TY  - JOUR
AU  - Gligorović-Barhanović, Najdana
AU  - Antunović, Tanja
AU  - Kavarić, Sreten
AU  - Đogo, Aleksandar
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3321
AB  - Background: Laboratory thyroid function tests play a central role in the diagnosis of thyroid disorders. The aim of our cross-sectional study was to determine reference values for thyroid tests in a rigorously selected group of Montenegrin females, investigate the impact of possible age-related changes and the influence of the interassay bias between three frequently used immunoassays. Methods: Female subjects were randomly selected, aged between 20 and 69 and 946 of them met the selection criteria. TSH, fT3, fT4, thyroid peroxidase and thyroglobulin antibodies were measured. Eighty samples were further analyzed on two other immunochemistry platforms. Results: Median TSH progressively increased with age, there was no difference in fT3, while fT4 was significantly higher in the two oldest groups compared to the others. When using the age-related 97.5 percentile of TSH the percentage of reclassification was highest in the 20-29 years of age group (5.2%, p lt 0.05). In the oldest band, 7.7% had TSH values above cohort-specific and below the age-related upper reference limit. Bland-Altman bias plots revealed the highest interassay absolute mean difference between compared TSH assays of 24.5% and for fT4 assays of 13.8%. Conclusions: The correlation coefficients between fT3 assays from different manufacturers were low. Serum TSH and fT4 concentrations increased with age and the implementation of age-specific TSH reference intervals would be of interest. The bias between the three commercial immunoassays indicated that the standardization of thyroid function tests is a task of great importance.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Age and assay related changes of laboratory thyroid function tests in the reference female population
VL  - 38
IS  - 1
SP  - 22
EP  - 32
DO  - 10.2478/jomb-2018-0020
ER  - 

@article{
author = "Gligorović-Barhanović, Najdana and Antunović, Tanja and Kavarić, Sreten and Đogo, Aleksandar and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background: Laboratory thyroid function tests play a central role in the diagnosis of thyroid disorders. The aim of our cross-sectional study was to determine reference values for thyroid tests in a rigorously selected group of Montenegrin females, investigate the impact of possible age-related changes and the influence of the interassay bias between three frequently used immunoassays. Methods: Female subjects were randomly selected, aged between 20 and 69 and 946 of them met the selection criteria. TSH, fT3, fT4, thyroid peroxidase and thyroglobulin antibodies were measured. Eighty samples were further analyzed on two other immunochemistry platforms. Results: Median TSH progressively increased with age, there was no difference in fT3, while fT4 was significantly higher in the two oldest groups compared to the others. When using the age-related 97.5 percentile of TSH the percentage of reclassification was highest in the 20-29 years of age group (5.2%, p lt 0.05). In the oldest band, 7.7% had TSH values above cohort-specific and below the age-related upper reference limit. Bland-Altman bias plots revealed the highest interassay absolute mean difference between compared TSH assays of 24.5% and for fT4 assays of 13.8%. Conclusions: The correlation coefficients between fT3 assays from different manufacturers were low. Serum TSH and fT4 concentrations increased with age and the implementation of age-specific TSH reference intervals would be of interest. The bias between the three commercial immunoassays indicated that the standardization of thyroid function tests is a task of great importance.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Age and assay related changes of laboratory thyroid function tests in the reference female population",
volume = "38",
number = "1",
pages = "22-32",
doi = "10.2478/jomb-2018-0020"
}

Gligorović-Barhanović, N., Antunović, T., Kavarić, S., Đogo, A.,& Spasojević-Kalimanovska, V.. (2019). Age and assay related changes of laboratory thyroid function tests in the reference female population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(1), 22-32.
https://doi.org/10.2478/jomb-2018-0020

Gligorović-Barhanović N, Antunović T, Kavarić S, Đogo A, Spasojević-Kalimanovska V. Age and assay related changes of laboratory thyroid function tests in the reference female population. in Journal of Medical Biochemistry. 2019;38(1):22-32.
doi:10.2478/jomb-2018-0020 .

