dragica, Elezović, Ivo, "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia" in Clinical Laboratory, 60, no. 8 (2014):1325-1331,
https://doi.org/10.7754/Clin.Lab.2013.130817 . .