TY  - JOUR
AU  - Gligorović-Barhanović, Najdana
AU  - Antunović, Tanja
AU  - Kavarić, Sreten
AU  - Đogo, Aleksandar
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3321
AB  - Background: Laboratory thyroid function tests play a central role in the diagnosis of thyroid disorders. The aim of our cross-sectional study was to determine reference values for thyroid tests in a rigorously selected group of Montenegrin females, investigate the impact of possible age-related changes and the influence of the interassay bias between three frequently used immunoassays. Methods: Female subjects were randomly selected, aged between 20 and 69 and 946 of them met the selection criteria. TSH, fT3, fT4, thyroid peroxidase and thyroglobulin antibodies were measured. Eighty samples were further analyzed on two other immunochemistry platforms. Results: Median TSH progressively increased with age, there was no difference in fT3, while fT4 was significantly higher in the two oldest groups compared to the others. When using the age-related 97.5 percentile of TSH the percentage of reclassification was highest in the 20-29 years of age group (5.2%, p lt 0.05). In the oldest band, 7.7% had TSH values above cohort-specific and below the age-related upper reference limit. Bland-Altman bias plots revealed the highest interassay absolute mean difference between compared TSH assays of 24.5% and for fT4 assays of 13.8%. Conclusions: The correlation coefficients between fT3 assays from different manufacturers were low. Serum TSH and fT4 concentrations increased with age and the implementation of age-specific TSH reference intervals would be of interest. The bias between the three commercial immunoassays indicated that the standardization of thyroid function tests is a task of great importance.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Age and assay related changes of laboratory thyroid function tests in the reference female population
VL  - 38
IS  - 1
SP  - 22
EP  - 32
DO  - 10.2478/jomb-2018-0020
ER  - 

@article{
author = "Gligorović-Barhanović, Najdana and Antunović, Tanja and Kavarić, Sreten and Đogo, Aleksandar and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background: Laboratory thyroid function tests play a central role in the diagnosis of thyroid disorders. The aim of our cross-sectional study was to determine reference values for thyroid tests in a rigorously selected group of Montenegrin females, investigate the impact of possible age-related changes and the influence of the interassay bias between three frequently used immunoassays. Methods: Female subjects were randomly selected, aged between 20 and 69 and 946 of them met the selection criteria. TSH, fT3, fT4, thyroid peroxidase and thyroglobulin antibodies were measured. Eighty samples were further analyzed on two other immunochemistry platforms. Results: Median TSH progressively increased with age, there was no difference in fT3, while fT4 was significantly higher in the two oldest groups compared to the others. When using the age-related 97.5 percentile of TSH the percentage of reclassification was highest in the 20-29 years of age group (5.2%, p lt 0.05). In the oldest band, 7.7% had TSH values above cohort-specific and below the age-related upper reference limit. Bland-Altman bias plots revealed the highest interassay absolute mean difference between compared TSH assays of 24.5% and for fT4 assays of 13.8%. Conclusions: The correlation coefficients between fT3 assays from different manufacturers were low. Serum TSH and fT4 concentrations increased with age and the implementation of age-specific TSH reference intervals would be of interest. The bias between the three commercial immunoassays indicated that the standardization of thyroid function tests is a task of great importance.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Age and assay related changes of laboratory thyroid function tests in the reference female population",
volume = "38",
number = "1",
pages = "22-32",
doi = "10.2478/jomb-2018-0020"
}

Gligorović-Barhanović, N., Antunović, T., Kavarić, S., Đogo, A.,& Spasojević-Kalimanovska, V.. (2019). Age and assay related changes of laboratory thyroid function tests in the reference female population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(1), 22-32.
https://doi.org/10.2478/jomb-2018-0020

Gligorović-Barhanović N, Antunović T, Kavarić S, Đogo A, Spasojević-Kalimanovska V. Age and assay related changes of laboratory thyroid function tests in the reference female population. in Journal of Medical Biochemistry. 2019;38(1):22-32.
doi:10.2478/jomb-2018-0020 .