Gligorović-Barhanović, Najdana, Antunović, Tanja, Kavarić, Sreten, Đogo, Aleksandar, Spasojević-Kalimanovska, Vesna, "Age and assay related changes of laboratory thyroid function tests in the reference female population" in Journal of Medical Biochemistry, 38, no. 1 (2019):22-32,
https://doi.org/10.2478/jomb-2018-0020 . .

TY  - THES
AU  - Antunović, Tanja
PY  - 2018
UR  - http://nardus.mpn.gov.rs/handle/123456789/10109
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6048
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:18382/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=2048262498
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3678
AB  - Mortalitet pacijenata na hemodijalizi (HD) je uprkos napretku nauke i dalje izuzetno visok. Vodeći uzročnici mortaliteta su kardiovaskularne bolesti (KVB) i infekcije. U ovoj studiji istraživana je potencijalna prediktivna sposobnost mortaliteta (opšteg i KVB) biohemijskih markera konvencionalnih faktora rizika za nastanak KVB (holesterol, trigliceridi, HDL- i LDL-holesterol, ApoAI, ApoB, homocistein i troponin I kao markera koronarne ishemije) i biomarkera, netradicionalnih faktora rizika povezanih sa uremijom i hemodijaliznim procesom. To su biomarkeri inflamacije (hsCRP, IL-6), oksidativnog stresa/antioksidativne zaštite (TAS, TOS, MDA, PAB, SOD, MPO, mokraćna kiselina) i nutritivnog statusa (albumin, transferin, prealbumin, RBP, BuChE, IGF-1 i IGFBP-3). Pacijentima su određene bazne vrijednosti svih parametara, a ishodi su praćeni tokom dvije godine.U studiju je uključeno 79 pacijenata (39 muškaraca i 40 žena) prosječne starosti 57,6±10,4 godine. Karakteristike hemodijalizne terapije ustanovljene su na osnovu kT/V vrijednosti i URR. Pacijente smo podijelili u tri grupe: preživjeli, ukupan mortalitet i mortalitet usled KVB i testirali smo postojanje razlike u nivoima ispitivanih biomarkera između grupa. PAB je bio statistički značajno viši u obje grupe preminulih (p<0,001). hsCRP, IL-6, hsTnI su takođe bili statistički značajno viši kod svih preminulih (p<0,001), kao i kod umrlih usled KVB (p<0,05). Prealbumin je bio značajno niži u grupi opšteg mortaliteta (p<0,001) i u grupi KVB mortaliteta (p<0,05), dok su BuChE, albumin, RBP i IGF-1 bili statistički značajno niži u grupi opšteg mortaliteta (p<0,05), dok se značajnost u grupi KVB mortaliteta zadržala samo za BuChE i RBP (p<0,05). MPO i mokraćna kiselina su bili statistički značajno viši u obje grupe preminulih (p<0,05). Cox regresiona hazard analiza pokazala je da hsCRP, IL-6, PAB, prealbumin, hsTnI (p<0,001), albumin, RBP, IGF-1, mokraćna kiselina i BuChE imaju statistički značajan uticaj na opšti mortalitet (p<0,05). Statistički značajan uticaj na KVB mortalitet se zadržao za mokraćnu kiselinu, PAB, IL-6, prealbumin, RBP i hsTnI (p<0,05). Kaplan-Meierova (KM) analiza i log rank test pokazali su da postoji statistički značajna razlika između grupa definisanih na osnovu cut-off vrijednosti biomarkera u odnosu na opšti moratalitet i to za: mokraćnu kiselinu, hsCRP, IL-6, prealbumin, hsTnI (p<0,001), RBP, IGF-1, PAB, BuChE i albumin, (p<0,05). Statistički značajna razlika između grupa definisanih na osnovu cut-off vrijednosti biomarkera u odnosu na KVB mortalitet dokazana je za: mokraćnu kiselinu, hsCRP, IL-6, prealbumin, RBP i hsTnI (p<0,05). Testirana je kombinacija dva biomarkera, pokazatelja istih ili različitih patofizioloških procesa. KM analizom i hi-kvadrat testom utvrđena je statistički značajna razlika između grupa definisanih cut-off vrijednostima kako za opšti, tako i za KVB mortalitet.Pacijenti umrli nakon dvije godine bili su u stanju intenzivnije hronične inflamacije i oksidativnog stresa, a njihov nutritivni status je bio lošiji u odnosu na preživjele. Kao najbolji prediktori mortaliteta u ovoj studiji pokazali su se IL-6, prealbumin, hsTnI koji se u našoj studiji pokazao kao dobar prediktor i KVB i opšteg mortaliteta; zatim mokraćna kiselina, rutinski biomarker, čiji se značaj u predikciji mortaliteta često zapostavlja i PAB, biomarker oksidativnog stresa koji je do sada nedovoljno istraživan. Kombinacija bilo koja dva statistički značajna biomarkera pokazala je veći potencijal u predikciji mortaliteta od pojedinačnih markera. PAB se u našoj studiji pokazao kaonajosetljiviji biomarker oksidativnog stresa. S obzirom da je ovaj biomarker do sada rijetko korišćen, njegov potencijal bi trebalo dokazati u budućim multicentričnim studijama sa većim brojem pacijenata.
