TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Jelić-Ivanović, Zorana
AU  - Pejović, Biljana
AU  - Peco-Antić, Amira
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2998
AB  - Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates
VL  - 272
SP  - 47
EP  - 52
DO  - 10.1016/j.cbi.2017.04.014
ER  - 

@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Miljković, Milica and Jelić-Ivanović, Zorana and Pejović, Biljana and Peco-Antić, Amira",
year = "2017",
abstract = "Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates",
volume = "272",
pages = "47-52",
doi = "10.1016/j.cbi.2017.04.014"
}

Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Miljković, M., Jelić-Ivanović, Z., Pejović, B.,& Peco-Antić, A.. (2017). Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 272, 47-52.
https://doi.org/10.1016/j.cbi.2017.04.014

Ivanišević J, Kotur-Stevuljević J, Stefanović A, Miljković M, Jelić-Ivanović Z, Pejović B, Peco-Antić A. Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates. in Chemico-Biological Interactions. 2017;272:47-52.
doi:10.1016/j.cbi.2017.04.014 .

Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Miljković, Milica, Jelić-Ivanović, Zorana, Pejović, Biljana, Peco-Antić, Amira, "Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates" in Chemico-Biological Interactions, 272 (2017):47-52,
https://doi.org/10.1016/j.cbi.2017.04.014 . .

TY  - JOUR
AU  - Pejović, Biljana
AU  - Erić-Marinković, Jelena
AU  - Pejović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2329
AB  - Introduction: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. Materials and methods: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase >= 26.5 mu mol/L from baseline (the lowest previous sCr). According to the increase of sCr, AKI patients were divided in AKIN1 (sCr increase up to 1.9 baseline) and AKIN2 (sCr increase from 2.0 to 2.9 baseline). sNGAL levels were measured on DOL 1, 3 and 7. Results: AKI was diagnosed in 73 (0.676) of 108 enrolled premature asphyxiated neonates. Sixty one patients (0.836) were classified in AKIN1 and 12 patients (0.164) in AKIN2. sNGAL reached the maximal concentrations on DOL 1 within 4 hours after admission to NICU, being higher in AKI compared with no-AKI group (160.8 +/- 113.1 vs. 87.1 +/- 81.6; P  lt  0.001) as well as in AKIN2 compared with AKIN1 group (222.8 +/- 112.9 vs. 147.8 +/- 109.9; P  lt  0.001). The best areas under the receiver operating characteristic curves (AUC) for prediction of AKI were 0.72 [95% (0.62-0.80) P  lt  0.001] on DOL1 at 2h and 0.72 [95% (0.63-0.80) P  lt  0.001] at 4th hour after admission respectively. The corresponding sNGAL cutoff concentrations were 84.87 ng/mL (sensitivity 69.0% and specificity 71.9%) and 89.43 ng/mL (sensitivity 65.7% and specificity 74.3%). Conclusions: In premature asphyxiated neonates sNGAL measured within the first 4 hours of DOL 1 is predictive of the occurrence and severity of AKI. Therefore, plasma levels of NGAL may be used for early diagnosis of AKI in these patients.
PB  - Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
T2  - Biochemia Medica
T1  - Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker
VL  - 25
IS  - 3
SP  - 450
EP  - 459
DO  - 10.11613/BM.2015.046
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2329
ER  - 

@article{
author = "Pejović, Biljana and Erić-Marinković, Jelena and Pejović, Marija and Kotur-Stevuljević, Jelena and Peco-Antić, Amira",
year = "2015",
abstract = "Introduction: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. Materials and methods: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase >= 26.5 mu mol/L from baseline (the lowest previous sCr). According to the increase of sCr, AKI patients were divided in AKIN1 (sCr increase up to 1.9 baseline) and AKIN2 (sCr increase from 2.0 to 2.9 baseline). sNGAL levels were measured on DOL 1, 3 and 7. Results: AKI was diagnosed in 73 (0.676) of 108 enrolled premature asphyxiated neonates. Sixty one patients (0.836) were classified in AKIN1 and 12 patients (0.164) in AKIN2. sNGAL reached the maximal concentrations on DOL 1 within 4 hours after admission to NICU, being higher in AKI compared with no-AKI group (160.8 +/- 113.1 vs. 87.1 +/- 81.6; P  lt  0.001) as well as in AKIN2 compared with AKIN1 group (222.8 +/- 112.9 vs. 147.8 +/- 109.9; P  lt  0.001). The best areas under the receiver operating characteristic curves (AUC) for prediction of AKI were 0.72 [95% (0.62-0.80) P  lt  0.001] on DOL1 at 2h and 0.72 [95% (0.63-0.80) P  lt  0.001] at 4th hour after admission respectively. The corresponding sNGAL cutoff concentrations were 84.87 ng/mL (sensitivity 69.0% and specificity 71.9%) and 89.43 ng/mL (sensitivity 65.7% and specificity 74.3%). Conclusions: In premature asphyxiated neonates sNGAL measured within the first 4 hours of DOL 1 is predictive of the occurrence and severity of AKI. Therefore, plasma levels of NGAL may be used for early diagnosis of AKI in these patients.",
publisher = "Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb",
journal = "Biochemia Medica",
title = "Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker",
volume = "25",
number = "3",
pages = "450-459",
doi = "10.11613/BM.2015.046",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2329"
}

Pejović, B., Erić-Marinković, J., Pejović, M., Kotur-Stevuljević, J.,& Peco-Antić, A.. (2015). Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker. in Biochemia Medica
Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb., 25(3), 450-459.
https://doi.org/10.11613/BM.2015.046
https://hdl.handle.net/21.15107/rcub_farfar_2329

Pejović B, Erić-Marinković J, Pejović M, Kotur-Stevuljević J, Peco-Antić A. Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker. in Biochemia Medica. 2015;25(3):450-459.
doi:10.11613/BM.2015.046
https://hdl.handle.net/21.15107/rcub_farfar_2329 .

Pejović, Biljana, Erić-Marinković, Jelena, Pejović, Marija, Kotur-Stevuljević, Jelena, Peco-Antić, Amira, "Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker" in Biochemia Medica, 25, no. 3 (2015):450-459,
https://doi.org/10.11613/BM.2015.046 .,
https://hdl.handle.net/21.15107/rcub_farfar_2329 .