TY  - JOUR
AU  - Jerotić, Đurđa
AU  - Matić, Marija
AU  - Suvakov, Sonja
AU  - Vučićević, Katarina
AU  - Damnjanović, Tatjana
AU  - Savić-Radojević, Ana
AU  - Plješa-Ercegovac, Marija
AU  - Ćorić, Vesna
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Jelić-Ivanović, Zorana
AU  - McClements, Lana
AU  - Dimković, Nada
AU  - Simić, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4825
AB  - The oxidative stress response via Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) interlinks inflammation- and metabolism-related pathways in chronic kidney disease. We assessed the association between polymorphisms in Nrf2, superoxide dismutase (SOD2), glutathione peroxidase (GPX1), and the risk of end-stage renal disease (ESRD). The modifying effect of these polymorphisms on both oxidative phenotype and ESRD prognosis, both independently and/or in combination with the glutathione S-transferase M1 (GSTM1) deletion polymorphism, was further analyzed. Polymorphisms in Nrf2 (rs6721961), SOD2 (rs4880), GPX1 (rs1050450), and GSTM1 were determined by PCR in 256 ESRD patients undergoing hemodialysis and 374 controls. Byproducts of oxidative stress were analyzed spectrophotometically or by ELISA. Time-to-event modeling was performed to evaluate overall survival and cardiovascular survival. The SOD2 Val/Val genotype increased ESRD risk (OR = 2.01, p = 0.002), which was even higher in combination with the GPX1 Leu/Leu genotype (OR = 3.27, p = 0.019). Polymorphism in SOD2 also showed an effect on oxidative phenotypes. Overall survival in ESRD patients was dependent on a combination of the Nrf2 (C/C) and GPX1 (Leu/Leu) genotypes in addition to a patients’ age and GSTM1 polymorphism. Similarly, the GPX1 (Leu/Leu) genotype contributed to longer cardiovascular survival. Conclusions: Our results show that SOD2, GPX1, and Nrf2 polymorphisms are associated with ESRD development and can predict survival.
PB  - MDPI
T2  - Toxins
T1  - Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients
VL  - 11
IS  - 7
DO  - 10.3390/toxins11070431
ER  - 

@article{
author = "Jerotić, Đurđa and Matić, Marija and Suvakov, Sonja and Vučićević, Katarina and Damnjanović, Tatjana and Savić-Radojević, Ana and Plješa-Ercegovac, Marija and Ćorić, Vesna and Stefanović, Aleksandra and Ivanišević, Jasmina and Jelić-Ivanović, Zorana and McClements, Lana and Dimković, Nada and Simić, Tatjana",
year = "2019",
abstract = "The oxidative stress response via Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) interlinks inflammation- and metabolism-related pathways in chronic kidney disease. We assessed the association between polymorphisms in Nrf2, superoxide dismutase (SOD2), glutathione peroxidase (GPX1), and the risk of end-stage renal disease (ESRD). The modifying effect of these polymorphisms on both oxidative phenotype and ESRD prognosis, both independently and/or in combination with the glutathione S-transferase M1 (GSTM1) deletion polymorphism, was further analyzed. Polymorphisms in Nrf2 (rs6721961), SOD2 (rs4880), GPX1 (rs1050450), and GSTM1 were determined by PCR in 256 ESRD patients undergoing hemodialysis and 374 controls. Byproducts of oxidative stress were analyzed spectrophotometically or by ELISA. Time-to-event modeling was performed to evaluate overall survival and cardiovascular survival. The SOD2 Val/Val genotype increased ESRD risk (OR = 2.01, p = 0.002), which was even higher in combination with the GPX1 Leu/Leu genotype (OR = 3.27, p = 0.019). Polymorphism in SOD2 also showed an effect on oxidative phenotypes. Overall survival in ESRD patients was dependent on a combination of the Nrf2 (C/C) and GPX1 (Leu/Leu) genotypes in addition to a patients’ age and GSTM1 polymorphism. Similarly, the GPX1 (Leu/Leu) genotype contributed to longer cardiovascular survival. Conclusions: Our results show that SOD2, GPX1, and Nrf2 polymorphisms are associated with ESRD development and can predict survival.",
publisher = "MDPI",
journal = "Toxins",
title = "Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients",
volume = "11",
number = "7",
doi = "10.3390/toxins11070431"
}