AB  - Despite modern technology and the development of medicine, mortality levels for patients on hemodialysis (HD) continue to be high. The leading causes of death are cardiovascular diseases (CVD) and infections.In this study, we investigated whether the levels of CVD conventional risk factors (cholesterol, triglycerides, HDL-, LDL-cholesterol, ApoAI, ApoB, homocystein, and hsTnI) and non-traditional factors like those related to uremia and hemodialysis patophysiological processes, could be predictors of mortality. These are markers of inflammation (hsCRP, IL-6), oxidative stress (TAS, TOS, MDA, PAB, SOD, MPO, uric acid) and nutrition (albumin, transferrin, prealbumin, RBP, BuChE, IGF-1, IGFBP-3). The basal values of all the parameters were recorded and the outcomes (both all-cause and CVD mortality) were monitored over two years.In the study, 79 patients (39 men and 40 women), aged 57.6±10.4 years were enrolled. The adequacy of HD treatment was estimated through kT/V and URR. The patients were divided into three groups: survivors after two years, all-cause mortality and CVD mortality. PAB was statistically higher in both mortality groups (p<0,001). In addition, hsCRP, IL-6 and hsTnI were also higher in the all-cause (p<0.001) and CVD mortality (p<0.05) groups. Prealbumin was significantly lower in the all-cause (p<0.001), and in the CVD mortality group (p<0.05). BuChE, albumin, RBP and IGF-1 were lower in the all-cause mortality group (p<0.05), and the significance for CVD mortality remained only for BuChE and RBP (where p<0.05). MPO and uric acid levels were higher in both mortality groups (p<0.05). Cox regression hazard analysis shows a statistical significance after two years in the all-cause mortality patients for hsCRP, IL-6, PAB, prealbumin and hsTnI (at p<0.001), albumin, RBP, IGF-1, uric acid and BuChE (at p<0.05), and for CVD mortality for uric acid, PAB, IL-6, prealbumin, RBP and hsTnI (at p<0.05). Kaplan-Meier (KM) analysis and log-rank tests proved a statistically significant difference between groups defined by the parameter cut-off values in all-cause mortality for: uric acid, hsCRP, IL-6, prealbumin and hsTnI (at p<0.001) and RBP, IGF-1, PAB, BuChE and albumin, (at p<0.05). In CVD mortality, a significance was detected for: uric acid, hsCRP, IL-6, prealbumin, RBP and hsTnI (at p<0.05). A combination of two markers of the same or different patophysiological processes was tested. The Kaplan-Meier analysis and chi-square test showed statistically significant differences between groups for both all-cause and CVD mortality.The deceased patients were more exposed to inflammation and oxidative stress compared to the survivors and they had a worse nutritional status. The most important biomarkers for mortality prediction in our study were: IL-6, prealbumin, uric acid, PAB and hsTnI. hsTnI was good predictor of both overall and CVD mortality. Uric acid is a routine biomarker whose significance in mortality prediction is undervalued. PAB is a rarely used oxidative stress biomarker.Combinations of two biomarkers have a stronger mortality predictive power in comparison to single markers. In our study, PAB was the best oxidative stress biomarker with significant potential for mortality prediction. In order to prove this, we believe that such an investigation should be part of a multicentric study comprising of larger number of patients.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Biohemijski parametri oksidativnog, nutritivnog i inflamatornog statusa u predikciji mortaliteta kod pacijenata na hemodijalizi
UR  - https://hdl.handle.net/21.15107/rcub_nardus_10109
ER  - 