Gligorović-Barhanović, Najdana, Antunović, Tanja, Kavarić, Sreten, Đogo, Aleksandar, Spasojević-Kalimanovska, Vesna, "Age and assay related changes of laboratory thyroid function tests in the reference female population" in Journal of Medical Biochemistry, 38, no. 1 (2019):22-32,
https://doi.org/10.2478/jomb-2018-0020 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Soldatović, Ivan
AU  - Gligorović-Barhanović, Najdana
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2800
AB  - Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI  lt  30, n = 80; 30 = FLI  lt  60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p  lt  0.001), and retinol-binding protein 4 (beta = 0.226, p  lt  0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women.
PB  - Termedia Publishing House Ltd, Poznan
T2  - Archives of Medical Science
T1  - Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women
VL  - 13
IS  - 5
SP  - 1188
EP  - 1196
DO  - 10.5114/aoms.2017.68972
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Jovanović, Milovan and Soldatović, Ivan and Gligorović-Barhanović, Najdana and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI  lt  30, n = 80; 30 = FLI  lt  60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p  lt  0.001), and retinol-binding protein 4 (beta = 0.226, p  lt  0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women.",
publisher = "Termedia Publishing House Ltd, Poznan",
journal = "Archives of Medical Science",
title = "Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women",
volume = "13",
number = "5",
pages = "1188-1196",
doi = "10.5114/aoms.2017.68972"
}

Klisić, A., Kavarić, N., Jovanović, M., Soldatović, I., Gligorović-Barhanović, N.,& Kotur-Stevuljević, J.. (2017). Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women. in Archives of Medical Science
Termedia Publishing House Ltd, Poznan., 13(5), 1188-1196.
https://doi.org/10.5114/aoms.2017.68972

Klisić A, Kavarić N, Jovanović M, Soldatović I, Gligorović-Barhanović N, Kotur-Stevuljević J. Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women. in Archives of Medical Science. 2017;13(5):1188-1196.
doi:10.5114/aoms.2017.68972 .

Klisić, Aleksandra, Kavarić, Nebojša, Jovanović, Milovan, Soldatović, Ivan, Gligorović-Barhanović, Najdana, Kotur-Stevuljević, Jelena, "Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women" in Archives of Medical Science, 13, no. 5 (2017):1188-1196,
https://doi.org/10.5114/aoms.2017.68972 . .

TY  - JOUR
AU  - Antunović, Tanja
AU  - Stefanović, Aleksandra
AU  - Gligorović-Barhanović, Najdana
AU  - Miljković, Milica
AU  - Radunović, Danilo
AU  - Ivanišević, Jasmina
AU  - Prelević, Vladimir
AU  - Bulatović, Nebojša
AU  - Ratković, Marina
AU  - Stojanov, Marina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2984
AB  - Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin. The overall all-cause mortality was 37.1% and CVD mortality 16.1%. By univariate and multivariate logistic regression, our findings suggest that good predictors of all-cause mortality include hsCRP and PAB (p lt .05) and of CVD mortality hsCRP (p lt .05) and hsTnI (p lt .001). To evaluate the relationship between the combined parameter measurements and all-cause/CVD mortality risk, patients were divided into three groups according to their PAB, hsCRP and hsTnI concentrations. The cutoffs for hsCRP and hsTnI and the median for PAB were used. Kaplan-Meier survival curves pointed out that the highest mortality risk of all-cause mortality was in the group with hsCRP levels above the cutoff and PAB levels above the median (p lt .001). The highest risk of CVD mortality was found in the group with hsCRP and hsTnI levels above the cutoff levels (p =.001). Our data suggest that hsCRP and PAB are very good predictors of all-cause mortality. For CVD complications and mortality prediction in HD patients, the most sensitive parameters appear to be hsTnI and hsCRP.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Reproductive Toxicology
T1  - Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up
VL  - 39
IS  - 1
SP  - 491
EP  - 499
DO  - 10.1080/0886022X.2017.1323645
ER  - 