Jerotić, Đ., Matić, M., Suvakov, S., Vučićević, K., Damnjanović, T., Savić-Radojević, A., Plješa-Ercegovac, M., Ćorić, V., Stefanović, A., Ivanišević, J., Jelić-Ivanović, Z., McClements, L., Dimković, N.,& Simić, T.. (2019). Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients. in Toxins
MDPI., 11(7).
https://doi.org/10.3390/toxins11070431

Jerotić Đ, Matić M, Suvakov S, Vučićević K, Damnjanović T, Savić-Radojević A, Plješa-Ercegovac M, Ćorić V, Stefanović A, Ivanišević J, Jelić-Ivanović Z, McClements L, Dimković N, Simić T. Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients. in Toxins. 2019;11(7).
doi:10.3390/toxins11070431 .

Jerotić, Đurđa, Matić, Marija, Suvakov, Sonja, Vučićević, Katarina, Damnjanović, Tatjana, Savić-Radojević, Ana, Plješa-Ercegovac, Marija, Ćorić, Vesna, Stefanović, Aleksandra, Ivanišević, Jasmina, Jelić-Ivanović, Zorana, McClements, Lana, Dimković, Nada, Simić, Tatjana, "Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients" in Toxins, 11, no. 7 (2019),
https://doi.org/10.3390/toxins11070431 . .

TY  - CONF
AU  - Simić, Tatjana
AU  - Jerotić, D.
AU  - Matić, Marija
AU  - Šuvakov, Sonja
AU  - Vučićević, Katarina
AU  - Damjanović, Tatjana
AU  - Pljesa-Ercegovac, Marija
AU  - Savić-Radojević, Ana
AU  - Dimković, Nada
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3353
PB  - Elsevier Science Inc, New York
C3  - Free Radical Biology and Medicine
T1  - Effects of polymorphisms in Nrf2, SOD2 and GPX1 on biomarkers of oxidative distress and survival in dialysis patients: a step closer towards prognostic antioxidant multimarker panel
VL  - 139
IS  - Suppl. 1
SP  - S50
EP  - S50
DO  - 10.1016/j.freeradbiomed.2019.05.021
ER  - 

@conference{
author = "Simić, Tatjana and Jerotić, D. and Matić, Marija and Šuvakov, Sonja and Vučićević, Katarina and Damjanović, Tatjana and Pljesa-Ercegovac, Marija and Savić-Radojević, Ana and Dimković, Nada",
year = "2019",
publisher = "Elsevier Science Inc, New York",
journal = "Free Radical Biology and Medicine",
title = "Effects of polymorphisms in Nrf2, SOD2 and GPX1 on biomarkers of oxidative distress and survival in dialysis patients: a step closer towards prognostic antioxidant multimarker panel",
volume = "139",
number = "Suppl. 1",
pages = "S50-S50",
doi = "10.1016/j.freeradbiomed.2019.05.021"
}

Simić, T., Jerotić, D., Matić, M., Šuvakov, S., Vučićević, K., Damjanović, T., Pljesa-Ercegovac, M., Savić-Radojević, A.,& Dimković, N.. (2019). Effects of polymorphisms in Nrf2, SOD2 and GPX1 on biomarkers of oxidative distress and survival in dialysis patients: a step closer towards prognostic antioxidant multimarker panel. in Free Radical Biology and Medicine
Elsevier Science Inc, New York., 139(Suppl. 1), S50-S50.
https://doi.org/10.1016/j.freeradbiomed.2019.05.021

Simić T, Jerotić D, Matić M, Šuvakov S, Vučićević K, Damjanović T, Pljesa-Ercegovac M, Savić-Radojević A, Dimković N. Effects of polymorphisms in Nrf2, SOD2 and GPX1 on biomarkers of oxidative distress and survival in dialysis patients: a step closer towards prognostic antioxidant multimarker panel. in Free Radical Biology and Medicine. 2019;139(Suppl. 1):S50-S50.
doi:10.1016/j.freeradbiomed.2019.05.021 .