@phdthesis{
author = "Antunović, Tanja",
year = "2018",
abstract = "Mortalitet pacijenata na hemodijalizi (HD) je uprkos napretku nauke i dalje izuzetno visok. Vodeći uzročnici mortaliteta su kardiovaskularne bolesti (KVB) i infekcije. U ovoj studiji istraživana je potencijalna prediktivna sposobnost mortaliteta (opšteg i KVB) biohemijskih markera konvencionalnih faktora rizika za nastanak KVB (holesterol, trigliceridi, HDL- i LDL-holesterol, ApoAI, ApoB, homocistein i troponin I kao markera koronarne ishemije) i biomarkera, netradicionalnih faktora rizika povezanih sa uremijom i hemodijaliznim procesom. To su biomarkeri inflamacije (hsCRP, IL-6), oksidativnog stresa/antioksidativne zaštite (TAS, TOS, MDA, PAB, SOD, MPO, mokraćna kiselina) i nutritivnog statusa (albumin, transferin, prealbumin, RBP, BuChE, IGF-1 i IGFBP-3). Pacijentima su određene bazne vrijednosti svih parametara, a ishodi su praćeni tokom dvije godine.U studiju je uključeno 79 pacijenata (39 muškaraca i 40 žena) prosječne starosti 57,6±10,4 godine. Karakteristike hemodijalizne terapije ustanovljene su na osnovu kT/V vrijednosti i URR. Pacijente smo podijelili u tri grupe: preživjeli, ukupan mortalitet i mortalitet usled KVB i testirali smo postojanje razlike u nivoima ispitivanih biomarkera između grupa. PAB je bio statistički značajno viši u obje grupe preminulih (p<0,001). hsCRP, IL-6, hsTnI su takođe bili statistički značajno viši kod svih preminulih (p<0,001), kao i kod umrlih usled KVB (p<0,05). Prealbumin je bio značajno niži u grupi opšteg mortaliteta (p<0,001) i u grupi KVB mortaliteta (p<0,05), dok su BuChE, albumin, RBP i IGF-1 bili statistički značajno niži u grupi opšteg mortaliteta (p<0,05), dok se značajnost u grupi KVB mortaliteta zadržala samo za BuChE i RBP (p<0,05). MPO i mokraćna kiselina su bili statistički značajno viši u obje grupe preminulih (p<0,05). Cox regresiona hazard analiza pokazala je da hsCRP, IL-6, PAB, prealbumin, hsTnI (p<0,001), albumin, RBP, IGF-1, mokraćna kiselina i BuChE imaju statistički značajan uticaj na opšti mortalitet (p<0,05). Statistički značajan uticaj na KVB mortalitet se zadržao za mokraćnu kiselinu, PAB, IL-6, prealbumin, RBP i hsTnI (p<0,05). Kaplan-Meierova (KM) analiza i log rank test pokazali su da postoji statistički značajna razlika između grupa definisanih na osnovu cut-off vrijednosti biomarkera u odnosu na opšti moratalitet i to za: mokraćnu kiselinu, hsCRP, IL-6, prealbumin, hsTnI (p<0,001), RBP, IGF-1, PAB, BuChE i albumin, (p<0,05). Statistički značajna razlika između grupa definisanih na osnovu cut-off vrijednosti biomarkera u odnosu na KVB mortalitet dokazana je za: mokraćnu kiselinu, hsCRP, IL-6, prealbumin, RBP i hsTnI (p<0,05). Testirana je kombinacija dva biomarkera, pokazatelja istih ili različitih patofizioloških procesa. KM analizom i hi-kvadrat testom utvrđena je statistički značajna razlika između grupa definisanih cut-off vrijednostima kako za opšti, tako i za KVB mortalitet.Pacijenti umrli nakon dvije godine bili su u stanju intenzivnije hronične inflamacije i oksidativnog stresa, a njihov nutritivni status je bio lošiji u odnosu na preživjele. Kao najbolji prediktori mortaliteta u ovoj studiji pokazali su se IL-6, prealbumin, hsTnI koji se u našoj studiji pokazao kao dobar prediktor i KVB i opšteg mortaliteta; zatim mokraćna kiselina, rutinski biomarker, čiji se značaj u predikciji mortaliteta često zapostavlja i PAB, biomarker oksidativnog stresa koji je do sada nedovoljno istraživan. Kombinacija bilo koja dva statistički značajna biomarkera pokazala je veći potencijal u predikciji mortaliteta od pojedinačnih markera. PAB se u našoj studiji pokazao kaonajosetljiviji biomarker oksidativnog stresa. S obzirom da je ovaj biomarker do sada rijetko