@article{
author = "Antunović, Tanja and Stefanović, Aleksandra and Gligorović-Barhanović, Najdana and Miljković, Milica and Radunović, Danilo and Ivanišević, Jasmina and Prelević, Vladimir and Bulatović, Nebojša and Ratković, Marina and Stojanov, Marina",
year = "2017",
abstract = "Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin. The overall all-cause mortality was 37.1% and CVD mortality 16.1%. By univariate and multivariate logistic regression, our findings suggest that good predictors of all-cause mortality include hsCRP and PAB (p lt .05) and of CVD mortality hsCRP (p lt .05) and hsTnI (p lt .001). To evaluate the relationship between the combined parameter measurements and all-cause/CVD mortality risk, patients were divided into three groups according to their PAB, hsCRP and hsTnI concentrations. The cutoffs for hsCRP and hsTnI and the median for PAB were used. Kaplan-Meier survival curves pointed out that the highest mortality risk of all-cause mortality was in the group with hsCRP levels above the cutoff and PAB levels above the median (p lt .001). The highest risk of CVD mortality was found in the group with hsCRP and hsTnI levels above the cutoff levels (p =.001). Our data suggest that hsCRP and PAB are very good predictors of all-cause mortality. For CVD complications and mortality prediction in HD patients, the most sensitive parameters appear to be hsTnI and hsCRP.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Reproductive Toxicology",
title = "Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up",
volume = "39",
number = "1",
pages = "491-499",
doi = "10.1080/0886022X.2017.1323645"
}

Antunović, T., Stefanović, A., Gligorović-Barhanović, N., Miljković, M., Radunović, D., Ivanišević, J., Prelević, V., Bulatović, N., Ratković, M.,& Stojanov, M.. (2017). Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up. in Reproductive Toxicology
Taylor & Francis Ltd, Abingdon., 39(1), 491-499.
https://doi.org/10.1080/0886022X.2017.1323645

Antunović T, Stefanović A, Gligorović-Barhanović N, Miljković M, Radunović D, Ivanišević J, Prelević V, Bulatović N, Ratković M, Stojanov M. Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up. in Reproductive Toxicology. 2017;39(1):491-499.
doi:10.1080/0886022X.2017.1323645 .

Antunović, Tanja, Stefanović, Aleksandra, Gligorović-Barhanović, Najdana, Miljković, Milica, Radunović, Danilo, Ivanišević, Jasmina, Prelević, Vladimir, Bulatović, Nebojša, Ratković, Marina, Stojanov, Marina, "Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up" in Reproductive Toxicology, 39, no. 1 (2017):491-499,
https://doi.org/10.1080/0886022X.2017.1323645 . .

TY  - JOUR
AU  - Antunović, Tanja
AU  - Stefanović, Aleksandra
AU  - Ratković, Marina
AU  - Gledović, Branka
AU  - Gligorović-Barhanović, Najdana
AU  - Bozović, Dragica
AU  - Ivanišević, Jasmina
AU  - Prostran, Milica
AU  - Stojanov, Marina
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1974
AB  - We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p  lt  0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p  lt  0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p  lt  0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p  lt  0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.
PB  - Springer, Dordrecht
T2  - International Urology and Nephrology
T1  - High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
VL  - 45
IS  - 4
SP  - 1111
EP  - 1119
DO  - 10.1007/s11255-012-0233-x
ER  - 

@article{
author = "Antunović, Tanja and Stefanović, Aleksandra and Ratković, Marina and Gledović, Branka and Gligorović-Barhanović, Najdana and Bozović, Dragica and Ivanišević, Jasmina and Prostran, Milica and Stojanov, Marina",
year = "2013",
abstract = "We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p  lt  0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p  lt  0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p  lt  0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p  lt  0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.",
publisher = "Springer, Dordrecht",
journal = "International Urology and Nephrology",
title = "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients",
volume = "45",
number = "4",
pages = "1111-1119",
doi = "10.1007/s11255-012-0233-x"
}

Antunović, T., Stefanović, A., Ratković, M., Gledović, B., Gligorović-Barhanović, N., Bozović, D., Ivanišević, J., Prostran, M.,& Stojanov, M.. (2013). High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology
Springer, Dordrecht., 45(4), 1111-1119.
https://doi.org/10.1007/s11255-012-0233-x

Antunović T, Stefanović A, Ratković M, Gledović B, Gligorović-Barhanović N, Bozović D, Ivanišević J, Prostran M, Stojanov M. High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology. 2013;45(4):1111-1119.
doi:10.1007/s11255-012-0233-x .

Antunović, Tanja, Stefanović, Aleksandra, Ratković, Marina, Gledović, Branka, Gligorović-Barhanović, Najdana, Bozović, Dragica, Ivanišević, Jasmina, Prostran, Milica, Stojanov, Marina, "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients" in International Urology and Nephrology, 45, no. 4 (2013):1111-1119,
https://doi.org/10.1007/s11255-012-0233-x . .