Simić, Tatjana, Jerotić, D., Matić, Marija, Šuvakov, Sonja, Vučićević, Katarina, Damjanović, Tatjana, Pljesa-Ercegovac, Marija, Savić-Radojević, Ana, Dimković, Nada, "Effects of polymorphisms in Nrf2, SOD2 and GPX1 on biomarkers of oxidative distress and survival in dialysis patients: a step closer towards prognostic antioxidant multimarker panel" in Free Radical Biology and Medicine, 139, no. Suppl. 1 (2019):S50-S50,
https://doi.org/10.1016/j.freeradbiomed.2019.05.021 . .

TY  - JOUR
AU  - Šuvakov, Sonja
AU  - Jerotić, D
AU  - Damjanović, Tatjana
AU  - Milić, N
AU  - Pekmezović, T
AU  - Đukić, Tatjana
AU  - Jelić-Ivanović, Zorana
AU  - Savić-Radojević, Ana
AU  - Pljesa-Ercegovac, Marija
AU  - Matić, Marija
AU  - McClements, L
AU  - Dimković, Nada
AU  - Garović, V.D
AU  - Albright, R.C
AU  - Simić, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3277
AB  - Introduction: Overall survival of patients with end-stage renal disease (ESRD) remains poor. Oxidative stress is one of the major risk factors associated with mortality in this patient group. As glutathione S-transferases (GST) are well-established antioxidants, we hypothesized that a model including GST gene polymorphisms, oxidative damage byproducts and cell adhesion markers has a prognostic role in ESRD patient survival. Methods: A prospective study of 199 patients with ESRD on haemodialysis was conducted. GST genotype, oxidative stress byproducts and cell adhesion molecules were measured in plasma. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to test the predictive ability of these parameters in the 8-year follow-up period. Results: GSTM1-null genotype was associated with significantly shorter overall (HR 1.6, p = 0.018) and cardiovascular-specific (HR 2.1, p = 0.010) survival. Oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) demonstrated a significant predictive role in terms of overall and cardiovascular survival. When 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/-sVCAM-1/sICAM-1) were combined into a scoring model, a significantly shorter overall and cardiovascular survival was observed for patients with the highest score (p  lt  0.001). Conclusion: We identified a novel panel of biomarkers that can be utilized in predicting survival in ESRD patients. This biomarker signature could enable better monitoring of patients and stratification into appropriate treatment groups.
PB  - S. Karger AG
T2  - American Journal of Nephrology
T1  - Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival
DO  - 10.1159/000501300
ER  - 

@article{
author = "Šuvakov, Sonja and Jerotić, D and Damjanović, Tatjana and Milić, N and Pekmezović, T and Đukić, Tatjana and Jelić-Ivanović, Zorana and Savić-Radojević, Ana and Pljesa-Ercegovac, Marija and Matić, Marija and McClements, L and Dimković, Nada and Garović, V.D and Albright, R.C and Simić, Tatjana",
year = "2019",
abstract = "Introduction: Overall survival of patients with end-stage renal disease (ESRD) remains poor. Oxidative stress is one of the major risk factors associated with mortality in this patient group. As glutathione S-transferases (GST) are well-established antioxidants, we hypothesized that a model including GST gene polymorphisms, oxidative damage byproducts and cell adhesion markers has a prognostic role in ESRD patient survival. Methods: A prospective study of 199 patients with ESRD on haemodialysis was conducted. GST genotype, oxidative stress byproducts and cell adhesion molecules were measured in plasma. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to test the predictive ability of these parameters in the 8-year follow-up period. Results: GSTM1-null genotype was associated with significantly shorter overall (HR 1.6, p = 0.018) and cardiovascular-specific (HR 2.1, p = 0.010) survival. Oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) demonstrated a significant predictive role in terms of overall and cardiovascular survival. When 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/-sVCAM-1/sICAM-1) were combined into a scoring model, a significantly shorter overall and cardiovascular survival was observed for patients with the highest score (p  lt  0.001). Conclusion: We identified a novel panel of biomarkers that can be utilized in predicting survival in ESRD patients. This biomarker signature could enable better monitoring of patients and stratification into appropriate treatment groups.",
publisher = "S. Karger AG",
journal = "American Journal of Nephrology",
title = "Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival",
doi = "10.1159/000501300"
}