korišćen, njegov potencijal bi trebalo dokazati u budućim multicentričnim studijama sa većim brojem pacijenata., Despite modern technology and the development of medicine, mortality levels for patients on hemodialysis (HD) continue to be high. The leading causes of death are cardiovascular diseases (CVD) and infections.In this study, we investigated whether the levels of CVD conventional risk factors (cholesterol, triglycerides, HDL-, LDL-cholesterol, ApoAI, ApoB, homocystein, and hsTnI) and non-traditional factors like those related to uremia and hemodialysis patophysiological processes, could be predictors of mortality. These are markers of inflammation (hsCRP, IL-6), oxidative stress (TAS, TOS, MDA, PAB, SOD, MPO, uric acid) and nutrition (albumin, transferrin, prealbumin, RBP, BuChE, IGF-1, IGFBP-3). The basal values of all the parameters were recorded and the outcomes (both all-cause and CVD mortality) were monitored over two years.In the study, 79 patients (39 men and 40 women), aged 57.6±10.4 years were enrolled. The adequacy of HD treatment was estimated through kT/V and URR. The patients were divided into three groups: survivors after two years, all-cause mortality and CVD mortality. PAB was statistically higher in both mortality groups (p<0,001). In addition, hsCRP, IL-6 and hsTnI were also higher in the all-cause (p<0.001) and CVD mortality (p<0.05) groups. Prealbumin was significantly lower in the all-cause (p<0.001), and in the CVD mortality group (p<0.05). BuChE, albumin, RBP and IGF-1 were lower in the all-cause mortality group (p<0.05), and the significance for CVD mortality remained only for BuChE and RBP (where p<0.05). MPO and uric acid levels were higher in both mortality groups (p<0.05). Cox regression hazard analysis shows a statistical significance after two years in the all-cause mortality patients for hsCRP, IL-6, PAB, prealbumin and hsTnI (at p<0.001), albumin, RBP, IGF-1, uric acid and BuChE (at p<0.05), and for CVD mortality for uric acid, PAB, IL-6, prealbumin, RBP and hsTnI (at p<0.05). Kaplan-Meier (KM) analysis and log-rank tests proved a statistically significant difference between groups defined by the parameter cut-off values in all-cause mortality for: uric acid, hsCRP, IL-6, prealbumin and hsTnI (at p<0.001) and RBP, IGF-1, PAB, BuChE and albumin, (at p<0.05). In CVD mortality, a significance was detected for: uric acid, hsCRP, IL-6, prealbumin, RBP and hsTnI (at p<0.05). A combination of two markers of the same or different patophysiological processes was tested. The Kaplan-Meier analysis and chi-square test showed statistically significant differences between groups for both all-cause and CVD mortality.The deceased patients were more exposed to inflammation and oxidative stress compared to the survivors and they had a worse nutritional status. The most important biomarkers for mortality prediction in our study were: IL-6, prealbumin, uric acid, PAB and hsTnI. hsTnI was good predictor of both overall and CVD mortality. Uric acid is a routine biomarker whose significance in mortality prediction is undervalued. PAB is a rarely used oxidative stress biomarker.Combinations of two biomarkers have a stronger mortality predictive power in comparison to single markers. In our study, PAB was the best oxidative stress biomarker with significant potential for mortality prediction. In order to prove this, we believe that such an investigation should be part of a multicentric study comprising of larger number of patients.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Biohemijski parametri oksidativnog, nutritivnog i inflamatornog statusa u predikciji mortaliteta kod pacijenata na hemodijalizi",
url = "https://hdl.handle.net/21.15107/rcub_nardus_10109"
}