Šuvakov, S., Jerotić, D., Damjanović, T., Milić, N., Pekmezović, T., Đukić, T., Jelić-Ivanović, Z., Savić-Radojević, A., Pljesa-Ercegovac, M., Matić, M., McClements, L., Dimković, N., Garović, V.D, Albright, R.C,& Simić, T.. (2019). Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival. in American Journal of Nephrology
S. Karger AG..
https://doi.org/10.1159/000501300

Šuvakov S, Jerotić D, Damjanović T, Milić N, Pekmezović T, Đukić T, Jelić-Ivanović Z, Savić-Radojević A, Pljesa-Ercegovac M, Matić M, McClements L, Dimković N, Garović V, Albright R, Simić T. Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival. in American Journal of Nephrology. 2019;.
doi:10.1159/000501300 .

Šuvakov, Sonja, Jerotić, D, Damjanović, Tatjana, Milić, N, Pekmezović, T, Đukić, Tatjana, Jelić-Ivanović, Zorana, Savić-Radojević, Ana, Pljesa-Ercegovac, Marija, Matić, Marija, McClements, L, Dimković, Nada, Garović, V.D, Albright, R.C, Simić, Tatjana, "Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival" in American Journal of Nephrology (2019),
https://doi.org/10.1159/000501300 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Martinović, Milica
AU  - Matić, Marija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3039
AB  - Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.
PB  - Springer, New York
T2  - Eating and Weight Disorders
T1  - The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
VL  - 23
IS  - 1
SP  - 133
EP  - 141
DO  - 10.1007/s40519-016-0325-1
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Martinović, Milica and Matić, Marija",
year = "2018",
abstract = "Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.",
publisher = "Springer, New York",
journal = "Eating and Weight Disorders",
title = "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women",
volume = "23",
number = "1",
pages = "133-141",
doi = "10.1007/s40519-016-0325-1"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Martinović, M.,& Matić, M.. (2018). The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders
Springer, New York., 23(1), 133-141.
https://doi.org/10.1007/s40519-016-0325-1

Klisić A, Kotur-Stevuljević J, Kavarić N, Martinović M, Matić M. The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders. 2018;23(1):133-141.
doi:10.1007/s40519-016-0325-1 .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Martinović, Milica, Matić, Marija, "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women" in Eating and Weight Disorders, 23, no. 1 (2018):133-141,
https://doi.org/10.1007/s40519-016-0325-1 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Matić, Marija
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2640
AB  - Background: We alined to examine the relationship between high levels of cystatin C, retinol-binding protein 4 (RBP4) and cardiovascular risk score [determined by Framingham Risk Score (FRS)] in postmenopausal women. Methods: A total 01 apparently healthy 129 postmenopausal Women (mean age 57.1 +/- 4.6 years) were included. Serum cystatin C, RBP4, glucose, lipid parameters, creatinine, uric acid and high sensitivity C-reactive protein (hsCRP) were determined. Anthropometric parameters and blood pressure were also obtained. FRS was calculated. Multiple linear regression analysis (MLR) was performed to identify independent factors affecting FRS and to estimate the final predictors of its variability. Receiver Operating Characteristic (ROC) curve analysis was used with the purpose of testing discriminatory potential of a group of parameters selected in MLR analysis, with FRS level as dependent variable. Results: We found Significantly higher levels of both proteins, cystatin C (P = 0.001) and RBP4 (P = 0.006), in the FRS higher (medium and high) risk groups (FRS >= 10%) compared to low risk FRS group (FRS  lt  10%). MLR revealed the best model consisting of 4 parameters (e.g., body mass indek (BMI) (P  lt  0.001), triglycerides (TG) (P = 0.004), RBP4 (P = 0.021), and cystatin C (P = 0.046), R-2-adjusted = 0.347) for FRS prediction. Cbnstruction of a model consisted of those 4 FRS formula independent parameters (BMI, TG, cystatin C and RBP4) using logistic regression analysis showed that new ROC curve had excellent discriminatory capability (area under the curve = 0.820). Conclusion: High cystatin C and retinol-binding protein 4 may contribute significantly to cardiovascular risk burden in addition to traditional cardiovascular markets.
PB  - Acad Medical Sciences I R Iran, Tehran
T2  - Archives of Iranian Medicine
T1  - Relationship between Cystatin C, Retinol-binding Protein 4 and Framingham Risk Score in Healthy Postmenopausal Women
VL  - 19
IS  - 12
SP  - 845
EP  - 851
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2640
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Matić, Marija",
year = "2016",
abstract = "Background: We alined to examine the relationship between high levels of cystatin C, retinol-binding protein 4 (RBP4) and cardiovascular risk score [determined by Framingham Risk Score (FRS)] in postmenopausal women. Methods: A total 01 apparently healthy 129 postmenopausal Women (mean age 57.1 +/- 4.6 years) were included. Serum cystatin C, RBP4, glucose, lipid parameters, creatinine, uric acid and high sensitivity C-reactive protein (hsCRP) were determined. Anthropometric parameters and blood pressure were also obtained. FRS was calculated. Multiple linear regression analysis (MLR) was performed to identify independent factors affecting FRS and to estimate the final predictors of its variability. Receiver Operating Characteristic (ROC) curve analysis was used with the purpose of testing discriminatory potential of a group of parameters selected in MLR analysis, with FRS level as dependent variable. Results: We found Significantly higher levels of both proteins, cystatin C (P = 0.001) and RBP4 (P = 0.006), in the FRS higher (medium and high) risk groups (FRS >= 10%) compared to low risk FRS group (FRS  lt  10%). MLR revealed the best model consisting of 4 parameters (e.g., body mass indek (BMI) (P  lt  0.001), triglycerides (TG) (P = 0.004), RBP4 (P = 0.021), and cystatin C (P = 0.046), R-2-adjusted = 0.347) for FRS prediction. Cbnstruction of a model consisted of those 4 FRS formula independent parameters (BMI, TG, cystatin C and RBP4) using logistic regression analysis showed that new ROC curve had excellent discriminatory capability (area under the curve = 0.820). Conclusion: High cystatin C and retinol-binding protein 4 may contribute significantly to cardiovascular risk burden in addition to traditional cardiovascular markets.",
publisher = "Acad Medical Sciences I R Iran, Tehran",
journal = "Archives of Iranian Medicine",
title = "Relationship between Cystatin C, Retinol-binding Protein 4 and Framingham Risk Score in Healthy Postmenopausal Women",
volume = "19",
number = "12",
pages = "845-851",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2640"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N.,& Matić, M.. (2016). Relationship between Cystatin C, Retinol-binding Protein 4 and Framingham Risk Score in Healthy Postmenopausal Women. in Archives of Iranian Medicine
Acad Medical Sciences I R Iran, Tehran., 19(12), 845-851.
https://hdl.handle.net/21.15107/rcub_farfar_2640

Klisić A, Kotur-Stevuljević J, Kavarić N, Matić M. Relationship between Cystatin C, Retinol-binding Protein 4 and Framingham Risk Score in Healthy Postmenopausal Women. in Archives of Iranian Medicine. 2016;19(12):845-851.
https://hdl.handle.net/21.15107/rcub_farfar_2640 .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Matić, Marija, "Relationship between Cystatin C, Retinol-binding Protein 4 and Framingham Risk Score in Healthy Postmenopausal Women" in Archives of Iranian Medicine, 19, no. 12 (2016):845-851,
https://hdl.handle.net/21.15107/rcub_farfar_2640 .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Damjanović, Tatjana
AU  - Šuvakov, Sonja
AU  - Matić, Marija
AU  - Savić-Radojević, Ana
AU  - Simić, Tatjana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Gojković, Tamara
AU  - Spasić, Slavica
AU  - Dimković, Nada
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2157
AB  - Objectives: End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD. Design and methods: GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods. Results: GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P  lt  0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P  lt  0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P  lt  0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P  lt  0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P  lt  0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P  lt  0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions. Conclusions: Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients
VL  - 47
IS  - 6
SP  - 398
EP  - 403
DO  - 10.1016/j.clinbiochem.2013.11.011
ER  - 