Antunović, T.. (2018). Biohemijski parametri oksidativnog, nutritivnog i inflamatornog statusa u predikciji mortaliteta kod pacijenata na hemodijalizi. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_10109

Antunović T. Biohemijski parametri oksidativnog, nutritivnog i inflamatornog statusa u predikciji mortaliteta kod pacijenata na hemodijalizi. in Универзитет у Београду. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_10109 .

Antunović, Tanja, "Biohemijski parametri oksidativnog, nutritivnog i inflamatornog statusa u predikciji mortaliteta kod pacijenata na hemodijalizi" in Универзитет у Београду (2018),
https://hdl.handle.net/21.15107/rcub_nardus_10109 .

TY  - JOUR
AU  - Antunović, Tanja
AU  - Stefanović, Aleksandra
AU  - Gligorović-Barhanović, Najdana
AU  - Miljković, Milica
AU  - Radunović, Danilo
AU  - Ivanišević, Jasmina
AU  - Prelević, Vladimir
AU  - Bulatović, Nebojša
AU  - Ratković, Marina
AU  - Stojanov, Marina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2984
AB  - Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin. The overall all-cause mortality was 37.1% and CVD mortality 16.1%. By univariate and multivariate logistic regression, our findings suggest that good predictors of all-cause mortality include hsCRP and PAB (p lt .05) and of CVD mortality hsCRP (p lt .05) and hsTnI (p lt .001). To evaluate the relationship between the combined parameter measurements and all-cause/CVD mortality risk, patients were divided into three groups according to their PAB, hsCRP and hsTnI concentrations. The cutoffs for hsCRP and hsTnI and the median for PAB were used. Kaplan-Meier survival curves pointed out that the highest mortality risk of all-cause mortality was in the group with hsCRP levels above the cutoff and PAB levels above the median (p lt .001). The highest risk of CVD mortality was found in the group with hsCRP and hsTnI levels above the cutoff levels (p =.001). Our data suggest that hsCRP and PAB are very good predictors of all-cause mortality. For CVD complications and mortality prediction in HD patients, the most sensitive parameters appear to be hsTnI and hsCRP.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Reproductive Toxicology
T1  - Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up
VL  - 39
IS  - 1
SP  - 491
EP  - 499
DO  - 10.1080/0886022X.2017.1323645
ER  - 

@article{
author = "Antunović, Tanja and Stefanović, Aleksandra and Gligorović-Barhanović, Najdana and Miljković, Milica and Radunović, Danilo and Ivanišević, Jasmina and Prelević, Vladimir and Bulatović, Nebojša and Ratković, Marina and Stojanov, Marina",
year = "2017",
abstract = "Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin. The overall all-cause mortality was 37.1% and CVD mortality 16.1%. By univariate and multivariate logistic regression, our findings suggest that good predictors of all-cause mortality include hsCRP and PAB (p lt .05) and of CVD mortality hsCRP (p lt .05) and hsTnI (p lt .001). To evaluate the relationship between the combined parameter measurements and all-cause/CVD mortality risk, patients were divided into three groups according to their PAB, hsCRP and hsTnI concentrations. The cutoffs for hsCRP and hsTnI and the median for PAB were used. Kaplan-Meier survival curves pointed out that the highest mortality risk of all-cause mortality was in the group with hsCRP levels above the cutoff and PAB levels above the median (p lt .001). The highest risk of CVD mortality was found in the group with hsCRP and hsTnI levels above the cutoff levels (p =.001). Our data suggest that hsCRP and PAB are very good predictors of all-cause mortality. For CVD complications and mortality prediction in HD patients, the most sensitive parameters appear to be hsTnI and hsCRP.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Reproductive Toxicology",
title = "Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up",
volume = "39",
number = "1",
pages = "491-499",
doi = "10.1080/0886022X.2017.1323645"
}