@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Damjanović, Tatjana and Šuvakov, Sonja and Matić, Marija and Savić-Radojević, Ana and Simić, Tatjana and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Spasić, Slavica and Dimković, Nada",
year = "2014",
abstract = "Objectives: End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD. Design and methods: GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods. Results: GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P  lt  0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P  lt  0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P  lt  0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P  lt  0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P  lt  0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P  lt  0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions. Conclusions: Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients",
volume = "47",
number = "6",
pages = "398-403",
doi = "10.1016/j.clinbiochem.2013.11.011"
}

Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Damjanović, T., Šuvakov, S., Matić, M., Savić-Radojević, A., Simić, T., Spasojević-Kalimanovska, V., Gojković, T., Spasić, S.,& Dimković, N.. (2014). Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 47(6), 398-403.
https://doi.org/10.1016/j.clinbiochem.2013.11.011

Vekić J, Zeljković A, Jelić-Ivanović Z, Damjanović T, Šuvakov S, Matić M, Savić-Radojević A, Simić T, Spasojević-Kalimanovska V, Gojković T, Spasić S, Dimković N. Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients. in Clinical Biochemistry. 2014;47(6):398-403.
doi:10.1016/j.clinbiochem.2013.11.011 .

Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Damjanović, Tatjana, Šuvakov, Sonja, Matić, Marija, Savić-Radojević, Ana, Simić, Tatjana, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Spasić, Slavica, Dimković, Nada, "Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients" in Clinical Biochemistry, 47, no. 6 (2014):398-403,
https://doi.org/10.1016/j.clinbiochem.2013.11.011 . .

TY  - JOUR
AU  - Šuvakov, Sonja
AU  - Damjanović, Tatjana
AU  - Stefanović, Aleksandra
AU  - Pekmezović, Tatjana
AU  - Savić-Radojević, Ana
AU  - Pljesa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Đukić, Tatjana
AU  - Corić, Vesna
AU  - Jakovljević, Jovana
AU  - Ivanišević, Jasmina
AU  - Plješa, Steva
AU  - Jelić-Ivanović, Zorana
AU  - Mimić-Oka, Jasmina
AU  - Dimković, Nada
AU  - Simić, Tatjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1949
AB  - Background. Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. We hypothesized that genetic polymorphism in antioxidant enzymes GSTA1, GSTM1, GSTP1 and GSTT1 is more frequent in ESRD and modulates the degree of oxidative stress in these patients. Methods. GSTA1, GSTM1, GSTP1 and GSTT1 genotypes were determined in 199 ESRD patients and 199 age- and gender-matched controls. Markers of protein and lipid oxidative damage [thiol groups, carbonyl groups, advanced oxidative protein products, nitrotyrosine, malondialdehyde (MDA) and MDA adducts], together with total oxidant status and pro-oxidant antioxidant balance were determined. Results. Individual GST polymorphisms influence vulnerability to both protein and lipid oxidation, with GSTM1-null gene variant having the most pronounced effect. Furthermore, a strong combined effect of null/low-activity GSTM1, GSM, GSTA1 and GSTP1 genotypes in terms of susceptibility towards oxidative and carbonyl stress was found in ESRD patients. When patients were stratified according to GSTM1 and GSTT1, the highest oxidant damage was noted in those with the GSTM1-null/GSTT1-null genotype. The observed effect was even stronger in patients with the third low-activity GSTP1 or GSTA1 genotype. Finally, the level of oxidative and carbonyl stress was most pronounced in the subgroup of patients with all four null or low-activity GSTM1, GSTT1, GSTP1 and GSTA1 genotypes. Conclusions. According to the GST genotype, ESRD patients may be stratified in terms of the level of oxidative and carbonyl stress that might influence cardiovascular prognosis, but could also improve efforts towards individualization of antioxidant treatment.
PB  - Oxford Univ Press, Oxford
T2  - Nephrology Dialysis Transplantation
T1  - Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients
VL  - 28
IS  - 1
SP  - 202
EP  - 212
DO  - 10.1093/ndt/gfs369
ER  - 