Antunović, T., Stefanović, A., Gligorović-Barhanović, N., Miljković, M., Radunović, D., Ivanišević, J., Prelević, V., Bulatović, N., Ratković, M.,& Stojanov, M.. (2017). Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up. in Reproductive Toxicology
Taylor & Francis Ltd, Abingdon., 39(1), 491-499.
https://doi.org/10.1080/0886022X.2017.1323645

Antunović T, Stefanović A, Gligorović-Barhanović N, Miljković M, Radunović D, Ivanišević J, Prelević V, Bulatović N, Ratković M, Stojanov M. Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up. in Reproductive Toxicology. 2017;39(1):491-499.
doi:10.1080/0886022X.2017.1323645 .

Antunović, Tanja, Stefanović, Aleksandra, Gligorović-Barhanović, Najdana, Miljković, Milica, Radunović, Danilo, Ivanišević, Jasmina, Prelević, Vladimir, Bulatović, Nebojša, Ratković, Marina, Stojanov, Marina, "Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up" in Reproductive Toxicology, 39, no. 1 (2017):491-499,
https://doi.org/10.1080/0886022X.2017.1323645 . .

TY  - JOUR
AU  - Antunović, Tanja
AU  - Stefanović, Aleksandra
AU  - Ratković, Marina
AU  - Gledović, Branka
AU  - Gligorović-Barhanović, Najdana
AU  - Bozović, Dragica
AU  - Ivanišević, Jasmina
AU  - Prostran, Milica
AU  - Stojanov, Marina
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1974
AB  - We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p  lt  0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p  lt  0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p  lt  0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p  lt  0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.
PB  - Springer, Dordrecht
T2  - International Urology and Nephrology
T1  - High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
VL  - 45
IS  - 4
SP  - 1111
EP  - 1119
DO  - 10.1007/s11255-012-0233-x
ER  - 

@article{
author = "Antunović, Tanja and Stefanović, Aleksandra and Ratković, Marina and Gledović, Branka and Gligorović-Barhanović, Najdana and Bozović, Dragica and Ivanišević, Jasmina and Prostran, Milica and Stojanov, Marina",
year = "2013",
abstract = "We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p  lt  0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p  lt  0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p  lt  0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p  lt  0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.",
publisher = "Springer, Dordrecht",
journal = "International Urology and Nephrology",
title = "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients",
volume = "45",
number = "4",
pages = "1111-1119",
doi = "10.1007/s11255-012-0233-x"
}

Antunović, T., Stefanović, A., Ratković, M., Gledović, B., Gligorović-Barhanović, N., Bozović, D., Ivanišević, J., Prostran, M.,& Stojanov, M.. (2013). High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology
Springer, Dordrecht., 45(4), 1111-1119.
https://doi.org/10.1007/s11255-012-0233-x

Antunović T, Stefanović A, Ratković M, Gledović B, Gligorović-Barhanović N, Bozović D, Ivanišević J, Prostran M, Stojanov M. High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology. 2013;45(4):1111-1119.
doi:10.1007/s11255-012-0233-x .

Antunović, Tanja, Stefanović, Aleksandra, Ratković, Marina, Gledović, Branka, Gligorović-Barhanović, Najdana, Bozović, Dragica, Ivanišević, Jasmina, Prostran, Milica, Stojanov, Marina, "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients" in International Urology and Nephrology, 45, no. 4 (2013):1111-1119,
https://doi.org/10.1007/s11255-012-0233-x . .