@article{
author = "Šuvakov, Sonja and Damjanović, Tatjana and Stefanović, Aleksandra and Pekmezović, Tatjana and Savić-Radojević, Ana and Pljesa-Ercegovac, Marija and Matić, Marija and Đukić, Tatjana and Corić, Vesna and Jakovljević, Jovana and Ivanišević, Jasmina and Plješa, Steva and Jelić-Ivanović, Zorana and Mimić-Oka, Jasmina and Dimković, Nada and Simić, Tatjana",
year = "2013",
abstract = "Background. Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. We hypothesized that genetic polymorphism in antioxidant enzymes GSTA1, GSTM1, GSTP1 and GSTT1 is more frequent in ESRD and modulates the degree of oxidative stress in these patients. Methods. GSTA1, GSTM1, GSTP1 and GSTT1 genotypes were determined in 199 ESRD patients and 199 age- and gender-matched controls. Markers of protein and lipid oxidative damage [thiol groups, carbonyl groups, advanced oxidative protein products, nitrotyrosine, malondialdehyde (MDA) and MDA adducts], together with total oxidant status and pro-oxidant antioxidant balance were determined. Results. Individual GST polymorphisms influence vulnerability to both protein and lipid oxidation, with GSTM1-null gene variant having the most pronounced effect. Furthermore, a strong combined effect of null/low-activity GSTM1, GSM, GSTA1 and GSTP1 genotypes in terms of susceptibility towards oxidative and carbonyl stress was found in ESRD patients. When patients were stratified according to GSTM1 and GSTT1, the highest oxidant damage was noted in those with the GSTM1-null/GSTT1-null genotype. The observed effect was even stronger in patients with the third low-activity GSTP1 or GSTA1 genotype. Finally, the level of oxidative and carbonyl stress was most pronounced in the subgroup of patients with all four null or low-activity GSTM1, GSTT1, GSTP1 and GSTA1 genotypes. Conclusions. According to the GST genotype, ESRD patients may be stratified in terms of the level of oxidative and carbonyl stress that might influence cardiovascular prognosis, but could also improve efforts towards individualization of antioxidant treatment.",
publisher = "Oxford Univ Press, Oxford",
journal = "Nephrology Dialysis Transplantation",
title = "Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients",
volume = "28",
number = "1",
pages = "202-212",
doi = "10.1093/ndt/gfs369"
}

Šuvakov, S., Damjanović, T., Stefanović, A., Pekmezović, T., Savić-Radojević, A., Pljesa-Ercegovac, M., Matić, M., Đukić, T., Corić, V., Jakovljević, J., Ivanišević, J., Plješa, S., Jelić-Ivanović, Z., Mimić-Oka, J., Dimković, N.,& Simić, T.. (2013). Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients. in Nephrology Dialysis Transplantation
Oxford Univ Press, Oxford., 28(1), 202-212.
https://doi.org/10.1093/ndt/gfs369

Šuvakov S, Damjanović T, Stefanović A, Pekmezović T, Savić-Radojević A, Pljesa-Ercegovac M, Matić M, Đukić T, Corić V, Jakovljević J, Ivanišević J, Plješa S, Jelić-Ivanović Z, Mimić-Oka J, Dimković N, Simić T. Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients. in Nephrology Dialysis Transplantation. 2013;28(1):202-212.
doi:10.1093/ndt/gfs369 .

Šuvakov, Sonja, Damjanović, Tatjana, Stefanović, Aleksandra, Pekmezović, Tatjana, Savić-Radojević, Ana, Pljesa-Ercegovac, Marija, Matić, Marija, Đukić, Tatjana, Corić, Vesna, Jakovljević, Jovana, Ivanišević, Jasmina, Plješa, Steva, Jelić-Ivanović, Zorana, Mimić-Oka, Jasmina, Dimković, Nada, Simić, Tatjana, "Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients" in Nephrology Dialysis Transplantation, 28, no. 1 (2013):202-212,
https://doi.org/10.1093/ndt/gfs369 . .